1029results about How to "Good inhibitory effect" patented technology

The invention belongs to the field of pharmaceutical agents, relates to a polymer micelle lyophilized agent encapsulating an insoluble antitumor drug as well as a preparation method and an application thereof. The polymer micelle lyophilized agent is prepared by carrying out molecular self-assembly on a methoxy poly(ethylene glycol) 2000-polyester block copolymer to form micelles, and then encapsulating the insoluble antitumor drug in a hydrophobic core formed by the polyester. The lyophilized agent has high encapsulation rate, high drug loading and small particle size, can significantly improve the water solubility of the insoluble drug and result in passive targeting of more antitumor drugs to concentrate in the tumor tissues, thus improving an anti-tumor treatment effect and reducing the toxic and side effects of drugs, and can be used to prepare the drugs used for the treatment of lung cancer, intestinal cancer, mammary cancer, ovarian cancer, etc. The lyophilized agent can also be quickly dissolved and dispersed to form a transparent micellar solution after water for injection, normal saline solution and the like are added, and is used for the preparation of the drugs for treating primary intestinal cell carcinoma.

The invention belongs to the field of complicated copper-lead-zinc sulphide ore beneficiation separation and provides a copper-lead separation flotation inhibitor and applications thereof. The copper-lead separation flotation inhibitor is formed by mixing polymeric ferric sulfate solution with a mass concentration of 5.0%-6.0% and glycerin solution with a mass concentration of 0.8%-1.2%, wherein the mass ratio of the polymeric ferric sulfate solution to the glycerin solution is 1:1-4. Addition of the inhibitor in copper-lead separation operation can remarkably improve copper and lead concentrate qualities, evidently lower mutual containing of copper and lead, and improve flotation recovery rate of copper and lead minerals. The copper-lead separation flotation inhibitor and the applications thereof have the advantages that the copper-lead separation flotation inhibitor is environment-friendly, efficient in sorting, low in reagent cost, easy to operate and the like and applicable to the complicated copper-lead-zinc sulphide ore beneficiation separation.

The present invention discloses a social network based message propagation model, which is a method, based on the special line of the crowd in the network and the average degree of the nodes in the social network, for carrying out modeling analysis on message propagation in the social network and proposing a node importance based rumor immune strategy. The dynamic equations of the <k> SLIR message propagation model are established in the small-world network; by virtue of the method disclosed by the present invention, influences of nodes in various states in the social network, on message propagation can be realistically taken into consideration; and according to the node importance based improved rumor immune strategy proposed by the present invention, propagation of rumors in social network can be better inhibited.

The invention provides a bacteriostatic and deodorant SAP (super absorbent polymer). The bacteriostatic and deodorant SAP is prepared through steps as follows: a primary crosslinking agent and a primary dispersing agent are added to an acrylic acid / acrylate mixed solution which is prepared from a basic compound by neutralizing an acrylic monomer solution, the mixed solution is uniformly stirred, an antibacterial agent is added, uniform stirring is continued, the temperature is increased to 35-70 DEG C, an initiating agent is added, polymerization is performed, and a colloidal SAP is obtained;the colloidal SAP is granulated and dried in sequence and is subjected to surface treatment with a composite antibacterial crosslinking agent at the temperature of 110-180 DEG C, and accordingly, theshell-core type SAP with a three-dimensional crosslinked network structure is obtained. The antibacterial agent is one or two of amino acid metal salt ion chelate and chitosan metal salt ion chelate.The bacteriostatic and deodorant SAP is applied to hygroscopic hygienic products, has remarkable bacteriostatic and deodorant properties, is low in cost and has great benefit, and the raw materials are available.

The environment protecting water quality stabilizer consists of scale inhibitor, corrosion inhibitor, assistant compounded together, and has the features of high efficiency, low toxicity and environment friendship. The water treating agent may be used in water system to produce corrosion inhibiting and scale inhibiting dispersion effect and may be used in the conditions of high hardness, high pHand high concentration multiple. The water treating agent may be used in circulating cooling water system with calcium hardness up to 750-1300 ppm, and in make-up water calcium hardness of 120 ppm, the concentration multiple may reach 10, being in zero-exhaust level.

