39 results about "Isopropylamine" patented technology

The application discloses a hydroxylamine hydrochloride detection method in azithromycin dry suspension, and relates to the trace detection field. The method uses isoamyl aldehyde as a derivatizing agent, generates isoamyl aldoxime by performing derivatization treatment on a sample to be measured, and then uses N-nitrosodiisopropylamine as an internal standard substance to quantitatively determine the isoamyl aldoxime by using liquid chromatography-tandem mass spectrometry. The detection method adopts an isoamyl aldehyde derivatizing agent-N-nitrosodiisopropylamine internal standard substance system, can correct detection errors caused by factors such as matrix effect, pretreatment loss and derivatization efficiency fluctuation, and improves the accuracy and sensitivity of the trace hydroxylamine hydrochloride detection result, thereby guaranteeing the safety of the medicine.

The invention discloses a glyphosate soluble concentrate and a preparation method, and the glyphosate soluble concentrate comprises the following raw material components in parts by weight: 30-40 parts of glyphosate, 10-15 parts of isopropylamine, 8-12 parts of a composite synergist, 2-3 parts of an anti-freezing agent, 0.05-0.1 part of a pH regulator, 2-3 parts of an additive, 0.1-0.5 part of a defoaming agent, 1-2 parts of a loading agent and 40-50 parts of water. Compared with the prior art, the glyphosate soluble concentrate prepared by the invention has the advantages that the propoxylated quaternary ammonium salt and the ethyoxyl alkyl phosphate are mixed according to a certain mass ratio to form the synergist, so that the pesticide effect of glyphosate is remarkably improved. Meanwhile, the aluminum pillared clay is introduced to load the glyphosate and is cooperatively used with the polydopamine-sodium alginate compound, so that the prepared glyphosate soluble concentrate has relatively high leaf deposition rate and rain wash resistance and also has excellent ultraviolet resistance.

The application belongs to the technical field of coordination complex catalysts, and particularly relates to a chromium-nickel bimetallic center complex catalyst and a preparation method and application thereof. Isopropylamine, a cyclohexyl benzyl chlorophosphine and an acid binding agent are added into a solvent to react, and a PNP ligand is obtained; the PNP ligand, acetylacetone chromium and acetylacetone nickel are respectively dissolved in a solvent to obtain a PNP ligand solution, an acetylacetone chromium solution and an acetylacetone nickel solution, and the PNP ligand solution, the acetylacetone chromium solution and the acetylacetone nickel solution are mixed and stirred to react, and a chromium-nickel bimetallic center complex catalyst is obtained. The chromium-nickel bimetallic center complex catalyst prepared by the application can be used for ethylene oligomerization reaction, can quickly activate ethylene molecules and accurately control the chain growth process, and meets the dual demands of high activity and high selectivity of the catalyst for industrial production.

The invention discloses a method for preparing magnesium borohydride by a solution method, and relates to the technical field of hydrogen storage materials. The method comprises the following steps: dissolving MgCl2 in tetrahydrofuran to form a magnesium source solution, dissolving NaBH4 in isopropylamine to form a boron-hydrogen source solution, mixing the two solutions, and stirring to react; carrying out centrifugation and microfiltration membrane suction filtration separation on the reacted mixture to remove solid impurities so as to obtain a clarified filtrate; and carrying out vacuum desolventizing treatment on the filtrate to finally obtain solid magnesium borohydride. The method is simple in process flow, can be completed under mild conditions, and has the advantages of low raw material cost and high operation safety; the prepared magnesium borohydride product has excellent performance of lower initial hydrogen desorption temperature, and the temperature is only 115.8 DEG C. The method is especially suitable for large-scale industrial production.

The invention discloses a bentazone intermediate sulfonation-chlorination two-step continuous preparation process which comprises the following steps: continuously metering and adding a solvent, chlorosulfonic acid, triethylamine, isopropylamine and a catalyst into a first-section tubular reactor, and carrying out sulfonation reaction to obtain a reaction material isopropylaminosulfonic acid; continuously introducing the reaction material isopropylamine sulfonic acid into a second section of tubular reactor, and simultaneously continuously metering and adding methyl anthranilate and phosphorus oxychloride for chlorination reaction; after the reaction is finished, quenching the reaction liquid with water, and carrying out layering and distillation treatment to obtain an intermediate o-isopropylamine sulfonamide methyl benzoate solid; and carrying out ring-closure reaction on the intermediate o-isopropylamino sulfonamido methyl benzoate solid and sodium methoxide in a methanol solution to prepare the bentazone active compound. According to the method, the defects of low bentazone product content and poor yield caused by high temperature of intermittent sulfonation and chlorination are effectively overcome, the operation time is shortened, and the productivity is improved.

