229 results about "Animal disease" patented technology

The invention belongs to the technical field of disease source prevention and control, and particularly relates to an animal skin harmful factor detection method and system for animal disease source prevention and control, and the system comprises a multi-mode sensor detection module which can respectively detect microorganisms, chemical residues and other harmful factors on animal skins; the intelligent analysis and machine learning module is used for fusing the multi-modal data acquired by the sensor, and classifying, identifying and analyzing various data through a machine learning algorithm; a detection model is continuously optimized through machine learning, and the recognition precision of pathogens and harmful factors is gradually improved; and the Internet of Things real-time monitoring and automatic alarm module uploads detection data of each sensor to a cloud platform in real time through the Internet of Things technology, so that managers and technicians can monitor the state of the leather at any time. According to the invention, real-time and automatic detection of animal skin harmful factors is realized, improvement of the overall effect of animal disease source prevention and control is facilitated, and the method has a wide application prospect.

Provided are immediate or prolonged administration of certain potassium ATP (KATP) channel openers, optionally in combination with growth hormone, to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of KATP channel openers that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are methods of co-administering KATP channel openers with other drugs (e.g., in combination with growth hormone) to treat diseases of humans and animals (e.g., Prader-Willi Syndrome (PWS), Smith-Magenis syndrome (SMS), and the like.

The invention discloses a black pig breeding disease intelligent monitoring management method based on big data, and relates to the technical field of animal husbandry intelligent management and animal disease monitoring, and the method comprises the following steps: obtaining multi-dimensional data information of pigs in a black pig breeding scene in real time through a sensor network, a video monitoring system and a physiological information collection device; the multi-dimensional data collected in real time is preprocessed and standardized, and the original data quality and the data analysis effectiveness are improved. According to the invention, by introducing an adaptive adjustment mechanism, the problem of pathological data loss caused by excessive elimination of abnormal values in the prior art is solved, and accurate retention and dynamic tracking of early disease signals of pigs are realized. The method integrates multi-dimensional feature extraction and intelligent evaluation, has pathological trend perception and processing strategy adaptive adjustment capabilities, effectively improves the early recognition sensitivity and discrimination accuracy of a disease early warning system, and provides more scientific health management support for farms.

The invention discloses a chicken infectious anemia virus subunit vaccine, and belongs to the technical field of animal disease vaccines. The invention provides a chicken infectious anemia virus subunit vaccine. Active ingredients of the chicken infectious anemia virus subunit vaccine are recombinant fusion protein of chicken infectious anemia virus VP1 protein B cell epitope and salmonella typhimurium flagellin. The B cell epitope of the chicken infectious anemia virus VP1 protein is obtained by connecting B cell antigen epitopes contained in the chicken infectious anemia virus VP1 protein through a connecting peptide. The salmonella typhimurium flagellin is obtained by deleting a hypervariable region of the salmonella typhimurium flagellin FliC. The fusion expression protein provided by the invention can induce generation of a specific IgG antibody after one-day-old SPF chicken, and after immunization for 28 days, immunized chicken flocks can resist challenge of chicken infectious anemia virus virulent strains, and 70% of challenge chicken flocks are protected without disease attack. The invention has great potential for clinical prevention and control of chicken infectious anemia virus infection.

Provided are immediate or prolonged administration of certain potassium ATP (KATP) channel openers, optionally in combination with growth hormone, to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of KATP channel openers that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are methods of co-administering KATP channel openers with other drugs (e.g., in combination with growth hormone) to treat diseases of humans and animals (e.g., Prader-Willi Syndrome (PWS), Smith-Magenis syndrome (SMS), and the like.

According to the implantable animal data detector and the detection method thereof provided by the invention, the main body and the sealing cover which are in threaded connection are adopted to seal an internal component of the shell and are implanted into an animal body, so that the internal component of the shell is effectively isolated from an external organism, and the safety of the animal body is ensured while the internal component is ensured to stably run for a long time; by integrating a temperature sensor, an acceleration sensor and a gyroscope sensor, the body temperature, activity data, lying posture and other data of the implanted animal can be rapidly and accurately collected in the animal body, the behavior and physiological state of the animal can be rapidly obtained through an external receiving device, and therefore early warning of animal diseases is achieved; early intervention treatment is realized, the normal production cycle of animals is prevented from being influenced by diseases, and the production benefit is improved; in addition, a strong magnet is arranged in the shell, so that the detector can be conveniently and safely taken out from the animal body through an external magnet when needed, and the injury to the animal and the operation risk are reduced.

