22 results about "Isopropylamine" patented technology

The application discloses a hydroxylamine hydrochloride detection method in azithromycin dry suspension, and relates to the trace detection field. The method uses isoamyl aldehyde as a derivatizing agent, generates isoamyl aldoxime by performing derivatization treatment on a sample to be measured, and then uses N-nitrosodiisopropylamine as an internal standard substance to quantitatively determine the isoamyl aldoxime by using liquid chromatography-tandem mass spectrometry. The detection method adopts an isoamyl aldehyde derivatizing agent-N-nitrosodiisopropylamine internal standard substance system, can correct detection errors caused by factors such as matrix effect, pretreatment loss and derivatization efficiency fluctuation, and improves the accuracy and sensitivity of the trace hydroxylamine hydrochloride detection result, thereby guaranteeing the safety of the medicine.

The invention discloses a glyphosate soluble concentrate and a preparation method, and the glyphosate soluble concentrate comprises the following raw material components in parts by weight: 30-40 parts of glyphosate, 10-15 parts of isopropylamine, 8-12 parts of a composite synergist, 2-3 parts of an anti-freezing agent, 0.05-0.1 part of a pH regulator, 2-3 parts of an additive, 0.1-0.5 part of a defoaming agent, 1-2 parts of a loading agent and 40-50 parts of water. Compared with the prior art, the glyphosate soluble concentrate prepared by the invention has the advantages that the propoxylated quaternary ammonium salt and the ethyoxyl alkyl phosphate are mixed according to a certain mass ratio to form the synergist, so that the pesticide effect of glyphosate is remarkably improved. Meanwhile, the aluminum pillared clay is introduced to load the glyphosate and is cooperatively used with the polydopamine-sodium alginate compound, so that the prepared glyphosate soluble concentrate has relatively high leaf deposition rate and rain wash resistance and also has excellent ultraviolet resistance.

The application belongs to the technical field of coordination complex catalysts, and particularly relates to a chromium-nickel bimetallic center complex catalyst and a preparation method and application thereof. Isopropylamine, a cyclohexyl benzyl chlorophosphine and an acid binding agent are added into a solvent to react, and a PNP ligand is obtained; the PNP ligand, acetylacetone chromium and acetylacetone nickel are respectively dissolved in a solvent to obtain a PNP ligand solution, an acetylacetone chromium solution and an acetylacetone nickel solution, and the PNP ligand solution, the acetylacetone chromium solution and the acetylacetone nickel solution are mixed and stirred to react, and a chromium-nickel bimetallic center complex catalyst is obtained. The chromium-nickel bimetallic center complex catalyst prepared by the application can be used for ethylene oligomerization reaction, can quickly activate ethylene molecules and accurately control the chain growth process, and meets the dual demands of high activity and high selectivity of the catalyst for industrial production.

The invention discloses a bentazone intermediate sulfonation-chlorination two-step continuous preparation process which comprises the following steps: continuously metering and adding a solvent, chlorosulfonic acid, triethylamine, isopropylamine and a catalyst into a first-section tubular reactor, and carrying out sulfonation reaction to obtain a reaction material isopropylaminosulfonic acid; continuously introducing the reaction material isopropylamine sulfonic acid into a second section of tubular reactor, and simultaneously continuously metering and adding methyl anthranilate and phosphorus oxychloride for chlorination reaction; after the reaction is finished, quenching the reaction liquid with water, and carrying out layering and distillation treatment to obtain an intermediate o-isopropylamine sulfonamide methyl benzoate solid; and carrying out ring-closure reaction on the intermediate o-isopropylamino sulfonamido methyl benzoate solid and sodium methoxide in a methanol solution to prepare the bentazone active compound. According to the method, the defects of low bentazone product content and poor yield caused by high temperature of intermittent sulfonation and chlorination are effectively overcome, the operation time is shortened, and the productivity is improved.

Present invention relates to a method for producing green fluorescent paint for use as a lighting for energy-efficient highway lane and park markings, characterized as comprising following production steps; adding 9,10-dibromoanthracene, CuI, Pd catalyst, diisopropylamine and toluene in a reaction flask under nitrogen atmosphere and stirring them on a magnetic stirrer, adding tetraphenylsilanacetylenyl to the mixture and performing reflux distillation by increasing the reaction temperature, after 24 hours bringing the temperature to room temperature, obtaining pure product from the mixture brought to room temperature using column chromatography, taking 0-1% by mass of the product and mixing it in resin and an aromatic solvent for 6-24 hours.

