45 results about "Cupric bromide" patented technology

The invention provides a method for preparing ethyl bromodifluoroacetate and relates to a preparation method of a chemical reagent. The method takes trichloro ethylene as a raw material, and comprisesthe following steps: under the action of ultraviolet light of a catalytic medium, an oxidation reaction happens between trichloro ethylene and oxygen in a reactor to synthesize dichloracetyl chloride; an amination reaction happens between dichloracetyl chloride and diethylamine under the action of a catalyst to synthesize dichloroacetyl diethylamine; a fluorination reaction happens between dichloroacetyl diethylamine and anhydrous potassium fluoride under the action of a solvent and a phase transfer catalyst to synthesize difluoroacetyl diethylacetamide; difluoroacetyl diethylacetamide is esterified to synthesize ethyl difluoroacetate; and by taking cupric bromide as a brominating agent, ethyl difluoroacetate is bromized to prepare the end product (ethyl bromodifluoroacetate). The methodhas the characteristics that the equipment investment is low, reaction conditions are mild, the method is safely implemented at normal pressure, and after-treatment is simple.

The invention discloses an ultralow-mercury catalyst, and particularly relates to a catalyst with the ultralow content of mercuric chloride and suitable for acetylene hydrochlorination to synthesize chloroethylene. The catalyst comprises a main activity component, auxiliary component A metal bromide, auxiliary component B metal bromide and carriers, wherein the main activity component is mercuric chloride, and the content of the mercuric chloride accounts for 0.5-4% of the total mass of the catalyst carriers; the auxiliary component A metal bromide includes one or more of cupric bromide, cobaltous bromide, manganous bromide, nickel bromide and zinc bromide, and the metal element content of the auxiliary component A metal bromide accounts for 0.1-15% of the total mass of the catalyst carriers; the auxiliary component B metal bromide includes one or more of potassium bromide, barium bromide, sodium bromide and lithium bromide, and the metal element content of the auxiliary component B metal bromide accounts for 0.01-10% of the total mass of the catalyst carriers; the carriers include activated carbon with the specific surface area of 300-2500 m<2>/g and molecular sieve, or silica gel, or zeolite or kieselguhr. While activity and stability of the ultralow-mercury catalyst are ensured, the mercury resource in the catalyst is brought into full play to reach the maximum use efficiency, and the novel ultralow-mercury catalyst is environmentally friendly.

The invention relates to a method for synthesizing copper-based perovskite powder by a low-temperature solvent method. The method comprises the following steps: adding CsX and CuX into a polar organicmixed solution, and stirring for 4-6 hours at 40-70 DEG C, wherein the polar organic mixed solution is a mixed solution of N, N-dimethylformamide (DMF)and dimethyl sulfoxide (DMSO), the CsX is cesiumchloride, cesium bromide or cesium iodide, and the CuX is copper chloride, copper bromide or copper iodide. According to the synthesis process, constant-temperature growth on a hot plate is not needed, synthesis is directly conducted on a magnetic stirrer, the synthesis process has the advantages of being short in manufacturing period, low in cost, simple in growth step, environmentally friendlyand the like, and Cs3Cu2X5 powder with high crystallization quality is separated out within 5 hours.

The present invention relates to an artemisinin molecular imprinting composite film, a preparation method and applications thereof, and belongs to the technical field of environmental material preparation. The present invention especially relates to a method comprising the following steps: adopting a polyvinylidene fluoride membrane as a substrate, firstly activating the surface of the polyvinylidene fluoride membrane, then making up a combination of cupric bromide and 2, 2-bipyridine as a catalyst system, selecting artemisinin as a template molecule, acrylamide as a functional monomer and ethylene glycol dimethacrylate as a crosslinking agent, conducting activator generated by electron transfer for atom transfer radical polymerization, and synthesizing the artemisinin molecular imprinting composite film by one-step method. The adsorption balance, dynamics and selective recognition performance of the imprinting film prepared in the present invention is studied by static adsorption experiments, the results show that the imprinting film prepared in the present invention has very rapid absorption dynamic properties and superior artemisinin molecular recognition performance, and can be used for selective recognition and separation of artemisinin.

The invention relates to a method for synthesizing aliphatic propargylamines, belonging to the field of the synthesis of aliphatic compounds. The method comprises the following steps: acetylene, aliphatic amine and formaldehyde are synthesized into the aliphatic propargylamines under normal pressure and a certain temperature according to a certain proportion, DMSO or N, N-DMF is used as a reactive solvent, cupric salt is used as a catalyst, and hydrochloric acid is used as a cocatalyst, wherein the cupric salt catalyst is one of cuprous chloride, cuprous bromide, cuprous iodide, cuprous oxide, cupric chloride, cupric bromide and cupric sulfate; the cocatalyst is the hydrochloric acid; the solvent is the DMSO or the N, N-DMF; and the aliphatic amine contains 3 to 30 carbon atoms. The invention has the advantages of low reaction cost, high yield, little side reactions, low difficulty of a reaction technology, simple operation, easy subsequent-separation operation of a product, reaction time shortening and obvious enhancement of the economical efficiency.