The invention relates to a preparation method of diisopropylamine silane, which comprises the following steps: (1) reacting dichlorosilane with diisopropylamine to obtain diisopropylamine chlorosilane; and (2) carrying out a reaction on the diisopropylamine chlorosilane obtained in the step (1) and lithium hydride to obtain the diisopropylamine silane. The preparation method of diisopropylamine silane in the prior art is optimized, a complex catalyst does not need to be prepared in advance, raw materials are simple and easy to obtain, reaction steps are simple, high-temperature and high-pressure reaction conditions are avoided, the reaction conditions are mild, the obtained target product has high yield and purity, and industrial large-scale production is facilitated.

Present invention relates to a method for producing green fluorescent paint for use as a lighting for energy-efficient highway lane and park markings, characterized as comprising following production steps; adding 9,10-dibromoanthracene, CuI, Pd catalyst, diisopropylamine and toluene in a reaction flask under nitrogen atmosphere and stirring them on a magnetic stirrer, adding tetraphenylsilanacetylenyl to the mixture and performing reflux distillation by increasing the reaction temperature, after 24 hours bringing the temperature to room temperature, obtaining pure product from the mixture brought to room temperature using column chromatography, taking 0-1% by mass of the product and mixing it in resin and an aromatic solvent for 6-24 hours.

The invention belongs to the technical field of coordination complex catalysts, and particularly relates to a chromium-nickel bimetallic center complex catalyst as well as a preparation method and application thereof. The preparation method comprises the following steps: adding isopropylamine, cyclohexylphenylphosphonium chloride and an acid-binding agent into a solvent for reaction to obtain a PNP ligand; the preparation method comprises the following steps: respectively dissolving a PNP ligand, chromium acetylacetonate and nickel acetylacetonate in a solvent to obtain a PNP ligand solution, a chromium acetylacetonate solution and a nickel acetylacetonate solution, and mixing and stirring the PNP ligand solution, the chromium acetylacetonate solution and the nickel acetylacetonate solution for reaction to obtain the chromium-nickel bimetallic center complex catalyst. The prepared chromium-nickel bimetallic center complex catalyst can be used for ethylene oligomerization reaction, ethylene molecules can be rapidly activated, the chain growth process can be accurately controlled, and the dual requirements of industrial production for high activity and high selectivity of the catalyst are met.

The invention belongs to the field of oilfield chemical treatment agents, and particularly relates to a preparation method of a thickening agent for oil extraction fracturing, which comprises the following steps: 1, uniformly mixing 25 parts of acrylamide, 15 parts of acrylic acid, 4 parts of Tween-80, 1.5 parts of dodecyl benzene sulfonic acid isopropylamine salt, 90 parts of deionized water and 2.5 parts of azodiisobutylimidazoline hydrochloride to obtain a water phase; 2, uniformly mixing 45 parts of 0 # diesel oil, 14 parts of methyl methacrylate, 7 parts of butadiene, 7 parts of diacetone acrylamide and 6 parts of butanol polyoxypropylene ether to obtain an oil phase; and 3, putting the oil phase into a reaction kettle, adding the water phase into the oil phase, uniformly stirring at the rotating speed of a motor of 9000rpm for 30 minutes, adjusting the rotating speed to 700rpm, introducing nitrogen for 30 minutes, heating to 535 DEG C, stirring for reacting for 10 hours, and cooling to obtain the fracturing fluid thickening agent for oil extraction. The shearing resistance, the temperature resistance, the salt resistance and the sand suspending property of the thickening agent are superior to those of the existing thickening agent.

The present invention relates to the technical field of camptothecin derivative preparation, particularly to a camptothecin derivative synthesis method, which uses 2-nitroacetophenone and isopropylamine as raw materials, and the camptothecin derivative is obtained through a Mannich reaction, a methylsulfonylation reaction, a nitro reduction reaction and a ring closing reaction. According to the synthetic method of the camptothecin derivative, the complex camptothecin derivative is split into two segments 1-(2-aminophenyl)-3-(N-isopropyl-N-methylsulfonylamino) propan-1-one and a compound V which are easy to prepare, and finally, a plurality of rings and chemical bonds are constructed simultaneously through one-step efficient ring closing reaction. The yield attenuation caused by progressive multiplication of the yield in the traditional linear synthesis is avoided, and the total yield is improved.

