11results about How to "Strong irritant" patented technology

The invention discloses perfume lemon compound essential oil as well as a preparation method and application thereof. The perfume lemon compound essential oil comprises an active component A and an active component B, the active component A comprises perfume lemon essential oil, rosemary oil, tea tree oil and cedar oil; the active ingredient B comprises at least one of thyme oil, schizonepeta oil, lemongrass oil, peppermint oil and eucalyptus oil. According to the prepared perfume lemon compound essential oil, the perfume lemon essential oil is creatively used as a main component and forms molecular-level cooperation with other plant essential oil in a specific proportion, scientific component selection and proportion optimization are achieved, the perfume lemon essential oil and other plant essential oil jointly act on olfactory receptors of mosquitoes, a strong repelling signal is generated, and the mosquito repelling effect is achieved. The key technical problems that an existing plant mosquito repellent product is insufficient in mosquito repellent durability, high in skin irritation, poor in formula stability and the like are successfully solved, and the plant mosquito repellent has good application prospects.

The invention relates to a preparation method of a senbacolide intermediate, and belongs to the technical field of medicine synthesis. The preparation method comprises the following steps: dissolving o-chloroacetophenone in a solvent, adding copper bromide, heating to reflux, carrying out a reaction, filtering after the reaction is finished, adding a sulfite aqueous solution or a hydrosulfite aqueous solution, carrying out a stirring reaction, washing with water after the reaction is finished, and concentrating to obtain the senbacolide intermediate which is 2-bromo-2 '-chloroacetophenone. According to the method, copper bromide is used as a bromination reagent, so that the selectivity is good, and the yield and purity of the product are relatively high. According to the preparation method, bromine can be generated in situ for reaction by using copper bromide, so that direct use of bromine which is high in toxicity, strong in irritation and high in environmental pollution is avoided, and the process is safer and more suitable for the field of pharmacy. White precipitate cuprous bromide is generated in the reaction, so that the reaction process is convenient to observe, the cuprous bromide is easily removed by filtration, and the product is simple and convenient to purify.

The invention relates to the technical field of material preparation, in particular to a preparation method of an organic silicon modified ultraviolet-moisture dual-curing material, the dual-curing material takes polymer polyol as a main body, diisocyanate is adopted for end sealing to obtain a prepolymer A containing an NCO group at the end part, and the prepolymer A is used for preparing an organic silicon modified ultraviolet-moisture dual-curing material. Reacting NCO at the end part of the prepolymer with OH of a hydroxyl acrylate monomer to obtain a prepolymer B containing an acrylic acid active group; modifying by ETM silane, and partially grafting by controlling reaction conditions to obtain a prepolymer C; and then carrying out photo-initiation-moisture curing. After the material is subjected to ultraviolet-moisture curing, a coating is high in hardness, strong in adhesive force, relatively high in elastic modulus and high in mechanical strength, and is suitable for being used for a long time in a temperature range of-40 to 120 DEG C.

The invention provides a preparation method and application of rosemary fermentation filtrate. The invention firstly adopts ultra-low temperature means to quickly freeze rosemary stems and leaves, and adopts means such as high-speed grinding, ultra-high pressure nano homogenization and ultrafiltration to obtain rosemary homogenate filtrate; then the rosemary homogenate filtrate is pumped into a microbial fermentation process through a feed pump, rosemary is fermented and processed by microorganisms, and then subjected to multiple high-pressure homogenization, ultrasonic crushing, high-speed centrifugation, filtration and sterilization treatment steps to finally obtain rosemary fermentation filtrate. The whole process not only has mild reaction conditions and does not require additional addition of chemical reagents, but also reduces the large amount of loss and destruction of active ingredients in rosemary stems and leaves in the traditional high-temperature steaming and extraction process, and retains the original multiple natural active ingredients in the rosemary raw materials to the maximum extent, effectively solving the main defects of the traditional extraction method.

The invention provides a nano-emulsion composition for repairing a scald wound, a preparation method and application, and belongs to the technical field of pharmaceutical preparations. The composition comprises madecassoside raw material medicine, lemon essential oil, an emulsifying agent and water. The preparation method comprises the following steps: dissolving madecassoside powder in water, adding the madecassoside powder into lemon essential oil containing a W / O type emulsifier after the madecassoside powder is completely dissolved, crushing under a cell crusher to form primary emulsion, adding the primary emulsion into a solution containing an O / W type emulsifier, and continuously crushing and stirring to obtain the madecassoside nano-emulsion. The fat solubility of madecassoside can be improved, the permeation effect of madecassoside on the skin is enhanced, the absorption of madecassoside is greatly improved, and the madecassoside has a good application prospect in scald repair.

The invention belongs to the field of tobaccos, and provides a method for improving the quality of a heated cigarette core material by an embedding method under a mild condition, which comprises the following steps of: reacting a smoke agent with a tobacco matrix at 70-100 DEG C in the presence of micromolecular low-boiling-point alcohol, and loading the smoke agent in the tobacco matrix to obtain the heated cigarette core material. According to the invention, the micromolecular low-boiling-point alcohol is used as the auxiliary agent, so that the reaction temperature of the smoke agent and the tobacco powder is effectively reduced, the loading capacity of the smoke agent and the tobacco quality are improved, and the purpose of improving the quality of the heated cigarette core material by an embedding method under a mild condition is achieved.

