3 results about "Vinpocetine" patented technology

This invention belongs to the field of pharmaceutical formulation technology and provides a vinpocetine suspension and its preparation method. The vinpocetine suspension of this invention comprises the following raw materials in specific mass parts: vinpocetine, a suspending agent, a solubilizer, a stabilizer, and water. The vinpocetine suspension of this invention is suitable for oral administration. The excipients in the suspension include a suspending agent, a solubilizer, and a stabilizer. The solubilizer inhibits the aggregation of vinpocetine nanoparticles and improves the solubility and dispersion uniformity of vinpocetine nanoparticles in water. The suspending agent and stabilizer together construct a spatially stable structure, ensuring the suspension and dispersion of vinpocetine nanoparticles and resisting sedimentation. The suspending agent, solubilizer, and stabilizer work synergistically to achieve nanoscale distribution and uniform dispersion and suspension of vinpocetine, significantly improving the bioavailability of vinpocetine. High-pressure homogenization achieves nanoscale distribution of vinpocetine, with a particle size of 200-300 nm.

The application discloses a lenvatinib-polyethylene glycol coupling compound and a preparation method and application thereof. The lenvatinib-polyethylene glycol coupling compound has a structure as shown in the formula (I): in the formula (I), n is greater than or equal to 2. The application further provides a nano preparation containing vinpocetine and the lenvatinib-polyethylene glycol coupling compound and used for manufacturing drugs, which can be applied to tumor treatment, effectively improves the limitation of a single drug treatment method on tumor inhibition, and shows a positive application potential in the tumor treatment field.

The invention belongs to the technical field of pharmaceutical preparations, and discloses a nasal vinpocetine salt gel as well as a preparation method and application thereof. The vinpocetine salt type derivative in the nasal vinpocetine salt gel precursor composition provided by the invention is used as a key functional component, relatively high bioavailability and brain entry efficiency are shown, the central Abeta removal efficiency is enhanced, a nasal gel drug delivery system is formed by the chitosan / carboxymethyl cellulose and the derivative thereof, and the drug delivery effect is improved. The double functions of prolonging retention and efficiently entering the brain are achieved, and the problem that the first-pass effect of vinpocetine medicine is remarkable is solved through the system.