The application discloses SAPO-18-MeR molecular sieve and a preparation method and application thereof. The anhydrous chemical composition of the molecular sieve is mMe*nR(Si x Al y P z )O2; Me is at least one selected from Li + , Na + , K + and NH4 + ; R is at least one selected from N, N-diisopropyl ethylamine, tetraethyl ammonium hydroxide, triethylamine, diisopropylamine, diethylamine and ethylenediamine; m is the mole number of Me, m=0.05-0.2; n is the mole number of R, n=0.05-0.2; x is the mole fraction of Si, x=0.05-0.35; y is the mole fraction of Al, y=0.35-0.55; z is the mole fraction of P, z=0.25-0.45, and x+y+z=1. The molecular sieve has excellent silicon distribution and strong acid property, and has excellent catalytic performance as a denitration catalyst after loading Cu ions.

The invention discloses a herbicide for saccharum arundinaceum as well as a preparation method and application thereof. The herbicide for saccharum arundinaceum is prepared from a glyphosate isopropylamine salt aqueous solution and hexazinone granules, wherein the mass ratio of the effective components of the glyphosate isopropylamine salt aqueous solution to the effective components of the hexazinone granules is 1: (0.09-23.39). The herbicide for saccharum arundinaceum is prepared from glyphosate and hexazinone, and the nano-scale biochar, ferulic acid, dopamine hydrochloride, sodium alginate and calcium chloride are used for preparing the nano-auxiliary agent with adhesion, so that scientific and effective prevention and removal of saccharum arundinaceum in a dam region are guaranteed; and the labor intensity and the safety risk of workers in the dam region saccharum arundinaceum prevention and control area of the hydro-junction project with steep gradient and large height difference can be reduced. The herbicide provided by the invention fills up the blank of the herbicide for preventing and controlling malignant weeds such as saccharum arundinaceum in the hydro-junction project dam area, and has important significance for ensuring scientific and effective prevention and removal of saccharum arundinaceum in the hydro-junction project dam area.

The invention relates to a railway herbicide composition and application thereof, and the railway herbicide composition is prepared from the following components in parts by weight: 60 to 120 parts of ammonium glyphosate or isopropylamine salt, 15 to 60 parts of hexazinone, and 15 to 45 parts of 4-amino-3, 5-dichloro-6-fluoro-pyridine-2-oxyacetic acid derivative or quaternary ammonium salt of the 4-amino-3, 5-dichloro-6-fluoro-pyridine-2-oxyacetic acid derivative. All the components of the railway herbicide disclosed by the invention are combined in a certain ratio range to show a remarkable synergistic interaction effect, so that the pesticide cost is greatly reduced on the whole.

The invention relates to the technical field of fine chemical engineering, in particular to a continuous preparation process of N-methylisopropylamine, which comprises the following steps: dropwise adding a monomethylamine solution into acetone to obtain an imine solution, preserving heat, adding a platinum-carbon catalyst, and pulping to obtain a mixed solution; controlling the flow rate, and sequentially carrying out hydrogenation reaction on the mixed solution and hydrogen through a dynamic microreactor to obtain a mixture; the mixture is distilled, filtered and rectified to obtain the N-methylisopropylamine, monomethylamine and acetone are used as raw materials, continuous hydrogenation reaction is performed to prepare the N-methylisopropylamine, conditions are mild, operation is easy and convenient, safety is high, production efficiency is high, and the method is suitable for industrialization.

The present application relates to the technical field of enzyme engineering, and discloses an amino transferase mutant and application thereof.The present application provides a wild-type amino transferase mutant derived from Aspergillus avenaceus.The amino transferase mutant is obtained by carrying out single-point or multi-point combined mutation on the 20th, 60th, 92nd and 186th positions of the amino acid sequence shown in SEQ ID NO.2, and can directly take the sitagliptin intermediate precursor ketone as a substrate, take isopropylamine as an amino donor, take phosphopyridoxyl as a coenzyme, take dimethyl sulfoxide as a substrate solvent, catalyze the preparation of a sitagliptin intermediate with high optical purity, and the specific enzyme activity reaches 139.3 U / g in a reaction system with a final concentration of 50% DMSO, greatly improves the catalytic efficiency, and the product has high stereoselectivity (the e.e. value of the product reaches 99%), and has a wide industrial application prospect.

