41 results about "Calcium concentration" patented technology

The invention discloses a pretreatment method for efficiently extracting calcium in shrimp and crab shells. The pretreatment method comprises the following steps: carrying out microwave treatment on the shrimp and crab shells until the weight is constant, rehydrating for 10 minutes in a water bath at 90 DEG C, carrying out microwave treatment until the weight is constant, crushing, mixing with an acetic acid solution, stirring, centrifuging, and measuring the calcium concentration. According to the method, through microwave-rehydration-secondary microwave pretreatment, the carapace structure is destroyed, the contact area of organic acid and calcium is increased, the calcium recovery rate is increased, the treatment time is shortened, the energy consumption is reduced, the universality of raw materials is enhanced, comprehensive utilization of resources is facilitated, and the method is environmentally friendly and economical.

The invention discloses egg white protein peptide calcium oral liquid as well as a preparation method and application thereof, and relates to the field of calcium supplement products. The oral liquid comprises the following components in parts by weight: 30-50 parts of egg white protein peptide powder; 100 to 140 parts of calcium lactate; 20 to 35 parts of calcium gluconate; 100 to 140 parts of a sweetening agent; 1 to 3 parts of citric acid; 1 to 3 parts of essence; and 600 to 700 parts of water. The egg white peptide is chelated with calcium lactate and calcium gluconate to form a peptide-calcium chelate, the solubility is high, the solubility can be kept stable even after high-temperature sterilization treatment, suspended solids or precipitates are not separated out, the concentration of calcium dissolved in the solution is effectively increased, and the oral liquid is pure in sweet taste, rich in fragrance, high in palatability and suitable for large-scale production. The calcium element can be quickly supplemented by consumers.

A laminated ceramic electronic component capable of improving bias characteristics while maintaining ferroelectricity. [Solution] The multilayer ceramic electronic component has a core portion and a shell portion covering the core portion, and has a dielectric layer containing a plurality of crystal grains in which calcium is dissolved in the shell portion and the calcium concentration in the shell portion is 10 times or more higher than the calcium concentration in the core portion, the dielectric layer being sandwiched between internal electrodes containing nickel or copper as a main component, and an external electrode electrically connected to the internal electrode.

The invention relates to a method for the early detection of the presence of disease in graminivores, comprising the following steps: a) determining the calcium isotope ratio δ44 / 42Ca in a blood serum sample from the animal, and / or b) determining the copper isotope ratio δ65 / 63Cu in a blood serum sample from the animal, and / or c) determining the calcium concentration in a blood serum sample from the animal, d) comparing the relevant determined sample value with a fixed threshold value specific to the determined sample type, wherein the presence of disease in the graminivore is ruled as unlikely if a1) the sample value of the calcium isotope ratio δ44 / 42Caserum is above the fixed threshold value, and / or b1) the sample value of the copper isotope ratio δ65 / 63Cu is below the threshold value, and / or c1) the sample value of the calcium concentration is above the fixed threshold value.

A device comprising interconnected components for deoxygenating blood used in the treatment and prevention of reperfusion injury, including a configuration to reduce the ionized calcium concentration of the deoxygenated blood to less than 0.5 mmol / L. The components may include a syringe pump operably communicating with various configurations via a control unit / processor, a cannula, a pump communicating with the cannula, a heat exchanger, a device for generating / creating fluid flow, an infusion port, a mixing port, a device hub, and a catheter hub. These components are selectively connected to a subject, and monitoring and / or other lead wires / devices may be attached to the subject. The lead wires / devices may include sensors and other devices that can be attached to / connected to the subject, providing health indicators, such as a temperature sensor, electrodes for monitoring cardiac electrical activity, and an oxygen saturation (SpO2) sensor for monitoring the patient's blood oxygen saturation.

