121 results about "Isopropylamine" patented technology

The invention belongs to the technical field of 4-BMA mother liquor recycling, and relates to a method for recycling 4-BMA in mother liquor by adopting a membrane treatment technology, which comprises the following steps: dropwise adding isopropylamine into 4-BMA refining wastewater, adjusting the pH value to 8-9, selecting a proper filter membrane, and filtering by using membrane filtering equipment at a certain temperature to obtain concentrated liquor and permeate liquid; the maximum separation effect is achieved by controlling the volume ratio of the permeate to the concentrated solution, and the 4-BMA isopropylamine salt concentrated solution is obtained; ethyl acetate is added into the 4-BMA isopropylamine salt concentrated solution for extraction, then 13.5 wt% hydrochloric acid is dropwise added for crystallization, and a 4-BMA product is obtained. According to different solubility of 4-BMA, isomer and isopropylamine after salification in water, the isomer salt is dissolved in water to be removed, 4-BMA salt with high purity is obtained, qualified 4-BMA with the purity larger than or equal to 98.00% is obtained through acid adjustment, and the purity of 4-BMA is larger than or equal to 98.00%. The method is low in energy consumption, simple in process, simpler to operate and easier to convert.

The present invention relates to the technical field of reaction kettles, particularly to a glyphosate isopropylamine salt aqueous solution production reaction kettle, which comprises a stirring tank, the top end of the stirring tank is provided with a support frame, the inner wall of the stirring tank is provided with a stirring cooling mechanism, and the outer wall of the support frame is provided with a liquid storage tank. Through cooperation of a second stirring piece, a storage shell, a communicating pipe, a first pull rod and a first hydraulic plug, in the rotary stirring process of the second stirring piece, cooling kerosene directly dissipates heat of reactants, and the situation that the temperature of the reactants exceeds 80 DEG C, and consequently the quality of the reactants is reduced is avoided; in the prior art, the temperature of the stirring tank is reduced firstly and then the temperature of the reactant is reduced, so that the steps of reducing the temperature of the stirring tank, reducing the cooling time and avoiding quality reduction caused by overlong heat dissipation time of the reactant are omitted, meanwhile, when cooling is not needed, cooling kerosene enters the liquid storage tank through the storage shell and air pressure, and the cooling effect is improved. And the cooling effect of the device is improved, and the cooling time is shortened.

A cleaning solution for a turbine engine includes water; a first organic acidic component that comprises citric acid; a second organic acidic component that comprises glycolic acid; isopropylamine sulphonate; alcohol ethoxylate; triethanol amine; and sodium lauriminodipropionate. The cleaning solution has a pH value between about 2.5 and about 7.0.

The invention belongs to the technical field of pesticide preparation preparation, and discloses a glyphosate isopropylamine salt aqueous solution preparation device and a preparation method.The glyphosate isopropylamine salt aqueous solution preparation device comprises a shell and a support, a stirring device is fixedly arranged on the inner wall of the shell, a cleaning device is arranged on the surface of the stirring device, a filter plate is arranged below the stirring device, and a plurality of feeding devices are evenly arranged above the shell; a circulating device is fixedly arranged on one side above the shell, and a heat exchanger is arranged on the surface of the shell; the problems that in the prior art, mixing is not uniform, precipitated raw materials cannot be subjected to secondary mixing, so that raw materials are wasted, the raw materials cannot be automatically supplemented according to the mixing frequency and the proportion, and the interior of the device is inconvenient to clean are solved, and the device is suitable for preparing the glyphosate isopropylamine salt aqueous solution.

