22 results about "Calcium concentration" patented technology

The invention discloses a pretreatment method for efficiently extracting calcium in shrimp and crab shells. The pretreatment method comprises the following steps: carrying out microwave treatment on the shrimp and crab shells until the weight is constant, rehydrating for 10 minutes in a water bath at 90 DEG C, carrying out microwave treatment until the weight is constant, crushing, mixing with an acetic acid solution, stirring, centrifuging, and measuring the calcium concentration. According to the method, through microwave-rehydration-secondary microwave pretreatment, the carapace structure is destroyed, the contact area of organic acid and calcium is increased, the calcium recovery rate is increased, the treatment time is shortened, the energy consumption is reduced, the universality of raw materials is enhanced, comprehensive utilization of resources is facilitated, and the method is environmentally friendly and economical.

The invention relates to a method for the early detection of the presence of disease in graminivores, comprising the following steps: a) determining the calcium isotope ratio δ44 / 42Ca in a blood serum sample from the animal, and / or b) determining the copper isotope ratio δ65 / 63Cu in a blood serum sample from the animal, and / or c) determining the calcium concentration in a blood serum sample from the animal, d) comparing the relevant determined sample value with a fixed threshold value specific to the determined sample type, wherein the presence of disease in the graminivore is ruled as unlikely if a1) the sample value of the calcium isotope ratio δ44 / 42Caserum is above the fixed threshold value, and / or b1) the sample value of the copper isotope ratio δ65 / 63Cu is below the threshold value, and / or c1) the sample value of the calcium concentration is above the fixed threshold value.

A device comprising interconnected components for deoxygenating blood used in the treatment and prevention of reperfusion injury, including a configuration to reduce the ionized calcium concentration of the deoxygenated blood to less than 0.5 mmol / L. The components may include a syringe pump operably communicating with various configurations via a control unit / processor, a cannula, a pump communicating with the cannula, a heat exchanger, a device for generating / creating fluid flow, an infusion port, a mixing port, a device hub, and a catheter hub. These components are selectively connected to a subject, and monitoring and / or other lead wires / devices may be attached to the subject. The lead wires / devices may include sensors and other devices that can be attached to / connected to the subject, providing health indicators, such as a temperature sensor, electrodes for monitoring cardiac electrical activity, and an oxygen saturation (SpO2) sensor for monitoring the patient's blood oxygen saturation.

The invention concerns the use of compounds represented by formula (I)as inotropic agents. The compounds of formula (I), which include, as preferred, 1-[(1S)-1-(2,3-dichloro-4-methoxyphenyl)ethyl]-3-methyl-3-[(4R)-1-methyl-3,3-dimethyl-4-piperidyl]-urea and its hydrochloride salt, are herein reported to have a significant inotropic activity on cardiomyocytes from both normal and myocardial infarction-induced heart failure animal models, which makes them useful for treating cardiovascular patients in need thereof. Differently from known inotropic agents, the present compounds are effective on cardiomyocyte contractility without influencing calcium mobilization. Accordingly, they are advantageously free from adverse effects caused by increased calcium concentrations, such as increased oxygen demand, tachycardia, arrhythmia, ischemia, etc. Overall, a new, safe and effective inotropic treatment is thus made available.

The present invention relates to a pharmaceutical composition for preventing or treating endoplasmic reticulum stress-associated diseases. It has been identified that a peptide having a specific amino acid sequence exhibits the effects of inhibiting endoplasmic reticulum stress, inhibiting fat synthesis, and reducing intracellular reactive oxygen species (ROS) or calcium concentration, and thus the composition can be effectively used to prevent, treat or alleviate endoplasmic reticulum stress-associated diseases.

The invention relates to a bone volume evaluation system (100) based on magnetic resonance (MRI) patient scan data and / or at least one combined computed tomography (CT) data, comprising at least one processor module (110) and at least one memory module (120) for storing patient data. The processor module (110) is configured to process and / or analyze MRI patient scan data, at least one combination of CT data and / or simplified patient data, preferably to process the data combinations to determine at least one bone volume parameter of the first patient, including bone mineral density, fat percentage, calcium concentration, total bone trabecular interstitial density, etc. In addition, the invention also relates to a corresponding method 200 and a computer readable medium.