The invention discloses a high-sensitivity method for detecting calcium ions inside and outside cells, and belongs to the field of laser technology and photonics. An optical microcavity doped with a fluorescent dye is used as a micro laser, the surface of the optical microcavity is functionalized, the optical microcavity is connected with a calcium ion probe to form a sensing system, the sensing system is placed in solutions containing different free calcium concentrations and different types of cells, the change of a microcavity emission spectrum is monitored, and the calcium level is rapidly analyzed on the basis of the displacement difference of a central wavelength. The detection limit of calcium ions reaches pM order of magnitude, the dynamic range at least reaches 6 order of magnitude, and non-toxic, rapid, real-time and accurate quantification of calcium concentrations in different cells is realized.

The invention concerns the use of compounds represented by formula (I)as inotropic agents. The compounds of formula (I), which include, as preferred, 1-[(1S)-1-(2,3-dichloro-4-methoxyphenyl)ethyl]-3-methyl-3-[(4R)-1-methyl-3,3-dimethyl-4-piperidyl]-urea and its hydrochloride salt, are herein reported to have a significant inotropic activity on cardiomyocytes from both normal and myocardial infarction-induced heart failure animal models, which makes them useful for treating cardiovascular patients in need thereof. Differently from known inotropic agents, the present compounds are effective on cardiomyocyte contractility without influencing calcium mobilization. Accordingly, they are advantageously free from adverse effects caused by increased calcium concentrations, such as increased oxygen demand, tachycardia, arrhythmia, ischemia, etc. Overall, a new, safe and effective inotropic treatment is thus made available.

The present invention relates to a pharmaceutical composition for preventing or treating endoplasmic reticulum stress-associated diseases. It has been identified that a peptide having a specific amino acid sequence exhibits the effects of inhibiting endoplasmic reticulum stress, inhibiting fat synthesis, and reducing intracellular reactive oxygen species (ROS) or calcium concentration, and thus the composition can be effectively used to prevent, treat or alleviate endoplasmic reticulum stress-associated diseases.

The invention relates to a bone volume evaluation system (100) based on magnetic resonance (MRI) patient scan data and / or at least one combined computed tomography (CT) data, comprising at least one processor module (110) and at least one memory module (120) for storing patient data. The processor module (110) is configured to process and / or analyze MRI patient scan data, at least one combination of CT data and / or simplified patient data, preferably to process the data combinations to determine at least one bone volume parameter of the first patient, including bone mineral density, fat percentage, calcium concentration, total bone trabecular interstitial density, etc. In addition, the invention also relates to a corresponding method 200 and a computer readable medium.

The utility model provides a CRRT finished product liquid bag with selectable potassium-calcium concentration, which comprises a small liquid bag, the small liquid bag comprises a K + solution bag and a Ca < 2 + > solution bag, the small liquid bag is arranged in a bag body, the front and back sides of the small liquid bag are provided with medicine marks, the bottom of the small liquid bag is provided with a partition, the front and back sides of the liquid bag at the partition are provided with parallel lines, and the K + solution bag and the Ca < 2 + > solution bag are arranged in the bag body. The lower end of the partition is connected with a communicating pipeline. A cavity is formed in the replacement liquid bag, and a solution containing Ca < 2 + > and K < + > is isolated from the replacement liquid; according to the utility model, the partition in the replacement liquid bag is broken by pressure through extrusion, so that the solution containing Ca < 2 + > and K < + > is communicated with the replacement liquid to complete the configuration in the closed bag.

The present invention relates to a composition for regulating at least one of an intracellular calcium concentration and a calcium-dependent signaling pathway, the composition containing citicoline or a salt thereof. The present invention also relates to a composition for regulating the expression of at least one of a Neuronal Calcium Sensor-1 (NCS-1) gene and a Two Pore Segment Channel 1 (TPCN1) gene, the composition containing citicoline or a salt thereof.　

