340 results about "Catechin" patented technology

According to the antibacterial and antioxidant composite film applied to food preservation and the production method of the antibacterial and antioxidant composite film, the chlorogenic acid, the catechin, the montmorillonite and the zeolite are introduced, and a drying process is optimized, so that the antibacterial performance, the antioxidant performance and the mechanical performance of the preservative film are remarkably improved, and meanwhile, the water vapor permeability and the oxygen permeability are reduced. The method comprises the specific steps of raw material preparation, polyphenol compound and mineral substance preparation, membrane liquid preparation and treatment, drying process optimization and finished product membrane uncovering. According to the preparation method disclosed by the invention, components such as chlorogenic acid, catechin, montmorillonite and zeolite are introduced, and a drying process is optimized, so that the food preservative film with synergistic antibacterial and antioxidant properties is prepared.

The invention belongs to the technical field of soil improvement, and relates to a soil saline-alkali improver as well as a preparation method and application thereof. The invention provides a soil saline-alkali modifier. The soil saline-alkali modifier is composed of a shell slow-release layer, a middle conditioning layer and an internal functional layer, the internal functional layer is prepared from a saline-alkali soil improving fungicide, biochar and a granulation adhesive; the middle conditioning layer is composed of a conditioner, a first slow-release agent and a first solvent; the shell slow-release layer is prepared from humic acid, furfural residues, a calcium ion compound, a second slow-release agent and a second solvent; the calcium ion compound is at least one of phosphogypsum, desulfurized gypsum, calcium chloride and calcium sulfate; the conditioner is at least one of coumarin, resveratrol and catechin. A multi-layer slow-release structure is constructed, through a multi-layer slow-release mode, all the improvement components make contact with the saline-alkali soil in sequence, and the excellent improvement effect is achieved.

The invention relates to the technical field of polymer degradable materials, in particular to a biodegradable material as well as a preparation method and application thereof. The material takes modified polylactic acid as a main body, and an antioxidant, a plasticizer, a flame retardant and an inorganic filler are used as auxiliary materials in parts by weight. The method is characterized in that lactic acid and an epicatechin imidazole ammonium chloride polymer are polymerized under the catalysis of stannous octoate, and an epicatechin bioactive group is introduced into a polylactic acid main chain in a chemical bonding manner, so that the biodegradation rate, the mechanical property and the thermal stability of the material are remarkably improved. Bioactive substances and ionic groups in the material promote microbial degradation, and the material can be completely decomposed in a compost environment in a short time; meanwhile, the strength, the toughness and the high-temperature processability of the polylactic acid are effectively improved through molecular-level enhancement and an ionic cross-linking effect. The material can be widely applied to the fields of disposable tableware, food packaging films, degradable agricultural mulching films and the like.

The present invention discloses coated hydrophobic polyphenol nanoparticles, preparation method therefor and application thereof. The preparation method for coated hydrophobic polyphenol nanoparticles includes: (1) obtaining a hydrophobic polyphenol nanoparticles suspension; (2) injecting a catechin aqueous solution and a metal salt aqueous solution into the hydrophobic polyphenol nanoparticles suspension to obtain a composite nanoparticles suspension; (3) removing excess catechin and metal ions from the composite nanoparticles suspension to obtain a coated hydrophobic polyphenol nanoparticles suspension. The present invention provides an application of the coated hydrophobic polyphenol nanoparticles in the preparation of pectin gel. The coated hydrophobic polyphenol nanoparticles exhibit significantly enhanced biological activity and long-term stability, developing a pectin gel with long-term stability.

