The invention belongs to the technical field of pharmaceutical
adjuvant synthesis, and particularly relates to a novel
aqueous dispersion as well as a preparation method and application thereof. The novel
aqueous dispersion comprises a film-forming agent, a
plasticizer, an emulsifier and a
solvent, wherein the film-forming agent is
methyl cellulose and
ethyl cellulose, the
plasticizer is
dibutyl sebacate, the emulsifier is
ammonium oleate, and the
solvent is
purified water; the proportions of the
methyl cellulose, the
ethyl cellulose, the
dibutyl sebacate, the
ammonium oleate and the
purified water in the total
mass of the
aqueous dispersion are 0.9 to 1.7 percent, 19 percent, 2.3 to 3.4 percent, 1.9 to 2.3 percent and 74 to 76 percent respectively; the
solid content of the aqueous dispersion is 23%-26%, the
viscosity of a 24.5%
aqueous solution is 400-1500 mPa.s, and the pH value is 9.5-11.5. The novel aqueous dispersion disclosed by the invention has the characteristics of excellent performance, good film-forming property, high stability and the like, is convenient to apply, does not need additional auxiliary materials and heat treatment for
coating, and more importantly, has an excellent slow-release effect, can realize long-time uniform release of medicines, and meets the slow-release
coating requirements of oral medicines.