164 results about "Phosphine oxide" patented technology

The invention discloses an aluminum substrate UV matt finish paint and a preparation process thereof, and relates to the technical field of paints.The aluminum substrate UV matt finish paint is prepared from, by mass, 10%-20% of modified polyurethane acrylate, 25%-32% of high-functionality aliphatic polyurethane acrylate, 18%-30% of special modified epoxy acrylate resin, 0.5%-2% of dispersing agent, 0.1%-0.5% of defoaming agent, 1%-3% of anti-settling powder and the balance water. The paint is prepared from the following components in percentage by weight: 10 to 15 percent of magnesium silicate mineral, 1 to 10 percent of matting powder, 0.2 to 1 percent of 1-hydroxycyclohexyl phenyl ketone, 0.5 to 3 percent of trimethylbenzoyl-diphenyl phosphine oxide, 1 to 3 percent of acrylate flatting agent, 0.2 to 1.2 percent of polyurea modified polyurethane rheological agent and 5 to 15 percent of trimethylolpropane triacrylate. According to the UV matte finishing paint disclosed by the invention, through compounding of ternary resin and enhancement of nano silicon dioxide, a rigid and tough cross-linked network is constructed, a paint film is free of cracks when being bent at 180 degrees, the adhesive force reaches grade 0, and a coating is resistant to acid and alkali etching liquid and free of corrosion by cooperating with a silane coupling agent and a light stabilization system, and the color difference is delta Elt after the UV matte finishing paint is subjected to high temperature of 260 DEG C; and 1.5, the anti-yellowing performance is excellent.

The invention belongs to the technical field of UV visbreaking polymers, and particularly relates to a UV visbreaking film and a preparation method thereof. Wherein the UV viscosity-reducing film sequentially comprises a base film (1), a first viscosity-reducing adhesive layer (5), a second viscosity-reducing adhesive layer (4) and a release film (3) from bottom to top, the first viscosity-reducing adhesive layer (5) and the second viscosity-reducing adhesive layer (4) both comprise a photoinitiator, the photoinitiator in the first viscosity-reducing adhesive layer (5) is 1-hydroxy-cyclohexyl phenyl ketone, and the content of the photoinitiator in the formula of the adhesive layer is 0.1%-10% by mass; a photoinitiator in the second viscosity-reducing adhesive layer (4) is bis (2, 4, 6-trimethylbenzoyl) phenyl phosphine oxide, and the content of the photoinitiator in the adhesive layer formula is 0.1-10% by mass; in the preparation method, ultraviolet irradiation precuring is carried out, so that the UV viscosity-reducing film has light selectivity and high cohesion strength, and the residual adhesive is remarkably reduced.

The invention belongs to the technical field of UV ink formula design and digital printing application, and particularly relates to scratch-resistant UV ink, a preparation method thereof and application of the scratch-resistant UV ink to digital printing. The scratch-resistant UV ink comprises the following raw materials in parts by weight: 15-25 parts of epoxy acrylate; 10 to 20 parts of polyurethane acrylate; 15 to 25 parts of a bifunctional monomer; 5-10 parts of a monomer with three functional groups and more than three functional groups; 3 to 5 parts of an alpha-hydroxy ketone photoinitiator; 2 to 4 parts of an acyl phosphorus oxide photoinitiator; 2 to 5 parts of organically modified nano silicon dioxide; 0.1 part to 0.5 part of a flatting agent; 0.5 to 1.5 parts of a dispersing agent; 10 to 15 parts of pigment; the bifunctional monomer is tripropylene glycol diacrylate; the monomer with three functional groups and more than three functional groups is trimethylolpropane triacrylate. The ink has pencil hardness greater than or equal to 3H and excellent flexibility, the adhesive force on substrates such as PC, PET, metal and the like reaches 0 level, the printing process is simplified, and the ink is suitable for digital printing in various scenes.

