668 results about "Miscibility" patented technology

Methods and compositions for systemically or locally administering a beneficial agent to a subject are described, and include, for example, implantable elastomeric depot compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible, elastomeric polymer, a biocompatible solvent having low water miscibility that forms an elastomeric viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

The instant invention provides a method for improving the miscibility of the lower molecular weight unsaturated siloxane-polyether copolymers with the alpha , omega -divinylpolysiloxanes without loss of storage stability, or delay of cure at the vulcanization temperature, or loss of permanent hydrophilicity or other desirable features of the cured polysiloxane. The compositions of the present invention comprise one or more alpha , omega -divinylpolysiloxanes, unsaturated polysiloxane-polyether copolymers having from 2 to 5 silicon atoms per molecule which are preferably trisiloxanes, and a compatibilizing additive. The permanently hydrophilic, rapidly wettable polysiloxane compositions yield static water contact angles <50 DEG dynamic advancing contact angles of less than about 100.

The invention relates to derivatized, well-dispersed CNTs that have enhanced miscibility with organic agents. Composite materials may be made using such CNTs. The composite materials, in turn, may be used in optical and electronic applications.

Injectable depot compositions are provided that include a polymer matrix having a plurality of bioerodible, biocompatible polymers wherein wherein each polymer of the plurality of polymers has a specified weight average molecular weight; and the polymer matrix has a broad molecular weight distribution of the plurality of polymers; a solvent having a miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith; and a beneficial agent. The compositions are have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.

A method of reducing oxidative stress in the brain of an organism having a blood brain barrier and suffering an ischemic brain injury, the method comprising the step of administering a compound to the organism, the compound having (a) a combination of molecular weight and membrane miscibility properties for permitting the compound to cross the blood brain barrier of the organism; (b) a readily oxidizable chemical group for exerting antioxidation properties; and (c) a chemical make-up for permitting the compound or its intracellular derivative to accumulate within the cytoplasm of cells.

An improved, user-friendly silane/silica sol copolymer hardcoating composition for protecting optical plastic and other substrates (including wood, metals, glass, plastics and most coated articles) from scratching is able to be manufactured at lower costs and to provide much-improved ease of use in transportation, storage, dipbath (or other coating tank) stability, and blush resistance in ordinary cleanroom atmospheres. The silane/silica sol copolymer is formed as a direct reaction product of an acidic silica sol and monomethyltrialkoxysilane, preferably substantially monomethyltriethoxysilane, in ratios of 30:70 to 70:30, most preferably about 40:60. A tail solvent aids blush resistance, reduces internal stress and permits adhesion to unprimed polycarbonate. Optionally, colloidal silica sol dissolved in water-miscible solvent may be reacted in a second stage with acidic aqueous colloidal silica sol earlier silanized with monomethyltrialkoxysilane.

The present invention is directed to polymeric materials (e.g., coatings) comprising biodegradable copolymers and implantable devices (e.g., drug-delivery stents) formed of such materials. The biodegradable copolymers are derived from at least two relatively polar monomers and at least one relatively nonpolar monomer. Incorporation of at least one relatively nonpolar monomer into the copolymer improves controlled release of a hydrophobic drug from the polymeric material by increasing the copolymer's miscibility with and permeability to the hydrophobic drug. The polymeric materials can also contain at least one biocompatible moiety, at least one non-fouling moiety, at least one biobeneficial material, at least one bioactive agent, or a combination thereof. The polymeric materials are designed to improve the mechanical, physical and biological properties of implantable devices formed thereof.

A variety of compositions that are particularly applicable for removing one or more of resist, etching residue, planarization residue, and copper oxide from a substrate comprising copper and a low-k dielectric material are described. The resist, residues, and copper oxide are removed by contacting the substrate surface with the composition, typically for a period of 30 seconds to 30 minutes, and at a temperature between 25° and 45° C. The composition includes a fluoride-providing component; at least 1% by weight of a water miscible organic solvent; an organic acid; and at least 81% by weight water. Typically the composition further includes up to about 0.4% of one or more chelators.

Methods and compositions for systemically or locally administering a beneficialagent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a non-crosslinkable hydrophilic polymer into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the non-crosslinkable hydrophilic polymer and to provide a disparity of about 10 N or less in mold separation force. The non-crosslinkable hydrophilic polymer has a limited miscibility with the lens-forming material low enough to successfully and timely form an intact interfacial film with a sufficient thickness at an interface between the mold and the fluid composition therein, and has a structure that minimizes entanglement of the non-crosslinkable hydrophilic polymer in the interfacial film with the polymer matrix of the formed lens.

An ink jet ink composition including from 40.0 to 99.0% by weight of water; from 0.1 to 20.0% by weight of a pigment dispersed with an oleoyl methyl taurine salt dispersant from 0 to 70.0% by weight of a water miscible co-solvent; and from 0.1 to 20.0% by weight of a water-reducible addition polymer; wherein the weight average molecular weight of the polymer is from 2,000 to 100,000; the acid number is from 50 to 400; and the acid group on the polymer is neutralized by an alkaline metal hydroxide such as lithium hydroxide, sodium hydroxide potassium hydroxide, or a mixture thereof; and wherein all weight percentages are based on the total weight of the ink composition. An ink jet printing method is also disclosed.

