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Method for extracting arteannuic acid from extracting solution for producing artemisinin

A technology of artemisinic acid and extract, which is applied in organic chemical methods, separation/purification of carboxylic acid compounds, organic chemistry, etc., can solve problems such as waste of artemisinic acid and ineffective use of resources, and reduce production costs Effect

Inactive Publication Date: 2017-08-04
CHONGQING HOLLEY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The produced artemisinic acid can also be processed into artemisinin, so the utilization value of artemisinin is still very high, but in the process of extracting artemisinin, it will cause a lot of waste of artemisinin, and the resources will not be effectively used

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Collect 2000L of petroleum ether-ethyl acetate eluate from a certain batch of artemisinin production process, concentrate to 400L, and use silica gel with an activity of 200% for chromatographic separation, elute with different concentrations of methanol, and enrich the content of Artemisia annua The acid eluate was concentrated to 1 / 80 of its original volume and crystallized to obtain coarse crystals. After heating and dissolving the crude crystals with petroleum ether as a solvent, place to cool and crystallize, and dry to obtain 1.02 kg of artemisininic acid.

Embodiment 2

[0036] Collect 2200L of petroleum ether-ethyl acetate eluate from a certain batch of artemisinin production process, concentrate to 600L, use silica gel with an activity of 240% for chromatographic separation, elute with different concentrations of ethanol, and enrich the content of Artemisia annua The acid eluate was concentrated to 1 / 60 of its original volume and crystallized to obtain coarse crystals. After heating and dissolving the crude crystals with petroleum ether as a solvent, place to cool and crystallize, and dry to obtain 0.99 kg of artemisininic acid.

Embodiment 3

[0038] Collect 2400L of petroleum ether-ethyl acetate eluate from a certain batch of artemisinin production process, concentrate to 500L, use silica gel with an activity of 180% for chromatographic separation, and elute with different concentrations of methanol to enrich the content of Artemisia annua. The acid eluate was concentrated to 1 / 70 of its original volume and crystallized to obtain coarse crystals. After heating and dissolving the crude crystals with petroleum ether as a solvent, place to cool and crystallize, and dry to obtain 1.04 kg of artemisininic acid.

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Abstract

The invention discloses a method for extracting arteannuic acid from an extracting solution for producing artemisinin. The method comprises the following steps: (a) collecting petroleum ether-ethyl acetate eluant; (b) concentrating the collected petroleum ether-ethyl acetate eluant, separating by virtue of a chromatography, carrying out elution by virtue of methanol, ethanol, acetone or a ethyl acetate solvent, and collecting eluant rich in arteannuic acid; (c) carrying out concentration and standing crystallization on the collected eluant rich in arteannuic acid, so as to obtain coarse crystals; and (d) dissolving the arteannuic acid coarse crystals by virtue of petroleum ether, and carrying out recrystallization, so as to obtain an arteannuic acid finished product. According to the method for extracting arteannuic acid from the extracting solution for producing the artemisinin, the arteannuic acid is an available byproduct in the production process of the artemisinin and is a raw material for semisynthesis of the artemisinin, so that arteannuic acid with a relatively high content can be timely separated in the production process and is taken as a product, and the production cost of the artemisinin can be remakrbly lowered.

Description

technical field [0001] The invention belongs to the technical field of artemisinin extraction, and in particular relates to a method for extracting artemisinin from an extract solution for producing artemisinin. Background technique [0002] Artemisinin is a sesquiterpene lactone drug with peroxy groups extracted from the stems and leaves of the plant Artemisia annua. Its effect on the ultrastructure of the red inner stage of Plasmodium murine is mainly the change of the membrane system structure of Plasmodium. The drug first acts on the food vesicle, pellicle, mitochondria, and endoplasmic reticulum. In addition, it also has a certain effect on the chromatin in the nucleus. Impact. It is suggested that the mode of action of artemisinin is mainly to interfere with the function of pellicle-mitochondria. It may be that artemisinin acts on food vesicles, thereby blocking the earliest stage of nutrient intake, causing Plasmodium to starve amino acids quickly, forming autophagi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/42C07C51/43C07C51/47C07C57/26
CPCC07C51/42C07B2200/07C07C51/43C07C51/47C07C57/26
Inventor 刘永源罗晓江欧阳敏杨再辉刘晓东邓飞
Owner CHONGQING HOLLEY PHARMA
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