Glycyrrhizic acid removal glycyrrhiza flavonoid and medicament composition thereof

A technology of glycyrrhizic acid licorice flavonoids and licorice flavonoids is applied in the field of medicine, which can solve the problems of glycyrrhizic acid removal and inconsistency, and achieve the effects of controllable quality, strong practicability and good repeatability

Inactive Publication Date: 2010-06-23
JIANGSU TIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] There are also many preparation methods about licorice flavonoids in some other published documents, which basically use licorice or licorice dregs as raw materials, which are different from the raw materials selected by the present invention. In addition, there is no such method in the preparation process of these documents. The glycyrrhizic acid in the sample is removed, therefore, all the prepared samples contain more than 5% glycyrrhizic acid, which is different from the "glycyrrhizinated licorice flavonoids (glycyrrhizic acid content is controlled below 1%)" provided in the present invention. have significant differences

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Get 800L of waste water and 40kg of waste residue produced by the production of glycyrrhizic acid, add sodium hydroxide solution with a concentration of 10% after mixing to adjust the pH to 10.0, stir to dissolve, heat to 80 ° C and be incubated for 2 hours, the glycyrrhizic acid composition wherein is fully transformed After glycyrrhizic acid trisodium salt, filtered, the filtrate was concentrated under reduced pressure to a thick paste;

[0052] Add 100L of 85% ethanol to the thick paste under stirring, carry out alcohol precipitation, let it cool for 6 hours to fully precipitate glycyrrhizic acid trisodium salt, centrifugal filter to remove glycyrrhizic acid trisodium salt, add appropriate amount of hydrochloric acid to the filtrate to adjust pH to 6.6, concentrated under reduced pressure to a thick paste, dissolved in 200 L of water, filtered, and the filtrate was obtained;

[0053] The filtrate was placed on a D101 macroporous adsorption resin column, and thin-laye...

Embodiment 2

[0055] Get 1500L of waste water and 60kg of waste residue produced by the production of glycyrrhizic acid, add the ammonia solution of concentration 20% after mixing to adjust pH to 11.0, stir to dissolve, be heated to 95 ° C and be incubated for 4 hours, and the glycyrrhizic acid composition wherein is fully converted into licorice After the acid triammonium salt, filtered, and the filtrate was concentrated under reduced pressure to a thick paste;

[0056] Add 200L of 65% ethanol to the thick paste under stirring, carry out alcohol precipitation, let it cool for 8 hours, make triammonium glycyrrhizinate fully precipitate, centrifugal filter, remove triammonium glycyrrhizinate, add an appropriate amount of hydrochloric acid to the filtrate to adjust the pH to 5.5, concentrated under reduced pressure to a thick paste, add 300 L of water to dissolve, filter, and take the filtrate;

[0057] The filtrate was placed on a HPD-400 macroporous adsorption resin column and monitored by ...

Embodiment 3

[0059] Get the waste water 1000L and 50kg of waste residue produced by the production of glycyrrhizic acid, add the potassium hydroxide solution of concentration 5% after mixing and adjust the pH to 9.5, stir to dissolve, be heated to 75 ° C and be incubated for 3 hours, the glycyrrhizic acid composition wherein is fully transformed After the tripotassium glycyrrhizate is formed, it is filtered, and the filtrate is concentrated under reduced pressure to a thick paste;

[0060] Add 200L of 70% ethanol to the thick paste under stirring, carry out alcohol precipitation, let it cool for 4 hours to fully precipitate the tripotassium glycyrrhizinate, remove the tripotassium glycyrrhizinate by centrifugal filtration, add an appropriate amount of hydrochloric acid to the filtrate to adjust the pH to 6.0, concentrated under reduced pressure to a thick paste, dissolved in 200 L of water, filtered, and the filtrate was obtained;

[0061] The filtrate was placed on a HPD-100 macroporous a...

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Abstract

The invention provides glycyrrhizic acid removal glycyrrhiza flavonoid for treating a canker disease and a medicament composition thereof. The preparation method comprises the following steps: taking wastewater generated by producing glycyrrhizic acid and waste dregs as raw materials and then carrying out a series of steps like alkalization reaction, separate deacidification, acid-base conversion, macro porous resin absorption and purification and the like. In a prepared sample, the content of the glycyrrhiza flavonoid is high and can maximally reach 98 percent, and the content of the glycyrrhizic acid is very low and is only 0.1-1 percent; and the glycyrrhiza flavonoid is further prepared into various preparations suitable for clinical application. The glycyrrhizic acid removal glycyrrhiza flavonoid and the preparation method thereof adopts the acid-base reaction, conversion and traditional Chinese medicine modern separation and purification technology and has the advantages of novel process, suitable industrialized production and strong practicability.

Description

technical field [0001] The invention relates to a deglycyrrhizic acid flavonoid and a pharmaceutical composition thereof for treating ulcer disease, belonging to the field of medicine. Background technique [0002] Ulcer disease is a common chronic systemic disease, divided into gastric ulcer and duodenal ulcer, also known as peptic ulcer. The reason why it is called peptic ulcer is because it was believed that gastric ulcer and duodenal ulcer were formed due to the self-digestion of the mucosa by gastric acid and pepsin. In fact, gastric acid and pepsin are only one of the main reasons for the formation of ulcers. , there are other reasons for the formation of ulcers. Because there are many similarities in the etiology and clinical symptoms of gastric and duodenal ulcers, it is sometimes difficult for doctors to distinguish between gastric ulcers and duodenal ulcers, so they are often diagnosed as peptic ulcers, or gastric and duodenal ulcers . If it is clear that the ul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/36C07D311/40A61K31/352A61P1/04
Inventor 杨永安季浩
Owner JIANGSU TIANSHENG PHARMA
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