The present invention discloses a weather-resistance and low-temperature-resistance chloroprene rubber adhesive, wherein the raw materials comprise a chloroprene rubber, a natural rubber, an alkyl benzoic acid resin, a phenolic resin, an epoxy resin, a terpene resins, a trans-1,4-polyisoprene rubber, active magnesium oxide, nanometer silicon dioxide, ethylene thiourea, zinc oxide, ethyl acetate, cyclohexane, acetone, propylene glycol, methyl cyclopentane, dimethyl carbonate, an anti-aging agent, cerium oxide, 3-aminopropyl trimethoxy silane, a silane coupling agent KH-560, and a plasticizer. The weather-resistance and low-temperature-resistance chloroprene rubber adhesive of the present invention has characteristics of high bonding strength, good low-temperature resistance, good weather resistance, and excellent storage stability.