The invention aims to provide bacillus subtilis WL-04 and application thereof to livestock breeding. The preservation number of the bacillus subtilis WL-04 is CCTCC NO:M 2013343. The bacillus subtilis WL-04 can be used for remarkably inhibiting the growth of Escherichia coli, salmonella, clostridium pefringens and other conditional pathogenic bacteria of the intestinal canal of livestock, and particularly, the bacteriostasis rate of the bacillus subtilis WL-04 to Escherichia coli and clostridium perfingens is above 75%; the enzyme production is stable; the average activity of alpha-amylase is 22U / mL, and the average activity of neutral protease is 170U / mL; the reproduction of probiotics of intestinal canal can be promoted; high temperature for pelletizing can be endured; the influence of inverse environments with low-pH gastric fluid and high-concentration cholate is endured; the production performance of breeding animals can be effectively improved; immune organ development can be promoted. The bacillus subtilis WL-04 can be widely applied to livestock feeds as a feed additive.

The invention discloses a lucid ganoderma substitute cultivation medium with momordica grosvenori. The lucid ganoderma substitute cultivation medium comprises, by weight, 35-70 parts of sawdust, 25-60 parts of auxiliary material, 0.5-1.5 parts of gypsum, 0.1-1 part of sugar and 1-5 parts of momordica grosvenori, and the proportion of the materials to water is 1: 1.3-1.5. By means of the lucid ganoderma substitute cultivation medium, the growth of infectious microbe can be restrained very well in the cultivating process of lucid ganoderma, and the lucid ganoderma substitute cultivation medium has an obvious effect.

The invention discloses pig-chicken excrement fermenting compound bacteria, a preparation method and a method of utilizing the compound bacteria to ferment and prepare an organic fertilizer. The fermenting compound bacteria comprise the following raw material bacteria: bacillus subtilis, bacillus licheniformis, bacillus coagulans, bacillus megatherium and trichoderma viride. The method for preparing the organic fertilizer comprises the following steps: mixing pig-chicken excrement with crushed straws, adding the fermenting compound bacteria to the mixture according to a dosage of 1-2 Kg per ton, mixing uniformly, the moisture being 50-65 wt%, stacking the mixed raw materials, keeping the temperature at 55-65 DEG C to conduct fermentation, two days after the fermentation, turning the stacked materials for the first time, and then turning the materials once every one or two days, keeping the moisture at 50-65 wt% during the fermentation phase, and after fermentation, obtaining the organic fertilizer with a moisture content of 20-30 wt%. The pig-chicken excrement fermenting compound bacteria disclosed by the invention can be used for fermenting the pig and chicken excrement; compared to the prior art, the method for preparing the organic fertilizer is low in productive investment and production cost, convenient to use, free of odor, and good in the fermentation and decomposing effect.

The invention discloses Bacillus amyloliquefaciens and application thereof. The Bacillus amyloliquefaciens ASAG1 is a biocontrol bacterium, wherein the collection number is CGMCC No.3056. The invention also provides a microbial inoculum comprising the collected bacterial strain. The Bacillus amyloliquefaciens or the microbial inoculum has remarkable inhibition activity on stored grain fungi and extinction effect on stored grain mycotoxin.

The invention discloses a 4-carbamate-3-methoxy cinnamic acid cyclamine alkyl amide compound, and a preparation method and application thereof. The compound prepared in the invention has low toxic and side effect, and can treat neurodegenerative diseases including, but not limited to, vascular dementia, the Alzheimer's disease, the Parkinson's disease, the Huntington's disease, HIV-associated dementia, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, glaucoma and the like.

