416 results about "Isopropylamine" patented technology

This invention relates to a storage stable, aqueous, herbicidal formulation containing an ultra-high concentration of glyphosate in the isopropylamine, potassium or mixed salt form in combination with a surfactant system, to a method of making the formulation, and to a method of treating unwanted vegetation employing the formulation. The surfactant system employed in the concentrate comprises dialkoxylated alkylamine, water miscible solubilizer and amine oxide. The surfactant system unexpectedly permits the formulation of storage stable, ultra-high loaded aqueous glyphosate salt concentrates possessing high or no cloud points.

A synthetic method of Nanosized ZSM-23 zeolites belongs to the technical field of synthesis of inorganic chemistry. Firstly preparing reaction mixture from sodium metaaluminate or aluminum sulfate, silicasol or soluble glass, sodium hydroxide and isopropylamine, then hydrothermal crystallizing the reaction mixture, at last obtaining the Nanosized ZSM-23 zeolites through conventionally filtering, washing, drying and sintering the hydrothermal crystallized reaction mixture. The synthetic method has the advantages that average diameter of the cross sections of crystal grains of the synthesized ZSM-23 zeolites is not more than 100 nm, the specific surface area is comparatively high, production flow is short, the cost is low, and the method is favorable for industrial production and application.

Relating to an enzyme capable of efficiently converting a ketone compound to an optically active amino compound by transamination, and a process for preparing an optically active amino compound using the enzyme. An (S)-alpha-phenethylamine:pyruvate transaminase, which acts on (S)-alpha-phenethylamine and a ketone compound, thereby catalyzing transamination for forming acetophenone and an amino compound corresponding to the ketone compound; a process for preparing an optically active amino compound using the transaminase; and a method for culturing a microorganism for producing the above transaminase, comprising adding to a medium one or more compounds selected from the group consisting of propylamine, 1-butylamine, 2-butylamine, 2-pentylamine, isopropylamine and isobutylamine as an inducer for the enzyme when a microorganism for producing (S)-alpha-phenethylamine:pyruvate transaminase is cultured.

The invention discloses aminotransferase, a mutant and application to Sitagliptin preparation. According to the application, wet thalli obtained by performing fermentation culture on recombinant escherichia coli containing aminotransferase encoding genes are used as biocatalysts; Sitagliptin precursor ketone is used as a substrate; dimethyl sulfoxide is used as a latent solvent; phosphopyridoxal is used as a coenzyme; isopropylamine is used as an auxiliary substrate; a trolamine buffer solution with the pH being 8 to 9 is used as a reaction medium; a reaction system is formed; the biocatalytic reaction is performed under the conditions of the temperature being 30 to 45 DEG C and the stirring speed being 100 to 250 r/min; after the reaction is completed, the reaction liquid is separated and purified; the Sitagliptin is obtained. The aminotransferase and the mutant are used as biocatalysts; the latent carbonyl compound of Sitagliptin precursor ketone is directly used as the substrate; meanwhile, biocatalytic reaction is performed by using isopropylamine as the auxiliary substrate and using the pyridoxal phosphate as the coenzyme; the separation and purification is performed; Sitagliptin with high optical purity is prepared. The method has the advantages that the total yield is 76 percent; the product e.e. value reaches 99 percent.

The invention discloses a method for synthesizing nanometer ZSM-5 molecular sieve, which belongs to the technical field of inorganic chemosynthesis. The method comprises steps as follows: sodium metaaluminate or aluminium sulphate, silica sol or water glass, sodium hydroxide and isopropylamine are prepared into reaction mixer; the reaction mixer is subjected to hydrothermal crystallization; and the reaction mixer after the hydrothermal crystallization is filtered, washed, dried and baked conventionally to obtain nanometer ZSM-5 molecular sieve. The synthesized ZSM-5 molecular sieve has the advantages of higher specific surface, short production flow and low cost, and the section of the synthesized ZSM-5 molecular sieve crystal grain has an average diameter not larger than 100 nm, thereby facilitating industrialization production and application.

The invention relates to a synthetic method using hetero atoms to replace the AEL framework structure of a phosphoaluminate molecular sieve, and the method uses the hetero atoms of chlorine, titanium, cobalt, calcium, palladium, zinc, cerium, etc. as the materials of the hetero atoms to replace the AEL framework structure of the phosphoaluminate molecular sieve. In the synthesis process, aluminum isopropoxide or pseudo-boehmite is used as aluminum resources, and hexacosanoic propylamine and isopropylamine or the mixture of both are used as templates, thereby realizing the purposes of single feeding adoption, relatively mild crystallization condition, suitable water-solid ratio and great template dosage reduction. Once crystallization in the process can improve the crystallization efficiency, greatly improve the synthesis efficiency and control the formation of mixed crystal, having obvious advantages.

