10 results about "Potassium Clavulanate" patented technology

This invention discloses a powder containing doxycycline hydrochloride and potassium clavulanate for aquaculture, its preparation method, and its application, belonging to the field of biotechnology. This invention combines doxycycline hydrochloride and potassium clavulanate to enhance the antibacterial ability of aquatic animals against drug-resistant bacteria, thereby better treating various diseases caused by drug-resistant bacteria in aquatic animals. Further experiments demonstrate that potassium clavulanate can significantly reduce bacterial resistance and enhance the antibacterial activity of doxycycline hydrochloride. The preparation of a composite powder using the combination of doxycycline hydrochloride and potassium clavulanate is simple, uses readily available raw materials, and is suitable for large-scale industrial production. Its application in the treatment of aquatic animal diseases, verified through challenge experiments, demonstrates the effectiveness of this composite powder in treating bacterial infections in aquatic animals. It has broad application prospects.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a cefpodoxime proxetil and clavulanate potassium compound preparation and a preparation method thereof. In the cefpodoxime proxetil and potassium clavulanate compound preparation provided by the invention, the cefpodoxime proxetil and potassium clavulanate have a synergistic effect, so that the antibacterial effect can be enhanced, the antibacterial spectrum can be expanded, and drug-resistant bacterium infection can be effectively treated; according to the cefpodoxime proxetil premix, auxiliary materials such as lactose, calcium carboxymethyl cellulose and lauryl sodium sulfate are compounded, and a preparation process of firstly mixing cefpodoxime proxetil, lactose, a cosolvent and calcium carboxymethyl cellulose to prepare the premix is adopted, so that all the components are fully mixed and play a synergistic effect, the dissolution speed and bioavailability of the medicine are improved, and the bioavailability of the medicine is improved; the uniformity of preparation components is guaranteed, the stability of the whole process is enhanced, and the method is suitable for large-scale production.

The invention discloses a preparation method of amoxicillin sodium and clavulanate potassium for injection, belongs to the technical field of pharmaceutical preparations, and aims to solve the problems that related substances are easily generated in the production and storage of compound antibiotics, and the medication safety and the batch stability are influenced. According to the preparation, amoxicillin sodium and potassium clavulanate are used as main drugs, a specific antioxidant is compounded to inhibit potassium clavulanate oxidation and amoxicillin hydrolysis respectively, and a filling agent and a flow aid are used as auxiliary materials. During preparation, a premix is prepared through multi-step mixing, after wet granulation, segmented temperature control drying is adopted, temperature and vacuum degree are adjusted in a gradient mode, and nitrogen is filled for protection in the whole filling and capping process. According to the scheme, an oxidation and hydrolysis dual-degradation path is covered through antioxidant compounding, the dehydration efficiency and the drug stability are balanced through segmented drying, related substances can be reduced, the batch consistency is improved, the medication safety is guaranteed, and storage and transportation are convenient.

The application provides a spherical potassium clavulanate, a preparation method thereof and a compound preparation. The spherical potassium clavulanate has a spherical diameter of 25-150 microns. The preparation method of the spherical potassium clavulanate is as follows: 1. Dissolving a tertiary butylamine salt in an organic solvent to obtain an amine salt solution; 2. Preparing a potassium isooctanoate solution by dissolving potassium isooctanoate in an appropriate amount of organic solvent; 3. Removing carbon in the solution by adding activated carbon into the amine salt solution, stirring, filtering and washing the carbon with a small amount of organic solvent; 4. Crystallizing by controlling the temperature of the crystallization solution at 16-20 DEG C, stirring and adding the potassium isooctanoate solution at a constant speed; after the addition is completed, the temperature is lowered to 2-6 DEG C, and the stirring and heat preservation are performed for greater than or equal to 2 hours; 5. Filtering, washing and drying by filtering the crystallization solution, washing the solution with a solvent at 2-6 DEG C for 3-4 times, and vacuum drying the wet powder by cold pumping for 1 hour and drying at 35 DEG C for 6 hours. The spherical potassium clavulanate prepared by the method has uniform particle size distribution, good fluidity, easy dispensing and quality meeting the standard of the 2020 edition of the Chinese Pharmacopoeia.