The invention belongs to the technical field of petrochemical catalysis, and relates to a method for propylene liquid phase epoxidation on a zinc modified TS-1 zeolite catalyst. The zinc modified TS-1 zeolite catalyst is prepared by a combined modification method, and the method comprises the following steps: 1, carrying out hydrothermal modification treatment on a TS-1 zeolite matrix by using a tetrapropylammonium hydroxide aqueous solution containing isopropanolamine, adjusting the coordination state of TS-1 zeolite skeleton titanium, generating an open mononuclear hexa-coordination titanium catalytic active center, and improving the activity of the catalyst; in the second step, the microenvironment of the open type mononuclear hexa-coordinated titanium species is adjusted by using the fusible zinc salt, so that acidic silicon hydroxyl around the microenvironment is eliminated, and the selectivity of the catalyst is improved; the propylene liquid phase epoxidation method is technically characterized in that hydrogen peroxide with the concentration lower than 50 wt.% is used as an oxidizing agent on the catalyst to produce epoxypropane, and a gas-solid phase oxidation method is used for regenerating the deactivated catalyst.

The present application relates to oil and gas hydrogen sulfide absorption technical field, especially to a kind of for oil and gas exploitation, oil and gas environmental protection gathering and transportation hydrogen sulfide absorbent and preparation method thereof.Add 3-amino pentane and isopropylamine, 3-amino pentane and isopropylamine mixture and hydrogen sulfide reaction to form 3-sulfanyl pentane and 1-sulfanyl isopropylamine, reduce the content of hydrogen sulfide in oil and gas;In the reaction, appropriate solid catalyst is added, the reaction speed is improved, and the generation time is saved;And in the oil and gas of reaction kettle, bactericide propyl trimethyl ammonium chloride 2% to 4% and SAA are added, to avoid bacteria in oil and gas storage, sulfate and sulfur-containing organic compounds in sulfur are reduced to hydrogen sulfide;The use of precipitant adsorbs solid impurities in oil and gas and impurities generated after reaction, and the removal of impurities is facilitated;This scheme not only removes hydrogen sulfide in oil and gas, but also ensures that hydrogen sulfide is not generated again during oil and gas storage.

The invention belongs to the technical field of organic synthesis, and relates to a continuous synthesis method of 3-N-(1-ethoxyethyl)-5-methyl oxazolidine-2-ketone. Comprising the following steps: firstly, introducing isopropanolamine and dimethyl carbonate into a microchannel mixer for mixing, pumping the mixture and an ionic liquid catalyst into a primary tubular reactor for cyclization reaction, and separating to obtain 5-methyloxazolidine-2-ketone; and pumping an acetonitrile solution of 5-methyl oxazolidine-2-ketone, an acetonitrile solution of 1-bromoethyl ether and an acetonitrile solution of the composite ionic liquid catalyst into a diode reactor by using a feeding pump to carry out nucleophilic substitution reaction, and separating to obtain a high-purity product. The composite ionic liquid catalyst obtained by adopting an in-situ composite method shows a unique double-ion synergistic activation mechanism, the reaction rate can be remarkably increased, side reactions are reduced, safe and efficient continuous reactions are realized by adopting a tubular reactor, and the purity and yield of products are improved.

The invention belongs to the technical field of medicine, and particularly relates to a sotalol hydrochloride preparation method which comprises the following steps: generating a compound 3 from a compound 2 and methylsulfonyl chloride under the action of alkali, performing oxidation to obtain an intermediate compound 4, directly reacting with isopropylamine without separation, and salifying with hydrochloric acid to obtain a compound 1. The method is simple in route, simple to operate, high in yield, high in purity of the target product 1, low in cost and suitable for industrial production.

