156 results about "Copper bromide" patented technology

Compositions having antimicrobial activity contain particles comprising at least one inorganic copper salt; and at least one functionalizing agent in contact with the particles, the functionalizing agent stabilizing the particle in a carrier such that an antimicrobially effective amount of ions are released into the environment of a microbe. The average size of the particles ranges from about 1000 nm to about 3 nm. Preferred copper salts include copper iodide, copper bromide and copper chloride, most preferred being copper iodide. Preferred functionalizing agents comprise materials with a molecular weight of 60 or above, which include amino acids, other acidic materials, thiols, hydrophilic polymers, emulsions of hydrophobic polymers and surfactants. The functionalized particles are preferably made by a grinding process.

Embodiments of the invention are directed to a composition having antimicrobial activity comprising particles comprising at least one inorganic copper salt; and at least one functionalizing agent in contact with the particles, the functionalizing agent stabilizing the particle in a carrier such that an antimicrobially effective amount of ions are released into the environment of a microbe. The average size of the particles ranges from about 1000 nm to about 4 nm. Preferred copper salts include copper iodide, copper bromide and copper chloride. Preferred functionalizing agents include amino acids, thiols, hydrophilic polymers, emulsions of hydrophobic polymers and surfactants.

Embodiments of the invention are directed to a composition having antimicrobial activity comprising particles comprising at least one inorganic copper salt; and at least one functionalizing agent in contact with the particles, the functionalizing agent stabilizing the particle in a carrier such that an antimicrobially effective amount of ions are released into the environment of a microbe. The average size of the particles ranges from about 1000 nm to about 4 nm. Preferred copper salts include copper iodide, copper bromide and copper chloride. Preferred functionalizing agents include amino acids, thiols, hydrophilic polymers emulsions of hydrophobic polymers and surfactants.

Embodiments of the invention are directed to a composition having antimicrobial activity comprising particles comprising at least one inorganic copper salt; and at least one functionalizing agent in contact with the particles, the functionalizing agent stabilizing the particle in a carrier such that an antimicrobially effective amount of ions are released into the environment of a microbe. The average size of the particles ranges from about 1000 nm to about 4 nm. Preferred copper salts include copper iodide, copper bromide and copper chloride. Preferred functionalizing agents include amino acids, thiols, hydrophilic polymers emulsions of hydrophobic polymers and surfactants.

Embodiments of the invention are directed to a composition having antimicrobial activity comprising particles comprising at least one inorganic copper salt; and at least one functionalizing agent in contact with the particles, the functionalizing agent stabilizing the particle in a carrier such that an antimicrobially effective amount of ions are released into the environment of a microbe. The average size of the particles ranges from about 1000 nm to about 4 nm. Preferred copper salts include copper iodide, copper bromide and copper chloride. Preferred functionalizing agents include amino acids, thiols, hydrophilic polymers emulsions of hydrophobic polymers and surfactants.

An optical image amplifier comprising a copper bromide laser (10) to provide a source of optical radiation, an optical amplifier (18) for amplifying the optical radiation received from the laser (10), an optical image forming device (16) located intermediate the laser (10) and optical amplifier (18) for forming an image to spatially modulate the output of the laser (10), and optical focusing means (22) located at the output of the optical amplifier for translating the image or a portion thereof to a surface to be illuminated (30). The system increases the efficiency of irradiation of photo-sensitive films, used for example in the manufacture of integrated circuits and printed circuit boards using laser direct imaging.