The described techniques may include processes for modeling parathyroid gland (PTG) function and / or calcimimetic administration to patients with health abnormalities that affect PTG function. In one embodiment, a method may include providing a PTG function model configured to simulate the function of the PTG of a patient with at least one health abnormality that affects PTG function, the model may receive parameters configured to modulate calcium sensing receptor (CaSR) activity, the parameters may include calcium concentration, vitamin D concentration, and phosphorus concentration, simulate CaSR expression and vitamin D receptor (VDR) expression via a positive feedback loop between CaSR expression and VDR expression and inhibit CaSR expression and VDR expression through P, initiate at least one PTG adaptation based on the multiple parameters, and determine a model output comprising parathyroid hormone (PTH) concentration at one or more time intervals. Other embodiments are also described.

The invention concerns the use of compounds represented by formula (I)as inotropic agents. The compounds of formula (I), which include, as preferred, 1-[(1S)-1-(2,3-dichloro-4-methoxyphenyl)ethyl]-3-methyl-3-[(4R)-1-methyl-3,3-dimethyl-4-piperidyl]-urea and its hydrochloride salt, are herein reported to have a significant inotropic activity on cardiomyocytes from both normal and myocardial infarction-induced heart failure animal models, which makes them useful for treating cardiovascular patients in need thereof. Differently from known inotropic agents, the present compounds are effective on cardiomyocyte contractility without influencing calcium mobilization. Accordingly, they are advantageously free from adverse effects caused by increased calcium concentrations, such as increased oxygen demand, tachycardia, arrhythmia, ischemia, etc. Overall, a new, safe and effective inotropic treatment is thus made available.

The invention relates to a method for the early detection of the presence of disease in graminivores, comprising the following steps: a) determining the calcium isotope ratio δ44 / 42Ca in a blood serum sample from the animal, and / or b) determining the copper isotope ratio δ65 / 63Cu in a blood serum sample from the animal, and / or c) determining the calcium concentration in a blood serum sample from the animal, d) comparing the relevant determined sample value with a fixed threshold value specific to the determined sample type, wherein the presence of disease in the graminivore is ruled as unlikely if a1) the sample value of the calcium isotope ratio δ44 / 42Caserum is above the fixed threshold value, and / or b1) the sample value of the copper isotope ratio δ65 / 63Cu is below the threshold value, and / or c1) the sample value of the calcium concentration is above the fixed threshold value.

The present disclosure relates to synthesis of hepoxilin cyclopropane analogs of Formula I: Formula (I), uses, methods, and pharmaceutical compositions thereof. Said hepoxilin cyclopropane analogs are useful for the treatment of diseases and conditions, such as cancer, thromboxane-mediated diseases, cardiovascular diseases, inflammation, fibrosis, analgesia, and for modulating intracellular calcium concentration.

The present invention relates to squid-derived peptides and uses thereof and, more specifically, to uses of squid-derived peptides squidtocin and pro-sepiatocin for prevention or treatment of V1B receptor-related diseases. It has been confirmed that the squidtocin and pro-sepiatocin according to the present invention have an effect of inducing activation of a V1B receptor which is a type of vasopressin receptor. The V1B receptor which is a type of vasopressin receptor is present in the anterior pituitary and in the hippocampal CA2 region, and it is known that the V1B receptor increases intracellular calcium concentration and is involved in response to stress and sociality. Accordingly, the squidtocin and the pro-sepiatocin according to the present invention can be used in various ways in the field of prevention, amelioration, or treatment of V1B receptor-related diseases.

An object of the present invention is to provide a novel agent for treating, preventing or improving an inflammatory disease or an allergic disease. The present invention provides an agent for treating, preventing or improving an allergic disease, or as an agent for treating, preventing or improving an inflammatory disease or an allergic disease, comprising, as an active ingredient, (±) 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid (5,6-DiHETE). The inflammatory disease can be an inflammatory disease due to an increase of calcium concentration in vascular endothelial cells, and the inflammatory disease can be an inflammatory disease developed in a tissue or organ selected from the group consisting of digestive organs, circulatory organs, respiratory organs, urinary organs, genital organs, brain, skin, eyes, and fat.