The invention relates to an antagonistic bacterium for preventing and killing off tobacco black shank and a microbial organic fertilizer thereof, belonging to a production technology of intensive agriculture. An antagonistic bacterium (paenibacillus polymyxa C-5) having obvious antagonistic effect on the tobacco black shank pathogenetic bacteria is separated and utilized to prepare into the microbial organic fertilizer with organic compost, wherein the microbial organic fertilizer respectively contains more than 1*108 C-5 / g, the total-N content is 4-5 percent (more than 90 percent is organic nitrogen), the total nutrient content of nitrogen, phosphorus and potassium is 6-10 percent, and the content of organic matters is 30-35 percent. Proved by experiments, the microbial organic fertilizer enables the antagonistic bacterium to quickly breed and form a preponderant group in soil after being applied to the soil. The microbial organic fertilizer can greatly prevent the continuous cropping tobacco black shank if being applied to soil without continuous cropping obstacles for a long time.

The present invention relates to the field of medical technology, and in particular relates to a category of novel sulphonyl substituted xanthene ketone compounds that have a structural formula as shown in the right, a preparation method and application thereof. The compound has high inhibitory activity for ACAT1 / ACAT2; most of the compounds have high inhibitory activity for acyl coenzyme A cholesterol acyltransferase (ACAT). The compounds can be used for preparing anti-atherosclerosis drug combination. Furthermore, the compounds can be used as a preventive or a treating agent of such diseases as angina, myocardial infarction, cerebral infarction, apoplexy, Alzheimer's disease, acute coronary syndrome, PTCA or restenosis of coronary artery after a bracket is arranged. The compounds can be used as a treating agent to adjust the function of sebaceous glands of the skin and inhibit the excessive generation of sebum. And the compounds can be used for treating such diseases as acne-like damage caused by oily skin, acne, seborrhea and corticosteroids.

The invention belongs to the medical technical field and discloses the application of high-purity in the preparation of antibacterial medicine, antiviral medicine and other medicines. The invention proves the antipyretic, anti-inflammation, immunity enhancement, antibacterial and anti-virus effects of high-purity forsythiaside through the following experiments: (1) the experiment that high-purity forsythiaside has antipyretic effect on fever rats; (2) the experiment that high-purity forsythiaside inhibits xylene-induced mice ear edema, xylene-reduced capillary permeability of mice; (3) the experiment that high-purity forsythiaside increases carbon clearance ability of mice and increases the lymphocyte transformation rate; (4) the experiment that high-purity forsythiaside has vitro anti-influenza A type virus effect and in-vivo anti-respiratory syncytial virus effect; (5) the experiment that high-purity forsythiaside has vitro inhibition effects on beta-hemolytic streptococcus, staphylococcus aureus, streptococcus viridans and staphylococcus epidermidis.

The invention provides a lubricating oil composite antioxidant by using synergy generated by compounding among antioxidants of different types. The composite antioxidant at least comprises the following components: (1) alkylated diphenylamine antioxidant; (2) thiophenolic ester antioxidant; and (3) thioether phenolic antioxidant. The invention also provides a lubricating oil composition with oxidation stability. The invention also provides a method for improving oxidation stability of lubricating oil. The composite antioxidant does not contain diluent, can partially replace the consumption of zinc dialkyldithio-phosphate (ZDDP), has predominant effect of controlling the viscosity increment of oil, has obvious inhibiting effect on generation of sediments, and particularly has cleaning effect on the surface of a piston. The composite antioxidant has good compatibility with other component additives, and can be prepared into the lubricating oil composition such as hydraulic oil, steam turbine oil, gear oil, heat conducting oil and the like.

The invention discloses a preparation method of nano silver particle loaded antimicrobial titanium dioxide coating. The preparation method comprises the following steps of preparing a titanium dioxide nanotube array on the surface of pure titanium by an anodic oxidation method, and then loading even silver nano particles on the surface and pipe wall of the titanium dioxide nanotube. Through loading the silver particles with nano structure on the titanium dioxide nanotube, the particles are even in size and moderate in content and are distributed uniformly; the combination force of the nano particles and the nanotube is better, the nano particles are not likely to wash out. The process is simple, the implementation cost is low, the antimicrobial effect is significant, and the preparation is valuable for popularization and application.