The invention discloses a sugar-responsive medicament delivery material and a preparation method thereof, belonging to the field of biological materials. The chemical structure of the sugar-responsive polymer medicament delivery material is as follows, wherein n is not less than 22 and not more than 110, m is not less than 14 and not more than 100, and the n and the m are integers respectively. The preparation method comprises the following steps: enabling 1,1,1-trimethylolpropane and phenylboronic acid to react according to the molar ratio of 1:1, and getting a compound II; enabling the compound II, triethylamine and acryloyl chloride to react under the protection of nitrogen at the temperature of 0 DEG C, and getting a compound III; enabling polyethylene glycol monomethyl ether, the triethylamine and 2-bromopropionyl bromide to react for preparing a compound IV; and enabling a polyethylene glycol macroinitiator IV, copper bromide, cuprous bromide, pentylene diethylenetriamine and the compound III to react and further getting a compound I. The sugar-responsive medicament delivery material can form a nano-medicament delivery carrier via self-assembly in water solution, an amphiphilic polymer can be transformed from hydrophobicity to hydrophilicity in the place with high blood glucose concentration, and loaded medicament molecules are further released.

The invention discloses a method for synthesizing a 3-hydroxy-3-arylindole-2-one derivative shown as a structural formula (I), which comprises the following steps of: fully reacting raw materials such as an isatin compound shown as a structural formula (II) and arylboric acid shown as a structural formula (III) in an inert organic solvent in the presence of a copper catalyst, a nitrogen-containing bidentate ligand and an alkaline compound, and separating and purifying reaction liquid after the reaction is finished to obtain the 3-hydroxy-3-arylindole-2-one derivative, wherein the copper catalyst is one or any combination of copper trifluoromethanesulfonate, copper acetylacetonate, copper acetate, cuprous iodide, copper bromide, copper fluoride and copper chloride. The method is high in implementation value and good in social benefit and economic benefit.

The invention discloses a nanometer gold catalysis resonance scattering spectrum method for testing amylaceum, which is based on the catalysis of nanometer gold on the copper bromide particles generated by Cu(II)-amylaceum-KBr, and the linear relationship between amylaceum in some density and delta I610nm. The invention has the advantages that compared with prior art, the invention combines catalysis reaction with resonance scattering spectrum technique, with high analysis sensitivity, low check limit, ug / mL level, better selectivity, simple operation, simple device, easily accessible agents and low cost, which only needs fluorescence spectrometer.

The invention discloses a cheap and efficient synthesis method of an alpha-hydroxyketone compound. The synthesis method is characterized in that a carbonyl compound undergoes an oxidation hydroxylation reaction at 10-120DEG C under normal pressure with iodine simple substance, N-bromosuccimide, copper bromide, bromine simple substance, hydrogen bromide, N-iodosuccimide or hydrogen iodide as a catalyst, sulfoxide as an oxidant, water or sulfoxide as a hydroxy source and sulfoxide, ethyl acetate, N,N-dimethyl formamide, acetonitrile, toluene, 1,4-dioxane, 1,2-dichloroethane, tetrahydrofuran or H2O as a solvent, and converts into the alpha-hydroxyketone compound in a high selectivity manner. Compared with traditional synthesis methods, the method disclosed in the invention has the advantages of simple operation, high yield, simple conditions, easy purification, small waste discharge amount, simple reaction apparatus, and easy industrial production. The method has wide applicability and can be used for synthesizing various alpha-hydroxyketone compounds.

A method for synthesizing anti - AIDS medicine amprenavir intermediate is related to a synthesis method of a compound, especially for 4-amido-N-((2R,3S)-3-amido-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfamide (amprenavir intermediate), including taking the L-phenylalanine as material, adopting the benzyl protection and esterification, reaction of bromine with CuBr2 / DMF, Pd carbon deoxidization to synthesize amprenavir intermediate. We choose the economic means of protecting the amido by benzyl so as to avoid using the benzyl chloroformate. The copper bromide for halogenated use can be reacted in room temperature so as to avoid using the expensive reagent such as chlorobromomethane and chloroiodomethane and produce no pollution to the air. The debenzylation hydrogenation is finished by Pd / C so as to avoid using the expensive palladium dydroxide. The method uses cheaper materials and has a higher yield, which is suitable for commercial process.

