11 results about "Licorice acid" patented technology

Composition, in particular pharmaceutical composition, in the form of a fixed dosage (solid dosage form) for sucking and / or chewing, preferably for sucking, in particular lozenge, preferably for use in the prophylactic and / or therapeutic topical (local) treatment of inflammatory diseases of the mouth and throat, wherein the composition contains an effective, in particular pharmaceutically and / or therapeutically effective, amount of an active ingredient preferably suitable and / or effective for the topical (local) treatment of inflammatory diseases of the mouth and throat, in particular with antiseptic and / or antimicrobial properties, preferably with antibacterial and / or antiviral and / or antifungal properties, wherein the active ingredient is incorporated and / or embedded in a solid matrix, wherein the composition, in particular the solid dosage form and / or the matrix, releases the active ingredient upon topical (local) application and / or use, preferably by sucking and / or chewing, preferably by sucking, in the oral and pharyngeal cavity; wherein the active ingredient is octenidine, in particular in the form of a pharmaceutically compatible and / or physiologically acceptable salt or ester, preferably in the form of a pharmaceutically compatible and / or physiologically acceptable salt, particularly preferably octenidine dihydrochloride; and wherein the composition, in particular the solid dosage form and / or the matrix, furthermore and / or additionally contains at least one further ingredient (a) and / or (b), in particular (a) and (b), wherein the at least one further ingredient (a) and / or (b) is selected from the group of (a) Flavor modulators, in particular selected from the group of the following components (i), (ii) and / or (iii): (i) Bitter (taste) masking agents, in particular selected from the group consisting of bitter taste receptor antagonists, preferably 4-(2,2,3-trimethylcyclopentyl)butanoic acid, and saponins, preferably glycyrrhizic acid (glycyrrhizin) and its salts or esters and / or glycyrrhetinic acid (glycyrrhetin) and its salts or esters, complexing agents, in particular cyclodextrins, and combinations or mixtures thereof, (ii) Bitter substances, in particular coffee extract and / or tea extract and / or their respective bitter substances, preferably coffee extract and / or its bitter substances, (iii) preferably natural or nature-identical (aroma) oils and / or essential oils, in particular with antiseptic and / or antimicrobial properties, preferably with antibacterial, antifungal and / or antiviral properties, in particular selected from the group of anise oils, in particular star anise oil, peppermint oil, eucalyptus oil, lavender oil, tea tree oil, chamomile oil, clove oil, rosemary oil, caraway oil, cinnamon oil, sage oil and fennel oil, as well as combinations or mixtures thereof; in particular wherein the ingredient (a) and / or the flavor modulator comprises a combination of at least two different components (i), (ii) and / or (iii), preferably a combination of components (i), (ii) and (iii); (b) Acidulants, in particular saliva-stimulating and / or flavor-enhancing acidulants, preferably acidulants authorized under pharmaceutical and / or food law and / or acidulants authorized as pharmaceutical additives and / or food additives, in particular selected from the group of tartaric acid and its salts, in particular sodium tartrate, sodium potassium tartrate (Rochelle salt) and calcium tartrate, citric acid and its salts, metatartaric acid, fumaric acid, ascorbic acid, phosphoric acid and its salts, stannous chloride, in particular tin(II) chloride, malic acid, lactic acid, adipic acid, succinic acid and other pharmaceutically compatible and / or physiologically acceptable organic acids and their salts, as well as their combinations or mixtures.

The application provides a preparation method of licorice acid / fish gelatin double-network composite hydrogel which can promote wound healing. The application uses licorice acid and fish gelatin as main raw materials, utilizes the characteristics that the licorice acid can self-assemble into nanofibers under certain conditions and is mixed with fish gelatin, and respectively forms a physical network in a staged cooling process, so as to form a double-network hydrogel with excellent performance. The obtained hydrogel has the characteristics of high mechanical strength, anti-freezing and moisture retention, high transparency, high adhesion, high biocompatibility and the like. And the obtained hydrogel is used for wound treatment, and has obvious promoting effect on wound healing. The licorice acid / fish gelatin double-network composite hydrogel has excellent mechanical performance, good biocompatibility, simple preparation method, mild reaction condition, easy scale production, green environmental protection, and has potential application prospect in the field of medical hydrogel.