The invention provides a glyphosate isopropylamine salt water solution and a preparation method thereof. The glyphosate isopropylamine salt water solution comprises 30.3 percent of glyphosate, 11.5 to 13 percent of isopropamide, 8 to 12 percent of tallowamine polyoxyethylene ether, 3 to 6 percent of alkyl polyglucoside and the balance of deionized water. The formula cost is reduced greatly, and the medicine effect of the glyphosate isopropylamine salt water solution is the same as that of glyphosate isopropylamine salt water solution pesticide with an expensive aid.

The invention discloses a preparation method for metoprolol salt, which includes the steps of utilizing p-(2-methoxyethyl) phenol and epoxy chloropropane as raw materials and water or ethanol as dissolvent, and obtaining 3-[4-(2-methoxyethyl phenoxy)]-1,2-epoxypropane under the action of strong alkali; and utilizing water as dissolvent, carrying reaction between the 3-[4-(2-methoxyethyl phenoxy)]-1,2-epoxypropane and isopropylamine so that metoprolol alkali is obtained, and then carrying out reaction between the metoprolol alkali and saturated monohydric alcohol liquor of organic acid or saturated monohydric alcohol liquor of hydrochloric acid, so that the metoprolol salt is obtained. Clinically, hydrochloride, succinate, fumarate or tartrate of the compound is utilized as common medicinefor treating hypertensive disease, coronary disease, congestive heart failure and arrhythmia. The raw materials of the preparation method are cheap and easy to obtain, the water and the ethanol are utilized as the dissolvent so as to hardly cause pollution, the method is convenient in operation, high in purity of the prepared metoprolol salt, high in yield, lower in cost and extremely suitable for mass production.

The invention relates to a SAPO-34 molecular sieve microsphere catalyst preparation method, which comprises: adding an aluminum source into deionized water under a room temperature stirring state, adding a phosphorus source, uniformly stirring, slowly adding a silicon source, continuously and uniformly stirring, adding a tetraethyl ammonium hydroxide solution, continuously adding one and/or a plurality of materials selected from isopropylamine, diethylamine and triethylamine after uniformly stirring to form a uniform gel, crystallizing, unloading the synthesized product mother liquor from the autoclave after completing the crystallizing, carrying out spray drying, and calcining for 1.5-2.5 h to obtain the catalyst. According to the present invention, the synthesis yield is high, the separation and the washing on the molecular sieve synthetic product are not required, and the one-time catalyst molding granulation is achieved.

This invention provides a method for preparing solid isopropyl ammonium glyphosate. The method comprises: adding water-soluble salt and appropriate amount of water into a conventional reactor, stirring to completely dissolve the salt and obtain salt solution, adding glyphosate, uniformly dispersing, controlling the temperature, adding isopropylamine, reacting to obtain white crystals of isopropyl ammonium glyphosate, and filtering to obtain isopropyl ammonium glyphosate solid. The method can recycle the mother liquor to reduce water and water-soluble salt usage amounts and maximize precipitated solid amount.

Belonging to the field of pharmaceutical chemistry, the invention specifically relates to a method for preparing (S)-metoprolol succinate. The method comprises the steps of: pumping hydroxyphenylethyl methyl ether and (R)-chloropropylene oxide into a reaction vessel, and during the reaction process, pumping a reaction feed liquid into an external circulating dewatering system loaded with a dewatering agent for circulating dewatering, reacting the prepared (S)-3-[4-(2-methoxyethyl) phenoxyl]-1, 2-epoxypropane with isopropylamine so as to obtain an (S)-metoprolol base; mixing the (S)-metoprolol base with succinic acid, thus obtaining (S)-metoprolol succinate. During the first step of reaction in the invention, water generated in the reaction process can be effectively removed through the external circulating dewatering device, and the loss of (S)-3-[4-(2-methoxyethyl) phenoxyl]-1, 2-epoxypropane is reduced, thus realizing simple and fast production of low energy consumption. By the method of the invention, the conversion rate of the first step product (S)-3-[4-(2-methoxyethyl) phenoxyl]-1, 2-epoxypropane is over 90%, the final yield of (S)-metoprolol succinate is greater than 75%, and the utilization rate of the reaction substrate is obviously enhanced.