The invention discloses a making method of 2 alpha, 3 alpha-epoxy-16 alpha-bromine-5 alpha-androstane-17-ketone as intermediate of steroidal muscular relaxation drug, which comprises the following steps: dissolving epiandrosterone in the benzene; adding catalyst; stirring; heating; refluxing 8-12h; preparing 5 alpha-androst-2-olefin-17-ketone; reacting the 5 alpha-androst-2-olefin-17-ketone and copper bromide in the carbinol to produce 16 alpha-bromine-5 alpha-androst-2-olefin-17-ketone; reacting the 16 alpha-bromine-5 alpha-androst-2-olefin-17-ketone and m-perbenzoic acid in the composite solvent of water and dichloromethane; producing the product through eliminating, bromizing and epoxidising.

The invention discloses a preparation method of beta-aminoethylphosphonyl derivatives. The method comprises the following steps: adding an ethylene derivative, an ammonia derivative, an organic phosphine compound, silver nitrate, a catalytic amount of copper bromide, and a solvent into a reactor, reacting at 30-50DEG C to prepare a beta-aminoethylphosphonyl derivative, adding hydrochloric acid, and further reacting to obtain more beta-aminoethylphosphonyl derivatives. The ethylene derivative is used as an initiator, so raw materials are easy to obtain and have many kinds; and the products obtained by using the method are various, can be directly used, and can also be used in other further reactions. The method has the advantages of mild reaction conditions, simple reaction operation and post-treatment process, concise production technology, high yield, and suitableness for large scale production.

The invention belongs to the technical field of high molecular polymer materials for biomedicine, and discloses an amphiphilic pH-responsive 4 / 6 heteroarm star-shaped copolymer of which the number-average molecular weight is 30000-54000g / mol. The invention also discloses a preparation method of the amphiphilic pH-responsive 4 / 6 heteroarm star-shaped copolymer, which comprises the following steps: mixing epsilon-caprolactone, stannous octoate and low molecular initiator, reacting at 110-140 DEG C for 24-48 hours, performing reduced pressure distillation, precipitating, filtering, and drying to obtain polycaprolactone high molecular initiator; dissolving the polycaprolactone high molecular initiator, 2-diethylaminoethyl methacrylate, hexamethyltriethylenetetramine and copper bromide in toluene, stirring, then adding stannous octoate, and reacting at 60-90 DEG C for 5-12 hours; and adding methoxy polyoxyethylene methacrylate, continuously polymerizing for 5-12 hours, removing a catalyst, filtering, and performing posttreatment on the filtrate to obtain the amphiphilic pH-responsive 4 / 6 heteroarm star-shaped copolymer. The amphiphilic pH-responsive 4 / 6 heteroarm star-shaped copolymer is used for preparation of a micelle system for carrying water insoluble medicaments.

The invention discloses a preparation method of terbutaline sulfate. The method comprises the steps: taking 3,5-dihydroxyacetophenone as an initial raw material, firstly, carrying out benzyl protection to obtain 3,4-dibenzyloxyacetophenone, carrying out copper bromide bromination and DMSO oxidation on 3,5-dibenzyloxyacetophenone to obtain 3,5-dibenzyloxyacetophenone aldehyde, carrying out reductive amination on 3,5-dibenzyloxyacetophenone aldehyde and tert-butylamine to generate 1-[3,5-di(benzyloxy)phenyl]-2-(tert-butylamino)ethanol, and finally carrying out hydrogenation debenzylation and sulfuric acid salification, to obtain terbutaline sulfate. Compared with the prior art, the method has the advantages that the used raw materials and auxiliary materials are cheap and easily available, the use of high-risk and highly-toxic reagents is avoided, high-temperature and high-pressure reaction is avoided, the operation is simple and convenient, the reaction conditions are mild, and the defects of long steps, low yield, potential safety hazards and the like in the prior art are overcome.