This invention relates to a method for preparing sitagliptin phosphate to extend the lifespan of immobilized transaminases, belonging to the field of pharmaceutical synthesis technology. To address the problem of short lifespan of existing immobilized enzymes, this invention provides a method for preparing sitagliptin phosphate to extend the lifespan of immobilized transaminases. The method includes, in the presence of immobilized transaminases, carrying out an enzymatic reaction of sitagliptin precursor ketone and isopropylamine in a non-water-soluble organic solvent. The reaction is terminated after the raw material conversion rate is detected to be ≥75%, the immobilized transaminases are recovered, the filtrate is washed with water to remove acetone, and an aqueous phosphate solution is added to the filtrate for extraction. The aqueous phase is separated to obtain an aqueous sitagliptin phosphate solution, and the solvent is removed. The organic phase is washed with water and directly reused. This invention can significantly shorten the reaction time, reduce the contact time of the immobilized transaminases in a high-concentration acetone system, and avoid excessive soaking time, thereby extending the overall lifespan of the immobilized transaminases.

This invention discloses a mutant S-transaminase and an immobilized enzyme-linked method for preparing (S)-3-aminobutyric acid (aminobutyric acid). The method involves site-directed mutagenesis of a wild-type thermostable Bacillus transaminase to obtain a mutant S-transaminase capable of efficiently converting ethyl acetoacetate to ethyl (S)-3-aminobutyric acid (aminobutyric acid), followed by esterase hydrolysis to obtain (S)-3-aminobutyric acid. This invention utilizes high-concentration substrates and isopropylamine and provides a solution suitable for continuous industrial-scale production to address the high concentration of byproducts.

The invention discloses a solid thickening agent for fracturing and a preparation method thereof, and relates to the technical field of chemical treatment agents. The water-based adhesive is prepared from the following components in parts by weight: 30 to 35 parts of N-hydroxyethyl acrylamide, 18 to 24 parts of N-(3-methoxypropyl) acrylamide, 14 to 16 parts of vinyl sulfonate, 8 to 10 parts of vinyl benzoate, 6 to 8 parts of diacetone acrylamide, 4 to 6 parts of dimethyl itaconate, 2 to 4 parts of dodecyl benzene sulfonic acid isopropylamine salt, 120 to 140 parts of deionized water and 1 to 2 parts of azodiisobutylimidazoline hydrochloride. The materials are put into a blending tank to be uniformly mixed. According to the solid thickening agent for fracturing and the preparation method thereof, the shearing resistance, the temperature resistance, the salt resistance and the sand suspending property of the solid thickening agent are obviously superior to those of an existing thickening agent.

The invention discloses a preparation method of an organic-inorganic hybrid perovskite FAPbI3 modified by isopropylamine hydrochloride and an application of the organic-inorganic hybrid perovskite FAPbI3 modified by isopropylamine hydrochloride. The isopropylamine hydrochloride is used as an additive to modify FAPbI3, and due to the unique structure of the isopropylamine hydrochloride, the mass of FAPbI3 powder and a thin film can be improved, the grain size of the FAPbI3 powder and the thin film can be increased, and the light absorbance, the hydrophobicity and the stability of the FAPbI3 powder and the thin film can be enhanced.

The invention relates to the technical field of fine chemical engineering and resource utilization, and particularly discloses a method for recovering glyphosate active compound and isopropylamine from glyphosate isopropylamine salt aqueous solution, which comprises the following steps: S1, adding acid into the glyphosate isopropylamine salt aqueous solution, mixing, adjusting the pH value to be below 3.5, precipitating and separating out glyphosate in an acid form, and collecting the glyphosate active compound and isopropylamine in the glyphosate isopropylamine salt aqueous solution; filtering, washing and drying to obtain a glyphosate active compound; and S2, adding alkali into the filtrate obtained in S1, mixing, controlling the pH value to be 14 or above, distilling the feed liquid at the temperature of 60-100 DEG C, collecting distillate, and condensing to obtain isopropylamine. The method provided by the invention can efficiently and economically realize separation and recovery of glyphosate and isopropylamine, reduce environmental pollution and improve the resource utilization rate.

An herbicide is disclosed that allows an increase in the concentration of two types of glyphosate herbicide, monoisopropylamine (MIPA) and Potassium (K Salt) while maintaining efficacy without reliance on surfactants. The process and formulation produce a bioefficacy of a glyphosate composition that is significantly improved using specific combinations of natural inert ingredients, yielding higher concentrations of glyphosate salts while minimizing viscosity. That is, a formulation of a higher concentration product in a ready-to-sell form that has the same efficacy when diluted as less concentrated products currently available. This invention is more cost-effective to ship and takes up less storage space while requiring less manufacturing steps and cost associated.