The invention discloses a diterpenoid compound and the preparing method and application thereof. The diterpenoid compound is obtained by using aralia melanocarpa roots as the raw material through extractum extraction, organic solvent extraction, column chromatography on silica gel and high pressure liquid chromatography separation. The molecular formula of the diterpenoid compound is C20H30O3. The name of the diterpenoid compound is 14-oxygen-ent-8(9),15-(14-oxo-ent-pimara-8(9),15-diene-19-oic acid). The structural formula is as shown in the specification. According to the preparing method, aralia melanocarpa roots are used as the raw material, and extractum extraction, organic solvent extraction, column chromatography on silica gel and high pressure liquid chromatography separation are conducted to generate the diterpenoid compound. The diterpenoid compound can be applied to preparation of anti-inflammatory drugs for prevention and / or treatment. The diterpenoid compound is subjected to in-vitro anti-inflammatory activity testing, and experimental results show a good lipopolysaccharide (LPS) restraining effect and a good effect of inducting pulmonary alveolar macrophages (RAW264.7) to generate NO. A new compound or lead compound with high application value can be provided for the medical industry.

The invention discloses a photoresist detergent composition, which comprises quaternary ammonium hydroxides, water, aromatic alcohol, dimethyl sulfoxide, and at least one corrosion inhibitor selecting from citric acid, tricaprylyl citrate and citrate. The photoresist detergent composition can also comprise a polar organic cosolvent, a surface active agent and / or other corrosion inhibitors. The photoresist detergent composition can remove the photoresist (particuarly thick film negative photoresist) with the thickness of over 20 mu m on the metals, metal alloys or dielectric medium substrates, and other etching residues; and meanwhile, the composition has low causticity to the metals such as aluminum, copper and the like and the nonmetallic materials such as silicon dioxide and the like, thus, the composition has good application prospect in the micro-electronics fields such as semiconductor chip cleaning, and the like.

The invention discloses a microbial sludge deodorizer and a preparation method thereof. The preparation method comprises the following steps: conducting high-density culture on strains of streptococcus thermophilus, bacillus subtilis, aspergillus oryzae, photosynthetic bacteria, saccharomyces cerevisiae, lactobacillus casei and pseudomonas putida; dehydrating and drying the various single strains which are subjected to high-density culture, so that hypopus microbial dry powder is prepared; and mixing the streptococcus thermophilus, the bacillus subtilis, the aspergillus oryzae, the photosynthetic bacteria, the saccharomyces cerevisiae, the lactobacillus casei and the pseudomonas putida according to weight ratio of 10-20 parts of the streptococcus thermophilus, 10-15 parts of the bacillus subtilis, 20-30 parts of the aspergillus oryzae, 10-15 parts of the photosynthetic bacteria, 10-20 parts of the saccharomyces cerevisiae, 10-15 parts of the lactobacillus casei and 10-20 parts of the pseudomonas putida, so that the microbial sludge deodorizer is obtained. The microbial sludge deodorizer provided by the invention is applicable to garbage deodorization; and in comparison with the prior art, the microbial sludge deodorizer is low in production investment, low in production cost and convenient to use, and moreover, the microbial sludge deodorizer is good in deodorizing effect.

The invention discloses a method for preparing almond peptide from almond dregs, comprising the following steps of: drying, smashing and sieving the almond dregs; adding with deionized water; adjusting pH value; stirring, extracting, centrifuging and taking supernate under a certain temperature; adjusting pH value to be 1.4 with HCL; centrifuging; taking precipitation layer and washing with water;collecting the precipitation into an enzymolysis jar; adding with the deionized water according to solid-to-liquid ratio being 1:(10-15); stirring, mixing and heating to be 40-55 DEG C; adjusting pHvalue to be 5-8 with the HCL; enzymatically reacting by adding with prolease according to the mass ratio of the prolease to crude almond peptide being (1-2):100; adjusting pH value to be 5.5; heatingup to be 90 DEGE C for 20 min; blanching with enzyme and cooling to room temperature; centrifuging enzymatic hydrolyzate under 5000 r / min for 20 min and taking supernate; desalinating the almond protein enzymatic hydrolyzate with cation exchange resin and anion exchange resin; and ultra filtrating and separating to obtain almond peptide. the method has wide application value.