The invention discloses alkoxy amine and application of the alkoxy amine in induction of NMP (N-Methyl Pyrrolidone) polymerization of methacrylate monomers and styrene monomers. The alkoxy amine is a novel compound which is synthesized by taking benzaldehyde and isopropylamine as raw materials through three-step reaction of Schiff base reduction, oxidizing agent oxidation and free radical coupling. The obtained alkoxyamine can be used as a monomolecular initiator to effectively regulate and control controllable polymerization of methacrylate and styrene monomers under anaerobic or aerobic conditions, and the peak pattern of a gel chromatography outflow curve is symmetrical and has no obvious tailing phenomenon, so that the alkoxyamine can expand the range of nitroxide free radical polymerization regulation and control monomers, and the preparation method is simple and easy to implement. The method has a good application prospect in the aspect of synthesis of functional polymer materials.

The invention discloses a method for continuously producing a glyphosate isopropylamine salt aqueous solution, and belongs to the technical field of pesticide preparation production. Compared with a traditional intermittent production process, the continuous production process has the advantages that equipment is intelligently upgraded, high-precision automatic metering equipment is controlled by adopting a DCS (Distributed Control System), flow speed is controlled to realize precise gradient feeding, and after strict quality inspection of reaction raw materials, continuous production is carried out in a stirred tank reactor provided with an anti-explosion system and a waste gas absorption device; the defect that quality control is difficult due to manual operation is overcome, and the danger that an operator is prone to poisoning, combustion and explosion due to the fact that isopropylamine is low in boiling point and drastically releases heat when reacting with glyphosate raw acid is avoided. The content of effective components of the prepared product is stabilized at 62% + / -0.5%, the product quality consistency is good, and the product better conforms to the general direction of modern green automatic intelligent manufacturing.

The present invention discloses Pseudomonas WH‑3 and its application, belonging to the field of microbial technology. The Pseudomonas WH‑3, Latin name Pseudomonas juntendi WH‑3, is deposited in the General Microbiological Center of China Microbiological Culture Collection Administration Committee, with a deposit date of August 2, 2024, a deposit number of CGMCC No.31535, and a deposit location in Beijing, China. The Pseudomonas WH‑3 provided by the present invention is separated and screened from seawater contaminated by metolachlor. The strain is adapted to a wide range of salinities, can efficiently degrade metolachlor and 2‑methyl‑6‑ethylaniline, and has an efficient bioremediation effect on marine environments polluted by metolachlor and 2‑methyl‑6‑ethylaniline.

The application discloses a hydroxylamine hydrochloride detection method in azithromycin dry suspension, and relates to the trace detection field. The method uses isoamyl aldehyde as a derivatizing agent, generates isoamyl aldoxime by performing derivatization treatment on a sample to be measured, and then uses N-nitrosodiisopropylamine as an internal standard substance to quantitatively determine the isoamyl aldoxime by using liquid chromatography-tandem mass spectrometry. The detection method adopts an isoamyl aldehyde derivatizing agent-N-nitrosodiisopropylamine internal standard substance system, can correct detection errors caused by factors such as matrix effect, pretreatment loss and derivatization efficiency fluctuation, and improves the accuracy and sensitivity of the trace hydroxylamine hydrochloride detection result, thereby guaranteeing the safety of the medicine.

The invention discloses a glyphosate soluble concentrate and a preparation method, and the glyphosate soluble concentrate comprises the following raw material components in parts by weight: 30-40 parts of glyphosate, 10-15 parts of isopropylamine, 8-12 parts of a composite synergist, 2-3 parts of an anti-freezing agent, 0.05-0.1 part of a pH regulator, 2-3 parts of an additive, 0.1-0.5 part of a defoaming agent, 1-2 parts of a loading agent and 40-50 parts of water. Compared with the prior art, the glyphosate soluble concentrate prepared by the invention has the advantages that the propoxylated quaternary ammonium salt and the ethyoxyl alkyl phosphate are mixed according to a certain mass ratio to form the synergist, so that the pesticide effect of glyphosate is remarkably improved. Meanwhile, the aluminum pillared clay is introduced to load the glyphosate and is cooperatively used with the polydopamine-sodium alginate compound, so that the prepared glyphosate soluble concentrate has relatively high leaf deposition rate and rain wash resistance and also has excellent ultraviolet resistance.