The invention discloses a transaminase mutant as well as application thereof to preparation of sitagliptin midbody. The application adopts a wet thallus obtained by fermenting and culturing recombinant escherichia coli comprising aminotransferase coded gene as a biological catalyst, adopts sitagliptin midbody precursor ketone as a substrate, adopts dimethyl sulfoxide as a co-solvent and , adopts phosphopyridoxal as co-enzyme, adopts isopropylamine as an auxiliary substrate, adopts a pH 8-9 triethanolamine buffering solution as a reaction medium to form a reaction system to perform the biological catalytic reaction under the conditions that the temperature is 30 to 45 DEG C, and the stirring rate is 100 to 250 r/min, after the reaction is ended, the reaction solution is separated and purified to obtain sitagliptin; and the total yield of the method is about 81 percent, and a e.e. value of the product reaches 99 percent.

The invention provides a biological preparation method of R-3-aminobutanol. The method includes: conducting whole-gene synthesis according to an artificially designed sequence shown as SEQ ID NO:1, and performing cloning into pET24a so as to obtain a recombinant expression vector; transferring the recombinant expression vector into E.coli to obtain a recombinant D-transaminase genetic engineering bacterium; culturing the bacterium to prepare recombinant D-transaminase; adding 3-carbonyl butanol with a final concentration of 10-300mmol/L, dimethyl sulfoxide or acetonitrile with a mass percentage concentration of 2-15%, pyridoxal phosphate with a final concentration of 0.1-1mmol/L, isopropylamine or D-alanine with a final concentration of 0.02-1mol/L, and recombinant D-transaminase with a mass percentage concentration of 0.01-1% are added into the reaction solution to compose a reaction system for reaction; and at the end of the reaction, extracting R-3-aminobutanol from the reaction solution. With a low cost, the method provided by the invention can achieve a conversion rate of more than 97% and a product yield of greater than 87%, and does not generate by-product, thus being more suitable for industrial application.

The invention belongs to a pesticide glyphosate synergist and a preparation method thereof, and particularly relates to a herbicide glyphosate isopropamide salt water agent environment-friendly synergist and a preparation method thereof. The synergist disclosed by the invention comprises the following components in percentage by weight: 20-40% of alkyl glycoside, 40-20% of cationic alkyl glycoside, 12-18% of alkyl glycine betaine, 0.5-1.5% of organic silicon, 2.0-5.0% of ammonium sulfate and the balance of water. The preparation method comprises the steps of uniformly stirring the components in equipment with a stirring function at the temperature of 20-80 DEG C. The glyphosate isopropamide salt water agent environment-friendly synergist is high in quality, efficient and environment-friendly.

The invention relates to a treating method of high-concentration heavy metal polluted building waste. The method includes: stripping surfaces of the building waste, smashing, washing, separating solid and liquid to obtain the cleaned building waste the water-soluble heavy metal of which is removed, adding an isopropylamine glyphosate solution into the cleaned building waste, eluting to remove the heavy metals, adjusting the pH value to be neutral, separating solid and liquid, washing the waste after elution with water and separating solid and liquid. The heavy metal contents in the building waste after air drying are lower than the three-level standard thresholds of the environmental quality standards (GB15618-1995). The building waste after air drying is subjected to a leaching test by utilization of an HJ/T229 leaching method, and the heavy metal contents in the leachate are lower than the thresholds of the standards for hazardous wastes (GB5085.3-2007). The building waste after air drying can be directly buried and stacked without pollution to the soil, and can be used as a regenerated roadbed material and a concrete aggregate. The method is simple in process and capable of completely eliminating the hazard of the polluted building waste, and has good environmental benefit, economic benefit and social benefit.

The invention discloses a method for producing isopropylamine, which belongs to the technical field of amine. To solve the problem that the prior isopropylamine industrial production device cannot effectively convert diisopropylamine into the isopropylamine, a reactor for an acetone hydroamination reaction performs the sectional control of the reaction temperature, the reaction temperature of a first section positioned at an inlet of the reactor is between 110 and 150 DEG C, and the reaction temperature of a downstream section is 5 to 30 DEG C higher than that of an upstream section which is adjacent to the downstream section. Along with the gradual reduction of the concentration of acetone along a bed, the reaction temperature is improved section by section, which is favorable for converting the diisopropylamine and isopropanol into the isopropylamine, thereby reducing the circulation of the diisopropylamine and the isopropanol, reducing energy consumption, and preventing the diisopropylamine from being gradually accumulated in a system so as not to need operating a diisopropylamine rectification system with difficult operation. The method is simple, feasible and easy to realize,and has considerable industrial application value and economic benefit.

