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A pueraria root scutellaria and coptis extract

A technology of Pueraria chinensis and extract, applied in the field of traditional Chinese medicine compound extract and Pueraria chinensis extract, can solve the problems of difficult quality control, inability to guarantee stable curative effect, multiple impurities, etc., and achieves improved content, stable drug quality and curative effect. Effect

Inactive Publication Date: 2008-04-09
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The 2005 edition of the Pharmacopoeia recorded the preparations of this prescription as Gegenqinlian Tablets and Pellets, but these preparations are directly made from raw medicinal powder or crude extracts and extracts of medicinal materials, the extraction process is simple, and the content of each active ingredient in the prescription is low. , the quality is difficult to control, and the curative effect cannot be guaranteed to be stable
Using this method to prepare Gegen Qinlian Decoction, the transfer rate of puerarin, baicalin and berberine in the medicinal materials can reach more than 65%, but this method still adopts the crude extraction method for the medicinal materials, and the obtained extract contains more impurities

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0065] Take 2.4Kg of Pueraria Radix, 0.9Kg of Radix Scutellariae, 0.9Kg of Coptis Rhizoma, and 0.6Kg of Glycyrrhizae, decoct twice with 6 times and 4 times of water, each time for 0.5 hours, filter, combine the filtrates, concentrate to 1 / 4 of the original volume, Add conc The amount is 65%, filter, and the filtrate is concentrated to 1.6Kg, puts on macroporous resin column (macroporous resin consumption is 6.2Kg), first with 4 times column volume deionized water elution, then with 40% ethanol of 3 times resin volume Elution, collect the ethanol eluate, recover the solvent under reduced pressure, mix the extract with the above precipitation, and dry to obtain about 238g of total extract, which contains 13.5% of total isoflavones of Pueraria radix, 20.5% of total flavonoids of Scutellaria baicalensis; total alkaloids of Coptis chinensis 10.5%, glycyrrhizic acid 2.0%.

example 2

[0067] Take 2.4Kg of Pueraria Radix, 0.9Kg of Radix Scutellariae, 0.9Kg of Coptis Rhizoma, and 0.6Kg of Glycyrrhizae, decoct twice with 10 times and 8 times of water, each time for 1 hour, filter, combine the filtrates, concentrate to 1 / 3 of the original volume, Add concentrated hydrochloric acid to adjust the pH to 1-2, and then separate the precipitate and supernatant after standing for 18 hours; take the precipitate and wash it to pH 5-6 for later use; take the supernatant to adjust the pH to 5-6, concentrate to a density of 1.15, add ethanol until the alcohol content is 70%, filter, and the filtrate is concentrated to 2.0Kg, put on a macroporous resin column (the amount of macroporous resin is 9.6Kg), first elute with 5 times of column volume deionized water, and then elute with 50% ethanol of 4 times of resin volume , collect the ethanol eluate, recover the solvent under reduced pressure, mix the extract with the above precipitation, and dry to obtain about 354g of the tot...

example 3

[0069] Take 2.4Kg of Pueraria Radix, 0.9Kg of Radix Scutellariae, 0.9Kg of Coptidis Rhizoma, and 0.6Kg of Glycyrrhizae, decoct twice with 12 times and 10 times of water for 1.5 hours each time, filter, combine the filtrates, concentrate to 1 / 3 of the original volume, Add concentrated hydrochloric acid to adjust the pH to 1-2, and then separate the precipitate and supernatant after standing for 24 hours; take the precipitate and wash it to pH 5-6 for later use; take the supernatant to adjust the pH to 5-6, concentrate to a density of 1.20, add ethanol until the alcohol content is 75%, filter, and the filtrate is concentrated to 2.4Kg, put on a macroporous resin column (the amount of macroporous resin is 14.4Kg), first elute with 6 times the column volume of deionized water, and then elute with 70% ethanol with 5 times the volume of the resin , collect the ethanol eluate, recover the solvent under reduced pressure, mix the extract with the above precipitation, and dry to obtain a...

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Abstract

The invention provides Gegenqinlian extractive which is obtained by mixing four medicines of kudzuvine roots, baikal skullcap roots, goldthread roots, and licorice roots in the weight ratio of 8: 3: 3: 2, extracting effective parts and refining. The extractive has the main effective parts in the following weight percentage: total isoflavone of the kudzuvine roots is 13.5 to 21.0 percent, total flavone of the baikal skullcap roots is 20.5 to 32.5 percent, total alkaloid of the goldthread roots is 10.5 to 18.5 percent, and glycerrhizic acid is 2.0 to 5.0 percent. Through adding medicinal auxiliary materials into the extractive, and adopting a conventional method, various peroral preparation for treating bacillary dysentery, acute enteritis, and infantile virus diarrhea can be prepared.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a compound extract of traditional Chinese medicine, in particular to an extract of kudzu root qinlian. Background technique [0002] Gegen Qinlian Decoction comes from "Treatise on Febrile Diseases. Taiyang Chapter". It is a famous prescription of medical sage Zhang Zhongjing. It has good curative effect on treating bacillary dysentery, acute enteritis and viral diarrhea in children. The 2005 edition of the Pharmacopoeia recorded the preparations of this prescription as Gegenqinlian Tablets and Pellets, but these preparations are directly made from raw medicinal powder or crude extracts and extracts of medicinal materials, the extraction process is simple, and the content of each active ingredient in the prescription is low. , the quality is difficult to control, and the curative effect cannot be guaranteed to be stable. [0003] On October 25, 2006, the State Intell...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61K9/16A61K9/20A61K9/48A61P31/04A61P31/12A61P1/12
CPCY02A50/30
Inventor 罗佳波谭晓梅
Owner SOUTHERN MEDICAL UNIVERSITY
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