186 results about "Hesperetin" patented technology

The invention provides new technology for preparing luteolin by using hesperidin. The method includes a first step of hydrolyzing hesperidin to obtain hesperetin, a second step of dehydrogenizing the hesperetin to obtain diosmetin, and a third step of demethylating the diosmetin to obtain the luteolin. Compared with the prior art that the hesperidin is firstly dehydrogenized and then hydrolyzed, the method enables iodine using amount to be greatly reduced, and production cost is low. The invention further provides new technology for preparing the diosmetin.

The invention relates to a method for preparing mono-glucoside through selective hydrolysis of flavone rutinoside or neohesperidoside, and belongs to the fields of chemistry and medicine. The method comprises the following steps: mixing flavone rutinoside or neohesperidoside with macroporous absorption resin in water or alkaline water solution, heating or adding acid; wherein in this process the diglucoside is dispersed, absorbed, and cured by the macroporous absorption resin; after drying, in the catalysis of acid or a dewatering agent, rhamnose in the molecule carries out condensation reactions with a ketone agent, and the rhamnose in the molecule is removed in the action of acid; eluting with an organic solvent or an alkaline water solution; and recycling the solvent or acidifying so as to obtain the flavone mono-glucoside. The method solves the problems that flavone diglucoside is hard to disperse in a ketone reagent and the selectivity of rhamnose hydrolysis is low. The method has the advantages of simple operation, easy recycling of organic solvent, low cost, high yield, and easiness in industrial production. Compounds such as hesperetin mono-glucoside, diosmetin mono-glucoside, hesperetin dihydrochlcone mono-glucoside, and the like, can be industrially produced from flavones such as flavone neohesperidoside through the method.

The invention provides a medicinal composition mainly containing naringenin, Prunin, hesperetin and hesperetin-7-0-glucoside. A medicine containing naringin, narirutin, hesperidin and neohesperidin isutilized as a raw material, an extract of the medicine is hydrolyzed, or extracting and hydrolyzing are conducted simultaneously on the extract of the medicine, and the plant extract can be obtained.The medicinal composition can be used for development and production of foods, health foods and new traditional Chinese medicines.

The invention relates to a traditional Chinese medicine processing method, in particular to a traditional Chinese medicine processing method for fructus aurantii. The traditional Chinese medicine processing method comprises the following steps: the internal capsule of a traditional Chinese medicine raw material is cut out by using a knife, silt is washed, the traditional Chinese medicine raw material is soaked in water for 6 to 24 hours, an iron pressing component is used for extruding the traditional Chinese medicine raw material after being soaked, and then the traditional Chinese medicine raw material is put on a wooden stand, placed in an environment with the temperature of 30 DEG C to 35 DEG C and the relative humidity of 60% to 80% for 6 to 8 days, taken out, sliced firstly and then aired to obtain a traditional Chinese medicine decoction pieces, wherein, the traditional Chinese medicine raw material is the fructus aurantii. In the fructus aurantii after being processed by using the traditional Chinese medicine processing method, the existence of hesperetin-7-O-beta-D-glucopyranoside can be discovered by detection. hesperetin substances usually have a certain medicine effect, and the hesperetin-7-O-beta-D-glucopyranoside has stronger pharmacological activity. The traditional Chinese medicine taking the fructus aurantii as a representative is placed in an environment with high temperature and high humidity, processed and shaped by adopting the iron pressing component, which is a typical camphor type processing method.

The invention discloses a method for preparing hesperetin from enzymatic hydrolysis neohesperidin or hesperidin. Neohesperidin or hesperidin beta-D-glucoside bond can be hydrolyzed in one step through crude enzyme liquid to prepare corresponding aglycone hesperetin. The method includes the steps of preparing the crude enzyme liquid of Penicillium decumbens through fermentation, adjusting the content and reaction time of the crude enzyme liquid, directly converting neohesperidin or hesperidin into hesperetin, dissolving or extracting conversion liquid through organic solvent, and conducting chromatographic purification to obtain hesperetin. By means of the method, the defects that a traditional chemical method is strict in reaction condition, serious in pollution, low in conversion rate and the like when used for preparing hesperetin can be overcome, and the defects that when microbial fermentation is directly adopted, operation is complicated, products are not simplex, and products are difficult to purify can be overcome.

The invention belongs to the field of biological medicines, relates to hesperetin or novel application of hesperetin and particularly relates to hesperetin or pharmaceutically acceptable salts thereof or application of hesperetin or pharmaceutically acceptable salts to preparation of any one of the following medicines: (1) alpha-glucosidase inhibitors; (2) medicines for treating and / or preventing diabetes; and (3) medicines for treating and / or preventing tumor. The hesperetin is capable of effectively inhibiting alpha-glucosidase and has potential for preparing medicines for preventing and treating diabetes, especially type II diabetes.

The invention discloses a method for preparing high-bioavailability derivatives of hesperidin, which is characterized in that the method obtains hesperetin-7-glucoside and hesperetin with higher purity by appropriate hydrolysis of the hesperidin and a certain separation and purification method. The preparation method is as follows: the hesperidin extracted from citrus reticulata is taken as raw material and dissolved in a certain amount of alkaline solution, a certain amount of organic solvent is added, the mixture is pre-heated after the full dissolution, a certain amount of hydrochloric acid which is also pre-heated is finally added, and hydrolysis mixed products are obtained by refluxing in a boiling water bath for a certain time, cooling, regulating pH, standing and filtering. The hesperetin-7-glucoside and the hesperetin are obtained by separating and purifying the mixture. The hesperidin which is not decomposed after separating and purifying the products can be used for recycling in the next acid hydrolysis. The method can obtain the hesperetin-7-glucoside and the hesperetin which are the high-bioavailability derivatives of the hesperidin by the simple acid hydrolysis method, thereby having the advantages of low cost and simple process; furthermore, the method can realize the recycled production and is easy to realize the industrial production.

The invention discloses a method for extracting high-purity hesperetin from immature bitter orange, which comprises the following steps: 1. pulverizing immature bitter orange, extracting with alcohol solvent under reflux three times, filtering, merging the three filtrates, and concentrating; 2. adding inorganic acid into the concentrated solution for hydrolysis, naturally cooling to room temperature, filtering, washing the filter residues, and centrifugalizing to obtain a crude hesperetin product; and 3. dissolving the crude hesperetin product in ethanol, adding activated carbon to decolorize under reflux, filtering, concentrating, crystallizing, filtering, and drying the filtered solid matter to obtain the hesperetin crystals of which the mass purity is not lower than 95%.By using the immature bitter orange as the raw material for extraction, hydrolysis and refinement, compared with the traditional technique of extracting hesperetin from hesperidin, the invention reduces the intermediate links, lowers the production loss, enhances the production yield of hesperetin, lowers the production cost, and eliminates the hesperidin refinement, drying and other links in the original production process, thereby greatly shortening the production cycle.