The invention discloses a preparation method of 3, 6-dichloropyridazine, and belongs to the technical field of chemistry. According to the method, 3, 6-dihydroxypyridazine is used as a raw material, an organic solvent and triphenylphosphine oxide are combined to form a dichlorotriphenylphosphine intermediate state which is used as a chlorinating agent, dihydroxyl is substituted to generate 3, 6-dichloropyridazine, triphenylphosphine oxide and solid light are used as raw materials, heating reaction is performed to prepare 3, 6-dichloropyridazine, meanwhile, a one-pot method can be adopted in the two-step reaction, and operation is easy and convenient. The novel preparation method for synthesizing 3, 6-dichloropyridazine provided by the invention has the advantages of low raw material cost, high yield, high gas phase purity and no pollution, is suitable for industrial production, can meet industrial requirements, provides a new idea for later preparation of 3, 6-dichloropyridazine, has the remarkable advantages of high gas phase purity and high yield, and is suitable for industrial production. Wide application prospects are realized.

The invention provides a method for recovering rhodium in organic residual liquid containing triphenylphosphine / phosphine oxide, and relates to the technical field of precious metal recovery, and the method comprises the following steps: S1, carrying out reduced pressure rectification on the organic residual liquid containing triphenylphosphine / phosphine oxide to remove volatile components until the indexes of the residual liquid meet the feeding requirements of a subsequent process, and collecting light components for independent storage; s2, adding an acidic medium into the organic phase after light component removal, stirring and heating, introducing an oxidizing agent to carry out oxidation-complexation reaction, maintaining reaction conditions until the reaction is complete, standing for phase splitting, and collecting a water phase containing rhodium complex ions; according to the method, a core process combining oxidation-chlorination transfer and anion exchange adsorption is adopted, and key parameters of each process are accurately controlled, so that the rhodium recovery rate is stabilized at 95% or above, the rhodium content in the residual liquid can be reduced to 5 ppm or below, the industrial emission standard is completely met, and compared with the prior art, the resource recovery efficiency is greatly improved, and the cost is reduced. And waste of precious metal resources is effectively reduced.

The invention provides a preparation method of photocatalytic hydrogel, belongs to the technical field of photocatalysis, and aims at solving the problems that traditional hydrogen production is high in energy consumption and pollution, and existing photocatalytic hydrogel is low in purity and unstable in performance. The method comprises the following steps: firstly, preparing seven precursors of CPDT-1, CPDT-2Br-SO3Na, PCT-SO3Na, Flu-2Br-SO3Na, PFT-SO3Na, PCBT-SO3Na and PFBT-SO3Na step by step, and carrying out nitrogen purging to prevent oxidation, acetone precipitation, recrystallization and Soxhlet extraction and purification in the process; the four active precursors are mixed with acrylic acid, pentaerythritol triallyl ether and (2, 4, 6-trimethylbenzoyl) diphenyl phosphine oxide respectively, the mixture is subjected to 365nm ultraviolet irradiation polymerization, and four photocatalytic hydrogels are prepared. The method has the advantages of mild conditions, controllable operation, high product purity and stable photocatalytic performance, and is suitable for hydrogen energy preparation and water pollution treatment.

The application provides a kind of eutectic solvent and its preparation method and application, the eutectic solvent includes hydrogen bond donor compound and hydrogen bond acceptor compound, the structural formula of hydrogen bond donor compound is wherein, R1 and R2 independently selected from n-octyl or iso-octyl, the hydrogen bond acceptor compound includes tri-n-octyl phosphine oxide.The eutectic solvent can be efficiently extracted from the permanent magnet rare earth waste hydrochloric acid solution of transition metal, can reduce the use of a large amount of organic solvent in the traditional extraction process.

This invention provides a novel phosphine oxide compound that inhibits SHP2, a composition thereof, a method for preparing the compound, and a method for treating SHP2-related diseases (such as cancer).