The invention discloses an mRNA (messenger ribonucleic acid) transcription skeleton vector and application thereof in preparation of a self-amplification type mRNA vaccine, and belongs to the technical field of veterinary biological products. According to the invention, alphavirus non-structural protein regions NSP2 and NSP3 of a self-amplification type mRNA skeleton are modified, a polyA tail is optimized, and a novel self-amplification type mRNA skeleton is constructed; the self-amplification type mRNA vaccine can improve the antigen expression efficiency, reduce the toxicity of non-structural protein to cells and improve the encapsulation efficiency and delivery efficiency by combining with the optimization of the components and proportion of a lipid nano delivery system, and meanwhile, the self-amplification type mRNA vaccine is wide in applicable pathogen antigen range and can be popularized to more animal epidemic diseases. The characteristics of high-efficiency expression, low-toxicity delivery and single-dose immunization are expected to renovate the immunization strategy of the existing animal vaccine, the epidemic prevention cost of the breeding industry is reduced, and the method has a wide industrial application prospect.

The invention discloses an intelligent animal epidemic disease monitoring management and early warning workstation, which comprises a multi-modal data acquisition module, an epidemic disease risk assessment module, a dynamic early warning threshold generation and judgment module, a visual human-computer interaction interface and a block chain storage module, the multi-modal data acquisition module is used for acquiring animal data of each monitoring point in a preset monitoring area and environment data of animals; the epidemic disease risk assessment module is used for comprehensively analyzing the animal data and the data of the environment where the animals are located to obtain epidemic disease risk indexes of all monitoring points in the current monitoring area; the dynamic early warning threshold generation module is used for dynamically generating an early warning threshold and judging an epidemic disease risk index to obtain an epidemic disease risk level and an epidemic disease risk area; the visual human-computer interaction interface is used for displaying the epidemic disease risk condition in the monitoring area; and the block chain storage module is used for data storage. According to the invention, the accuracy and timeliness of early warning of epidemic diseases are improved.

The present invention relates to recombinant binding proteins comprising an ankyrin repeat domain, wherein the ankyrin repeat domain has binding specificity for CD2. In addition, the invention relates to nucleic acids encoding such recombinant binding proteins, pharmaceutical compositions comprising such proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions in methods for treating diseases, such as cancer, in a mammal, including a human.

The present invention provides a preparation for animals, with which a medicine can be retained in an oral cavity of an animal for a sufficient time or a medicine can be released rapidly in an oral cavity of an animal.　The present invention relates to a film preparation capable of adhering to oral cavities of animals, the film preparation having at least one film layer containing a prophylactic or therapeutic medicine for an animal disease and an easily-water-soluble polymer.

The invention discloses a method for simulating a spreading rule of African swine fever virus aerosol in a pig farm, and relates to the technical field of animal epidemic disease spreading simulation. Comprising the following steps: selecting fluorescent microspheres, and preparing a fluorescent microsphere suspension; building a fluorescent microsphere suspension release system; dividing a pig farm into a plurality of cells, and arranging a sampling network in the pig farm; starting all the samplers of the sampling network, idling for a certain time, and closing all the samplers after measuring the environment background concentration; synchronously starting a fluorescent microsphere suspension release system and samplers of all sampling networks, and synchronously recording environment temperature and humidity, wind speed and wind direction; and performing quantitative analysis on the fluorescence of the pig farm at different time points, and generating a distribution diagram and a dynamic change diagram of the fluorescence in the pig farm according to an analysis result. According to the invention, by releasing the fluorescent microspheres with matched particle sizes and combining with a gridding monitoring network, a distribution diagram and a dynamic change diagram during virus diffusion are dynamically generated, and data support is provided for pig farm ventilation optimization and accurate disinfection.

The present invention provides novel carboxamide-4-quinoline compounds that can be used as medicaments, particularly in the treatment and prevention of diseases in animals caused by helminths.

The invention discloses a universal method for preparing circular RNA (Ribonucleic Acid) and application of the circular RNA. Specifically, an optimized ribozyme recognition site is determined based on a specific local secondary structure, and a ribozyme sequence is designed correspondingly, so that the circular RNA precursor molecule is constructed, and the invention provides a method for preparing the circular RNA based on the precursor molecule and application of the circular RNA prepared by the method. The cyclic RNA is high in cyclization efficiency, any sequence except the target cyclic RNA sequence is not introduced into the cyclization product, the cyclization efficiency is not influenced by different sequences of the cyclized RNA, and the method is a universal method for preparing the cyclic RNA. The circular RNA prepared by the method can be used in various biological medicine fields such as diagnosis, prevention and treatment of human or animal diseases.

