Dripping pill for treating coronary heart diseases and preparation method thereof

A technique for coronary heart disease and dripping pills, which is applied in the field of pharmaceutical preparations, can solve the problems of poor plasticity, easy sticking of dripping pills, poor stability of dripping pills, etc., and achieves benefits for production and storage, fast dissolution time, and improved compliance Effect

Active Publication Date: 2010-05-26
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, the current drop pill preparations generally face the following problems: the drop pill auxiliary materials are not purely natural
These synthetic auxiliary materials are all mixtures with a certain range of molecular weight distribution, resulting in difficult control of the quality of the drop pills, and there are differences between batches; from the perspective of safety, the traditional drop pill base auxiliary materials of polyethylene glycol have certain gastrointestinal tract irritation and hemolysis, affecting the compliance of patients with medication; the prepared drop pills have poor stability, are easy to absorb moisture, and are easy to stick when heated, etc.
And the finding of new natural matrix auxiliary ...

Method used

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  • Dripping pill for treating coronary heart diseases and preparation method thereof
  • Dripping pill for treating coronary heart diseases and preparation method thereof
  • Dripping pill for treating coronary heart diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Danshen and Panax notoginseng liquid extract 18g (prepared according to the method of extract preparation example), borneol 1.2g, erythritol 54g, propylene glycol 3g.

[0072] Thoroughly mix erythritol, salvia miltiorrhiza and Panax notoginseng liquid extract, borneol and propylene glycol, put it into the dripping device, heat it in a circulating oil bath until it melts, keep the temperature of the material at 101°C, and dissolve the melt at 35 drops / Drop into the methyl silicone oil condensate at a temperature of 5°C at a speed of 1 min. After forming, filter the drop pills, and use absorbent paper to absorb the methyl silicone oil adhering to the surface of the drop pills, and dry at low temperature. The results showed that the prepared dropping pills were round, uniform in size, consistent in color and without adhesion. According to the method of disintegration time limit of Chinese Pharmacopoeia 2005 edition, the results show that the average 1.96min without baffle...

Embodiment 2

[0074] Salvia miltiorrhiza and Panax notoginseng dry extract (fluid extract prepared according to the method of extract preparation example, obtained by conventional spray drying) 19.2g, borneol 4.8g, erythritol 32.7g, propylene glycol 2.4g, water 0.9g.

[0075] Fully mix erythritol, salvia miltiorrhiza and Panax notoginseng dry extract, borneol, propylene glycol and water, put it into the dripping device, heat it in a circulating oil bath until it melts, keep the temperature of the material at 105°C, and melt the melt at 40°C Drop into the liquid paraffin condensate at a temperature of 7°C at a rate of drops / min. After forming, filter the drop pills, use absorbent paper to absorb the liquid paraffin adhering to the surface of the drop pills, and dry at low temperature. The results showed that the prepared dropping pills were round, uniform in size, consistent in color and without adhesion. According to the method of disintegration time limit of Chinese Pharmacopoeia 2005 edit...

Embodiment 3

[0077] Danshen and Panax notoginseng liquid extract (prepared according to the method of extract preparation example) 12g, borneol 1.2g, erythritol 36.3g, propylene glycol 0.5g.

[0078] Fully mix erythritol, salvia miltiorrhiza and Panax notoginseng liquid extract, borneol and propylene glycol in the prescription, put it into the dripping device, heat it in a circulating oil bath until it melts, keep the temperature of the material at 103 ° C, and melt the melt at 45 Drop into the liquid paraffin condensate at a temperature of 6°C at a rate of drops / min. After forming, filter the drop pills, use absorbent paper to absorb the liquid paraffin adhering to the surface of the drop pills, and dry at low temperature. The results showed that the prepared dropping pills were round, uniform in size, consistent in color and without adhesion. According to the method of disintegration time limit of Chinese Pharmacopoeia 2005 edition, the test results show that it passes through the sieve ...

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Abstract

The invention relates to a dripping pill for treating coronary heart diseases, which comprises a medicinal active component, a substrate auxiliary material, a plastic component, propylene glycol and water, wherein the medicinal active component is prepared from radix salviae miltiorrhizae, radix notoginseng and borneol; the substrate auxiliary material is erythrol; the plastic component is selected from one or more of polyethylene glycol, xylitol, lactitol, manna sugar, glycerol, soluble starch, gelatin, methyl cellulose, sodium carboxymethylcellulose, hydroxypropyl methylcellulose, acacia, alginic acid, dextrin, schardinger dextrin, citric acid ester, acetoglyceride, dibutyl sebacate, refined coconut oil and castor oil; and relative to the total weight of the dripping pill, the dripping pill comprises the following components by weight percent: 1-40% of medicinal active component, 0-10% of plastic component, 1-10% of propylene glycol, 0-10% of water and the balance substrate auxiliary material. The dripping pill has safety, no toxicity, low moisture-absorption property and high dissolution and dispersion speed.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a dropping pill and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular diseases are the first disease that causes human death. With the improvement of social living standards and the aging of the population, the research on drugs for cardiovascular and cerebrovascular diseases has become a hot spot in drug development. Coronary heart disease is the abbreviation of coronary heart disease. It is a disease with high morbidity and mortality and seriously endangers the health of human beings, so it is called "the first killer of human beings". Angina pectoris is a clinical syndrome caused by coronary artery blood supply insufficiency, myocardial acute, transient ischemia and hypoxia. It often occurs when you are tired, full of food, cold and emotional, and there is a sudden pain behind the sternum with an unclear range. Squeezing ...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/20A61P9/10A61K31/045
Inventor 陈建明闫希军朱永宏高保安章顺楠董海欧张继仲李伟彦新江赵颖
Owner TIANJIN TASLY PHARMA CO LTD
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