A process for the preparation of a compound of the sterically hindered alkoxyamine class is described, the process comprises the step of alkylating a sterically hindered hydroxylamine compound to a corresponding sterically hindered alkoxyamine by reacting said sterically hindered nitroxyl compound with a compound capable of producing a carbon-central alkyl radical, typically a territorial or secondary alkyl radical, the compounds capable of generating carbon-center alkyl radicals are selected from thermal radical initiators that form radical species in the temperature range of 40 DEG C to 200 DEG C, and from photoinitiators that undergo light excitation when irradiated with UV light or visible light in the range of 180 to 700 nm, in particular UV light in the range of 180 to 380 nm, the compounds capable of generating carbon center alkyl radicals are typically selected from the class of organic peroxides, azo compounds, benzoyl derivatives, benzophenone derivatives, thioxanthone derivatives, benzoin derivatives, benzoyl phosphine oxide derivatives, and the like. The invention relates to a peroxide, for example, selected from the group consisting of diacyl peroxides of formula (A), peracid esters of this formula (A), and oxalic acid peracid esters of formula (D) R-CO-O-O-Z-R (A), r-Z ''-X-CO-CO-O-O-Z''-R (D) wherein each R independently represents a primary or secondary alkyl or cycloalkyl group, preferably comprising from 1 to 15 carbon atoms, and X is oxygen-O-or peroxy-O-O-, Z represents CO or an alkylene group bonded to a quaternary carbon atom, the quaternary carbon atom being an alkylene group of formula (C) R '-C-R' (C), wherein each R'is selected from alkyl groups having 1 to 15 carbon atoms, and Z "represents the alkylene group bonded to a quaternary carbon atom having the formula (C). The described process produces the corresponding O-alkylated derivatives of the sterically hindered hydroxylamines, typically compounds of the class referred to as N-O-alkyl HALS, with very high selectivity and conversion and without the need for the use of catalysts, in particular metal catalysts.

The invention relates to the field of organic synthesis, in particular to a synthesis method of gamma-aminophosphine oxide compounds and derivatives thereof. According to the synthesis method disclosed by the invention, alpha, beta-unsaturated amide, diaryl phosphine oxide or phosphite ester is taken as raw materials, and under the action of acid, the gamma-aminophosphine oxide compound can be rapidly and efficiently synthesized by a one-pot method. The preparation method comprises the following steps of: generating conjugated nitrile positive ions or imine salt intermediates with strong electrophilicity from alpha, beta-unsaturated amide under the activation of acid, converting diaryl phosphine oxide or phosphite ester into strong nucleophilic three-coordination phosphorus species under the action of alkali, and further performing phosphorus-doped Michael addition reaction on the conjugated intermediates to finally generate the gamma-aminophosphine oxide compounds. According to the method disclosed by the invention, diaryl phosphine oxide or phosphite which is cheap, easy to obtain and stable in structural property is used as a phosphorus source, the substrate applicability is wide, and the economic cost is relatively low; in addition, the method realizes synthesis of a target product without participation of a metal catalyst, and is rapid and efficient.

The invention provides a method for preparing a chiral helicene compound through cyclization reaction of an iridium-catalyzed 3-aryl indazole biaryl compound and disubstituted alkyne. The method comprises the following steps: under the action of an iridium catalyst, a chiral cyano phosphorus-oxygen ligand and an additive, carrying out an intermolecular asymmetric carbon-hydrogen bond activation reaction on a 3-aryl indazole biaryl compound and disubstituted alkyne, and after the reaction is finished, separating to obtain the chiral diazaspirene-containing compound, according to the invention, synthesis of the chiral helicene compound is realized through a transition metal catalysis asymmetric carbon-hydrogen bond activation method, the research technology of Cp metal catalysis asymmetric carbon-hydrogen bond activation is further developed, and the synthesis strategy of the chiral helicene compound is expanded at the same time; reaction substrates are wide in universality, and chiral control in the reaction process is realized through the chiral cyano phosphine oxide, so that the product has very high enantioselectivity; various chiral helicene compounds are synthesized, the synthesis method is simple and convenient, and the atom economy is high.