The present invention relates to the technical field of camptothecin derivative preparation, particularly to a camptothecin derivative synthesis method, which uses 2-nitroacetophenone and isopropylamine as raw materials, and the camptothecin derivative is obtained through a Mannich reaction, a methylsulfonylation reaction, a nitro reduction reaction and a ring closing reaction. According to the synthetic method of the camptothecin derivative, the complex camptothecin derivative is split into two segments 1-(2-aminophenyl)-3-(N-isopropyl-N-methylsulfonylamino) propan-1-one and a compound V which are easy to prepare, and finally, a plurality of rings and chemical bonds are constructed simultaneously through one-step efficient ring closing reaction. The yield attenuation caused by progressive multiplication of the yield in the traditional linear synthesis is avoided, and the total yield is improved.

The present application relates to the technical field of enzyme engineering, and discloses an amino transferase mutant and application thereof.The present application provides a wild-type amino transferase mutant derived from Aspergillus avenaceus.The amino transferase mutant is obtained by carrying out single-point or multi-point combined mutation on the 20th, 60th, 92nd and 186th positions of the amino acid sequence shown in SEQ ID NO.2, and can directly take the sitagliptin intermediate precursor ketone as a substrate, take isopropylamine as an amino donor, take phosphopyridoxyl as a coenzyme, take dimethyl sulfoxide as a substrate solvent, catalyze the preparation of a sitagliptin intermediate with high optical purity, and the specific enzyme activity reaches 139.3 U / g in a reaction system with a final concentration of 50% DMSO, greatly improves the catalytic efficiency, and the product has high stereoselectivity (the e.e. value of the product reaches 99%), and has a wide industrial application prospect.

The invention belongs to the technical field of petrochemical catalysis, and relates to a method for propylene liquid phase epoxidation on a zinc modified TS-1 zeolite catalyst. The zinc modified TS-1 zeolite catalyst is prepared by a combined modification method, and the method comprises the following steps: 1, carrying out hydrothermal modification treatment on a TS-1 zeolite matrix by using a tetrapropylammonium hydroxide aqueous solution containing isopropanolamine, adjusting the coordination state of TS-1 zeolite skeleton titanium, generating an open mononuclear hexa-coordination titanium catalytic active center, and improving the activity of the catalyst; in the second step, the microenvironment of the open type mononuclear hexa-coordinated titanium species is adjusted by using the fusible zinc salt, so that acidic silicon hydroxyl around the microenvironment is eliminated, and the selectivity of the catalyst is improved; the propylene liquid phase epoxidation method is technically characterized in that hydrogen peroxide with the concentration lower than 50 wt.% is used as an oxidizing agent on the catalyst to produce epoxypropane, and a gas-solid phase oxidation method is used for regenerating the deactivated catalyst.

The invention belongs to the technical field of medicine, and particularly relates to a sotalol hydrochloride preparation method which comprises the following steps: generating a compound 3 from a compound 2 and methylsulfonyl chloride under the action of alkali, performing oxidation to obtain an intermediate compound 4, directly reacting with isopropylamine without separation, and salifying with hydrochloric acid to obtain a compound 1. The method is simple in route, simple to operate, high in yield, high in purity of the target product 1, low in cost and suitable for industrial production.

This invention relates to a method for preparing sitagliptin phosphate to extend the lifespan of immobilized transaminases, belonging to the field of pharmaceutical synthesis technology. To address the problem of short lifespan of existing immobilized enzymes, this invention provides a method for preparing sitagliptin phosphate to extend the lifespan of immobilized transaminases. The method includes, in the presence of immobilized transaminases, carrying out an enzymatic reaction of sitagliptin precursor ketone and isopropylamine in a non-water-soluble organic solvent. The reaction is terminated after the raw material conversion rate is detected to be ≥75%, the immobilized transaminases are recovered, the filtrate is washed with water to remove acetone, and an aqueous phosphate solution is added to the filtrate for extraction. The aqueous phase is separated to obtain an aqueous sitagliptin phosphate solution, and the solvent is removed. The organic phase is washed with water and directly reused. This invention can significantly shorten the reaction time, reduce the contact time of the immobilized transaminases in a high-concentration acetone system, and avoid excessive soaking time, thereby extending the overall lifespan of the immobilized transaminases.

This invention discloses a mutant S-transaminase and an immobilized enzyme-linked method for preparing (S)-3-aminobutyric acid (aminobutyric acid). The method involves site-directed mutagenesis of a wild-type thermostable Bacillus transaminase to obtain a mutant S-transaminase capable of efficiently converting ethyl acetoacetate to ethyl (S)-3-aminobutyric acid (aminobutyric acid), followed by esterase hydrolysis to obtain (S)-3-aminobutyric acid. This invention utilizes high-concentration substrates and isopropylamine and provides a solution suitable for continuous industrial-scale production to address the high concentration of byproducts.