Disclosed herein are methods of producing low immunogen cells and methods of using low immunogen cells to treat mammalian diseases and to prepare biomimetic nanovesicles (BioNVs). The method comprises (a) reducing or eliminating the expression and / or activity of one or more immunogenic proteins in a cell; and (b) expressing or increasing the expression and / or activity of one or more immunoprotective proteins in the cell, thereby producing the low immunogen cell.

The utility model discloses a quality control and protection detection die body for animal digital X-ray photography equipment, which comprises a water die, an upper lead point and a lower lead point are respectively arranged at the centers of the upper surface and the lower surface of the water die, and the upper lead point and the lower lead point are positioned on the central axis of the water die; a first detection plate, a second detection plate and a third detection plate are movably arranged above and below the water mold; a cross lead wire is arranged on the first detection plate; a low-contrast resolution module and a high-contrast resolution module are arranged on the second detection plate; and a groove with the same shape as the detector is formed in the third detection plate. The utility model can be used for quality control detection of digital X-ray photography equipment, ensures the shooting quality of the equipment, meets the requirements of veterinarians for diagnosing animal diseases, and can also be used as a scatterer for radiation protection detection in an X-ray place.

The invention provides an animal epidemic disease monitoring data statistical analysis geographic information system and an implementation method, and relates to the technical field of animal epidemic disease monitoring. According to the animal epidemic disease monitoring data statistical analysis geographic information system and the implementation method, the system comprises an animal disease data collection system, an animal type recording module, a disease type grading module, a disease time statistical module, a disease region statistical module and an animal disease high-incidence time period. The invention provides an animal epidemic disease monitoring data statistical analysis geographic information system and an implementation method, and the system carries out classified statistics on various animals with different diseases, can classify the diseases of the animals, carries out classified data storage on the names of the different diseases, and carries out statistical analysis on the names of the different diseases. Meanwhile, classified data recording is carried out on drugs for treating corresponding diseases, convenience can be brought to later treatment work of a worker on sick animals through treatment drug data, and then the advantages of early discovery, early medication and early treatment are achieved.

The utility model relates to the technical field of animal epidemic disease disinfection, and discloses an animal epidemic disease detection disinfection spraying device which comprises an intelligent robot, a vertical plate is connected to the upper end of the intelligent robot, a movable plate is slidably connected to the side wall of one side of the vertical plate, a mounting plate is arranged above the movable plate, and a medicine box is mounted at the upper end of the mounting plate; a water pump is installed at the upper end of the pesticide box and communicates with the pesticide box, a spraying pipe is installed on the side wall of one side of the water pump, a reciprocating lead screw is rotationally installed at the upper end of the intelligent robot and is in threaded connection with the movable plate, and a lifting pipe is rotationally connected to the upper end of the intelligent robot. According to the technical scheme, through mutual cooperation of the intelligent robot, the mounting plate, the pesticide box, the water pump, the spraying pipe, a reciprocating lead screw, a lifting pipe, a lifting rod, a motor, a first bevel gear, a second bevel gear and other structures, the pesticide box can rotate while moving in the vertical direction, so that the pesticide spraying range is enlarged, time is saved, and the pesticide spraying efficiency is improved. The working efficiency is improved.

The invention relates to a method for the early detection of the presence of disease in graminivores, comprising the following steps: a) determining the calcium isotope ratio δ44 / 42Ca in a blood serum sample from the animal, and / or b) determining the copper isotope ratio δ65 / 63Cu in a blood serum sample from the animal, and / or c) determining the calcium concentration in a blood serum sample from the animal, d) comparing the relevant determined sample value with a fixed threshold value specific to the determined sample type, wherein the presence of disease in the graminivore is ruled as unlikely if a1) the sample value of the calcium isotope ratio δ44 / 42Caserum is above the fixed threshold value, and / or b1) the sample value of the copper isotope ratio δ65 / 63Cu is below the threshold value, and / or c1) the sample value of the calcium concentration is above the fixed threshold value.

The animal epidemic disease excrement harmless treatment device comprises a fermentation tank and further comprises a fermentation assembly, an excrement inlet is formed in the top of the fermentation tank, a driving rod fixedly penetrates through the bottom of the fermentation tank, a driving plate is fixedly mounted on the circumferential surface of the driving rod, and a moving hole is formed in the top of the fermentation tank; the fermentation assembly comprises a hollow frame, a shielding plate, a control plate, a control groove, a sealing plate, a sliding groove, a sliding frame, an elastic telescopic plate and an arc-shaped plate, the hollow frame is slidably mounted on the inner wall of the moving hole, the shielding plate is slidably mounted on the inner wall of the hollow frame, and the shielding plate moves leftwards to increase the shielding area of the shielding plate on the excrement inlet; the feeding amount is adjusted according to the excrement type, it can be ensured that the standing time of the excrement in the fermentation tank is matched with the temperature, the harmless treatment effect is further optimized, and the animal excrement feeding amount control device has the advantage that the excrement feeding amount can be controlled according to different animal excrement.