To provide a composition which increases contractility of cardiac muscle without increasing the cell death in contrast to a commonly used β-agonist, isoproterenol.SOLUTION: A composition containing probenecid and administered by at least one of injection, oral administration and transdermal administration can increase the calcium concentration in a heart cell without increasing the cell death.SELECTED DRAWING: None

An optical sensor may be used to measure the concentration of calcium in a water sample, such as a water sample obtained from industrial process water system like a cooling tower system, a boiler water system, or a waste water system. To measure the concentration of calcium, an indicator or reagent may be added to the water sample to form a complex that absorbs light. The absorbance profile of the complex may be non-linear over a range of calcium concentrations. However, the absorbance profile can be linearized to provide calibration coefficients that are subsequently used to determine the concentration of calcium in samples having unknown calcium concentrations. The linearization of the absorbance profile can allow the optical sensor to be calibrated using two solutions. This can reduce the complexity and cost of calibrating the optical sensor, which may otherwise require at least three calibration solutions to capture the non-linear profile of the absorbance curve.

The utility model discloses a special calcium concentration monitoring device for CRRT (China Railway Reverse Transcription), which comprises a detection pool, a waste liquid collecting box and a cleaning mechanism for cleaning residual samples in the detection pool. A fixed plate is driven by a rotating motor to rotate, so that a cleaning brush scrubs a residual sample on the inner wall of the detection pool, and while the cleaning brush scrubs, a cleaning agent in a cleaning agent box is pumped into the detection pool through a micro infusion pump; under the action of a cleaning agent, half-flow samples on the inner wall of the detection pool can be fully brushed, the cleaning efficiency is guaranteed, after brushing is completed, a switch valve is turned on, waste liquid in the detection pool is discharged into a waste liquid collecting box, the waste liquid is collected, and detection personnel can conveniently clean the waste liquid regularly.

The present invention relates to a system (100) for bone volume assessment based on MRI patient scan data and / or at least one set of composite CT data, the system comprising at least one processor module (110) and at least one storage module (120) for storing patient data, the processor module (110) being configured to process and / or analyze MRI patient scan data, at least one set of composite CT data and / or reduced patient data, preferably in combination with each other, so as to identify at least one bone volume parameter of a first patient, in particular bone mineral density, fat percentage, calcium concentration, total density, intertrabecular space, etc. Furthermore, the present invention relates to a corresponding method 200 and a computer-readable medium.

The invention concerns the use of compounds represented by formula (I)as inotropic agents. The compounds of formula (I), which include, as preferred, 1-[(1S)-1-(2,3-dichloro-4-methoxyphenyl)ethyl]-3-methyl-3-[(4R)-1-methyl-3,3-dimethyl-4-piperidyl]-urea and its hydrochloride salt, are herein reported to have a significant inotropic activity on cardiomyocytes from both normal and myocardial infarction-induced heart failure animal models, which makes them useful for treating cardiovascular patients in need thereof. Differently from known inotropic agents, the present compounds are effective on cardiomyocyte contractility without influencing calcium mobilization. Accordingly, they are advantageously free from adverse effects caused by increased calcium concentrations, such as increased oxygen demand, tachycardia, arrhythmia, ischemia, etc. Overall, a new, safe and effective inotropic treatment is thus made available.

The invention relates to a method for the early detection of the presence of a disease in graminivores comprising the following steps: a) Determine the calcium isotope ratio δ 44 / 42 Ca in a blood serum sample of the animal, and / or b) Determine the copper isotope ratio δ 65 / 63 Cu in a blood serum sample of the animal, and / or c) Determining the calcium concentration in a blood serum sample of the animal, d) comparing the respective determined sample value with a fixed threshold value specific to the particular sample type, whereby the presence of a disease of the graminivore is excluded as unlikely if a1) the sample value of the calcium isotope ratio δ 44 / 42 Ca Serum is above the fixed threshold, and / or b1) the sample value of the copper isotope ratio δ 65 / 63 Cu is below the threshold, and / or c1) the sample value of the calcium concentration is above the fixed threshold.