The invention discloses a solid thickening agent for fracturing and a preparation method thereof, and relates to the technical field of chemical treatment agents. The water-based adhesive is prepared from the following components in parts by weight: 30 to 35 parts of N-hydroxyethyl acrylamide, 18 to 24 parts of N-(3-methoxypropyl) acrylamide, 14 to 16 parts of vinyl sulfonate, 8 to 10 parts of vinyl benzoate, 6 to 8 parts of diacetone acrylamide, 4 to 6 parts of dimethyl itaconate, 2 to 4 parts of dodecyl benzene sulfonic acid isopropylamine salt, 120 to 140 parts of deionized water and 1 to 2 parts of azodiisobutylimidazoline hydrochloride. The materials are put into a blending tank to be uniformly mixed. According to the solid thickening agent for fracturing and the preparation method thereof, the shearing resistance, the temperature resistance, the salt resistance and the sand suspending property of the solid thickening agent are obviously superior to those of an existing thickening agent.

The invention discloses a preparation method of an organic-inorganic hybrid perovskite FAPbI3 modified by isopropylamine hydrochloride and an application of the organic-inorganic hybrid perovskite FAPbI3 modified by isopropylamine hydrochloride. The isopropylamine hydrochloride is used as an additive to modify FAPbI3, and due to the unique structure of the isopropylamine hydrochloride, the mass of FAPbI3 powder and a thin film can be improved, the grain size of the FAPbI3 powder and the thin film can be increased, and the light absorbance, the hydrophobicity and the stability of the FAPbI3 powder and the thin film can be enhanced.

The invention belongs to the technical field of biology, and particularly relates to a metolachlor and chloroacetamide herbicide degrading bacterium, an enzyme and application. According to the present invention, the degrading bacterium Rhodococcus sp. L-9 capable of efficiently degrading metolachlor and other chloroacetamide herbicides is found through screening, and the degrading bacterium Rhodococcus sp. L-9 can be used for efficiently degrading metolachlor and other chloroacetamide herbicides. Furthermore, according to the invention, a gene cluster metABD for degrading the metolachlor and other chloroacetamide herbicides is cloned from a strain L-9, and the gene cluster metABD can encode three-component cytochrome P450 oxidase MetABD to catalyze the degradation of the metolachlor and other five chloroacetamide herbicides (alachlor, acetochlor, propisochlor, pretilachlor and butachlor); and enantiomer selectivity is achieved in catalysis of chiral herbicide metolachlor, and good social and economic benefits are achieved.

The invention discloses an (S)-transaminase mutant and an application of the (S)-transaminase mutant in preparation of (R)-3-([1, 1 '-biphenyl]-4-yl)-2-aminopropyl-1-alcohol. The (S)-transaminase mutant is obtained by mutating wild type (S)-transaminase with the NCBI (National Center of Biotechnology Information) login number of KRF52528.1. According to the (S)-transaminase mutant, pyridoxal phosphate is used as a cofactor, and isopropylamine and 3-([1, 1 '-biphenyl]-4-yl)-2-ketopropyl-1-ol are catalyzed to synthesize (R)-3-([1, 1'-biphenyl]-4-yl)-2-aminopropyl-1-ol. When the (S)-transaminase mutant is used for producing (R)-3-([1, 1 '-biphenyl]-4-yl)-2-aminopropyl-1-ol, the (S)-transaminase mutant has the following advantages: (1) the production process is simple, and the reaction conditions are mild; (2) the (S)-transaminase mutant is high in selectivity, the optical purity of the product is high, and splitting is not needed; (3) the atom utilization rate is high, the production process is environment-friendly, and the green chemistry concept is met; and (4) the product is simple to separate and purify and low in subsequent treatment difficulty.

The invention discloses a method for preparing thiophanate by a pipeline reaction device. The method comprises the following steps: mixing cyanuric chloride and tetrahydrofuran to obtain a cyanuric chloride homogeneous solution; mixing isopropylamine, methanol and tetrahydrofuran to obtain an isopropylamine homogeneous solution; a cyanuric chloride homogeneous solution and an isopropylamine homogeneous solution respectively enter a mixing valve through a liquid inlet pipe to be mixed and then enter a pipeline reactor to react; the reaction temperature is 0-5 DEG C; a product obtained after the reaction flows out through a discharging pipe, and reaction liquid is taken for a reaction to obtain the put-out. The method disclosed by the invention has the characteristics of high productivity, good production stability, high efficiency, high product quality and the like, is particularly suitable for technical transformation of existing production enterprises, has the characteristics of low transformation cost, less production land, safety, reliability and the like compared with a traditional kettle type device, and has important application potential in industrial production.