The application discloses a compound preparation capable of reducing drug resistance of pathogenic bacteria to florfenicol and a preparation method thereof, and belongs to the technical field of medicines. The compound preparation comprises a composition of florfenicol and potassium clavulanate, wherein the composition comprises 2-60 parts of the florfenicol and 0.5-15 parts of the potassium clavulanate by weight. The application further provides application of the potassium clavulanate in preparation of a product for reducing antibacterial activity of florfenicol to pathogenic bacteria and application of the potassium clavulanate in preparation of a product for reducing drug resistance of pathogenic bacteria to florfenicol. The results of examples of the application show that the potassium clavulanate can reduce drug resistance of florfenicol and enhance antibacterial activity of florfenicol, the compound preparation provided by the application is simple to prepare, raw materials are easy to obtain, and the compound preparation is suitable for industrial large-scale production, and has a wide application prospect.

The invention relates to the field of biological medicine preparations, and particularly discloses compound amoxicillin powder and a preparation process thereof. The compound amoxicillin powder is prepared from the following raw material components in parts by weight: 100 parts of amoxicillin; 15 to 18 parts of potassium clavulanate; 400 to 420 parts of lipid; 6-8 parts of a stabilizer; 0.4 to 0.5 part of a meglumine surfactant; the lipid comprises soybean lecithin and cholesterol in a weight ratio of (3.8-4): 1; the preparation method comprises the following steps: S1, blending the amoxicillin and the lipid to obtain the amoxicillin liposome; s2, dispersing the amoxicillin liposome and a meglumine surfactant in water, stirring, adding a stabilizer, stirring, filtering, freeze-drying, and blending with potassium clavulanate to obtain the compound amoxicillin powder. The compound amoxicillin powder disclosed by the invention has relatively high bioavailability, does not need to be frequently administered to an organism, and is relatively high in practicability and good in drug effect.

The invention discloses amoxicillin sodium and clavulanate potassium for injection and a preparation method of the amoxicillin sodium and clavulanate potassium, and relates to the technical field of pharmaceutical preparations. The preparation method comprises the following steps: adding vitamin E acetate and poloxamer 124 into absolute ethyl alcohol, and uniformly mixing to obtain a mixed solution A; adding amoxicillin sodium and potassium clavulanate into the mixed solution, and uniformly mixing to obtain a mixed solution B; and adding the mixed solution B into a spray dryer, and carrying out spray drying in an inert dry atmosphere to obtain the amoxicillin sodium and clavulanate potassium powder. Vitamin E acetate and poloxamer 124 are added into medicine molecules, and the inlet and outlet temperatures are controlled in cooperation with a spray drying process, so that the amoxicillin sodium and clavulanate potassium powder is obtained. The stability of amoxicillin sodium and clavulanate potassium for injection can be effectively improved.

The utility model discloses a potassium clavulanate activated carbon filtering device. The device comprises a dissolving liquid tank, a feed liquid delivery pump, a rotary ceramic membrane, a cooler and a crystallizing tank which are sequentially connected through pipelines, a feeding valve is arranged on the pipeline between the feed liquid delivery pump and an inlet of the rotary ceramic membrane, a discharging valve is arranged on the pipeline between an outlet of the rotary ceramic membrane and the cooler, and the crystallizing tank is connected with the feeding valve. The outlet of the rotary ceramic membrane is also connected to the dissolving liquid tank through a reflux pipeline; and a reflux valve is arranged on the reflux pipeline. The device can be used for filtering active carbon in the potassium clavulanate organic solvent, and has the advantages of good filtering effect, simplicity in operation and easiness in cleaning.

The invention discloses compound amoxicillin powder and a preparation process thereof, and belongs to the technical field of medicines, the key point of the technical scheme is that the compound amoxicillin powder comprises the following raw materials in parts by weight: 55-60 parts of amoxicillin, 10-15 parts of potassium clavulanate, 22-27 parts of sulfobutyl ether-beta-cyclodextrin, 2.5-3 parts of a cosolvent, 3.5-4.5 parts of a stabilizer and 18-24 parts of an auxiliary material; the stabilizing agent comprises colloidal silicon dioxide, EDTA-disodium and povidone K30 according to the weight ratio of (2.5-3): (0.2-0.4): 1, through cooperation of the specific stabilizing agent and sulfobutyl ether-beta-cyclodextrin, the stability of potassium clavulanate is effectively improved, and wide application of the compound amoxicillin powder to livestock and poultry is facilitated.

The invention relates to the field of preparation of potassium clavulanate. The potassium clavulanate prepared by the preparation method disclosed by the invention is high in purity, reduces the use of organic solvents, and is more environment-friendly and safer.