The application belongs to the technical field of coordination complex catalysts, and particularly relates to a chromium-nickel bimetallic center complex catalyst and a preparation method and application thereof. Isopropylamine, a cyclohexyl benzyl chlorophosphine and an acid binding agent are added into a solvent to react, and a PNP ligand is obtained; the PNP ligand, acetylacetone chromium and acetylacetone nickel are respectively dissolved in a solvent to obtain a PNP ligand solution, an acetylacetone chromium solution and an acetylacetone nickel solution, and the PNP ligand solution, the acetylacetone chromium solution and the acetylacetone nickel solution are mixed and stirred to react, and a chromium-nickel bimetallic center complex catalyst is obtained. The chromium-nickel bimetallic center complex catalyst prepared by the application can be used for ethylene oligomerization reaction, can quickly activate ethylene molecules and accurately control the chain growth process, and meets the dual demands of high activity and high selectivity of the catalyst for industrial production.

The invention discloses a method for preparing magnesium borohydride by a solution method, and relates to the technical field of hydrogen storage materials. The method comprises the following steps: dissolving MgCl2 in tetrahydrofuran to form a magnesium source solution, dissolving NaBH4 in isopropylamine to form a boron-hydrogen source solution, mixing the two solutions, and stirring to react; carrying out centrifugation and microfiltration membrane suction filtration separation on the reacted mixture to remove solid impurities so as to obtain a clarified filtrate; and carrying out vacuum desolventizing treatment on the filtrate to finally obtain solid magnesium borohydride. The method is simple in process flow, can be completed under mild conditions, and has the advantages of low raw material cost and high operation safety; the prepared magnesium borohydride product has excellent performance of lower initial hydrogen desorption temperature, and the temperature is only 115.8 DEG C. The method is especially suitable for large-scale industrial production.

The invention belongs to the technical field of pharmacy, and relates to a method for recovering effective components from ampicillin sodium crystallization mother liquor, which comprises the steps of diisopropylamine recovery, ampicillin trihydrate acid recovery and sodium isooctanoate recovery. According to the method, the diisopropylamine, the ampicillin trihydrate and the sodium isooctanoate are effectively recovered from the solvent-method ampicillin sodium crystallization mother liquor, the recovery rates of the diisopropylamine, the ampicillin trihydrate and the sodium isooctanoate recovered by the method are all higher than 80%, and the quality of the recovered product is good. According to the method, various effective components of the ampicillin sodium crystallization mother liquor are effectively recovered, the production cost can be greatly reduced, meanwhile, the discharge amount of sewage is reduced, and the economic benefits and social benefits of enterprises are improved.

The invention discloses a bentazone intermediate sulfonation-chlorination two-step continuous preparation process which comprises the following steps: continuously metering and adding a solvent, chlorosulfonic acid, triethylamine, isopropylamine and a catalyst into a first-section tubular reactor, and carrying out sulfonation reaction to obtain a reaction material isopropylaminosulfonic acid; continuously introducing the reaction material isopropylamine sulfonic acid into a second section of tubular reactor, and simultaneously continuously metering and adding methyl anthranilate and phosphorus oxychloride for chlorination reaction; after the reaction is finished, quenching the reaction liquid with water, and carrying out layering and distillation treatment to obtain an intermediate o-isopropylamine sulfonamide methyl benzoate solid; and carrying out ring-closure reaction on the intermediate o-isopropylamino sulfonamido methyl benzoate solid and sodium methoxide in a methanol solution to prepare the bentazone active compound. According to the method, the defects of low bentazone product content and poor yield caused by high temperature of intermittent sulfonation and chlorination are effectively overcome, the operation time is shortened, and the productivity is improved.