The invention discloses a production process of a cellulose acetate fiber fabric containing natural fragrance, a solvent formed by mixing a modified polymer, 2, 4, 6-trimethylbenzoyl-diphenyl phosphine oxide, a modified microcapsule and dimethylformamide is subjected to dry spinning to prepare the cellulose acetate fiber fabric, and the weight part ratio of the modified polymer to the modified microcapsule is (70-80): (6-8). The preparation method comprises the following steps: by taking an isocyanate group on excessive hexamethylene diisocyanate as a reaction site, firstly reacting with an intermediate containing dihydroxyl, and then reacting with cellulose acetate containing free hydroxyl, so as to prepare the modified polymer. The halamine structure on the molecular chain can destroy cell membranes, enzyme systems or genetic materials through oxidation. The modified capsule has a lavender essential oil and cinnamon essential oil double-component double-capsule-wall structure, the fragrance durability can be improved, the copper sulfide nanoparticles and quaternized chitosan structures can destroy the bacterial cell structure, and the antibacterial performance of the material is improved.

This invention discloses a photosensitive supramolecular fluorescent polymer, its preparation method, and its anti-counterfeiting application in water, using trifluoroethyl methacrylate, hexafluorobutyl acrylate, 4-(acryloyloxy)butyl4-(2-methyl-3-(2-(2-methylbenzo[b]thiophen-3-yl)-4-oxo-5,6-2H-4H-thiaran[2,3-)b]thiaran-3-yl)benzo[b]thiophen-6-yl)-4-oxobutyrate, 4 This polymer was prepared by a simple one-step free radical copolymerization method using 1,1-(acryloyloxy)butyl3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-1,1-dioxide benzo[b]thiophene-3-yl)cyclopent-1-en-1-yl)-2-methylbenzo[b]thiophene-6-carboxylate 1,1-dioxide and phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide (photoinitiator-819) as raw materials. The polymer exhibits excellent multicolor light-switching performance, high stretch ratio, high self-healing efficiency, strong substrate adhesion, and antifouling properties, especially demonstrating excellent stability under strong acid, strong alkali, and high salt environments. The synthetic route is simple, and it has great application potential in underwater anti-counterfeiting and encryption technologies.

The application provides a method for constructing a C-P bond through a nickel-catalyzed Hirao reaction, comprising the following steps: coupling a substituted aromatic compound 1 and a diphenyl phosphine oxide 2 in an organic solvent in the presence of a nickel catalyst, an additive and a base to generate an aromatic phosphine oxide compound 3, and the reaction formula is as follows: wherein X is any one of F, Cl, Br, I, OTf, B(OH)2 and OCF3; and Ar is an aromatic group. The method has the effects of universality of substrates, simple operation, mild conditions, low cost of noble metal catalysts and phosphine ligands and high yield.

The application relates to a method for synthesizing ferrocene phosphine oxide compounds. Specifically, a ferrocene-substituted compound, diaryl phosphine oxide is used as raw material to realize C-H phosphine oxide reaction of ferrocene under the promotion of electricity. The application has the following advantages: the ferrocene-substituted compound is directly used as a C-H donor without guidance, no additional oxidant and metal catalyst are needed, the condition is mild, the substrate range is wide, and the yield is good.

The invention discloses a self-repairing mute tire and a preparation method thereof, and relates to the technical field of tires, the self-repairing mute tire comprises a tire body, and a self-repairing rubber layer and a mute material which are sequentially attached to the inner wall of the tire body from inside to outside; the self-repairing adhesive layer is prepared from the following components: epichlorohydrin rubber, acrylate rubber, a rosinyl phenyl phosphine oxide isoxazolyl functional polymer, 4, 4-chloroformyl phenyl ether, a catalyst, 2, 2-bis [4-(4-aminophenoxy) phenyl]-1, 1, 1, 3, 3, 3-hexafluoropropane, trithiocyanuric acid, a filler, an accelerant TMTD (Tetramethylthiuram Disulfide) and an auxiliary agent; the rosinyl phenyl phosphine oxide isoxazolyl functional polymer comprises structural units introduced through a condensation polymerization reaction of the following monomers: glycerol triabietate, bis (4-carboxyl phenyl) phenyl phosphine oxide and 3, 5-isoxazoledicarboxylic acid. The tire is remarkable in self-repairing effect, good in mute performance, sufficient in performance stability and long in service life.

