The invention relates to a zero discharge process for high-salt wastewater discharged from titanium dioxide production, and the steps are as follows: high-salt wastewater, removal of silicon by a magnesium agent, medicinal agent softening, high-density precipitation, immersion-type ultrafiltration, brackish water reverse osmosis membrane concentration, seawater desalination reverse osmosis membrane concentration, reduction of COD by catalytic oxidation, ion exchange softening, multi-stage nanofiltration salt separation, high pressure reverse osmosis membrane concentration, DTRO/ED electrodialysis concentration, and evaporation crystallization/freezing crystallization. The zero discharge process adopts corresponding treatment processes separately, realizes for the first time the zero discharge of the high-salt wastewater of titanium dioxide by a detailed control technology of each specific process in the system, ensures the normal and smooth operation of the system, and recovers a largeamount of fresh water resources and industrial salts. The purpose of resource recycling of the titanium dioxide production wastewater is realized, and on the basis of creating of certain economic benefits, significant environmental and social benefits are reflected.