84 results about "Semisynthesis" patented technology

The invention provides engine oil of a long-service life diesel engine, which comprises basic oil and additives, wherein the additives comprise the following ingredients in percentage by weight: 4.0 percent to 6.5 percent of detergent additives, 3.0 percent to 5.5 percent of dispersing agents, 0.2 percent to 0.8 percent of corrosion inhibitors, 0.1 percent to 0.2 percent of antioxidizers, 0.01 percent to 0.15 percent of nanometer wear resistance agents, 5.0 percent to 9.0 percent of viscosity index improving agents, 0.3 percent to 0.5 percent of pour point reducers and the balance of basic oil, wherein the basic oil is semisynthesis composite basic oil consisting of API type III basic oil accounting for 45 percent to 65 percent of the mass percentage of the basic oil and 35 percent to 55 percent of poly-alpha olefin synthesis oil. The engine oil of the diesel engine provided by the invention can adapt to the requirements of various diesel engines, the performance meets the quality requirements of the engine oil of the diesel engine API CH-4, the engine can be ensured to be always in a good lubricating state, the service life of the engine oil is long, the environment pollution is little, and in addition, the cost is low.

The invention provides engine oil of a long-service life gasoline engine, which comprises basic oil and additives, wherein the additives comprise the following ingredients in percentage by weight: 4.0 percent to 6.0 percent of dispersing agents, 2.5 percent to 4.5 percent of detergent additives, 0.2 percent to 0.8 percent of corrosion inhibitors, 0.1 percent to 0.2 percent of antioxidizers, 0.01 percent to 0.15 percent of nanometer copper wear resistance agents, 5.0 percent to 9.0 percent of viscosity index improving agents, 0.3 percent to 0.5 percent of pour point reducers and the balance ofbasic oil, wherein the basic oil is semisynthesis composite basic oil consisting of API type III basic oil accounting for 40 percent to 65 percent of the mass percentage of the basic oil and 35 percent to 60 percent of poly-alpha olefin synthesis oil. The engine oil can meet the requirements of high-temperature high-speed automobile and motorcycle engines, and can ensure that the engines are always in a good lubricating state, in addition, the service life is long, and the cost is low.

The invention discloses a semisynthesis cutting fluid for magnesium alloy. According to the invention, the hidden danger of fire hazard in the process of magnesium alloy processing is totally avoided by using an environment-friendly water-soluble system; excellent reasonable proportioning of additives and combined application of corrosion inhibitors effectively prevent the surface of processed magnesium alloy from corrosion and blackening; designing of a low foam type formula enables generation of foam in the cutting fluid for the magnesium alloy to be totally inhibited; application of a delicate low-foam surfactant enables the problem of difficult cleaning of workpiece surface due to excessive oil stains to be overcome; application of an additive with resistance to hard water enables hard water-resistance of the fluid to be effectively improved, the fluid has hard water-resistance of 15000 ppm, allowing the service life of the fluid to be prolonged, all the indexes of the fluid reach or exceed relevant indexes in GB6144-2010, anti-rust performance lasts for more than 72 h per sheet, and the life cycle of the fluid is more than 8 months, 3 to 6 times the life cycle of magnesium alloy cutting fluid on the market; and reasonable design of an environment-friendly formula enables the problems of difficulty in treating waste liquid and the like to be effectively overcome.

The invention relates to a semisynthesis process route which takes tabersonine salt as raw material for producing vincamine. Catalytic hydrogenation, peroxidation, rearrangement, crystallization and recrystallization are sequentially performed on the tabersonine salt for getting the high-purity vincamine, and the content is greater than 99.0%. Calculated according to the tabersonine salt, the overall yield of the vincamine is 55.3%. The method has the characteristics of low cost, high yield, short time, and simplicity and safety in operation, and is completely applicable to industrialized large-scale production.

The invention provides semisynthesis luteolin preparation new process. The process includes a first step of hydrolyzing hesperidin to obtain hesperetin, a second step of demethylating the hesperetin to obtain eriodictyol, and a third step of dehydrogenizing the eriodictyol to obtain the luteolin. Compared with the prior art that the hesperidin is firstly dehydrogenized and then hydrolyzed, the process enables the iodine using amount to be greatly reduced, and production cost is low. The invention further provides technology for preparing the eriodictyol.