The invention provides a method for preparing cyclohexenone through oxidizing cyclohexene with molecular oxygen. According to the method, the cyclohexenone is prepared by taking reaction at 0.1 to 1.0MPa and 80 to 160 DEG C through using easy-to-obtain cyclohexene as raw materials and using oxygen or air as oxygen sources under the existence of copper compound catalysts such as copper acetate, copper trifluoroacetate, copper sulfate, copper oxide, copper chloride, copper bromide and the like. According to the method, low-price clean oxidizing agents are adopted, the addition of solvents is not needed, the catalysts are simple and are easy to obtain, the conversion rate and the selectivity are high, the production cost is low, and the method is suitable for large-scale industrial production.

The invention discloses a preparation method of 3-methyl-2-butenoic acid. The existing method has great amount of three wastes which pollute the environment heavily. The method is characterized in that: 2-methyl-3-butyne-2-alcohol is adopted as a raw material; 3-methyl-2-butenoic aldehyde is obtained by the complex system of acetylacetone titania-copper bromide-benzoic acid through catalytic reforming, and finally the 3-methyl-2-butenoic acid is obtained by oxidizing 3-methyl-2-butenoic aldehyde; and an oxidizer adopted is air or oxygen or the mixture of air and oxygen, wherein, the preference is air. The oxidizer adopted by the method is safe, avirulent and easy to be controlled, and has low cost; in addition, the reaction yield is high and the product purity is high on the premise of ensuring no pollution to the environment.

The invention provides a biodegradable and sugar responsive Y type polymer drug delivery material and preparation, which belongs to the field of biological materials. The structural formula of the compound is obtained by the following steps of firstly preparing a compound III, and then, preparing a compound V, and reacting the compound III with the compound V under conditions of cuprous bromide, copper bromide and divinyl pentamethylene triamine. The material provided by the invention has glucose responsive self-discipline insulin release ability and has selectivity on glucose concentration.

The invention relates to a preparation method for a molecularly imprinted microsphere surface grafted hydrophilic polymer brush, and belongs to the technical field of environment function material preparation. The method comprises the steps of using sulfamethazine as template molecules, using 4-vinylpyridine as a functional monomer, using ethylene glycol dimethacrylate as a cross-linking agent, using methyl alcohol and water as a solvent, using copper bromide / N,N,N',N,'N''-pentamethyldiethylenetriamine / azodiisobutyronitrile as an initiating system to initiate reverse atom transfer radical precipitation and polymerization, so as to prepare the molecularly imprinted polymer microsphere with the surface containing active initiators, using the molecularly imprinted polymer microsphere as the macroinitiator, using cuprous bromide / N,N,N',N',N''-pentamethyldiethylenetriamine as a catalyst, and polymerizing surface initiated atom transfer radical on a molecularly imprinted microsphere surface grafted hydrophilic hydroxyethylmethacylate brush in the methyl alcohol / water mixed solvent. The molecularly imprinted polymer microsphere prepared through the method has higher adsorption capacity, fast adsorption kinetics property and good selective adsorption performance.

The present invention relates to a preparation method for an illite magnetic composite surface imprinting temperature-sensitive adsorbent. The method comprises that: magnetic illite is prepared through solvothermal synthesis; the surface of magnetic illite undergoes ethylene functionalized modification performed by using KH570 and is used as a matrix material; ciprofloxacin is used as a template, hydroxyethyl methacrylate and methacrylic acid are used as a functional monomer; N-isopropyl acrylamide is used as a temperature-sensitive monomer; polyethylene glycol dimethacrylate and N,N'-methylene bisacrylamide are used as a crosslinking agent; copper bromide, N,N,N',N",N"-pentamethyldiethylene triamine and 2-bromoisobutyrate are used as a initiator; the illite magnetic composite surface imprinting temperature-sensitive adsorbent is prepared in a mixed system of methanol and water, and the adsorbent is used for selectively identifying and separating ciprofloxacin in an aqueous environment. The preparation method for illite magnetic composite surface imprinting temperature-sensitive adsorbent provided by the present invention is low in cost and simple in preparation, and the adsorbent is high in accuracy in identifying a target molecule, high in selectivity and excellent in the separation and enrichment capability.