The present invention relates to a method for regulating seedling formation of sandy locust seeds, belonging to the technical field of seed treatment and seedling cultivation, and the method comprises: step 1, disinfection and cleaning; step 2, seed soaking treatment: soaking sandy locust seeds in a mixed solution of cellulase and hemicellulase for 2-6 hours, and then soaking the seeds in 0.1%-0.3% KNO3 for 6-10 hours; step 3, placing on a bed for cultivation. The enzyme treatment is combined with KNO3 to treat sandy locust seeds, and the treatment can improve the emergence rate of sandy locust seeds and the number of branches, plant height and total biomass of sandy locust seedlings.

The invention relates to application of snake venom-like tripeptide in preparation of a medicine for preventing and / or treating pain, and belongs to the technical field of biological medicine. The invention provides an application of snake venom-like tripeptide in preparation of a medicine for preventing / or treating pain. Research finds that after injection administration and transdermal administration, the snake venom-like tripeptide can significantly inhibit pain caused by non-inflammation and non-muscle spasm, which is specifically embodied in that in a hot plate analgesia experiment, subcutaneous injection of the snake venom-like tripeptide can significantly improve the pain threshold of an ICR mouse; in a spiny frog reflex experiment, the medicine composition obtained through compatibility of transdermal drug delivery snake venom tripeptide can remarkably reduce the foot contraction frequency of brain-removed frogs. Therefore, the snake venom-like tripeptide has great application prospects in preparation of drugs for preventing / or treating pain, especially pain caused by non-inflammation and non-muscle spasm.

The invention provides a glycyrrhizic acid composition with functions of removing redness and resisting inflammation as well as a preparation method and application of the glycyrrhizic acid composition, and belongs to the technical field of cosmetics. The preparation method comprises the following steps: carrying out enzymolysis, supercritical fluid extraction and precipitation on liquorice to prepare glycyrrhizic acid, coupling glycyrrhizic acid with allantoin to prepare a glycyrrhizic acid-alkaloid conjugate, reacting glycyrrhizic acid with menthol to prepare glycyrrhizic acid menthol ester, adding glycyrrhizic acid menthol ester, the glycyrrhizic acid-alkaloid conjugate, phospholipid and cholesterol into ethanol for dissolving, and carrying out reduced pressure rotary evaporation to remove ethanol, so as to obtain the glycyrrhizic acid menthol ester. Adding an ethanol solution, performing ultrasonic treatment, and filtering with a microfiltration membrane, so as to obtain the glycyrrhizic acid composition with the redness-removing and anti-inflammatory functions. The glycyrrhizic acid composition with the functions of removing redness and resisting inflammation has the effects of removing redness, resisting allergy, diminishing inflammation, resisting bacteria, relieving, moisturizing and the like, the percutaneous infiltration capacity of active ingredients is effectively improved, the water-soluble capacity is improved, the bioavailability of a product is greatly improved, and therefore the application range of the glycyrrhizic acid composition is widened.

The invention discloses an oxazepam composition, and belongs to the field of pharmaceutical chemicals. The applicant applies a solid dispersion technology to solubilization of oxazepam for the first time, and provides an oxazepam dispersion and appropriate auxiliary materials and a preparation method. Compared with an oxazepam raw material medicine, the solid dispersion technology is adopted, so that the water solubility of oxazepam can be improved, the oral bioavailability is further improved, and meanwhile, the clinical use safety of oxazepam is improved. Compared with other conventional preparations, the tablet containing the oxazepam dispersoid has good physical stability, better dissolution and better bioavailability, and after a stability test is accelerated for 6 months, indexes such as solubility, related substances and the like of the tablet meet quality standard requirements.

This invention belongs to the field of daily chemical products technology, specifically relating to a pure herbal hair growth and anti-hair loss shampoo based on multi-pathway synergistic effects and its preparation method. The herbal hair growth and anti-hair loss shampoo comprises: hair follicle regulating ingredients, blood circulation promoting ingredients, antibacterial and antipruritic ingredients, and natural surfactant ingredients. This invention scientifically proportions the above ingredients. The extract obtained from the hair follicle regulating ingredients regulates sebum secretion in hair follicles; the extract obtained from the blood circulation promoting ingredients promotes blood circulation in scalp capillaries; the extract obtained from the antibacterial and antipruritic ingredients inhibits scalp infections and hair follicle inflammation; and the surfactants give the shampoo good stability. This invention, through the multi-pathway synergistic effects of the above components, solves the shortcomings of existing herbal shampoo products, such as simple formulas, insufficient extraction of effective ingredients, reliance on chemical surfactants, and limited efficacy. It has the advantages of being natural, gentle, non-irritating, and having a high utilization rate of effective ingredients.