The invention relates to 24(R)-pseudoginsenoside-GQ as well as a semisynthesis method and medicinal application thereof, belonging to a new compound as well as a synthesis method and medicinal application thereof. In the invention, 20(S)-ginsenoside Rg3 or 20(R)-ginsenoside Rg3 is used as a raw material, and under an acid condition, a new compound is synthesized through the steps of oxidization, cyclization, and the like, wherein the chemical name of the new compound is 3-O-[beta-D-glucopyranose-(1-2)-beta-D-glucopyranose group]-damma-20S, 24R-epoxy-3beta, 12beta, 25-triol being short for 24(R)-pseudoginsenoside-GQ, the productivity of which reaches higher than 80 percent. The 24(R)-pseudoginsenoside-GQ has wide medicinal application in preparing medicaments for treating coronary heart diseases, myocardial ischemia, ischemic shocks, arrhythmia and reperfusion damages and resisting cancer.

A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediates.

The invention relates to a technology for semisynthesis of a whitening and anti-skin cancer active ingredient phloretin from natural phlorizin. The technology includes: placing a phlorizin crude product in a stainless steel reaction kettle, dissolving the phlorizin crude product in a 5% strong alkaline solution, conducting simple refining and filtration to obtain a phlorizin salt solution, shifting the phlorizin salt solution into a jacket-equipped enamel reaction kettle, and adding Lewis acid and a metal catalyst at low temperature to let them react for 10-15h at 35DEG C, then lowering the temperature to 0DEG C to perform crystallization, carrying out pumping filtration and deionized water washing to obtain a phloretin coarse grain, then dissolving the coarse grain in a 95% ethanol solution, conducting fine filtration, concentration and cooling crystallization, then performing pumping filtration and drying, thus obtaining a high quality phloretin fine product with content and purity both greater than 99.0%. The technology is suitable for large-scale industrial production.

The invention relates to preparation of oleanolic acid structure analogues and a semisynthesis method of oleanolic acid, which belongs to a manufacturing method of a chemical substance or medicament. The invention solves the problem that the traditional extraction and preparation of oleanolic acid has low efficiency due to the limit of the oleanolic acid content in plants, prepares oleanolic acid structure analogues contained in the plants by separation, and further realizes the semisynthesis of the oleanolic acid by using the oleanolic acid structure analogues as raw materials so as to solve the problem of low extraction yield in the prior art. In the method, leaves of olea europaea l. (an oleaceae plant) or fruits of ligustrum lucidum ait. are extracted and separated into two oleanolic acid structure analogues, and the two oleanolic acid structure analogues are used to carry out the semisynthesis of the oleanolic acid. The method comprises the steps of pretreatment, extraction, crude separation, purification and semisynthesis. Thus, the invention ensures the quality of the finished product, saves the production cost and improves the production efficiency.

Provided is a water-based antirust semisynthesis cutting fluid. The cutting fluid is prepared from the following raw materials, by weight, 1-2 parts of triethanolamine, 3-4 parts of boric acid ester, 12-14 parts of polyethylene glycol, 3-4 parts of stearic acid, 1-2 parts of 4-methyl salicylic acid, 1-2 parts of 2-aminoethyl heptadecenyl imidazoline, 1-2 parts of triethanolamine, 10-12 parts of white oil, 1-2 parts of sodium laurate, 6-8 parts of auxiliary agents and 200 parts of water. The cutting fluid has good lubricating effect, cooling effect and cleaning effect, has dispersion stability characteristics, has good extreme pressure wear resistance, has excellent anti-oxidation, anti-corrosion and antirust effects, can form a protection film on a metal surface, decreases corrosion and rusting of machine tools, workpieces and cutters, raises the finished product rate, and lowers production cost.