The invention provides a portable animal epidemic disease detection box, and relates to the field of animal epidemic disease detection. The detection box comprises a rectangular detection box main body, the front, rear, left and right side surfaces of the rectangular detection box main body are respectively provided with a first mounting groove, a second mounting groove, a third mounting groove and a fourth mounting groove, the first mounting groove is provided with a first storage drawer, the first storage drawer is provided with a placement rack, and the second mounting groove is provided with a second storage drawer; a third storage drawer is arranged in the third mounting groove; the detector is detachably matched with the fourth mounting groove; the auxiliary operation platform comprises a first bearing plate, a second bearing plate and a third bearing plate, the first bearing plate and the second bearing plate are both arranged at the top of the rectangular detection box body, the opposite ends of the first bearing plate and the second bearing plate are hinged to the rectangular detection box body, and the third bearing plate is hinged to the outer ring face of the rectangular detection box body. The device has the advantages of function division, convenient fetching, stable cold chain, universal instruments, anti-pollution and portability, and is provided with a platform.

The invention belongs to the technical field of animal epidemic disease pathogen detection, and particularly relates to a primer composition and a kit for identifying a Brucella universal type and a vaccine strain, the primer composition comprises primer pairs and probes for identifying the Brucella universal type, a pig breed S2 vaccine strain and a cattle breed A19 vaccine strain; the primer pair for identifying the universal type of Brucella is shown as SEQ ID NO.1-2, and the probe is shown as SEQ ID NO.3; a primer pair for identifying the pig breed S2 vaccine strain is SEQ ID NO.4-5, and a probe is SEQ ID NO.6; the primer pair for identifying the bovine species A19 vaccine strain is SEQ ID NO.7-8, and the probe is SEQ ID NO.9; the specificity and the sensitivity are good.

This invention is related, generally, to a novel assay for Feline Chronic Kidney Disease (CDK) and, more particularly, to detecting the presence of a target compound in a sample which may contain the target compound, amplification, and subsequent quantitation of the detector molecule to permit both the diagnosis and staging of feline CDK. The present assay is particularly useful for diagnosing early CDK, when clinical signs may not be present, to permit intervention and treatment. Another embodiment provides target compounds, such as antibodies, and methods using these compounds for the treatment of renal fibrosis associated with chronic kidney disease. In one embodiment, the present invention provides a pharmaceutical composition comprising a mRNA encoding a chimeric antigen receptor (CAR) antibody, and a transfer vehicle comprising a lipid nanoparticle (LNP), and methods of producing CAR-T cells that limit the progression of renal disease in mammal.

The present invention discloses a subunit vaccine against chicken infectious anemia virus, belonging to the technical field of animal disease vaccines. The present invention provides a subunit vaccine against chicken infectious anemia virus, and the active ingredient is a recombinant fusion protein of the B cell epitope of chicken infectious anemia virus VP1 protein and Salmonella typhimurium flagellin. The B cell epitope of chicken infectious anemia virus VP1 protein is obtained by connecting the B cell antigen epitopes contained in chicken infectious anemia virus VP1 protein through a linker peptide. The Salmonella typhimurium flagellin is obtained by deleting the hypervariable region of Salmonella typhimurium flagellin FliC. After the fusion expression protein of the present invention is administered to 1-day-old SPF chickens, it can induce the production of specific IgG antibodies, and after 28 days of immunization, the immunized chicken flock can resist the challenge of the virulent strain of chicken infectious anemia virus, and 70% of the challenged chicken flock is protected from disease. The present invention has great potential for clinical prevention and control of chicken infectious anemia virus infection.

The application discloses an antibody for detecting a novel duck reovirus (NDRV), and relates to the field of animal disease prevention and treatment.The antibody comprises a heavy chain and a light chain, wherein the amino acid sequence of the heavy chain is shown as SEQ ID NO.2, and the amino acid sequence of the light chain is shown as SEQ ID NO.4.The novel duck reovirus sigma C protein antibody can be used for directly and rapidly detecting the NDRV sigma C protein in a quick, sensitive and accurate manner when the novel duck reovirus is detected.The antibody can be used for early diagnosis of the NDRV, epidemiological investigation, and antibody screening in vaccine development, and provides an effective tool for preventing and controlling the novel duck reovirus infection.

