14 results about "Diethyl dithiocarbamate" patented technology

The invention provides application of a copper death inducer in preparation of a medicine for treating osimertinib-resistant non-small cell lung cancer, and belongs to the technical field of treatment of non-small cell lung cancer. According to the invention, through high-throughput drug screening, the copper death inducer copper diethyl dithiocarbamate (CuET) and osimertinib are combined for use, so that a remarkable synergistic anti-cancer effect is achieved; furthermore, through detection of a wild type and osimertinib drug-resistant cell line model, an osimertinib sensitive and drug-resistant patient-derived organoid and a mouse xenotransplantation model, it is found that the anti-tumor effect of osimertinib can be remarkably enhanced through copper death induction, and osimertinib drug resistance is overcome. According to the technical scheme provided by the invention, osimertinib drug-resistant non-small cell lung cancer cells can be effectively killed, the curative effect of osimertinib in sensitive and drug-resistant models is remarkably enhanced, and an application scene is provided for copper death in tumor treatment.

The invention discloses composite biological regenerated asphalt which comprises the following components in parts by weight: 66-85 parts of aged asphalt; 2 to 6 parts of modified ZDC; 5-20 parts of activated lignin; 8 parts of bio-oil; the modified ZDC is obtained by carrying out surface modification on zinc diethyldithiocarbamate through a silane coupling agent; the activated lignin is obtained by activating lignin through glycerol; the composite biological regenerated asphalt is prepared by compounding aged asphalt, modified zinc diethyldithiocarbamate (ZDC), activated lignin and bio-oil in parts by weight, the ZDC realizes an anti-oxidation effect by capturing free radicals, the lignin absorbs ultraviolet light by virtue of a benzene ring structure, and phenolic hydroxyl groups capture free radicals to realize an anti-ultraviolet-anti-oxidation synergistic function; the bio-oil supplements lost light components of the aged asphalt and reduces the penetration degree and the softening point to realize regeneration adjustment, and the anti-aging performance and the regeneration effect of the composite asphalt are remarkably improved through the synergistic effect of the bio-oil, the light components and the regeneration point.

The application discloses a long-acting anti-aging modified asphalt based on bionic inspiration and a preparation and application thereof. The long-acting anti-aging modified asphalt based on bionic inspiration comprises the following components in mass fractions: 2-4 parts of zinc diethyl dithiocarbamate, 0.5-1.5 parts of a bionic polymer-benzene and propylene copolymer grafted dopamine, 4 parts of a thermoplastic elastomer SBS and 400 parts of a base asphalt. Through the synergistic effect of the bionic polymer and the sulfur anti-aging agent, a double anti-aging protection system is constructed. After short-term thermal oxygen aging, the modified asphalt can still maintain excellent high-temperature stability and low-temperature crack resistance. After long-term pressure aging, the performance attenuation amplitude of the modified asphalt is significantly reduced compared with that of a traditional SBS modified asphalt, and the long-acting anti-aging characteristics are exhibited.

The application provides a tea polyphenol-copper nanomaterial and a construction method thereof; catechin compounds are dissolved in deionized water, an alkaline aqueous solution is added to adjust the pH value to 8-9, then a sodium diethyl dithiocarbamate aqueous solution and a copper salt aqueous solution are added respectively, and the tea polyphenol-copper nanomaterial is prepared. And the application in preparing a bacteriostatic agent is provided. The tea polyphenol-copper nanomaterial has the advantages of mild synthesis condition, fast reaction time, simple operation, low cost, strong bacteriostatic capacity, and the half-inhibitory concentration of MRSA and SE is less than 5 muM, and the tea polyphenol-copper nanomaterial can achieve high bacteriostatic effect at a low concentration. And the tea polyphenol-copper nanomaterial has good biological safety.

The application discloses application of sodium diethyl dithiocarbamate in preparation of a vaccine adjuvant, the adjuvant can effectively enhance immunogenicity of an antigen and stimulate the body to generate higher humoral and cellular immune responses, and can be combined with a traditional aluminum adjuvant to enhance the protection effect of the antigen, and is non-toxic and has no side effects.