The present application provides a kind of composition and preparation method and application for preventing cataract, macular lesion and diabetic retinopathy, belong to biological medicine technical field.The composition of the present application includes: nano active ingredient, plant extract, glycyrrhizic acid dipotassium, nicotinamide, taurine, ikdoin, caffeine and lutein;Plant extract is composed of wild chrysanthemum flower extract and gentian extract;Nano active ingredient is composed of nano-encapsulated astaxanthin and nanometer retinol.The composition of the present application effectively inhibits key pathological links such as lens protein oxidative denaturation, retinal pigment epithelial cell function decline and pathological angiogenesis by multi-dimensional synergistic mechanism of antioxidant-anti-inflammatory-vascular protection-metabolic regulation, thereby realizing the prevention and adjuvant therapy effect on three major blinding eye diseases of cataract, age-related macular degeneration and diabetic retinopathy.

The invention discloses a medicine detection method, which can simultaneously determine the contents of beta-asarone, schizandrin, hyperoside, verbenin, morinda officinalis verbenin, glycyrrhizic acid and other components in a medicine, and can be used for quality control of the medicine.

The application discloses a kind of all natural aggregation-induced emission glycyrrhizic acid active hydrogel and its preparation method and application. Contain the following steps: 1) by stirring and dissolving glycyrrhizic acid or its derivative and berberine derivative at a certain temperature, obtain transparent aqueous solution, and adjust pH to neutral;2) glycyrrhizic acid or its derivative solution and berberine derivative solution are mixed according to certain proportion;3) the pH of composite solution is adjusted to acid, and it is stationary at room temperature, and all natural aggregation-induced emission glycyrrhizic acid active hydrogel is obtained by using the interaction between the two co-assemblies.It has excellent AIE characteristics, high mechanical strength, excellent fluorescent environmental responsiveness, excellent injectable and structure recovery characteristics, significant photodynamic synergistic antibacterial ability, excellent immunomodulatory and anti-inflammatory ability, can promote skin wound healing.The raw material of the hydrogel is natural, biocompatibility is high, preparation process is simple, condition is mild, easy to scale production, has potential application prospect in medical gel field.

The invention discloses a method for simultaneously determining multiple indexes of a Mongolian medicine, i.e., Noutler-Wudahler, belongs to the technical field of medicine analysis, and solves the technical problem that various effective components and heavy metal elements in the Mongolian medicine cannot be rapidly and accurately determined at the same time by a traditional method. According to the technical scheme, the method is characterized by comprising the following steps: simultaneously determining the contents of eucalyptol, linalool, eugenol, alantolactone, isoalantolactone and dehydrocostunolide in a sample by adopting a gas chromatography-mass spectrometry method, wherein mass spectrometry detection adopts a multi-reaction monitoring mode and optimizes monitoring ion pairs and collision energy; simultaneously determining the contents of liquiritin, glycyrrhizic acid, gallic acid, piperine and alantolactone in the sample by adopting a liquid chromatography-mass spectrometry method; and simultaneously determining the contents of lead, cadmium, arsenic, mercury and copper heavy metal elements in the sample by adopting inductively coupled plasma mass spectrometry. The method is mainly used for controlling the quality of the Mongolian medicine, namely the frontalon-Wusunhler, so that the safety and effectiveness of the medicine are ensured.

The invention discloses a self-assembled hydrogel for treating ulcerative colitis and a preparation method and application thereof.The SPV-GA hydrogel with pH responsiveness and temperature-sensitive injectability is formed by dissolving and mixing evergreen gelsemine (SPV) and glycyrrhizic acid (GA) according to a certain molar ratio at the high temperature and conducting self-assembly at the temperature of 4 DEG C. The hydrogel can be rapidly degraded to release medicine in the intestinal pH environment (pH 7.4), and the hydrogel can be used for treating ulcerative colitis. The intestinal inflammation and barrier injury of ulcerative colitis are improved in a targeted manner, and the proinflammatory factor level is remarkably reduced; the temperature-sensitive injectable property is adapted to rectal administration, so that the problem of first-pass effect of a traditional oral preparation is solved, meanwhile, the preparation process is simple, the biocompatibility is excellent, and a novel targeted treatment strategy is provided for ulcerative colitis.