The invention relates to the medicine technology field, in particular relates to a new application of cardiac glycoside chemical compound having general formula (I) in preparing oncotherapy drug, wherein, R equals to 2-O-methyl-Beta-D-mycose, 6-deoxidation-Beta-D-gulose or 6-deoxidation-2-O-methyl-Beta-D-allose. The cardiac glycoside chemical compound can be obtained through a separation from upas in various conventional separation methods or be obtained through a synthesis or semisynthesis method.

A process is provided for the semi-synthesis and isolation of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis and isolation of 10-deacetylbaccatin III, the semi-synthesis of a mixture of 10-deacetylbaccatin III and baccatin III, and protected derivatives thereof, from a mixture of taxanes.

The invention provides a non-ferrous metal semisynthesis machining liquid, relating to a metal machining liquid. The non-ferrous metal semisynthesis machining liquid comprises the following components by weight percent: 20-56% of water, 5-20% of triethanolamine, 1-10% of 2-diamido-2-dimethyl pH stabilizing agent, 1-5% of benzotriazole (T706), a water-based antirusting agent (T485), 1-15% of boric acid, 5-10% of dipropylene glycol methyl ether coupling agent, 2-10% of bactericide BK, 5-20% of castor oil fatty acid, 1-20% of tallol fatty acid, 1-40% of No10 transformer oil, 1-30% of nonionic surfactant, 10-20% of anionicsurfactant and 10-20% of potassium sorbate oleate. The non-ferrous metal semisynthesis machining liquid has favorable quality and long shelf life, is green and environment-friendly, and can be widely used in machining of non-ferrous metal process.

The invention relates to split-ring lupinane derivatives, a medicinal composition containing the split-ring lupinane derivative and application of the split-ring lupinane derivatives in the preparation of medicine for prevention, treatment or slow-down of diseases of the central nervous system related to agonism of melatonin receptors. In the invention, through a semi-synthesis method, the structural limitation of natural products in the prior art is changed, a series of split-ring lupinane derivatives is designed and synthesized, and the agonist activity of the split-ring lupinane derivatives over the melatonin receptor in vitro is verified; through further experiments, the split-ring lupinane derivative compound can be applied to the research of the medicine for the treatment of the diseases related to a dysfunction of the central nervous system.

The invention relates to a preparation method of 3,5-cynarin methyl ester shown in a formula (1) as well as a medicament composition for preventing influenza and hepatitis. The preparation method comprises the following steps of: preparing 3,5-cynarin methyl ester as well as a medicament composition for preventing influenza and hepatitis by means of semisynthesis by using an extract of one or more of plants such as the composite family, Caprifoliaceae and the like as an intermediate. According to the preparation method of the 3,5-cynarin methyl ester, the 3,5-cynarin methyl ester with high purity can be massively produced from the plants with extremely-low content of the 3,5-cynarin methyl ester.

The invention discloses a semisynthesis process for producing benflumetol by taking alpha (di-n-butylamide)-2,7-dichloro-4-fluorenemethanol as a raw material. The process comprises the following steps: dispersing alpha (di-n-butylamide)-2,7-dichloro-4-fluorenemethanol in a mixed solvent, carrying out alkali catalysis and heating reflux on the obtained mixture, and carrying out condensation reaction on the obtained object and p-chlorobenzaldehyde, reducing the temperature to room temperature, and continuing to stir the obtained product so as to separate out coarse benflumetol grains; carrying out recrystallization on the coarse benflumetol grains by using acetone crystallization so as to obtain a fine benflumetol product with a content and a purity of more than 99.0%.

The invention relates to a high-efficiency high-stereoselectivity semisynthesis method of harringtonine and allied alkaloids, which uses optical pure cephalotaxin serving as a raw material to perform reactive synthesis with substituted silicon ketene in Lewis acid catalysis. The structural general formula of the compound is shown as (A), wherein the meaning of each group is shown as the specification. The method has the advantages of high chemical yield and diastereoselectivity of key reactions, convenient operation, short synthesis steps and the like. The method is a universal method for synthesizing the optical pure compound with the structural general formula shown as (A), and is suitable for massive preparation. The compound is widely applied to anti-tumor (malignant and non-malignant tumors), anti-parasitic, antifungal and antimicrobial chemotherapy medicaments.

