This invention discloses novel triazine compounds with anti-coccidial activity, their preparation method and application. The general structural formula of the compounds is shown in formula 1, wherein, R1 and R2 are the same or not, and are selected from H, halogen, alkyl, alkoxy, nitro and trifluoromethyl; R3 is COR7, cycloalkyl, or heterocycle; R4 is H or alkyl. The acids for forming pharmaceutically acceptable salts of the compounds include HCl, H2SO4, HBr, H3PO4, H2CO3, formic acid, acetic acid, citric acid, lactic acid, fumaric acid, tartaric acid, and gluconic acid. The alkalis for forming pharmaceutically acceptable salts of the compounds include NaOH, KOH, triethylamine, and t-butylamine. The compounds have good inhibitive effects on animal coccidiosis.