A method for producing biofuels is provided. A method of making biofuels includes dewatering substantially intact algal cells to make an algal biomass, sequentially adding solvent sets to the algal biomass, and sequentially separating solid biomass fractions from liquid fractions to arrive at a liquid fraction comprising neutral lipids. The method also includes esterifying the neutral lipids, separating a water miscible fraction comprising glycerin from a water immiscible fraction comprising fuel esters, carotenoids, and omega-3 fatty acids. The method also includes obtaining a C16 or shorter fuel esters fraction, a C16 or longer fuel ester fraction, and a residue comprising carotenoids and omega-3 fatty acids. The method includes hydrogenating and deoxygenating at least one of (i) the C16 or shorter fuel esters to obtain a jet fuel blend stock and (ii) the C16 or longer fuel esters to obtain a diesel blend stock.

The invention relates to aqueous fluoropolymer hybrid compositions made by a seeded emulsion polymerization process, having improved film formation properties. The seed is a fluoropolymer dispersion. At least two different monomer compositions are added sequentially to the seeded dispersion. These monomer compositions preferably include acrylic monomers. The first monomer composition is selected for miscibility with the fluoropolymer dispersion. The second monomer composition is selected to have a glass transition temperature (Tg) of less than 30° C. The final composition can be formulated to make coatings with a minimum film forming temperature (MFFT) of less than 5° C., and a maximum VOC of 50 g/liter. The composition is especially useful for coatings and films.

Lubricant compositions comprising certain mixtures of esters of pentaerythritol, di-pentaerythritol, tri-pentaerythritol and higher pentaerythritol oligomers are ideally suited for use with CO₂ as refrigerant in heat transfer devices provided that at least 30% by weight of the esters are esters of pentaerythritol oligomers containing 4 or more pentaerythritol monomer units and wherein a majority of the alkylcarboxylate groups are straight chain C_3-6 alkanoyl groups, such as n-pentanoyl. Said mixture of alkylcarboxylate esters are shown to not only have higher than expected viscosity and exceptional CO₂ miscibility, but also possess excellent lubricity, film building properties and load bearing properties even as part of a lubricant/CO₂ solution.

Methods and compositions for systemically or locally administering a beneficial agent to a subject are described, and include, for example, implantable elastomeric depot compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible, elastomeric caprolactone copolymer, a biocompatible solvent having low water miscibility that forms an elastomeric viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

A composition including 2,3,3,3-tetrafluoropropene and a lubricating oil including a polyalkylene glycol and a polyol ester, the polyol ester content in the lubricating oil being less than or equal to 25%. A method of lubricating a vapor compression circuit, the method including using a mixture including a polyalkylene glycol and a polyol ester as lubricating oil in the vapor compression circuit, in combination with a heat transfer fluid comprising 2,3,3,3-tetrafluoropropene, the content of polyol ester in the lubricating oil being less than or equal to 25%. Further, the use of said composition in methods for heating or cooling.

A concentrated developer can be prepared with less than 60 weight % water and still remain in a single phase with little or no haze or precipitation. This developer concentrate also includes a water-soluble or water-miscible organic solvent, one or more alkyl ether carboxylic acid, coconut oil alkanolamine, coconut fatty alcohol polyglycol ether, β-naphtholethoxylate, and block propylene oxide-ethylene oxide in an amount of at least 0.1 and up to 50 weight % solids, and optionally an alkyl naphthalene sulfonate in an amount of up to 40 weight % solids. The developer concentrate can be diluted up to 80:1 or greater with water and used to process imaged lithographic printing plate precursors.

The invention relates to a composition comprising:

• • a heat-transfer fluid comprising from 15% to 30% ammonia and from 70% to 85% 2,3,3,3-tetrafluoropropene; and
  • a lubricant oil comprising a polyalkylene glycol.

The invention also relates to the use of ammonia for increasing the miscibility of 2,3,3,3-tetrafluoropropene with the polyalkylene glycol, and vice versa.

Catheter injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions have substantially improved shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.

A process for recovering a base oil of lubricating viscosity from used oil in which, following optional pretreatment, used oil is re-refined by distilling it in distillation apparatus having multiple theoretical plates. Impurities are then extracted from the lube range distillate fraction or fractions with a liquid extractant such as N-Methyl-2-Pyrrolidone (NMP) at a temperature below the temperature, if any, of complete miscibility of the extractant and the oil. The oil and extractant are then separated whereupon the extractant is re-used in the process and the oil is subject to further treatment, as necessary, for targeted uses.

A method of making an anti-reflective film comprises preparing a liquid composition with specific amounts of tetraethyl orthosilicate, polyethylene glycol, HCl, ethanol and at least one alcohol having a higher boiling point than ethanol and miscibility with both ethanol and water; applying the liquid composition onto a surface of a substrate to form a liquid film; evaporating the ethanol and the at least one alcohol from the liquid film to form a solid film; and heating the solid film to form a silica film.

The present invention concerns methods and compositions to prepare biological samples to preserve the macromolecules in the samples. Embodiments of the invention concern the use of a soak solution that contains one or more water-miscible solvents. A sample is incubated with the soak solution to the point of saturation at a temperature above the melting temperature of the water-miscible solvent but below 0° C. The use of methods and compositions of the invention allow for subsequent preparation or analysis of the samples.