The invention relates to the technical field of antibacterial polyamide fiber preparation, and discloses a polyamide fiber with antibacterial performance and a preparation method thereof.The polyamide fiber is prepared from, by weight, 100 parts of PA6 slices, 10-15 parts of graphene oxide, 1-5 parts of surface amination mesoporous catechin-silver-loaded zirconium phosphate and related auxiliaries, after surface amination mesoporous catechin-silver-loaded zirconium phosphate and graphene oxide are subjected to amide linkage, the surface amination mesoporous catechin-silver-loaded zirconium phosphate and amide groups of polyamide fibers form a hydrogen bond network, the surface amination mesoporous catechin-silver-loaded zirconium phosphate and the amide groups of the polyamide fibers are mutually combined to play a synergistic effect, the interface binding energy is increased, and antibacterial components can stably exist in the polyamide fibers; meanwhile, the mesoporous structure provides multi-channel support, induces cracks to expand along the edge of a pore and increases the length of a fracture path, so that the stress transfer efficiency is obviously improved, and the problem of internal stress concentration caused by the addition of large-particle high-content rigid particles is avoided.

According to the preparation method disclosed by the invention, the whole fruit juice of the lonicera caerulea (which retains fruit residues) is fermented by virtue of the plant lactobacillus KLDS1.0391, KLDS1.0320 or KLDS1.0368, so that the xanthine oxidase (XO) inhibition activity is remarkably improved. After fermentation, the XO inhibition rate is increased to 48-50.87% (the content of unfermented juice is 31.21%), the total phenol content is increased by 15-24.3%, and the contents of main XO inhibitors in the lonicera caerulea: cyanidin-3-O-glucoside (IC50 = 115.28 [mu] M), cyanidin-3, 5-diglucoside (IC50 = 116.34 [mu] M), peonidin-3-glucoside (IC50 = 105.34 [mu] M), quercetin (IC50 = 88.75 [mu] M), catechin (IC50 = 110 [mu] M) and caffeoylquinic acid (IC50 = 250.35 [mu] M) are remarkably increased. Wherein the quercetin content is increased by 73.8% at most (KLDS1.0320 strain fermentation is performed for 24 hours), and the XO inhibition rate is increased from 31.21% to 50.87%. Technical support is provided for development of a natural XO inhibitor and a functional fermented beverage, so that a new thought is provided for functional fermented juice with lonicera caerulea as a key component.

The invention provides a stem cell culture medium and a preparation method and application of a stem cell exosome with oxidation resistance. The stem cell culture medium comprises baicalin, quercetin, liquiritin and catechin. According to the stem cell culture medium provided by the invention, a mixture of baicalin, quercetin, liquiritin and catechin is adopted as a component of the culture medium to stimulate the stem cells, and the oxidative stress state of the stem cells is changed, so that the stem cells can secrete exosomes with an antioxidant effect, and the secreted exosomes have higher antioxidant capacity. The corresponding stem cell exosome is relatively excellent in the aspect of oxidation resistance.

The invention discloses a preparation method of a lactoferrin-polyphenol nano compound with an intestinal immune function. The method comprises the following steps: firstly, moderately hydrolyzing lactoferrin under the action of compound protease, and optimizing a protein molecular structure; then, compounding with water-soluble polyphenol (such as chlorogenic acid or epicatechin) by utilizing a metal ion chelating technology, and inducing lactoferrin to be bridged and aggregated by Ca to form a compound; and then, carrying out ultrasonic homogenization treatment, and further controlling the particle size to enable the particle size to be distributed in a range of 100-300 nm. The obtained compound is subjected to nanofiltration concentration and electrostatic spray drying to obtain a shell-core nano compound with a stable structure, and nitrogen-filled packaging is adopted to prevent oxidation. The lactoferrin-polyphenol nano-composite prepared by the invention not only has good stability and intestinal immunity enhancement effect, but also has remarkable antibacterial activity, and can be widely applied to functional foods and nutritional health-care products.

The present invention provides a remediation composition for soil contaminated with hexavalent chromium and a soil remediation method. The composition comprises catechin, flavonoid isorhamnetin and humic acid with a mass ratio of 1:1 - 3:0.1 - 1. The remediation composition for soil contaminated with hexavalent chromium according to the present invention can achieve a leaching rate of 93% for the hexavalent chromium contamination in the soil. At the same time, the composition can reduce more than 95% of the hexavalent chromium in the leaching solution to trivalent chromium with low toxicity, achieving the purpose of completely removing hexavalent chromium from the soil and greatly reducing the material cost of chemical leaching.