The utility model provides a CRRT finished product liquid bag with selectable potassium-calcium concentration, which comprises a small liquid bag, the small liquid bag comprises a K + solution bag and a Ca < 2 + > solution bag, the small liquid bag is arranged in a bag body, the front and back sides of the small liquid bag are provided with medicine marks, the bottom of the small liquid bag is provided with a partition, the front and back sides of the liquid bag at the partition are provided with parallel lines, and the K + solution bag and the Ca < 2 + > solution bag are arranged in the bag body. The lower end of the partition is connected with a communicating pipeline. A cavity is formed in the replacement liquid bag, and a solution containing Ca < 2 + > and K < + > is isolated from the replacement liquid; according to the utility model, the partition in the replacement liquid bag is broken by pressure through extrusion, so that the solution containing Ca < 2 + > and K < + > is communicated with the replacement liquid to complete the configuration in the closed bag.

The present invention relates to a composition for regulating at least one of an intracellular calcium concentration and a calcium-dependent signaling pathway, the composition containing citicoline or a salt thereof. The present invention also relates to a composition for regulating the expression of at least one of a Neuronal Calcium Sensor-1 (NCS-1) gene and a Two Pore Segment Channel 1 (TPCN1) gene, the composition containing citicoline or a salt thereof.　

The invention concerns the use of compounds represented by formula (I)as inotropic agents. The compounds of formula (I), which include, as preferred, 1-[(1S)-1-(2,3-dichloro-4-methoxyphenyl)ethyl]-3-methyl-3-[(4R)-1-methyl-3,3-dimethyl-4-piperidyl]-urea and its hydrochloride salt, are herein reported to have a significant inotropic activity on cardiomyocytes from both normal and myocardial infarction-induced heart failure animal models, which makes them useful for treating cardiovascular patients in need thereof. Differently from known inotropic agents, the present compounds are effective on cardiomyocyte contractility without influencing calcium mobilization. Accordingly, they are advantageously free from adverse effects caused by increased calcium concentrations, such as increased oxygen demand, tachycardia, arrhythmia, ischemia, etc. Overall, a new, safe and effective inotropic treatment is thus made available.

The invention relates to a method for the early detection of the presence of disease in graminivores, comprising the following steps: a) determining the calcium isotope ratio δ44 / 42Ca in a blood serum sample from the animal, and / or b) determining the copper isotope ratio δ65 / 63Cu in a blood serum sample from the animal, and / or c) determining the calcium concentration in a blood serum sample from the animal, d) comparing the relevant determined sample value with a fixed threshold value specific to the determined sample type, wherein the presence of disease in the graminivore is ruled as unlikely if a1) the sample value of the calcium isotope ratio δ44 / 42Caserum is above the fixed threshold value, and / or b1) the sample value of the copper isotope ratio δ65 / 63Cu is below the threshold value, and / or c1) the sample value of the calcium concentration is above the fixed threshold value.

The utility model discloses a special calcium concentration monitoring device for CRRT (China Railway Reverse Transcription), which comprises a detection pool, a waste liquid collecting box and a cleaning mechanism for cleaning residual samples in the detection pool. A fixed plate is driven by a rotating motor to rotate, so that a cleaning brush scrubs a residual sample on the inner wall of the detection pool, and while the cleaning brush scrubs, a cleaning agent in a cleaning agent box is pumped into the detection pool through a micro infusion pump; under the action of a cleaning agent, half-flow samples on the inner wall of the detection pool can be fully brushed, the cleaning efficiency is guaranteed, after brushing is completed, a switch valve is turned on, waste liquid in the detection pool is discharged into a waste liquid collecting box, the waste liquid is collected, and detection personnel can conveniently clean the waste liquid regularly.