The related preparation method for antibiotic peptide comprises: with ES-2 strain of Bacillus amyloliquefaciens, amplifying culture with medium, taking 2% inoculation, and deep fermenting for 30-48h at 28-35h, or taking inoculation with solid fermentation medium for culturing 2-4day at 28-37Deg; extracting, concentrating, adsorbing, and drying to obtain the product with molecular weight as 994, 1008, 1022, 1036 and 1449, 1463, 1477, 1491 Da as the mixture of surfactin and fangycin. This product can bear heating at 100Deg for 30min, keeps activity in pH 2-12, and can be used as food preservative and additive.

The invention discloses a structure of a Glaucocalyxin A acid ester derivative as well as a preparation method and an application of the Glaucocalyxin A acid ester derivative in treating cancers. The molecular structure of the Glaucocalyxin A acid ester derivative has a general formula as shown in the specification, wherein R1 and R2 are succinic acid substituent-C4H5O4, glutaric acid substituent-C5H7O4M, glycine derivative substituent-C6H8NO5 of succinic acid, and glycine substituent-C7H10NO5 or glycine substituent-OH of glutaric acid. The preparation method has the following steps: in the presence of tetrahydrofuran and 4-dimethylamino pyridine, the extracted Glaucocalyxin A and succinic acid or glutaric acid are reacted to obtain the succinic acid ester or glutaric acid ester of the Glaucocalyxin A disclosed in the invention, and the Glaucocalyxin A acid ester derivative reacts with N-Hydroxysuccinimide and glycine in turn in the presence of a buffer solution of tetrahydrofuran and phosphate to obtain the derivative of the acid ester of the Glaucocalyxin A and the glycine disclosed in the invention.

The invention belongs to technique area for measuring appearance of surface, in order to raise resolving power and range, as well as guarantee high stability of the system. the disclosed device includes following parts: transverse Zeeman two-frequency laser, and beam splitter, first convergent lens, first pinhole, first contact lens, first semitransparent and half reflecting mirror, birefringence lens assembly and object lens of microscope setup on axis of laser in sequence; first photo detector on reflection path of the beam splitter; second semitransparent and half reflecting mirror; Glan prism, second contact lens, second pinhole etc. on reflection path of the second semitransparent and half reflecting mirror. Features are: low drift and high capability of antivibration and anti-interference.

The invention discloses trehalose synthase of streptomyces griseochromogenes and a coding gene and application of the trehalose synthase. The trehalose synthase gene is cloned from the streptomyces griseochromogenes. The trehalose synthase can convert maltose to generate trehalose, the proper reaction temperature of the trehalose synthase is 15-35 DEG C and is 20-25 DEG C preferably, and the proper pH (potential of hydrogen) of the trehalose synthase ranges from 6.0 to 8.0 and ranges from 7.0 to 7.5 preferably. The conversion efficiency of the trehalose synthase is high, the maltose is used as a substrate, conversion rate of the maltose is about 80% at the reaction temperature of 25 DEG C, and less than 5% of glucose is generated to be beneficial to increase of the conversion rate of the substrate. The trehalose synthase can be used for converting commercial ultrahigh malt syrup to prepare the trehalose, and a novel method using an enzymic method to produce the trehalose industrially can be provided.

An antibacterial powder paint able to generate decorative vein is prepared from thermosetting resin, nano-class antibacterial 0.1-3 wt.% agent, vein generating agent 0.5-5 wt.% and metallic pigment through proportionally high-speed mixing for 3-5 min, high-temp extruding out, cooling, pressing, breaking, pulverizing and sieving by 140 meshes. Its advantages are high antibacterial power and high decorative effect.

The invention discloses a vegetable source fruit-vegetable fresh-keeping agent, which is prepared from 4-6% of cinnamon essence, 1-2% of chitosan, 1-2% of CaCl2, 10-12% of emulsifier, 12-16% of solvent, and water in balancing amount, and the total amount of the raw material is 100%. The fresh-keeping agent has good fresh-keeping effect and is applied by mixing with water and coating film. The agent has good inhibiting effect on pathogenic bacteria which easily appears during the storage process of the picked fruits and vegetables, and also has a certain inhibiting effect on rottenness of the picked fruits and vegetables. The vegetable source fruit-vegetable fresh-keeping agent has the advantages of simple processing technology and low cost, follows the developing direction of the current fresh-keeping agent, and has good development and application potentials.

