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Semisynthesis luteolin preparation new process

A technology of luteolin and a new process, which is applied in the field of semi-synthetic preparation of luteolin, and can solve complex problems

Inactive Publication Date: 2013-06-12
李玉山
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The introduction of flavone synthase into flavanone recombinant yeast strains can convert a variety of phenolic acid precursors into flavone molecules. This method is relatively complicated and has not yet been industrialized.

Method used

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  • Semisynthesis luteolin preparation new process

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Embodiment Construction

[0010] Preparation of the first hesperidin: close the reaction kettle mouth, pump 1000Kg of ethanol with accurate measurement into the reaction kettle, adjust the pH of the ethanol to 1-2 with concentrated sulfuric acid, slowly add 80Kg of crude hesperidin from the reaction kettle mouth, seal the reaction kettle mouth, start Stir, turn on the heat-carrying steam valve of the reaction kettle to heat, turn on the circulating condensed water, and reflux at 70-75°C for reaction. After reacting for 10 hours, take a sample from the sampling port for testing. After the reaction is complete, add 2kg of activated carbon to close the kettle mouth, open the heat-carrying steam valve of the reactor, and close the reaction when the temperature of the reactor rises to 75°C and the pressure rises to 0.11MPa~0.13MPa. The kettle is loaded with hot steam, keep this condition and stir for 30 minutes to decolorize. Start to concentrate until the alcohol content of the concentrated solution reache...

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Abstract

The invention provides semisynthesis luteolin preparation new process. The process includes a first step of hydrolyzing hesperidin to obtain hesperetin, a second step of demethylating the hesperetin to obtain eriodictyol, and a third step of dehydrogenizing the eriodictyol to obtain the luteolin. Compared with the prior art that the hesperidin is firstly dehydrogenized and then hydrolyzed, the process enables the iodine using amount to be greatly reduced, and production cost is low. The invention further provides technology for preparing the eriodictyol.

Description

technical field [0001] The invention relates to a new process for semi-synthetic preparation of luteolin. Background technique [0002] Luteolin is named in nature because it was originally isolated from the leaves, stems and branches of the herb Resedaodorata L. in the family Resedaceae. Mainly from the shell of the fruit of leguminous plant Arachis hypogata L., Labiatae plant Ajuga decumbens Thunb. Black water valerian (Valeriana amurensis P.Smirn.) aerial part and Lonicera japonica Thunb. etc. Luteolin has the following pharmacological effects: 1) Anti-inflammatory The anti-inflammatory activity of luteolin is associated with the inhibition of the production of nitric oxide and other inflammatory cytokines, as well as the inhibition of phosphorylation of tyrosine and gene expression mediated by nuclear transcription factors related. 2) Antibacterial luteolin can inhibit Staphylococcus, Staphylococcus aureus, Escherichia coli, Herpes simplex, Bacillus subtilis, Cardi, R...

Claims

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Application Information

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IPC IPC(8): C07D311/30
Inventor 李玉山
Owner 李玉山
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