A pharmaceutical composition with dual anti-inflammatory and antiviral activity against COVID-19 and related respiratory pathogens, the composition comprising the following: (a) Curcumin in an amount of 1.5 to 5.0% by weight, which acts as a primary anti-inflammatory agent, suppressing cyclooxygenase-2 (COX-2) expression and interleukin-6 (IL-6) signaling; b) Quercetin in an amount of 2.0 to 6.0 wt%, which acts as an antiviral flavonoid and is able to inhibit SARS-CoV-2 proteases (3CLpro and PLpro) and the penetration of the virus; (c) Zinc oxide nanoparticles (ZnO-NPs) in an amount of 0.5 to 2.0 wt%, with an average particle size between 20 and 40 nm, which facilitate the destruction of viral envelope proteins and increase cellular zinc uptake; d) Ascorbic acid (vitamin C) in an amount of 1.0 to 4.0 wt.%, which acts as an antioxidant to neutralize reactive oxygen species (ROS) produced during viral infections and inflammatory reactions; (e) Glycyrrhizin, extracted from licorice glabra, in an amount of 1.0 to 3.0% by weight, acts as an immunomodulator, stabilizes cytokine levels and reduces pneumonia; and (f) a pharmaceutically acceptable carrier medium consisting of liposomal, polymeric or PEG-based excipients in an amount of 80 to 90 wt.%, which ensures sustained release and improved bioavailability of the active substances.

1. Name of the designed product: packing box (licorice acid scrub soap). 2. Use of the designed product: packing box for packing soap. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: perspective view.

The invention belongs to the technical field of biological medicines, and discloses paeoniflorin-glycyrrhizic acid carbon nano-enzyme, a preparation method thereof and application of the paeoniflorin-glycyrrhizic acid carbon nano-enzyme in preparation of a medicine for treating chemotherapy-induced peripheral neuropathy. The preparation method of the carbon nano-enzyme comprises the following steps: dissolving paeoniflorin and glycyrrhizic acid in deionized water, adjusting the pH value to 8-10, then carrying out a hydrothermal reaction, and filtering, purifying, concentrating and drying the obtained suspension to obtain the carbon nano-enzyme. The carbon nano enzyme can be applied to preparation of drugs for treating chemotherapy-induced peripheral neuropathy. The paeoniflorin-glycyrrhizic acid carbon nano enzyme provided by the invention has excellent water solubility, good biocompatibility and blood circulation stability, can be directly and efficiently delivered to the whole body and nervous tissues in an intravenous administration mode, solves the key bottleneck of drug delivery in CIPN acute stage treatment, and improves the accessibility and timeliness of treatment.

The invention provides a cream formula for comprehensively nourishing yin, moisturizing lung and repairing lung as well as a preparation method and application of the cream formula, and belongs to the technical field of health-care products. The radix codonopsis, the exocarpium citri grandis, the folium eriobotryae, the radix polygonati officinalis and the liquorice are used as core components, and the effects of the traditional Chinese medicine composition are enhanced through an innovative biotechnology. The method has the core advantages that the codonopsis pilosula and the liquorice are subjected to specific fermentation treatment; the codonopsis pilosula is subjected to a two-step process of aerobic fermentation of bacillus subtilis and anaerobic fermentation of lactobacillus plantarum, so that the content and bioavailability of active ingredients such as polysaccharide and saponin of the codonopsis pilosula are remarkably improved; the glycyrrhiza is subjected to aerobic fermentation with aspergillus oryzae through composite enzymolysis, and methyl jasmonate is added as an elicitor, so that glycyrrhizic acid and flavonoid functional components of the glycyrrhiza are greatly increased. According to the invention, the therapeutic principles of moistening lung, reducing phlegm, tonifying qi and nourishing yin in traditional Chinese medicine and the mechanisms of anti-inflammation, immunoregulation and antioxidation in modern medicine are fused, so that the health-care functions of efficiently moistening lung, protecting lung, relieving cough, reducing phlegm and enhancing the defense capability of the respiratory tract are realized on the whole.