The present invention relates to a system (100) for bone volume assessment based on MRI patient scan data and / or at least one set of composite CT data, the system comprising at least one processor module (110) and at least one storage module (120) for storing patient data, the processor module (110) being configured to process and / or analyze MRI patient scan data, at least one set of composite CT data and / or reduced patient data, preferably in combination with each other, so as to identify at least one bone volume parameter of a first patient, in particular bone mineral density, fat percentage, calcium concentration, total density, intertrabecular space, etc. Furthermore, the present invention relates to a corresponding method 200 and a computer-readable medium.

The invention relates to a method for the early detection of the presence of a disease in graminivores comprising the following steps: a) Determine the calcium isotope ratio δ 44 / 42 Ca in a blood serum sample of the animal, and / or b) Determine the copper isotope ratio δ 65 / 63 Cu in a blood serum sample of the animal, and / or c) Determining the calcium concentration in a blood serum sample of the animal, d) comparing the respective determined sample value with a fixed threshold value specific to the particular sample type, whereby the presence of a disease of the graminivore is excluded as unlikely if a1) the sample value of the calcium isotope ratio δ 44 / 42 Ca Serum is above the fixed threshold, and / or b1) the sample value of the copper isotope ratio δ 65 / 63 Cu is below the threshold, and / or c1) the sample value of the calcium concentration is above the fixed threshold.

To provide a technique that enables easy prediction of weight loss of a subject through dietary management.SOLUTION: A method of the present invention for qualitatively predicting weight loss of a subject through dietary management comprises an acquisition step of acquiring at least one indicator selected from a group consisting of: an indicator computed from physical indicators consisting of the pulse rate and MQP, blood indicators consisting of uric acid concentration and calcium concentration, and answer indicators consisting of answers to questions about awareness and / or behavior regarding irregular meal times; an indicator computed from answers regarding eating behavior self-efficacy scale; and an indicator computed from answers regarding rest behavior self-efficacy scale.SELECTED DRAWING: None

Control device (20), programmed to execute a method for controlling or regulating a device (4) for the extracorporeal treatment of blood in an extracorporeal blood circuit (1) by adding citrate for the purpose of anticoagulation, wherein the device (4) comprises an addition device (12) for adding a calcium solution to the extracorporeal blood circuit (1), or for controlling the addition device (12), the procedure includes the following steps: - Outputting a signal to the addition device (12) to change a setting of the addition device (12), wherein the setting corresponds to or causes an addition of calcium, a calcium dosage or concentration or amount or rate; characterized by the steps - Determining the signal taking into account the calcium content or calcium concentration of a substitution solution used in extracorporeal treatment of the blood; and - Determining the range of values ​​of a permissible or approved setting range for the calcium introduced or to be introduced into the extracorporeal blood circulation (1) by means of the addition device (12), in particular its quantity, concentration or dosage, under - Setting a lower limit value for the adjustment range that is considered the smallest permissible value.

The present disclosure relates to the synthesis, uses, methods and pharmaceutical compositions of hydroxyepoxide cyclopropane analogs of Formula I: Formula (I). The hydroxyepoxide cyclopropane analogs are useful in the treatment of diseases and conditions, such as cancer, thromboxane-mediated diseases, cardiovascular diseases, inflammation, fibrosis, pain deficiency, and in the modulation of intracellular calcium concentration. Formula (I)

The application provides a detection method and kit for TRPV4 channel mutant activity and application, and the kit comprises the following products: a host cell naturally lacking endogenous TRPV4 expression; an expression vector for expressing an exogenous TRPV4 gene or a mutant thereof; a ratio type calcium ion fluorescent indicator; and a TRPV4 channel specific agonist. The application has the beneficial effects that: the technology significantly improves the detection accuracy by selecting HeLa cells naturally lacking endogenous TRPV4, a low-concentration agonist of an nM level, and a ratio type indicator Fura-2-AM; the detection efficiency is greatly improved by optimizing PEI transfection, increasing the number of analyzable cells, and increasing the temperature to 28 DEG C; the stability of the results is ensured by detecting the background and peak calcium concentration; and finally, the stable, efficient and accurate determination of the TRPV4 mutant function is realized, which has important scientific research and application value.