The invention provides a Fe-Co-Ni series nano-alloy and a preparation method and application thereof, and belongs to the technical field of functional materials. The alloy is prepared by the following steps of: weighing and proportioning 0.5 mmol of each element by taking chlorate or acetylacetonate or acetate of iron, cobalt, nickel, manganese, copper, zinc and the like with the purity of more than 99.5% and other metal chlorides which are rich in earth surface and economical and practical as precursors, putting the precursors into a pressure-resistant bottle, taking n-trioctylphosphine oxide (TOPO) as a ligand, taking ethanol and 1-octadecene (ODE) as a mixed solvent, and uniformly stirring to prepare the alloy. And synthesizing the hexagonal nano-alloy at low temperature by using a wet chemical method. The method can be used for synthesizing 3-10-element medium-entropy and high-entropy alloy, and has a wide application prospect. The synthesis is a precise process which is guided by an organic ligand, is coordinated by multiple metals and is subjected to nucleation-self-assembly-anisotropic growth.

The application belongs to the technical field of asymmetric catalytic synthesis, and particularly relates to an alpha-carbon chiral phosphine compound and a preparation method thereof. In a protective gas atmosphere, an asymmetric boron protonation reaction is carried out on a dienyl phosphine oxide compound shown in a structure of formula II, pinacol borate, a copper (I) catalyst, a chiral ligand, an organic alkaline compound and a proton additive in a polar organic solvent to obtain an alpha-carbon chiral phosphine compound shown in a structure of formula I; the chiral ligand is a cyclic phosphine ligand (S, S)-Ph-BPE or a cyclic phosphine ligand (R, R)-Ph-BPE. The preparation method provided by the application can synthesize the alpha-carbon chiral phosphine compound shown in the structure of formula I with high yield and excellent enantioselectivity, the synthesis method is simple and low in cost, and the alpha-carbon chiral phosphine compound can be further converted into a new optically active product.

A process for manufacturing a masterbatch comprises the following steps: (a) bringing at least one initial polymer comprising at least one carbon-carbon unsaturation into contact with at least one 1,3-dipolar grafting agent bearing at least one nitrile oxide dipole in the presence of at least one organophosphorus additive selected from the group consisting of phosphoric acid triesters, phosphonates, phosphinates, phosphine oxides and the mixtures of these compounds, and (b) recovering the masterbatch obtained in the preceding step. The masterbatch and compositions containing it and also tires comprising such compositions are also disclosed.

The present invention provides: a carbon dioxide absorbing liquid which has excellent carbon dioxide absorbing performance; a carbon dioxide absorbing liquid which is capable of easily desorbing carbon dioxide when the absorbing liquid is regenerated in addition to having the above-described carbon dioxide absorbing performance; a method for separating carbon dioxide and a method for separating and recovering carbon dioxide, each using the carbon dioxide absorbing liquid; and a device using the carbon dioxide absorbing liquid. The present invention relates to a carbon dioxide absorbing liquid which contains a solvent and a phosphine oxide compound represented by general formula (1) (wherein a, b, and c each represent an integer of 1 to 10, R1, R2, and R3 each independently represent an amino group or a hydroxy group, and at least one of R1, R2, and R3 is an amino group).

The application discloses a preparation method and application of a multi-phenyl phosphorus oxide compound and belongs to the technical field of organic synthesis. Different properties of raw materials are respectively dissolved through double solvents, a catalyst is added into the system, and the entering of the alkali metal salt reactant into the organic phase reaction is helped to be dissolved to obtain a molecular level reactant, so that the reaction is promoted to be completely carried out, the yield of a product is improved, the proportion of impurities, such as the reactant, contained in the product is reduced, the purity of the product is improved, and the high-purity product is a material with low dielectric property. The material is tested in various performances, and excellent flame retardance and low dielectric constant are obtained.