The utility model relates to an animal epidemic disease material collecting device which comprises a box body with an opening in the upper portion and a box cover movably connected to one side of the top of the box body, a hasp capable of achieving opening and closing of the box cover is installed between the box body and the box cover, and the interior of the box body is divided into an upper sampling chamber and a lower tool chamber. A first placing rack for placing an injector and a second placing rack for placing a sampling tube are respectively arranged on the front side and the rear side in the sampling chamber; a first limiting plate used in cooperation with the first containing frame and a second limiting frame used in cooperation with the second containing frame are arranged on the back face of the box cover. A storage bin is mounted in the tool chamber, and the interior of the storage bin is divided into a sampling tool groove in the front side and a refrigeration groove in the rear side; and a temperature display instrument is arranged on the box cover. According to the utility model, orderly storage of collection tools, effective protection of samples and integration of necessary auxiliary functions are realized, the collection efficiency is improved, the sample quality is ensured, and powerful support is provided for animal epidemic disease prevention and control work.

The invention belongs to the technical field of biological medicine, and relates to an anticoagulant, in particular to an anticoagulant for a high-precision animal blood cell analyzer and application of the anticoagulant in leukocyte classification. The anticoagulant comprises a buffer and anticoagulation matrix component and an active component, wherein in every 100 mL of the anticoagulant, the buffer and anticoagulation matrix component formula comprises 1.5 to 2 g of citrate, 0.3 to 0.5 g of citric acid and 0.15 to 0.20 g of EDTA-K2 (Ethylene Diamine Tetraacetic Acid), and the active components comprise 0.08 to 0.10 g of low molecular weight enzymolysis carboxymethyl chitosan, 1.0 to 1.2 g of hydroxypropyl-beta-cyclodextrin, 10 to 15 mg of dipyridamole and 8 to 10 mg of aspirin. The anticoagulant effectively inhibits platelet activation, prevents platelet aggregation and leukocyte morphological deformation, realizes accurate identification in leukocyte five-classification, has a classification accuracy rate of 98%, and is suitable for veterinary clinical hematology examination and animal epidemic disease monitoring.

This invention discloses a powder containing doxycycline hydrochloride and potassium clavulanate for aquaculture, its preparation method, and its application, belonging to the field of biotechnology. This invention combines doxycycline hydrochloride and potassium clavulanate to enhance the antibacterial ability of aquatic animals against drug-resistant bacteria, thereby better treating various diseases caused by drug-resistant bacteria in aquatic animals. Further experiments demonstrate that potassium clavulanate can significantly reduce bacterial resistance and enhance the antibacterial activity of doxycycline hydrochloride. The preparation of a composite powder using the combination of doxycycline hydrochloride and potassium clavulanate is simple, uses readily available raw materials, and is suitable for large-scale industrial production. Its application in the treatment of aquatic animal diseases, verified through challenge experiments, demonstrates the effectiveness of this composite powder in treating bacterial infections in aquatic animals. It has broad application prospects.

The present invention discloses an animal disease early warning method and system based on behavior and body temperature dual sequences, wherein the animal disease early warning method based on behavior and body temperature dual sequences includes: real-time acquisition of animal body temperature index sequence and motion index sequence; inputting the animal motion index sequence into a behavior recognition network to identify the animal behavior recognition sequence; using a dual sequence decision network to fuse the body temperature index sequence and the behavior recognition sequence, and according to the fused body temperature index sequence and behavior recognition sequence, identifying the animal disease early warning information. The technical solution of the present invention can solve the problem in the prior art that it is difficult to determine whether an animal is sick only by detecting the animal's behavior, and it is difficult to timely warn of animal diseases.

The utility model discloses a clamping device for detecting animal epidemic diseases, which relates to the technical field of animal detection and comprises a head fixing frame and a limiting component, a bottom frame is mounted at the lower end of the head fixing frame, and the limiting component for limiting the heads of animals with different sizes is arranged in the head fixing frame. And the limiting assembly comprises a limiting rod, positive and negative tooth lead screws, turbines, a worm and a holding rod, the positive and negative tooth lead screws are arranged at the upper end and the lower end of the limiting rod, the turbines are installed at the ends of the positive and negative tooth lead screws, the worms are arranged on the side edges of the turbines, and the holding rod is installed in the middle of the worms. According to the clamping device for detecting the animal epidemic diseases, the two sides of the head and the neck of an animal are limited through the limiting rods, the situation that the head of the animal turns back to attack detection personnel is avoided, the positive and negative tooth lead screw rotates to drive the two limiting rods to be close to or away from each other, and the limiting rods can limit the heads of animals of different body types; the worm is rotated to drive the turbine to rotate to provide adjusting power for the positive and negative tooth lead screw.