The invention relates to the technical field of biological detection, in particular to a method for quantitatively determining the osteogenic differentiation capacity of mesenchymal stem cells based on calcium concentration and application. The osteogenic induction differentiation capacity of the MSCs is evaluated by determining the calcium content through mesenchymal stem cell osteogenic induction in combination with o-cresolphthalein complex ketone, the osteogenic induction differentiation capacity of the MSCs with different tissue sources and different generations can be accurately and quantitatively detected, and the method has the advantages of being high in sensitivity, good in specificity, excellent in repeatability, good in durability and the like.

The present disclosure relates to synthesis of hepoxilin cyclopropane analogs of Formula I: Formula (I), uses, methods, and pharmaceutical compositions thereof. Said hepoxilin cyclopropane analogs are useful for the treatment of diseases and conditions, such as cancer, thromboxane-mediated diseases, cardiovascular diseases, inflammation, fibrosis, analgesia, and for modulating intracellular calcium concentration.

To provide a technique that enables easy prediction of weight loss of a subject through dietary management.SOLUTION: A method of the present invention for qualitatively predicting weight loss of a subject through dietary management comprises an acquisition step of acquiring at least one indicator selected from a group consisting of: an indicator computed from physical indicators consisting of the pulse rate and MQP, blood indicators consisting of uric acid concentration and calcium concentration, and answer indicators consisting of answers to questions about awareness and / or behavior regarding irregular meal times; an indicator computed from answers regarding eating behavior self-efficacy scale; and an indicator computed from answers regarding rest behavior self-efficacy scale.SELECTED DRAWING: None

Control device (20), programmed to execute a method for controlling or regulating a device (4) for the extracorporeal treatment of blood in an extracorporeal blood circuit (1) by adding citrate for the purpose of anticoagulation, wherein the device (4) comprises an addition device (12) for adding a calcium solution to the extracorporeal blood circuit (1), or for controlling the addition device (12), the procedure includes the following steps: - Outputting a signal to the addition device (12) to change a setting of the addition device (12), wherein the setting corresponds to or causes an addition of calcium, a calcium dosage or concentration or amount or rate; characterized by the steps - Determining the signal taking into account the calcium content or calcium concentration of a substitution solution used in extracorporeal treatment of the blood; and - Determining the range of values ​​of a permissible or approved setting range for the calcium introduced or to be introduced into the extracorporeal blood circulation (1) by means of the addition device (12), in particular its quantity, concentration or dosage, under - Setting a lower limit value for the adjustment range that is considered the smallest permissible value.

The present disclosure relates to the synthesis, uses, methods and pharmaceutical compositions of hydroxyepoxide cyclopropane analogs of Formula I: Formula (I). The hydroxyepoxide cyclopropane analogs are useful in the treatment of diseases and conditions, such as cancer, thromboxane-mediated diseases, cardiovascular diseases, inflammation, fibrosis, pain deficiency, and in the modulation of intracellular calcium concentration. Formula (I)

The application provides a detection method and kit for TRPV4 channel mutant activity and application, and the kit comprises the following products: a host cell naturally lacking endogenous TRPV4 expression; an expression vector for expressing an exogenous TRPV4 gene or a mutant thereof; a ratio type calcium ion fluorescent indicator; and a TRPV4 channel specific agonist. The application has the beneficial effects that: the technology significantly improves the detection accuracy by selecting HeLa cells naturally lacking endogenous TRPV4, a low-concentration agonist of an nM level, and a ratio type indicator Fura-2-AM; the detection efficiency is greatly improved by optimizing PEI transfection, increasing the number of analyzable cells, and increasing the temperature to 28 DEG C; the stability of the results is ensured by detecting the background and peak calcium concentration; and finally, the stable, efficient and accurate determination of the TRPV4 mutant function is realized, which has important scientific research and application value.

An indicator composition may be used to measure calcium hardness within a water sample from an industrial water system. The indicator composition may include a calcium indicator, a range extender, and a buffer. The indicator composition can accurately measure the calcium concentration within the water sample at low, medium and high calcium levels, including at calcium concentrations greater than 50 ppm. The indicator composition can measure calcium hardness at a pH of less than about 7 without the use of a masking agent.