The invention provides a perovskite precursor solution, a perovskite solar cell and a preparation method and application thereof, the perovskite precursor solution comprises a perovskite precursor, a conductive phosphine oxide compound and a solvent, and the conductive phosphine oxide compound comprises a conductive bridged phosphine oxide compound and / or a conductive spiro phosphine oxide compound; the conductive phosphine oxide compound is introduced into the perovskite precursor solution, and the specific type of the conductive phosphine oxide compound is limited, so that uncoordinated lead ion defects in perovskite can be passivated, the surface defect state of perovskite crystals can be reduced, the crystallinity of the perovskite thin film can be improved, the excellent conductivity of the conductive phosphine oxide compound can be utilized, and the perovskite thin film can be prepared. The transmission of carriers from a perovskite interface to an electronic layer is promoted, so that the photoelectric conversion efficiency of the perovskite solar cell is improved, and the stability of a device is also improved.

The invention discloses a pressure-sensitive adhesive for thermosetting coating rolling and light curing bonding and a preparation method of the pressure-sensitive adhesive. The pressure-sensitive adhesive is prepared from the following raw materials: a polyurethane acrylate prepolymer, a dynamic disulfide bond cross-linking agent, an NCO-containing closed curing agent, a trifunctional acrylate monomer, a bifunctional diluting monomer and an acylphosphine oxide photoinitiator. Wherein the polyurethane acrylate prepolymer, the dynamic disulfide bond cross-linking agent and the closed curing agent form a thermocuring component; the three-functionality acrylate monomer, the double-functionality diluting monomer and the acylphosphine oxide photoinitiator form a photocuring component. The adhesive provided by the invention is widely applied to coiled material processing and terminal products, and effectively solves the dual requirements of insufficient initial adhesion and high peel strength.

The application discloses a high-flash-point fireproof coating based on heat-resistant phenyl phosphine oxide and a preparation method thereof, and relates to the technical field of fireproof and flame-retardant coating.The high-flash-point fireproof coating based on heat-resistant phenyl phosphine oxide comprises the following components in parts: heat-resistant phenyl phosphine oxide 10-15 parts, cobalt isooctoate 1-3 parts, methyl ethyl ketone peroxide 0.2-1 part, epoxy resin 140-160 parts and curing agent 90-110 parts; the epoxy resin is epoxy resin 828 or epoxy resin 815 or epoxy resin C 14 H 20 O4.The heat-resistant phenyl phosphine oxide contains phosphorus with flame-retardant effect and has a high thermal decomposition temperature; as a flame-retardant additive, the heat-resistant phenyl phosphine oxide can improve the thermal stability of the coating, thereby avoiding early degradation of the polymer and improving the flash point of the coating, and the flash point is greater than 60 DEG C.

The application discloses a high-temperature-resistant polyvinyl chloride adhesive tape and a preparation method thereof, and belongs to the technical field of polymer materials and adhesive products. The high-temperature-resistant polyvinyl chloride adhesive tape comprises the following raw materials in parts by weight: synergistically modified polyvinyl chloride, diphenyl phosphine oxide, chlorinated polyethylene, diisononyl phthalate, antimony trioxide, calcium stearate, zinc stearate, an antioxidant and a leveling agent; the synergistically modified polyvinyl chloride is obtained by introducing catechol structures on the surface of polyvinyl chloride through dopamine self-polymerization deposition, forming a dynamic borate ester structure with 3-aminobenzoic acid, and constructing a Si-O-Si network structure through hydrolytic condensation reaction of octa(3-aminopropyl)silsesquioxane and N-(beta-aminoethyl)-gamma-aminopropyl triethoxysilane. The dopamine-borate ester-silicone synergistic network structure is constructed, and the diphenyl phosphine oxide is introduced for function regulation, so that the heat resistance, mechanical properties and dimensional stability of the polyvinyl chloride adhesive tape are significantly improved.

The application discloses a method for synthesizing a chiral secondary phosphine oxide with a conjugated dienyl phosphorus center through desymmetrization. The method is that a primary phosphine oxide reacts with an alkyne to obtain the chiral secondary phosphine oxide with the conjugated dienyl phosphorus center under the joint catalysis of zero-valent nickel and a ligand and the action of an additive. The method realizes the preparation of the chiral secondary phosphine oxide with the conjugated dienyl phosphorus center with high enantioselectivity and specific chemical selectivity through the joint catalysis of the zero-valent nickel and the ligand.