The invention relates to an oxygen-containing polydentate ligand modified copper-based catalyst for acetylene hydrochlorination reaction as well as a preparation method and application thereof. According to the catalyst, activated carbon serves as a carrier, copper salt serves as a main active component, and the catalytic activity and stability of the catalyst are improved by adding an oxygen-containing polydentate ligand. The oxygen-containing polydentate ligand does not contain other hetero-atoms except oxygen, and can form a stable complex with copper; the copper salt is selected from one or more of copper chloride, copper bromide, copper nitrate and copper sulfate; and the mass ratio of the copper element to the catalyst is 2.5-16%. The copper ions can be firmly combined with the oxygen-containing polydentate ligand, so that the copper ions are prevented from being reduced into inactive zero-valent copper in the catalytic process. In addition, if the two can form a five-membered ring complex after coordination, the electrons of the copper ions can be regulated and controlled to tend to space distribution which is more favorable for catalysis.

The invention discloses a synthetic method of 3,6-dihydro-2H-pyran-4-boronic acid pinacol ester, which comprises the following steps: 1) carrying out a reaction of tetrahydro-4H-pyran-4-one and hydrazine hydrate in a solvent to generate single ketone hydrazone; 2) carrying out a reaction of the single ketone hydrazone and copper bromide in a solvent in the presence of triethylamine to obtain a dibromo intermediate; 3) carrying out an elimination reaction of the dibromo intermediate and an alkali in a solvent to obtain an alkenyl bromide compound; 4) carrying out a Suzuki-Miyaura reaction of the alkenyl bromide compound and bis(pinacolato)diboron in a solvent in the presence of a palladium complex to obtain the product. The synthetic method of the invention is simple, and low in cost, adopts no dangerous raw materials, and is safe and suitable for large-scale production.

The invention relates to a preparation method of a polyamide composite nanofiltration membrane. The method comprises the following steps: dispersing silicon dioxide nanoparticles in N, N-dimethylformamide to prepare a substance I; grinding the substance I to obtain modified silicon dioxide nanoparticles; dispersing an ionic liquid, 2, 2'-dipyridyl, copper bromide and the modified nanoparticles into N, N-dimethylformamide, and adding an azodiisobutyronitrile solution for reaction to obtain a substance II; grinding the substance II to obtain silicon dioxide-polyion liquid particles; mixing triethylamine and piperazine hexahydrate into water, adding the silicon dioxide-polyion liquid particles, and performing ultrasonic dispersion to obtain a water-phase solution; mixing trimesoyl chloride with n-hexane to obtain an organic phase solution; soaking the surface of the membrane with a water-phase solution and the organic-phase solution in sequence for reaction to obtain the composite polyamide nanofiltration membrane containing the silicon dioxide-polyion liquid particles. According to the method, the dispersity of the nanoparticles in the membrane and the electropositivity of the membrane can be improved, and the permeability of the membrane and the selectivity of part of heavy metal ions are effectively improved.

The invention relates to a sheet crystal copper powder, wherein its production comprises (1), adding disperser and ammonia I into reactant copper bromide suspension, to be mixed with reducer solution, and reacted at 40-70Deg. C; after 0.5h, adding ammonia II, reacting for 1-4h; the obtained copper powder is well grown crystal powder, with flat surface and sheet shape, whose diameter is 0.5-10mcirometer, thickness is 0.1-0.8micrometer and the length-width ratio of particle is 5-30.