The invention discloses a formula for low release amount of total volatile organic compounds in natural latex of a plant fiber mattress. The environment-friendly coating is prepared from the following components in parts by weight: 0.3 to 0.8 part of potassium hydroxide, 0.3 to 0.8 part of a dispersing agent, 0.2 to 0.6 part of a wetting agent, 2.2 to 3.2 parts of sulfur, 0.9 to 1.8 parts of zinc dibutyl dithiocarbamate, 0.3 to 1.0 part of zinc diethyl dithiocarbamate, 1.8 to 3.0 parts of zinc oxide, 0.8 to 1.8 parts of sodium sulfite, 1.0 to 2.0 parts of an antiozonant, 0.2 to 1.2 parts of a hindered phenol antioxidant, 1.0 to 2.0 parts of an anti-aging agent, 10 to 30 parts of light calcium carbonate and 0.05 to 0.16 part of a suspending agent. According to the low-release-amount formula of the total volatile organic compounds of the natural latex, the release amount of the total volatile organic compounds (TVOC) of a plant fiber elastic material mattress can be remarkably reduced.

The invention discloses an agronomic character regulation composition and application, and the composition contains a jasmonic acid synthetic pathway inhibitor, such as sodium diethyldithiocarbamate trihydrate. The agronomic character regulation composition is low in raw material price, easy to obtain and convenient to use, not only can be used for enhancing the commodity value of ornamental plants, but also can be used for increasing the yield of food crops, can realize low-cost and high-efficiency crop agronomic character improvement, and has relatively high industrial application value.

The application provides a treatment method of industrial organic wastewater, comprising the following steps: adjusting the pH of the industrial organic wastewater to 3.8-5.5, and performing a stirring reaction to obtain wastewater A; adding reagent B into the wastewater A, and performing a stirring reaction; and after standing, obtaining treated industrial organic wastewater; the reagent B is one or more of sodium dimethyl dithiocarbamate, sodium diethyl dithiocarbamate, trisodium trithiocyanate and sodium piperazine dithiocarbamate. The treatment method has the advantages of simple operation, simple process equipment, low investment cost, easy engineering promotion, cheap and easily available reagent, and can be used for treating heavy metal-containing organic wastewater in different industrial fields, and has good heavy metal removal effect and good industrial application value.

The present application belongs to the technical field of rare earth hydrometallurgy, and particularly relates to a purifying agent for treating a lead-containing rare earth solution and an application method. The purifying agent comprises the following raw materials in parts by weight: a sulfur source 5-30 parts, a magnesium source 3-15 parts, and water 40-95 parts; the sulfur source is any one or a combination of two of sodium dimethyl dithiocarbamate and sodium diethyl dithiocarbamate, and sodium pentathiocarbonates; the magnesium source is any one of magnesium chloride, magnesium sulfate, and magnesium nitrate. The present application improves the temperature and acidity application range of the purifying agent, reduces the cooling and neutralization cost of the rare earth solution, utilizes the insolubility of the purifying agent to avoid the residue of excessive purifying agent in the rare earth solution, forms a magnesium polysulfide carbonate salt, improves the ability of magnesium to replace lead ions, and ensures that the lead content in the rare earth solution is removed to a qualified level.

The application belongs to the technical field of transition metal catalysts, and discloses an iron-based sulfide with a hierarchical structure and a preparation method and application thereof. The preparation method comprises the following steps: reacting an iron source and diethyl dithiocarbamate in an aqueous solution, collecting and drying the precipitate to obtain iron diethyl dithiocarbamate; dispersing the iron diethyl dithiocarbamate in anhydrous ethylenediamine for a solvothermal reaction, collecting and drying the precipitate to obtain a precursor; dispersing the precursor in water, adding an organic exchanger for ion exchange, collecting and drying the precipitate, and the iron-based sulfide with a hierarchical structure is obtained. The specific surface area of the iron-based sulfide with a hierarchical structure is significantly increased, the exposed active sites are greatly increased, and the catalytic efficiency and selectivity of hydrazine hydrate in reducing nitroaromatic hydrocarbons are improved. The catalytic conversion rate of different nitroaromatic hydrocarbons is greater than 91%, and the highest can reach 100%, and the selectivity is greater than 99%.