The invention discloses a crystalline supramolecular polymer, preparation thereof and application of the crystalline supramolecular polymer in detection of amine steam. The crystalline supramolecular polymer is formed by self-assembly of an electron-rich host molecular cage (Cage) and an electron-deficient guest naphthalene diimide derivative (NDI-4 or NDI-8) through charge transfer interaction and pi-pi accumulation interaction. The preparation method comprises the two steps of synthesis of the naphthalimide derivative and co-crystallization of a subject and an object, and is simple in process and mild in condition. The crystalline supramolecular polymer has excellent gasochromic performance and has high selectivity and sensitivity to propylamine, isopropylamine and butylamine steam, the response time at the room temperature does not exceed 4 hours, and rapid and visual detection can be achieved through color change (from purple black to orange or brown) and / or reduction of absorption intensity at the position of 533 nm. The method enriches a supramolecular chemical research system, provides an efficient and low-cost amine steam detection scheme, and has wide application prospects in the fields of environmental monitoring, industrial safety and the like.

The application discloses modified mixed cat litter containing zeolite bentonite and a preparation method thereof, and belongs to the technical field of modified mixed cat litter preparation.The modified mixed cat litter containing zeolite bentonite is composed of the following components in parts by weight: 30-50 parts of modified cat litter, 10-20 parts of bentonite cat litter, and 0.1-0.3 parts of antibacterial agent, wherein the modified cat litter is prepared from corn straw, acrylic acid, zeolite, bean dregs, starch and polyacrylamide solution, and the antibacterial agent is prepared from ammonia water, methyl acrylate, sodium polysulfide, isopropylamine and sulfuryl chloride.The modified mixed cat litter prepared by the method has excellent water absorption rate, ammonia removal effect and antibacterial property.

A cooling medium inlet is formed in an upper cover, a cooling medium outlet is formed in one side of the lower portion of a tank body, a steam inlet is formed in one side of the upper portion of the tank body, a material outlet is formed in the lower surface of a lower cover, and a plurality of heat exchange plates are arranged in the tank body. Every two adjacent heat exchange plates are connected through a plurality of supporting rods and a connecting pipe, the interiors of the heat exchange plates are each of a hollow structure, every two adjacent heat exchange plates communicate with each other through the connecting pipe, flow channels are formed in the heat exchange plates in the axial direction, and a straight pipe is arranged in the center of the heat exchange plate located at the top end. And the top end of the straight pipe is inserted and welded with the cooling medium inlet, a bent pipe is arranged at the central position of the heat exchange plate positioned at the bottom end, and the outer end of the bent pipe is welded with the cooling medium outlet. Therefore, the heat exchange effect with diisopropylamine steam is greatly improved.

The application relates to the technical field of defoaming agent preparation, in particular to a high-content organic silicon defoaming agent composition for a high-temperature and high-shear system. The high-content organic silicon defoaming agent composition is prepared by the following steps: firstly, octamethylcyclotetrasiloxane, tetramethyltetraphenylcyclotetrasiloxane and hydrogen-containing polymethylsiloxane are copolymerized to construct a methylphenyl polysiloxane skeleton; secondly, acetyl-terminated allyl epoxy oxirane / epoxy propane copolyether and allyl glycidyl ether are introduced step by step; then, the obtained product is sequentially reacted with N,N-diethyl-1,3-propanediamine, phenyl isocyanate, diisopropylamine and maleic anhydride to obtain a urea-based / esterified modified polysiloxane; finally, the urea-based / esterified modified polysiloxane is compounded with methylphenyl silicone oil, dimethyl silicone oil, hydrophobic fumed silica and precipitated silica to obtain the high-content organic silicon defoaming agent composition. The obtained defoaming agent has the advantages of instant defoaming, excellent sustained defoaming, strong shear resistance, storage stability and no floating oil in a high-temperature circulating cleaning liquid system, a high-speed sand mill slurry system and the like.

The preparation method adopts a two-step method for preparation, and comprises the following steps: S1, taking a sodium hydrosulfide aqueous solution as a base material, synchronously dropwise adding a cyanuric chloride alcohol solution and a hydroxide aqueous solution, and controlling the temperature and the pH value to generate a dimercaptotriazine derivative intermediate; s2, synchronously dropwise adding functional monomers (such as isopropylamine and diisobutyl dithiophosphoric acid) and a hydroxide aqueous solution into the intermediate, and controlling the temperature to prepare a target derivative; according to the preparation method, the reaction yield reaches up to 95.84%-97.13%, the product content is 15.6%-17.01%, selectivity is high, side reactions are few, the structure can be regulated and controlled by replacing functional monomers, and the dimercaptotriazine derivative can serve as a core intermediate of a sulfide ore flotation collecting agent and has industrialization potential.