The invention discloses a histamine dihydrochloride synthesis method. Through addition of a catalyst (copper bromide), the decarboxylation temperature is reduced, the types and the contents of unknown impurities are reduced, the raw material conversion rate is increased, the end product purity is improved, and energy consumption reduction and easy industrialisation are realized. Through the step of injecting hydrogen chloride gas to prepare hydrochlorate, the step of preparing a hydrogen chloride solution is omitted and the operation is simplified.

Embodiments of the invention are directed to a composition having antimicrobial activity comprising particles comprising at least one inorganic copper salt; and at least one functionalizing agent in contact with the particles, the functionalizing agent stabilizing the particle in a carrier such that an antimicrobially effective amount of ions are released into the environment of a microbe. The average size of the particles ranges from about 1000 nm to about 4 nm. Preferred copper salts include copper iodide, copper bromide and copper chloride. Preferred functionalizing agents include amino acids, thiols, hydrophilic polymers emulsions of hydrophobic polymers and surfactants.

The invention provides a method for preparing high-performance all-inorganic perovskite solar cell based on copper bromide. The method comprises the following steps of: (1) depositing an electron transport layer TiO2 on a treated FTO substrate; (2) preparing a perovskite precursor solution doped with copper bromide powder; (3) preparing a film on an FTO substrate deposited with the TiO2 by employing the prepared perovskite precursor solution through adoption of the spin coating method, and transferring the substrate after spin coating to a heating platform to perform annealing treatment; (4) employing the spin coating method to prepare a hole transport layer; and (5) employing a thermal evaporation technology to deposit a thin film molybdenum trioxide and a silver electrode on the preparedhole transport layer. The method can effectively improve the carrier mobility and device stability of the device, successfully increases the PCE of the all-inorganic perovskite solar cell from 13.24%to 16.15% which is the highest efficiency of the CsPbBrI2 system all-inorganic perovskite solar cell so far.

The invention provides a method for modifying a metal-organic framework compound, belonging to the technical field of metal-organic frameworks. The invention is to solve the problem of limit of application fields of UiO-66 due to insolubilization of the UiO-66 in water. The method provided by the invention comprises the following steps: step 1, dispersing a metal-organic framework compound namelyUiO-66-NH2 in an organic solvent; step 2, adding an organic solvent solution of 2-bromoisobutyryl bromide and an organic solvent solution of triethylamine, and carrying out a reaction under heating under the protection of nitrogen; step 3, carrying out washing, then carrying out soaking with methanol, and carrying out cleaning, centrifugal separation and drying; step 4, dispersing an obtained material and sodium p-styrenesulfonate in water, adding a tris[2-(dimethylamino)ethyl]amine solution of copper bromide and a sodium ascorbate solution, carrying out a reaction, and carrying out centrifuging so as to obtain a clear liquid; and step 5, carrying out concentration, carrying out washing with methanol, repeatedly carrying out washing and concentration, and carrying out freeze-drying. The method provided by the invention increases the water solubility and surface charges of the UiO-66, and is applied to the fields of drug sustained release, pollutant adsorption, etc.

A two-in-one copper chloride / copper bromide disinfector and a method of controlling the same. In operation, when copper is released, the positive and negative electrodes of a copper billet are periodically reversed, while the positive and negative electrodes of a titanium plate / graphite polar plate are in an uncharged state. When chlorine / bromine is released, the positive and negative electrodes of a titanium plate / graphite polar plate are periodically reversed, while the positive and negative electrodes of the copper billet are short-connected, then connected to the negative electrode of the titanium plate / graphite polar plate, or applied thereon with an electric voltage that is lower than the electric voltage of the negative electrode of the titanium plate / graphite polar plate. With this method, the copper billet out of operation is shorted-connected to the negative electrode of the titanium plate / graphite polar plate or connected to an electric voltage that is lower than that of the negative electrode. Thus the release amount of copper ions is controllable, the volume of the disinfector is reduced, and the corrosion between the positive and negative electrodes of the copper billet is uniform.