13 results about "Calcium concentration" patented technology

A device comprising interconnected components for deoxygenating blood used in the treatment and prevention of reperfusion injury, including a configuration to reduce the ionized calcium concentration of the deoxygenated blood to less than 0.5 mmol / L. The components may include a syringe pump operably communicating with various configurations via a control unit / processor, a cannula, a pump communicating with the cannula, a heat exchanger, a device for generating / creating fluid flow, an infusion port, a mixing port, a device hub, and a catheter hub. These components are selectively connected to a subject, and monitoring and / or other lead wires / devices may be attached to the subject. The lead wires / devices may include sensors and other devices that can be attached to / connected to the subject, providing health indicators, such as a temperature sensor, electrodes for monitoring cardiac electrical activity, and an oxygen saturation (SpO2) sensor for monitoring the patient's blood oxygen saturation.

The invention concerns the use of compounds represented by formula (I)as inotropic agents. The compounds of formula (I), which include, as preferred, 1-[(1S)-1-(2,3-dichloro-4-methoxyphenyl)ethyl]-3-methyl-3-[(4R)-1-methyl-3,3-dimethyl-4-piperidyl]-urea and its hydrochloride salt, are herein reported to have a significant inotropic activity on cardiomyocytes from both normal and myocardial infarction-induced heart failure animal models, which makes them useful for treating cardiovascular patients in need thereof. Differently from known inotropic agents, the present compounds are effective on cardiomyocyte contractility without influencing calcium mobilization. Accordingly, they are advantageously free from adverse effects caused by increased calcium concentrations, such as increased oxygen demand, tachycardia, arrhythmia, ischemia, etc. Overall, a new, safe and effective inotropic treatment is thus made available.

The invention relates to a bone volume evaluation system (100) based on magnetic resonance (MRI) patient scan data and / or at least one combined computed tomography (CT) data, comprising at least one processor module (110) and at least one memory module (120) for storing patient data. The processor module (110) is configured to process and / or analyze MRI patient scan data, at least one combination of CT data and / or simplified patient data, preferably to process the data combinations to determine at least one bone volume parameter of the first patient, including bone mineral density, fat percentage, calcium concentration, total bone trabecular interstitial density, etc. In addition, the invention also relates to a corresponding method 200 and a computer readable medium.

The present invention relates to a composition for regulating at least one of an intracellular calcium concentration and a calcium-dependent signaling pathway, the composition containing citicoline or a salt thereof. The present invention also relates to a composition for regulating the expression of at least one of a Neuronal Calcium Sensor-1 (NCS-1) gene and a Two Pore Segment Channel 1 (TPCN1) gene, the composition containing citicoline or a salt thereof.　

The invention concerns the use of compounds represented by formula (I)as inotropic agents. The compounds of formula (I), which include, as preferred, 1-[(1S)-1-(2,3-dichloro-4-methoxyphenyl)ethyl]-3-methyl-3-[(4R)-1-methyl-3,3-dimethyl-4-piperidyl]-urea and its hydrochloride salt, are herein reported to have a significant inotropic activity on cardiomyocytes from both normal and myocardial infarction-induced heart failure animal models, which makes them useful for treating cardiovascular patients in need thereof. Differently from known inotropic agents, the present compounds are effective on cardiomyocyte contractility without influencing calcium mobilization. Accordingly, they are advantageously free from adverse effects caused by increased calcium concentrations, such as increased oxygen demand, tachycardia, arrhythmia, ischemia, etc. Overall, a new, safe and effective inotropic treatment is thus made available.

The utility model discloses a special calcium concentration monitoring device for CRRT (China Railway Reverse Transcription), which comprises a detection pool, a waste liquid collecting box and a cleaning mechanism for cleaning residual samples in the detection pool. A fixed plate is driven by a rotating motor to rotate, so that a cleaning brush scrubs a residual sample on the inner wall of the detection pool, and while the cleaning brush scrubs, a cleaning agent in a cleaning agent box is pumped into the detection pool through a micro infusion pump; under the action of a cleaning agent, half-flow samples on the inner wall of the detection pool can be fully brushed, the cleaning efficiency is guaranteed, after brushing is completed, a switch valve is turned on, waste liquid in the detection pool is discharged into a waste liquid collecting box, the waste liquid is collected, and detection personnel can conveniently clean the waste liquid regularly.

The present invention relates to a system (100) for bone volume assessment based on MRI patient scan data and / or at least one set of composite CT data, the system comprising at least one processor module (110) and at least one storage module (120) for storing patient data, the processor module (110) being configured to process and / or analyze MRI patient scan data, at least one set of composite CT data and / or reduced patient data, preferably in combination with each other, so as to identify at least one bone volume parameter of a first patient, in particular bone mineral density, fat percentage, calcium concentration, total density, intertrabecular space, etc. Furthermore, the present invention relates to a corresponding method 200 and a computer-readable medium.