The present invention discloses a method for efficiently catalyzing the preparation of isopropylamine from isopropyl alcohol. The catalyst used in this method is prepared by a preparation method including the following steps: 1) subjecting a support to acid treatment and / or alkali treatment to obtain a treated support, the support containing silicon and / or aluminum elements; 2) loading an oxide of an active metal component on the treated support to obtain a catalyst precursor; 3) performing hydrophobic modification on the catalyst precursor with a silane coupling agent, and obtaining the catalyst after reduction. By subjecting the support to acid treatment and / or alkali treatment, and performing hydrophobic modification treatment with a silane coupling agent after loading the active component, the present invention can form an anhydrous environment similar around the active component of the catalyst, which can significantly improve the conversion rate of isopropyl alcohol.

The invention relates to the technical field of silicon wafer polishing, in particular to a high-speed and low-defect silicon medium polishing liquid which comprises grinding particles, an alkaline compound, a surface protective agent and water. The content of the grinding particles is 4-10 wt%, the content of the alkaline compound is 0.05-1.5 wt%, the content of the surface protective agent is 0.1-3 wt%, and the balance is water; the alkali compound is at least one of tetramethylammonium hydroxide, piperazine, 1-(2-aminoethyl) piperazine, 1, 4-bis (3-aminopropyl) piperazine, 1, 4-bis (2-hydroxyethyl) piperazine, 1, 8-diazabicyclo (5, 4, 0) undec-7-ene, 4-aminopiperidine, monoethanolamine, 3-amino-1-propanol, n-propylamine, isopropylamine, diglycolamine, isopropanolamine, ethylenediamine, choline hydroxide and ammonia water. By adding the organic base with a special molecular structure and adjusting the concentration ratio of the organic base to the surface protecting agent, the high removal rate can be effectively achieved under the high dilution ratio, and the good surface quality without polishing marks / fog, with few particle defects and low roughness is obtained.

The invention belongs to the technical field of chemical synthesis, and discloses a method for synthesizing 3-hydroxy-3-alkyl propionate based on a continuous flow reaction technology. According to the method, a continuous flow reaction device is adopted for synthesis, acetate, lithium diisopropylamide and an aldehyde compound are taken as raw materials, and 3-hydroxy-3-alkyl propionate is synthesized through lithium-hydrogen exchange and alkyl aldehyde addition reaction. According to the method provided by the invention, the reaction process is easy to control, the danger coefficient of the reaction operation and process is greatly reduced, and the safety and reliability of the reaction are improved. Meanwhile, by the method, the reaction efficiency is remarkably improved, and the synthesis time is shortened from dozens of hours to dozens of minutes, even dozens of minutes; in addition, different 3-hydroxy-3-alkyl propionate products can be prepared by introducing different substrates and switching, the applicability is high, and the industrial application value is high.

The invention relates to a preparation method of diisopropylamine silane, which comprises the following steps: (1) reacting dichlorosilane with diisopropylamine to obtain diisopropylamine chlorosilane; and (2) carrying out a reaction on the diisopropylamine chlorosilane obtained in the step (1) and lithium hydride to obtain the diisopropylamine silane. The preparation method of diisopropylamine silane in the prior art is optimized, a complex catalyst does not need to be prepared in advance, raw materials are simple and easy to obtain, reaction steps are simple, high-temperature and high-pressure reaction conditions are avoided, the reaction conditions are mild, the obtained target product has high yield and purity, and industrial large-scale production is facilitated.

Present invention relates to a method for producing green fluorescent paint for use as a lighting for energy-efficient highway lane and park markings, characterized as comprising following production steps; adding 9,10-dibromoanthracene, CuI, Pd catalyst, diisopropylamine and toluene in a reaction flask under nitrogen atmosphere and stirring them on a magnetic stirrer, adding tetraphenylsilanacetylenyl to the mixture and performing reflux distillation by increasing the reaction temperature, after 24 hours bringing the temperature to room temperature, obtaining pure product from the mixture brought to room temperature using column chromatography, taking 0-1% by mass of the product and mixing it in resin and an aromatic solvent for 6-24 hours.