This invention discloses a method, liquid circuit system, and electrolyte analyzer for detecting TCO2 and TCa in blood. The method for detecting TCO2 and TCa in blood includes the following steps: providing a sample and a diluent; mixing the sample and the diluent to react and generate a mixture containing carbon dioxide gas and calcium ion complexes; detecting the carbon dioxide gas content; and detecting the calcium ion concentration in the mixture to obtain the total calcium concentration. In this invention, by mixing the diluent with the sample to generate carbon dioxide gas and calcium ion complexes, TCa can be directly tested after TCO2 detection. The mixing and reaction of the diluent with the sample is equivalent to diluting the sample once, allowing for testing with a small sample size, reducing the sample volume required for detection, and eliminating the need for additional reaction processes between the two tests, thus significantly shortening the detection time.

Devices, methods, and systems for providing interaction components for deoxygenated blood for the treatment or prevention of reperfusion injury, including the function of increasing the likelihood that the deoxygenated blood has an ionized calcium concentration of less than 0.5 mmol / L. System components may include one or more injection pumps in operative communication with various functions via a controller / processor, including: a cannula, a pump in communication with the cannula; a heat exchanger; means for generating / generating a fluid flow; one or more infusion ports; a mixing port; a device hub; a catheter interface; the present invention relates to a sensor that may be selectively connected to an object that optionally has one or more monitoring and / or other leads / devices attached thereto. The leads / devices may include sensors and / or other devices that may be attached / connected to the subject to provide health indicators, such as temperature sensors, electrodes for monitoring electrical activity of the heart, and / or SpO2 or other sensors for monitoring blood oxygen saturation levels of the patient.

The application relates to the technical field of biological detection, in particular to a method for quantitatively determining the osteogenic differentiation capacity of mesenchymal stem cells based on calcium concentration and application. The method can accurately and quantitatively detect the osteogenic differentiation capacity of MSCs from different tissues and different generations by inducing MSCs to differentiate into bone and determining the calcium content by combining with o-cresol purple complexone, and has the advantages of high sensitivity, good specificity, excellent repeatability and good durability.

The application relates to the technical field of water quality detection, and discloses a karst water quality detection method and system based on underground water dynamic data. The method comprises the following steps: acquiring a multi-dimensional sensing sequence composed of water level, turbidity, pH and calcium concentration; aligning the water level and the turbidity and performing difference, to obtain a change rate and a change sequence; calculating cross-correlation to extract a time delay feature, and modeling to obtain a coupling strength index; establishing a carbonate balance model based on the pH and the calcium concentration, to obtain a constraint parameter, combining the coupling strength to perform state estimation, and obtaining an adjusted coupling vector; performing high-frequency focusing on the multi-dimensional sequence, to obtain a high-frequency component, evaluating a driving strength, and obtaining a regulation degree value; fusing water level to reconstruct a dynamic feature, and performing deep inversion to obtain a deterioration trend; performing energy weighted fusion to calculate statistical moments, to obtain an inversion parameter set; performing drift verification to obtain a feature vector, and finally performing space-time fusion to output a dynamic detection result. The method can improve the accuracy of karst underground water quality detection.

The invention provides a method for extracting a lithium resource by using spodumene impurity removal slag, and relates to the technical field of extraction of lithium from solid waste. A method for extracting a lithium resource by using spodumene impurity-removed slag comprises the following steps: step S1, material leaching treatment: weighing the spodumene impurity-removed slag, mixing the spodumene impurity-removed slag with a frozen clear liquid, carrying out a stirring leaching reaction at normal temperature, and filtering after the reaction is finished to obtain a lithium-rich filtrate A and a filter residue A; s2, calcium removal and purification treatment: adding sodium hydroxide into the lithium-rich filtrate A to adjust the pH value, transferring into a constant-temperature water bath kettle for constant-temperature stirring reaction, and uniformly sampling after the reaction is finished; inspecting and analyzing calcium and magnesium components, adding sodium carbonate according to the calcium concentration, continuously reacting to remove calcium, and performing solid-liquid separation to obtain filter residue B and filtrate B; the lithium element is efficiently recovered from the spodumene impurity removal slag and the frozen clear liquid and is converted into a lithium phosphate product with a high additional value, so that the cyclic utilization of resources and the maximization of economic benefits are realized.