The application provides an alpha-ketone amide peroxide responsive drug precursor compound and a preparation method and application thereof, relates to the field of chemical biotechnology, and the alpha-ketone amide peroxide responsive drug precursor compound in the application is broken under the action of hydrogen peroxide, releases diethyl dithiocarbamate after chemical structure is changed and a benzyl group is eliminated, the released product is combined with copper ions to generate the metal drug copper diethyl dithiocarbamate CuET, and has a remarkable inhibiting growth effect on malignant tumor cells. The prepared drug precursor compound has a simple and easy-to-operate synthesis method, is strong in controllability, and has a wide application prospect in the field of malignant tumor treatment using the responsive drug precursor compound.

The application discloses a kind of composite biological regeneration asphalt, composition is according to weight part: 66-85 portion of aged asphalt;2-6 portions of modified ZDC;5-20 portions of activated lignin;8 portions of bio-oil;The modified ZDC is zinc diethyl dithiocarbamate and is modified by silane coupling agent on surface;The activated lignin is lignin and is activated by glycerol;The composite biological regeneration asphalt obtained in the application is compounded by aged asphalt, modified zinc diethyl dithiocarbamate (ZDC), activated lignin and bio-oil according to weight part, ZDC realizes antioxidation by capturing free radicals, lignin relies on benzene ring structure to absorb ultraviolet light, and phenolic hydroxyl captures free radicals to realize the synergistic function of ultraviolet resistance-antioxidation, bio-oil supplements the light component lost by aged asphalt, reduces its penetration and softening point to realize regeneration regulation, and the synergistic effect of the three significantly improves the anti-aging performance and regeneration effect of composite asphalt.

The application discloses a method for floating tin and zinc in polymetallic sulfide ore, which comprises the following steps: grinding and thickening the polymetallic sulfide ore, then stirring and desliming the polymetallic sulfide ore by adding papaya seed glue and polyacrylamide, grinding and thickening the polymetallic sulfide ore, and floating the polymetallic sulfide ore by adding a flotation agent A to obtain flotation concentrate C and flotation tailings D, wherein the flotation agent A comprises ethion, zinc sulfate, cationic starch, lime and pine oil; grinding and thickening the flotation concentrate C, and floating the flotation concentrate C by adding a flotation agent F to obtain lead concentrate and flotation tailings G, wherein the flotation agent F comprises sodium tartrate, zinc sulfate, sodium diethyl dithiocarbamate, ethion and pine oil; adding sulfuric acid solution to the flotation tailings D after concentration, and grinding and magnetic separating the flotation tailings D, adding a flotation agent to the magnetic separation tailings to obtain flotation concentrate J, and obtaining tin concentrate by table gravity separation of the flotation concentrate J. The application solves the problem of poor flotation or gravity separation effect of fine-grained tin ore, and can improve the recovery rate of tin and zinc in the polymetallic sulfide ore.

The invention discloses a method for constructing a dissolvable microneedle loaded with an MOFs (Metal Organic Frameworks) nano-drug, which comprises the following steps of: preparing a metal organic nano-drug diethyl dithiocarbamate modified copper-trimesic acid complex from a copper-trimesic acid complex and sodium diethyldithiocarbamate; the preparation method comprises the following steps: preparing a copper-trimesic acid complex modified by diethyldithiocarbamate, forming composite hydrogel by utilizing the interaction of polyvinylpyrrolidone and the diethyldithiocarbamate modified copper-trimesic acid complex, putting the composite hydrogel into a microneedle mold, preparing a soluble microneedle by adopting a vacuumizing method, and drying in a constant-temperature drying box for 24 hours, so as to obtain the soluble microneedle. And demolding to obtain the prepared soluble microneedle loaded with the MOFs nano-drug. According to the soluble microneedle manufactured by the method, the controllable release of the nano-drug loaded on the microneedle can be realized while the good mechanical property is ensured; the invention further provides a dissolvable microneedle loaded with the MOFs nano-drug. The invention belongs to a preparation technology of a dissolvable microneedle, and is applied to transdermal drug delivery.