A Chinese medicine for treating laryngolaryngitis and upper respiratory tract inflammation is prepared from 10 Chinese-medicinal materials including scrophularia root, ophiopogon root, ciccada slough, myrobalan seed, etc through proportionally mixing, extracting and mixing with sugar or syrup and additive.

The invention belongs to the technical field of biomedical materials, and discloses a pearl natural active peptide having a whitening efficacy, a method for extracting the pearl natural active peptide from nacre, and an application of the pearl natural active peptide. The pearl natural active peptide is obtained by extracting nanometer pearl powder as a raw material through heating water extraction and ultrasonic concussion conditions based on the full exposure of the effective active components of the nanometer pearl powder, and separating and purifying through technologies comprising ultrafiltration for removing macromolecular substances, membrane separation for removing salts, gel chromatographic purification and the like, and the relative molecular mass of the pearl natural active peptide is accurately detected through high performance liquid chromatography. The pearl natural active peptide has the characteristics of basically zero addition of any reagents in the whole extraction and purification processes, guarantee of the natural activities, and good safety, and can be widely used in the fields of cosmetics and medicines for inhibiting the synthesis of melanin in cells as a whitening agent.

The invention relates to a medicinal preparation with inhibiting effect on tumor metastasis, which contains steroidal saponin extractives. The effective active components of the medicinal preparation comprise the following eight steroidal saponin general extractives which are eight steroid saponins: steroidal saponin I, steroidal saponin II, dioscin, gracillin, steroidal saponin H, steroidal saponin VII, saponin A (pennogenin-3-O-alpha-L-isodulcitol-yl(1-4)-[alpha-L-isodulcitol-yl(1-2)]-alpha-L-isodulcitol-yl(1-2)-beta-D-heteroside) and saponin B (pennogenin-3-O-alpha-L-isodulcitol-yl(1-4)-[alpha-L-isodulcitol-yl(1-2)]-alpha-L-isodulcitol-yl(1-3)-beta-D-heteroside), and the effective active components of the medicinal preparation also comprise medical dressings. The weight content of the eight steroidal saponin general extractives is 5%-30%, and the weight content of the medical dressings is 70%-95%. The invention is a medicinal preparation with less toxic and side effects and inhibiting effect on tumor metastasis.

The invention relates to a composite antibacterial peptide produced by bacillus natto NT-6 and a production method thereof. The composite antibacterial peptide product is a mixture of three kinds of homologs of antibacterial lipopeptide substances iturins, fengycins and surfactins in the proportions of 10-20 percent, 25-35 percent and 50-60 percent respectively; the antibacterial peptide pure product is a yellow viscous substance which can resist heating of 30 minutes at the temperature of 100 DEG C, can keep activity at the pH of 2-12, has broad-spectrum antibacterial activity for bacteria and fungi and has strong killing effect on protozoa and cancer cells; and experiments prove that the peptide has high safety. The invention also discloses the production method of the composite antibacterial peptide. The peptide can be easily produced by using the process, is relatively low in cost, and can be used as a food preservative, a feed additive, an agricultural biological control agent, a medicament, an animal disease preventing agent and the like.

The present disclosure belongs to the technical field of microorganisms, and in particular relates to Bacillus amyloliquefaciens having growth promotion and disease resistance effects and an appliction thereof. In the prior art, certain use defects for the microbial preparation related to Bacillus amyloliquefaciens are existed, such as poor colonization ability in the field and single disease prevention effect. The present disclosure provides a B. amyloliquefaciens 44 which has the effect of inhibiting various plant pathogenic bacteria and promoting crop growth, and has a wide range of applications. In addition, the present application also provides a composite microbial composition, which is composed of B. amyloliquefaciens 44, R. aquatilis 27 and B. amyloliquefaciens B-1619, and the composite microbial composition has good antibacterial effect and growth-promoting ability, and also has good colonization ability.