The invention provides a semisynthesis method of 17-hydroxyjolkinolide B. The semisynthesis method comprises the following steps: carrying out a cyclization reaction on a double bond at the C11 position of an epoxy ring of Jolkinolide A serving as a raw material; bromizing a methyl at the C17 position of a lactonic ring, then carrying out debromination and acetylation, and finally hydrolyzing an acetyl to obtain 17-hydroxyjolkinolide B. The invention discloses a new method for synthesizing 17-hydroxyjolkinolide B and provides a basis for research and development of jolkinolide type medicines. The successful synthesis of 17-hydroxyjolkinolide B provides a new direction for research of anti-cancer drugs. The method has the advantages that the yield of 17-hydroxyjolkinolide B can be improved, the production cost can be reduced, the market supply is enlarged and the cancer treatment cost is lowered.

This invention relates to an eye use transmission system of macrolide type antibiotic hyaluronic acid natrium. The goal of this invention is to provide a macrolide type antibiotic eye use medicine preparation with carrier is hyaluronic acid or its salt. It is used to cure germ eye region infection. The macrolide type antibiotic in this invention includes antibiotic that has 14 yuan,15yuan, 16yuan large ring construction features , for example, natural antibiotic bring by streptomycete erythromycin, josamycin, spiramycin, medemycin etc. and semisynthesis derivant from by structure modification of natural antibiotic, such as roxithromycin, azithromycin, clarithromycin, rokitamycin, telithromycin.

The invention provides a vinpocetine semisynthesis process. The vinpocetine is obtained through hydrolysis, dehydration and esterification reactions by a one-pot method, and after the reactions are finished, extraction separation, purification and crystallization are performed, and finally, the high-content and high-purity product can be obtained. The method is few in reaction steps, simple in process flow, high in vinpocetine yield, simple in equipment, and green and environment-friendly in production procedure, and has tremendous economic and social benefits.

The invention discloses a method for extracting arteannuic acid from an extracting solution for producing artemisinin. The method comprises the following steps: (a) collecting petroleum ether-ethyl acetate eluant; (b) concentrating the collected petroleum ether-ethyl acetate eluant, separating by virtue of a chromatography, carrying out elution by virtue of methanol, ethanol, acetone or a ethyl acetate solvent, and collecting eluant rich in arteannuic acid; (c) carrying out concentration and standing crystallization on the collected eluant rich in arteannuic acid, so as to obtain coarse crystals; and (d) dissolving the arteannuic acid coarse crystals by virtue of petroleum ether, and carrying out recrystallization, so as to obtain an arteannuic acid finished product. According to the method for extracting arteannuic acid from the extracting solution for producing the artemisinin, the arteannuic acid is an available byproduct in the production process of the artemisinin and is a raw material for semisynthesis of the artemisinin, so that arteannuic acid with a relatively high content can be timely separated in the production process and is taken as a product, and the production cost of the artemisinin can be remakrbly lowered.

A semisynthesis cutting fluid is prepared from the following raw materials in parts by weight: 5 - 7 parts of boric acid ester, 3 - 4 of parts of phosphate, 10 - 12 parts of diethylene glycol, 3 - 4 parts of triazine, 1 - 2 parts of cellulose hydroxyethyl ether, 30 - 34 parts of 10# aviation hydraulic oil, 3 - 4 of parts of triethylene glycol dimethyl ether, 2- 3 parts of ammonium molybdate, 1 - 2 parts of trimethylolpropane, 1 - 2 parts of sodium dodecyl benzene sulfonate, 6 - 8 parts of an assistant and 200 parts of water; through the use of the boric acid ester, the phosphate, the10# aviation hydraulic oil and other lubricants, the semisynthesis cutting fluid is not only good in lubrication, and can form a protective film on the metal surface, increases extreme pressure resistance, is not easy to wear the metal surface, is good in cleaning performance, is friendly to the environment, has good anti corruption performance, is not easy to go bad and smell, is stable in dispersion and not easy to coagulation, is good in sedimentation performance, is long in the use time, has very good protection effects on workpieces and equipment, and after use, is simple in waste liquid treatment.