The invention discloses a method for high-selectivity separation of low-concentration coal bed gas by a hydrate method using tri-n-butylphosphine oxide as a thermodynamic accelerant. The method comprises the following steps: carrying out hydrate generation and separation on low-concentration coal bed gas in a 5 wt% tri-n-butyl phosphine oxide solution under the conditions of 277.15 K and 4 MPa, and increasing the methane concentration from 30.07 mol% to 88.17 mol% after purification; the separation performance is improved by further adding 0.5 wt% of a kinetic accelerator (preferably cocamidopropyl dimethylamine), and experimental results show that the methane concentration after single-stage separation can be improved from 30.07 mol% to 92.84 mol%, the separation factor reaches 40.93, and the system is in slurry dispersion and has no wall climbing phenomenon. The method is safe to operate, the accelerant can be recycled, and the method is suitable for efficient purification and resource utilization of methane in mixed gas such as low-concentration coal bed gas, biogas and coke-oven gas.

The invention relates to diarylamine compounds containing a dimethyl phosphine oxide structure as well as a preparation method and application of the diarylamine compounds. The compounds have a structural formula as shown in a general formula (I). The invention relates to a compound shown in a general formula (I), which has a strong effect of inhibiting L858R / T790M / C797S drug-resistant mutant EGFR kinase, and also relates to application of the compound and pharmaceutically acceptable salt thereof in preparation of drugs for treating and / or preventing diseases caused by drug-resistant mutation of EGFR kinase, the invention particularly relates to application in preparation of medicines for treating and / or preventing cancers. The invention also provides a preparation method of the compounds, a pharmaceutical composition containing the compounds and application of the pharmaceutical composition. The compound is especially used for preparing drugs for treating and / or preventing lung cancer, and has good antitumor drug development and application prospects.

The invention discloses an odorless scratch-resistant elastic bending UV (ultraviolet) excimer skin-touch varnish, which relates to the technical field of coatings and comprises the following components in percentage by mass: 10-30% of functional acrylate resin, 10-30% of a solvent, 10-30% of a solvent, 10-30% of a solvent and 10-30% of a solvent. 40 to 80% of modified polyurethane acrylate resin; 0.1-1% of a leveling agent; 0.1-1% of a defoaming agent; 0.1-4% of an organosilicon auxiliary agent; 0.5 to 2% of 2, 4, 6-trimethylbenzoyl diphenyl phosphine oxide; 0.5 to 7% of 2-hydroxy-4 '-(2-hydroxyethoxy)-2-methyl propiophenone, and the balance of water; 0.3-1% of a wetting dispersant; 2-5% of UV anti-settling slurry; 1-5% of wax powder; and 5-30% of nano sol. According to the UV quasi-molecular skin-touch varnish disclosed by the invention, through the combined action of an odorless resin system, fluorosilicone modified and enhanced three-functional-group elastic resin, nano-zirconia phase change toughening and a crosslinkable fixing auxiliary agent, multiple pairs of performance contradictions of elasticity and hardness, instant effect and durability, odorless effect and stability and the like in a traditional elastic bending UV coating are successfully solved; and the high-performance skin-touch coating with excellent elastic bending property, lasting high scratch resistance, real odor removal effect and good stability is obtained.

The application discloses a synthesis method of 2-aryl-4-phosphoryl-4H-chromene compounds, which comprises the following steps: dissolving 2-hydroxychalcone, diaryl phosphine oxide and mercury triflate in an organic solvent, and reacting at 80-100 DEG C; after the reaction is completed, 2-aryl-4-phosphoryl-4H-chromene compounds are obtained through separation and purification; the synthesis method is simple, the reaction condition is mild, and the operation is convenient; the raw materials are easy to prepare; the reaction byproduct is water; and the method has the advantages of high atomic economy, green environmental protection and the like.