Control device (20), programmed to execute a method for controlling or regulating a device (4) for the extracorporeal treatment of blood in an extracorporeal blood circuit (1) by adding citrate for the purpose of anticoagulation, wherein the device (4) comprises an addition device (12) for adding a calcium solution to the extracorporeal blood circuit (1), or for controlling the addition device (12), the procedure includes the following steps: - Outputting a signal to the addition device (12) to change a setting of the addition device (12), wherein the setting corresponds to or causes an addition of calcium, a calcium dosage or concentration or amount or rate; characterized by the steps - Determining the signal taking into account the calcium content or calcium concentration of a substitution solution used in extracorporeal treatment of the blood; and - Determining the range of values ​​of a permissible or approved setting range for the calcium introduced or to be introduced into the extracorporeal blood circulation (1) by means of the addition device (12), in particular its quantity, concentration or dosage, under - Setting a lower limit value for the adjustment range that is considered the smallest permissible value.

The present disclosure relates to the synthesis, uses, methods and pharmaceutical compositions of hydroxyepoxide cyclopropane analogs of Formula I: Formula (I). The hydroxyepoxide cyclopropane analogs are useful in the treatment of diseases and conditions, such as cancer, thromboxane-mediated diseases, cardiovascular diseases, inflammation, fibrosis, pain deficiency, and in the modulation of intracellular calcium concentration. Formula (I)

The application provides a detection method and kit for TRPV4 channel mutant activity and application, and the kit comprises the following products: a host cell naturally lacking endogenous TRPV4 expression; an expression vector for expressing an exogenous TRPV4 gene or a mutant thereof; a ratio type calcium ion fluorescent indicator; and a TRPV4 channel specific agonist. The application has the beneficial effects that: the technology significantly improves the detection accuracy by selecting HeLa cells naturally lacking endogenous TRPV4, a low-concentration agonist of an nM level, and a ratio type indicator Fura-2-AM; the detection efficiency is greatly improved by optimizing PEI transfection, increasing the number of analyzable cells, and increasing the temperature to 28 DEG C; the stability of the results is ensured by detecting the background and peak calcium concentration; and finally, the stable, efficient and accurate determination of the TRPV4 mutant function is realized, which has important scientific research and application value.

The application relates to the technical field of biological detection, in particular to a method for quantitatively determining the osteogenic differentiation capacity of mesenchymal stem cells based on calcium concentration and application. The method can accurately and quantitatively detect the osteogenic differentiation capacity of MSCs from different tissues and different generations by inducing MSCs to differentiate into bone and determining the calcium content by combining with o-cresol purple complexone, and has the advantages of high sensitivity, good specificity, excellent repeatability and good durability.

The application relates to the technical field of water quality detection, and discloses a karst water quality detection method and system based on underground water dynamic data. The method comprises the following steps: acquiring a multi-dimensional sensing sequence composed of water level, turbidity, pH and calcium concentration; aligning the water level and the turbidity and performing difference, to obtain a change rate and a change sequence; calculating cross-correlation to extract a time delay feature, and modeling to obtain a coupling strength index; establishing a carbonate balance model based on the pH and the calcium concentration, to obtain a constraint parameter, combining the coupling strength to perform state estimation, and obtaining an adjusted coupling vector; performing high-frequency focusing on the multi-dimensional sequence, to obtain a high-frequency component, evaluating a driving strength, and obtaining a regulation degree value; fusing water level to reconstruct a dynamic feature, and performing deep inversion to obtain a deterioration trend; performing energy weighted fusion to calculate statistical moments, to obtain an inversion parameter set; performing drift verification to obtain a feature vector, and finally performing space-time fusion to output a dynamic detection result. The method can improve the accuracy of karst underground water quality detection.

The invention provides a method for extracting a lithium resource by using spodumene impurity removal slag, and relates to the technical field of extraction of lithium from solid waste. A method for extracting a lithium resource by using spodumene impurity-removed slag comprises the following steps: step S1, material leaching treatment: weighing the spodumene impurity-removed slag, mixing the spodumene impurity-removed slag with a frozen clear liquid, carrying out a stirring leaching reaction at normal temperature, and filtering after the reaction is finished to obtain a lithium-rich filtrate A and a filter residue A; s2, calcium removal and purification treatment: adding sodium hydroxide into the lithium-rich filtrate A to adjust the pH value, transferring into a constant-temperature water bath kettle for constant-temperature stirring reaction, and uniformly sampling after the reaction is finished; inspecting and analyzing calcium and magnesium components, adding sodium carbonate according to the calcium concentration, continuously reacting to remove calcium, and performing solid-liquid separation to obtain filter residue B and filtrate B; the lithium element is efficiently recovered from the spodumene impurity removal slag and the frozen clear liquid and is converted into a lithium phosphate product with a high additional value, so that the cyclic utilization of resources and the maximization of economic benefits are realized.