The Bicao mixture is herbicide composition comprising glyphosate herbicide and pyrazosulfuron-ethyl herbicide in the ratio of 10-150, the glyphosate herbicide may be glyphosate, sodium salt of glyphosate, potassium salt of glyphosate, etc., and the pyrazosulfuron-ethyl herbicide may be pyrazosulfuron-ethyl, isopropylamide salt of pyrazosulfuron-ethyl, ammonium salt of pyrazosulfuron-ethyl, sodium salt of pyrazosulfuron-ethyl, potassium salt of pyrazosulfuron-ethyl, etc. The herbicide composition may be compounded into water preparation, water emulsion, wettable powder, soluble powder, oily suspension, dry suspending, water dispersed granular preparation, granular preparation or tablet. It is used in rice field to kill and prevent weed, and has the features of low labor strength, low dosage, low cost, less environmental pollution, etc.