The invention discloses a closed type polyisocyanate composition with stable storage and a preparation method and application thereof, the closed type polyisocyanate composition comprises a structure I, a structure II, a structure III and a structure IV, A represents a gel chromatography (GPC) integral area percentage of the structure I; b represents the gel chromatography test GPC integral area percentage of the structure II, C represents the gel chromatography test GPC integral area percentage of the structure III, and D represents the gel chromatography test GPC integral area percentage of the structure IV; wherein A / (A + B + C + D) = 0.15-0.25, and B / (A + B + C + D) = 0.30-0.45. The water-based polyurethane adhesive contains terminated polyisocyanate which is obtained by carrying out a reaction on a hexamethylene diisocyanate polymer, diethyl malonate and diisopropylamine. The composition is clear and transparent after being stored for 12 months at normal temperature.

The invention discloses a 2-methyl-4-chlorophenoxyacetic acid glyphosate soluble concentrate and a preparation method thereof. The 2-methyl-4-chlorophenoxyacetic acid glyphosate soluble concentrate is prepared from the following raw materials: 60.9%-67.4% of glyphosate isopropylamine salt, 3.2%-6.3% of 2-methyl-4-chlorophenoxyacetic acid, 8%-12% of an auxiliary agent and the balance of water, and the auxiliary agent is prepared from a cosolvent, a synergist and water. The preparation method comprises the following steps: firstly, mixing 2-methyl-4-chloro-phenoxyacetic acid with the auxiliary agent, then mixing with the glyphosate isopropylamine salt and water, and filtering to obtain the 2-methyl-4-chloro-phenoxyacetic acid glyphosate soluble concentrate. The 2-methyl-4-chloro-phenoxyacetic acid glyphosate soluble concentrate prepared by the invention has the advantages of low temperature resistance, thermal storage resistance, stable product quality, meeting of environmental protection requirements, fast weeding speed, thorough weeding and better weeding effect.

The invention discloses a method for simultaneously detecting nine nitrosamines in a medicinal infusion bag. Comprising the following steps: weighing standard substances of N-nitrosodimethylamine, N-nitrosodiethyl amine, N-nitrosodipropylamine, N-nitrosodibutylamine, N-nitrosopiperidine, N-nitrosopyrrolidine, N-nitrosomorpholine, N-nitrosodiisopropylamine and N-nitrosoethyl isopropylamine, and then preparing a standard solution by using an organic solvent; the method comprises the following steps: weighing standard substances of five internal standard substances, namely N-nitrosodimethylamine-d6, N-nitrosodipropylamine-d14, N-nitrosodiethylamine-d10, N-nitrosopyrrolidine-d4 and N-nitrosomorpholine-d8, and then preparing an internal standard solution by using an organic solvent; the method comprises the following steps: pretreating a medicinal infusion bag sample, extracting to obtain an extracting solution, mixing the extracting solution with an internal standard solution, extracting with a solid-phase extraction column, concentrating, and finally filtering with an organic filter membrane to obtain a sample solution; and detecting the sample solution and the standard solution by using ultra-high performance liquid chromatography-triple quadrupole mass spectrometry.

The invention discloses a method for improving aniline conversion rate in a diphenylamine synthesis process. The method comprises the following steps: reacting aniline and propylene which are used as raw materials in a fixed bed reactor containing an H beta zeolite catalyst under certain reaction conditions. The propylene gas is introduced into the reaction system, so that the conversion rate of aniline in the diphenylamine synthesis process is effectively improved, isopropylamine is generated in the product, and the economical efficiency of the product is further improved.