The invention relates to a method for preparing dasatinib tablets. The method comprises the following steps: enabling 3-oxo-ethyl propionate to react with 2-chlorine-6-methylaniline under an alkali condition, further adding a solvent in which cupric bromide is dissolved to carry out a reaction, further adding thiourea, and cyclizing with a catalyst so as to obtain 2-amino-N-(2-chlorine-6-methyphenyl)thiazole-5-formamide; further synthesizing dasatinib tablets from 4,6-dichloro-2-methyl pyrimidine, N-ethoxy piperazine and 2-amino-N-(2-chlorine-6-methyphenyl)thiazole-5-formamide according to a one-pot method under the action of an alkali and an ionic liquid 1-butyl-3-methylimidazole glycinate. The method is mild in condition, simple in step, environmentally friendly, high in yield and applicable to industrial production.

The invention discloses a high-efficiency and green preparation method of alpha-bromo aromatic ketone compounds. The preparation method comprises that under a certain temperature, alpha-H of aromaticketone compounds is brominated to prepare the alpha-bromo aromatic ketone compounds in an acidic medium with hydrogen peroxide as an oxidant and an inorganic bromide as a bromine source under the condition of an alcoholic solvent or solvent-free. The main features of the method are that bromination reagents such as bromine, bromine dioxane, 2,4,4,6-tetrabromocycloketone, perbrominated quaternary ammonium salts, C5H5N.HBr.Br, NBS, dibromohydantoin, copper bromide and cuprous bromide are not used as the bromine source, so that production cost is reduced, and environmental pollution caused by heavy metal bromination reagents is avoided; and in addition, the method uses hydrogen peroxide and inorganic bromide reagents to prepare the alpha-bromo aromatic ketone compounds in situ, the reaction conditions are mild, the experimental operation is simple, the selectivity is good, and the product is single, and therefore, the preparation method has very high applicability and universality, and has a very broad application prospect.

The invention relates to a preparation method of 5-bromo-2-chlorobenzoic acid, which is characterized by comprising the following steps: reacting 2-chlorobenzotrichloride used as a raw material with abromination reagent under the catalytic action of a first catalyst to generate 2-chloro-5-bromobenzotrichloride, adding water and a hydrolysis catalyst into the 2-chloro-5-bromobenzotrichloride, andcarrying out after-treatment and purification to obtain 5-bromo-2-chlorobenzoic acid, wherein the first catalyst is prepared by compounding iron bromide, ferrous bromide, copper bromide, (ferrocene methyl) trimethyl ammonium bromide and brominated ferrocene. The invention further discloses the 5-bromine-2-chlorobenzoic acid prepared according to the preparation method of the 5-bromine-2-chlorobenzoic acid. According to the preparation method of 5-bromine-2-chlorobenzoic acid disclosed by the invention, the traditional preparation process conditions are optimized and innovated, so that the product purity, the reaction conversion rate and the production efficiency are effectively improved, the preparation cost is low, the environmental pressure is low, the synthesis route is short, the operation is simple and feasible, the emission of three wastes is reduced, and the reaction yield is high.

The invention relates to the technical field of aluminum alloy material preparation, in particular to a low-slag-rate metal smelting technology. The slag rate generated when an alloy material is supplemented in the alloy smelting process can be effectively decreased, and the workload and the working difficulty in the smelting process can be reduced. The low-slag-rate metal smelting technology is characterized by comprising the steps that 1, aluminum ingots and silicon materials are added into a smelting furnace, and igniting is conducted for temperature rising and smelting; 2, copper wires areadded into the smelting furnace, and temperature rising and smelting continue being conducted; 3, after all the aluminum ingots are smelted, the silicon materials and an aluminum-strontium alloy areadded; 4, after all the materials are smelted, first-time slagging-off operation is conducted; 5, after first-time slagging-off operation is completed, molten aluminum is taken for component detection, and the alloy material containing corresponding elements and cupric bromide are supplemented according to a detection result; 6, when the molten aluminum components meet the requirements, a refiningagent is added for refining; 7, second-time slagging-off operation is conducted on the refined molten aluminum; and 8, after second-time slagging-off operation is completed, the molten aluminum is mixed and stirred to be uniform, and a sample can be cast.