The invention belongs to the technical field of biology, and particularly relates to a metolachlor and chloroacetamide herbicide degrading bacterium, an enzyme and application. According to the present invention, the degrading bacterium Rhodococcus sp. L-9 capable of efficiently degrading metolachlor and other chloroacetamide herbicides is found through screening, and the degrading bacterium Rhodococcus sp. L-9 can be used for efficiently degrading metolachlor and other chloroacetamide herbicides. Furthermore, according to the invention, a gene cluster metABD for degrading the metolachlor and other chloroacetamide herbicides is cloned from a strain L-9, and the gene cluster metABD can encode three-component cytochrome P450 oxidase MetABD to catalyze the degradation of the metolachlor and other five chloroacetamide herbicides (alachlor, acetochlor, propisochlor, pretilachlor and butachlor); and enantiomer selectivity is achieved in catalysis of chiral herbicide metolachlor, and good social and economic benefits are achieved.

The invention discloses an (S)-transaminase mutant and an application of the (S)-transaminase mutant in preparation of (R)-3-([1, 1 '-biphenyl]-4-yl)-2-aminopropyl-1-alcohol. The (S)-transaminase mutant is obtained by mutating wild type (S)-transaminase with the NCBI (National Center of Biotechnology Information) login number of KRF52528.1. According to the (S)-transaminase mutant, pyridoxal phosphate is used as a cofactor, and isopropylamine and 3-([1, 1 '-biphenyl]-4-yl)-2-ketopropyl-1-ol are catalyzed to synthesize (R)-3-([1, 1'-biphenyl]-4-yl)-2-aminopropyl-1-ol. When the (S)-transaminase mutant is used for producing (R)-3-([1, 1 '-biphenyl]-4-yl)-2-aminopropyl-1-ol, the (S)-transaminase mutant has the following advantages: (1) the production process is simple, and the reaction conditions are mild; (2) the (S)-transaminase mutant is high in selectivity, the optical purity of the product is high, and splitting is not needed; (3) the atom utilization rate is high, the production process is environment-friendly, and the green chemistry concept is met; and (4) the product is simple to separate and purify and low in subsequent treatment difficulty.

Provided is an omega-transaminase mutant acquired by a single-point mutation or multi-point mutation at positions 275, 115, and 97 of the amino acid sequence set forth in SEQ ID NO. 2. The transaminase mutant is derived from Aspergillus lentulus. It catalyzes bioreactions with a ketone precursor of a sitagliptin intermediate as the substrate, isopropylamine as the amino donor, pyridoxal phosphate as the coenzyme, and a protonic polar solvent as the cosolvent, thus separating and purifying sitagliptin or the sitagliptin intermediate with high optical purity.

This invention relates to the field of catalyst technology, specifically to a supported catalyst and its application in the production of isopropylamine from acetone. The supported catalyst is a granular formulation prepared by pretreatment of waste nickel-based catalysts and waste copper-zinc catalysts, followed by grinding, batching, extrusion, and impregnation activation with boehmite powder. The ratio of waste nickel-based catalyst to waste copper-zinc catalyst in the raw materials of the supported catalyst is 2-4:1, and the waste nickel-based catalyst and waste copper-zinc catalyst account for 40%-50% of the total mass of the supported catalyst. This invention utilizes waste hydrogenation catalysts and reforming catalysts to produce a supported catalyst, and applies it to the production of isopropylamine from acetone, achieving stable production of isopropylamine from acetone and fully realizing resource recycling and reuse.

The invention discloses a preparation method of N-methyl isopropylamine and a catalyst used thereof.The method comprises the steps that isopropylamine and methyl alcohol serve as reaction raw materials, the reaction raw materials and hydrogen are mixed according to a certain proportion, and a mixture is obtained; enabling the mixture to pass through a fixed bed continuous reactor, contacting with a heterogeneous catalyst, and reacting under set reaction conditions to obtain a crude product; the crude product sequentially passes through four rectifying towers, namely a methanol removing tower, a monoisopropylamine removing tower, a middle fraction removing tower and a finished product tower, and is purified to obtain the N-methylisopropylamine. The catalyst used in the method efficiently promotes the reaction to proceed forwards, generation of by-products is inhibited, the utilization rate of the raw materials is increased, and the stability of the N-methylisopropylamine generated through the reaction is improved.