The present invention relates to the field of new materials, and discloses a method for preparing a low-frequency band sound-absorbing functional nanofiber for high-end equipment. The method includes: adding diisopropylamine peroxide or hyperbranched polyester to a first polymer resin to prepare a first spinning solution, so that the dynamic viscosity of the first spinning solution at 300 degrees Celsius is 1-10Pa·s; melt-blowing equipment is used to melt-blown the first spinning solution to obtain a first polymer fiber; decalin is added to a second polymer resin to prepare a second spinning solution, so that the dynamic viscosity of the second spinning solution at 140 degrees Celsius is 10-50mPa·s, and a flash evaporation device is used to flash-evaporate the second spinning solution to obtain a second polymer fiber; under the traction of a fan, the first polymer fiber at the outlet of the melt-blown device and the second polymer fiber at the outlet of the flash evaporation device are mixed evenly using multiple air nozzles to obtain low-frequency band sound-absorbing functional nanofibers. The preparation method of the present invention is simple and has better sound absorption effect.

The invention relates to the technical field of membrane separation, in particular to a mixed matrix membrane and a preparation method and application thereof. The mixed matrix membrane comprises a polymer matrix and a filler dispersed in the polymer matrix, the filler comprises an MOF material and MA compound amine loaded on the MOF material; the MA compound amine is selected from one or more of ethanolamine, methyl monoethanolamine, diethanolamine, N-methyldiethanolamine (MDEA), diisopropylamine, hydroxyethyl ethylenediamine and 2-amino-2-methyl-1-propyl alcohol. The preparation method comprises the following steps: adding the MA compound amine into a reaction kettle; the mixed matrix membrane has high selectivity and high permeability, and is suitable for large-scale continuous preparation.

The invention discloses a membrane permeation-pressurized rectification coupling process of a diisopropylamine-isopropanol ternary water-containing system, which comprises the following steps: primarily separating by an azeotropic rectification tower to obtain a diisopropylamine-isopropanol-water homogeneous ternary mixture at the tower top, and cooling by a cooler to obtain a ternary mixture; conveying to a membrane dehydration assembly to selectively remove moisture; and the dehydrated diisopropylamine-isopropanol mixture enters a pressurized rectifying tower, so that high-purity recovery of diisopropylamine and isopropanol is realized. The process does not need to introduce a third component, equipment is simple, the recovery purity is high, meanwhile, chemical pollution is avoided, and the environmental protection requirement is met.

The invention belongs to the technical field of coordination complex catalysts, and particularly relates to a chromium-nickel bimetallic center complex catalyst as well as a preparation method and application thereof. The preparation method comprises the following steps: adding isopropylamine, cyclohexylphenylphosphonium chloride and an acid-binding agent into a solvent for reaction to obtain a PNP ligand; the preparation method comprises the following steps: respectively dissolving a PNP ligand, chromium acetylacetonate and nickel acetylacetonate in a solvent to obtain a PNP ligand solution, a chromium acetylacetonate solution and a nickel acetylacetonate solution, and mixing and stirring the PNP ligand solution, the chromium acetylacetonate solution and the nickel acetylacetonate solution for reaction to obtain the chromium-nickel bimetallic center complex catalyst. The prepared chromium-nickel bimetallic center complex catalyst can be used for ethylene oligomerization reaction, ethylene molecules can be rapidly activated, the chain growth process can be accurately controlled, and the dual requirements of industrial production for high activity and high selectivity of the catalyst are met.

The invention relates to the technical field of salt water agents, and discloses a glyphosate isopropylamine salt water agent and a manufacturing device thereof.The glyphosate isopropylamine salt water agent comprises a touch assembly, the touch assembly comprises a plurality of connecting rods connected to the outer wall of a motor output shaft and rotating blocks rotationally connected to the connecting rods, and in the touch process, a movable shell moves up and down on the outer side of the bottom of an inner shell; the inner shell is knocked by the vibration structure, so that the inner wall of the inner shell is shaken; through the arrangement of a vibration structure, when a connecting rod does not extrude a vertical rod, a first spring supports a movable shell upwards, at the moment, the movable shell drives a second spring and a steel ball to move upwards, the steel ball collides with the bottom of an inner shell to generate vibration, the second spring endows the steel ball with elasticity, and the steel ball collides with the inner shell for multiple times; and the inner shell is knocked in a circulating manner, so that the inner wall of the inner shell is shaken, and concentrated glyphosate isopropylamine salt is vibrated and loosened and is prevented from being excessively accumulated into blocks.