The invention discloses a phenylethanolamine-based beta receptor agonist synthesis method, which comprises: S1: dissolving 4-aminoacetophenone in an organic solvent, carrying out a halogenation reaction with an electrophilic substitution reagent at a benzene ring to generate a halobenzene intermediate, and carrying out a nucleophilic substitution reaction on the halobenzene intermediate and a cyaniding agent in an organic solvent or water under the catalysis of a metal catalyst to generate an acetophenone intermediate; S2, carrying out a carbonyl alpha bromination reaction on the acetophenoneintermediate and cupric bromide in an organic solvent to generate an alpha-bromoacetophenone intermediate; S3, carrying out a reaction on the alpha-bromoacetophenone intermediate and tert-butylamine or isopropylamine in an organic solvent to generate an acetophenone amine intermediate; and S4, carrying out a reaction on the acetophenone amine intermediate and a reducing hydrogenation reagent in anorganic solvent to generate a phenylethanolamine-based beta receptor agonist. According to the present invention, the synthesis method has characteristics of simpleness, high efficiency, inexpensiveand easily-available raw materials and high atom utilization rate, the chemical purity of the synthesized product is more than 99%, and the food safety testing requirements are met.

The invention discloses a preparation method and application of an oxamide homonuclear/heteronuclear compound containing fluorine. The structural formula of a monomer and coordination polymer is shownin the description. The preparation method comprises the steps that 2 mmol of a mononuclear oxamide copper ligand is dissolved in 10-20 ml of methyl alcohol, 1 mmol of metal salt is dissolved by 5-10ml of methyl alcohol and added into a mononuclear copper ligand solution, backflow is conducted for 5 hours at the temperature of 60 DEG C, filtering is conducted, and after filtered liquid slowly volatilizes for one week, blue crystal blocks, are obtained and are the oxamide homonuclear/heteronuclear compound containing the fluorine; the metal salt is manganese salt and copper salt, and the manganese salt is perchlorate manganese, manganous nitrate, manganous bromide, manganese sulfate, manganese chloride and the like; the copper salt is copper perchlorate, copper chloride, cupric bromide, copper sulfate and the like. Compared with anticancer platinum widely used now, the compound has the advantages of high anticancer activity, low cost, a simple preparation method and the like. It is firstly discovered that the poisonous activity of the synthesized compound on aedes albopictus can be detected, and a new way is provided for developing insecticides of related application.

The invention provides a nickel ion and solvent regulated interface rapid controllable preparation method of a cuprous bromide nanocrystal material. According to the method, a volatile liquid is usedas a solvent of a copper bromide solution, nickel chloride is added into a copper bromide solution as a regulating agent, the surface of a copper foil is uniformly coated with the copper bromide solution, and a spontaneous reaction is performed to prepare the cuprous bromide crystal material. According to the invention, by adding nickel ions and adjusting the types of solvents, cuprous bromide crystals with amorphous, polyhedral, cake-shaped and sheet-shaped structures are directly prepared on a copper foil substrate, so that the cuprous bromide crystal material is rapidly prepared, the reaction time is greatly shortened, the reaction process is not limited in a solution any more, the field of cuprous bromide preparation methods is expanded, reaction additives are reduced, and the method has the characteristics of simple preparation, low cost and easiness in industrial batch production.

The invention discloses a method for preparing an Iguratimod intermediate, i.e., 3-bromo-7-methsulfonamido-6-phenoxy-4H-1-benzo-2,3-dihydropyran-4-one. The method comprises the following steps: (1) dissolving cupric bromide in ethyl acetate and C1-C4 lower alkanol, and carrying out stirring for at least 30 minutes; (2) adding a dichloromethane solution of 7-sulfonamido-6-phenoxy-4H-1-benzo-2,3-dihydropyran-4-one into the solution obtained in the step (1), heating the temperature of the mixture to 20 DEG C to 50 DEG C with stirring, and performing a reaction for 2 to 6 hours; (3) carrying out filtering, washing filter liquor with an aqueous solution of sodium thiosulfate, and concentrating an organic phase, so as to obtain a crude product of the intermediate; and (4) carrying out refining with dichloromethane and petroleum ether, thereby obtaining a refined intermediate. The method is convenient in operation, high in conversion ratio and high in product purity, and the purity can reach96% or more.

The invention relates to a process for preparing dasatinib. The process includes steps of carrying out heating reflux on 3-oxo-propionic acid ethyl ester and 2-chlorine-6-methylaniline under alkalineconditions, adding cupric bromide, carrying out temperature-rise reflux, adding thiourea and a catalyst heteropoly acid salt, and carrying out room-temperature stirring reaction to obtain 2-amine-N-(2-chlorine-6-methyl phenyl)thiazole-5-formamide; carrying out 'one-pot reaction' on the 2-amine-N-(2-chlorine-6-methyl phenyl)thiazole-5-formamide, 4, 6-dichloro-2-methylpyrimidine and N-hydroxyethyl piperazine under the effects of catalysts to obtain the dasatinib. The process has the advantages of mild condition, simple step, environmental friendliness, high yield and applicability to industrialproduction.