The invention discloses a diisopropylamine fenofibrate, a preparation method of the same, a medicinal composition and use of the same, relating to the field of medicaments for lowering blood fat and treating fatty liver. The problems that fenofibric acid products is poor in water solubility, has toxic and side effects and the like in the prior art are solved. A product of the invention is obtained through the following steps of: adding a fenofibric acid and diisopropylamine into a solvent, heating to 35-70 DEG C, cooling, separating out a solid, pumping a filtrate, washing the solid with ether, and drying to obtain a white solid which is the diisopropylamine fenofibrate. A diisopropylamine part in the invention can overcome the side effect that the fenofibric acid is heated to be converted into ammonia enzyme and blood sugar and exerts a synergetic effect of lowering the blood fat together with fenofibrate.

The invention discloses a biological preparation method for R-3-aminopiperidine. The biological preparation method comprises the following steps: carrying out gene synthesis according to a sequence as shown in SEQ ID NO:1, cloning the gene into an expression vector pET22a to prepare a recombinant expression vector, and transferring the vector into escherichia coli to prepare a genetically engineered bacterium of recombinant D-transaminase; culturing the bacterium to prepare recombinant D-transaminase genetically engineered bacterium; adding 3-ketopiperidine with final concentration of 10-300mmol/L, 2-15wt% dimethyl sulfoxide or acetonitrile, phosphopyridoxal with final concentration of 0.1-1mmol/L, isopropylamine or D-alanine with final concentration of 0.02-1mol/L and 0.2-0.4wt% recombinant D-transaminase to form a reaction system to carry out reaction; and extracting the R-3-aminopiperidine in the reaction liquor after the reaction is ended. According to the biological preparation method, the cost is low, the conversion ratio is over 97%, the product yield is greater than 85% and byproducts are not produced, so that the biological preparation method is more suitable for industrial application.

The invention discloses a method for crystallizing and producing cefpiramide sodium crystals. The method comprises the steps that: (a) cefpiramide acid and an transamination agent are dissolved in a solvent I, wherein the transamination agent is any one selected from triethylamine, diisopropylamine, and isopropylamine; and a temperature is controlled, and the materials are stirred until completely dissolved; (b) a salt-forming agent is added into a solvent II, wherein when the salt-forming agent is sodium ethylhexanoate, the solvent II is an acetone solvent, and when the salt-forming agent is sodium hydroxide, the solvent II is any one or a mixture of two selected from methanol and tetrahydrofuran; and the materials are stirred until completely dissolved; (c) the salt-forming agent solution is uniformly added into the solution of cefpiramide amine salt; the temperature is controlled, and crystal seeds are added; curing crystallization is carried out; acetone is added into the crystallization system for regulating the pH value of the crystallization system and for carrying out solvent-out crystallization; and filtering, washing, and drying are carried out, such that the cefpiramide sodium crystals are obtained. The method provided by the invention has the advantages of simple operation, uniform crystals, high purity, low impurity content, good stability, easy storage, and the like.

The present invention discloses a synthesis method for a ZSM-23 molecular sieve, comprising the steps of: mixing an organic templating agent and an aluminum source, and processing the mixture in a closed reactor at 50 DEG C to 190 DEG C for at least 0.1 hours then cooling to obtain an intermediate product, wherein the organic templating agent isopropylamine and/or pyrrolidine; mixing the intermediate product with a silicon source , organic templating agent, water and seed crystals uniformly, placing the obtained mixture in a closed reactor and processing for 15-72 hours at 130-180 DEG C, and obtaining a ZSM-23 molecular sieve product by recovering. According to the method, via changing introduction ways of the aluminum source, the presence of alkali metal cations in the synthetic reaction system is prevented, and a sodium ion exchange step is saved in the post-treatment process for the molecular sieve, simplifying the production process, and reducing the production cost.

The invention discloses a novel synthesis process of atrazine, which has the following process steps of: adding a chemical compound containing a hydroxyl group into isopropylamine according to 1:1-1:3, and mixing to obtain a mixture solution for standby; feeding toluene into a reaction kettle, feeding cryosel into a cooling jacket to be stirred simultaneously, and then feeding cyanuric chloride; evenly adding the mixture solution into the reaction kettle; evenly adding 24 percent-30 percent of caustic soda liquid into the reaction kettle; evenly adding ethylamine into the reaction kettle; and then evenly adding 24 percent-30 percent of caustic soda liquid into the reaction kettle again, and finishing synthetic reaction. The novel synthesis process of the atrazine disclosed by the invention has the beneficial effects that: by adding the chemical compound containing the hydroxyl group into the isopropylamine, the synthetic reaction of the atrazine is more stable and balanced, meanwhile, impurity content generated by excessively vigorous reaction is reduced, and the content and the yield of the atrazine are effectively improved.