The invention belongs to the field of oilfield chemical treatment agents, and particularly relates to a preparation method of a thickening agent for oil extraction fracturing, which comprises the following steps: 1, uniformly mixing 25 parts of acrylamide, 15 parts of acrylic acid, 4 parts of Tween-80, 1.5 parts of dodecyl benzene sulfonic acid isopropylamine salt, 90 parts of deionized water and 2.5 parts of azodiisobutylimidazoline hydrochloride to obtain a water phase; 2, uniformly mixing 45 parts of 0 # diesel oil, 14 parts of methyl methacrylate, 7 parts of butadiene, 7 parts of diacetone acrylamide and 6 parts of butanol polyoxypropylene ether to obtain an oil phase; and 3, putting the oil phase into a reaction kettle, adding the water phase into the oil phase, uniformly stirring at the rotating speed of a motor of 9000rpm for 30 minutes, adjusting the rotating speed to 700rpm, introducing nitrogen for 30 minutes, heating to 535 DEG C, stirring for reacting for 10 hours, and cooling to obtain the fracturing fluid thickening agent for oil extraction. The shearing resistance, the temperature resistance, the salt resistance and the sand suspending property of the thickening agent are superior to those of the existing thickening agent.

The invention relates to a synthesis method of an abesilib intermediate, which comprises the following steps of: performing Grignard reagent treatment on 3, 5-difluorobromobenzene serving as a raw material, and reacting with 2-fluoro-N-methoxy-N-methylacetamide to obtain 1-(3, 5-difluorophenyl)-2-fluoroethane-1-ketone; then, carrying out nitration reaction to obtain 1-(3, 5-difluoro-4-nitrophenyl)-2-fluoroethane-1-ketone; in the presence of hydrogen and a catalyst, carrying out hydrogenation reduction to obtain 1-(4-amino-3, 5-difluorophenyl)-2-fluoroethane-1-ketone; the preparation method comprises the following steps: introducing acetyl through acetyl chloride, and condensing with N, N-dimethylformamide dimethyl acetal to prepare (Z)-N-(4-(3-(dimethylamino)-2-fluoroacryloyl)-2, 6-difluorophenyl) acetamide; the preparation method comprises the following steps: carrying out cyclization on 2-fluoro-1-(4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole-6-yl) prop-2-en-1-one and isopropylamine under an alkali condition to obtain an abesiril intermediate (Z)-3-(dimethylamino)-2-fluoro-1-(4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole-6-yl) prop-2-en-1-one; and finally, under an alkaline condition, carrying out cyclization on the compound and N-(5-(4-ethyl-piperazine-1-yl methyl) pyridine-2-yl) guanidine nitrate to obtain abesilib.

The present invention relates to the technical field of camptothecin derivative preparation, particularly to a camptothecin derivative synthesis method, which uses 2-nitroacetophenone and isopropylamine as raw materials, and the camptothecin derivative is obtained through a Mannich reaction, a methylsulfonylation reaction, a nitro reduction reaction and a ring closing reaction. According to the synthetic method of the camptothecin derivative, the complex camptothecin derivative is split into two segments 1-(2-aminophenyl)-3-(N-isopropyl-N-methylsulfonylamino) propan-1-one and a compound V which are easy to prepare, and finally, a plurality of rings and chemical bonds are constructed simultaneously through one-step efficient ring closing reaction. The yield attenuation caused by progressive multiplication of the yield in the traditional linear synthesis is avoided, and the total yield is improved.