The invention belongs to the technical field of biological materials, and particularly relates to a multifunctional beauty microneedle for improving skin photoaging and a preparation method and application thereof. According to the invention, water-soluble hyaluronic acid and chitosan / beta-sodium glycerophosphate temperature-sensitive hydrogel are used as a polymer of a microneedle substrate layer, and the polymer comprises exosome of human adipose-derived mesenchymal stem cells and epigallocatechin gallate. When the microneedle is inserted into the skin, hyaluronic acid is quickly dissolved after contacting with tissue fluid, the needle tip is implanted into the skin, and the CS / beta-GP temperature-sensitive hydrogel is in a solid-gel-like state and can slowly release two cosmetic active ingredients in a long-acting manner under the influence of environment temperature and humidity; the facial mask has the effects of promoting tissue regeneration, reducing hyperpigmentation, replenishing water, preserving moisture, resisting oxidation, delaying skin aging and the like, so as to achieve the medical beauty effects of reducing wrinkles, whitening, preserving moisture, rejuvenating the face and the like. The microneedle provided by the invention can be further prepared into a patch, and is beneficial to treatment of wrinkles and stains at specific parts.

The invention discloses a formula composition which is prepared from the following components in parts by weight: 100 to 400 parts by weight of grape seed procyanidine, 100 to 300 parts by weight of pomegranate polyphenol, 10 to 100 parts by weight of ergothioneine, 50 to 200 parts by weight of catechin and 100 to 400 parts by weight of astragalus polysaccharide. According to the invention, cell-level anti-aging is taken as a core logic, five active ingredients of grape seed procyanidine, pomegranate polyphenol, ergothioneine, catechin and astragalus polysaccharide are scientifically compounded, a multi-dimensional anti-oxidation defense system is constructed, and multiple effects of scavenging free radicals, repairing cell damage, delaying an aging process and the like can be realized.

The invention belongs to the technical field of hole sealing reagents, and discloses a high-color-fixation medium-temperature hole sealing agent for an aluminum alloy anodic oxide film as well as a preparation method and application of the high-color-fixation medium-temperature hole sealing agent. The medium-temperature hole sealing agent comprises hole sealing main salt, hole sealing auxiliary salt, a color fixing auxiliary agent and an auxiliary agent, the hole sealing main salt comprises nickel acetate or nickel acetate hydrate; the hole sealing secondary salt comprises at least one of cobalt acetate, magnesium acetate, lithium acetate and calcium acetate; the color fixing auxiliary agent comprises at least one of tannic acid, gallic acid, quercetin, ellagic acid, tannic acid and catechin. According to the medium-temperature hole sealing agent, hole sealing of the aluminum alloy oxidation film is achieved under the medium-temperature (55-65 DEG C) condition, meanwhile, the color fixing process of dye molecules in micropores of the oxidation film is synchronously completed through the effect of the specific color fixing auxiliary, and the problems of uneven hole sealing and color fading caused by a separation technology are solved. And after the hole sealing agent is used for treatment, the binding force of the dye and an oxidation film can be enhanced, and the dye is not easy to fade in a high-temperature and high-humidity environment for a long time.

The invention discloses application of catechin as a nitrification inhibitor, a use method of catechin as a nitrification inhibitor, a preparation method of a fertilizer formed by the catechin and the fertilizer. According to indoor simulation and field plot and field experiments, the catechin shows a good inhibition effect on soil ammonia oxidizing bacteria when the dosage per mu is 40.0-100.0 g, conversion from ammonium nitrogen to nitrate nitrogen can be effectively delayed, and compared with a traditional nitrification inhibitor, the catechin has the advantage in the later stage of nitrification inhibition.

The invention provides a self-assembled SDS-LC-LDH and a preparation method thereof as well as modified polypropylene and a preparation method thereof, and particularly relates to the technical field of high polymer materials. The self-assembled SDS-LC-LDH comprises a layered double metal hydroxide, and lignin and catechin which are intercalated between the layers of the layered double metal hydroxide. According to the invention, lignin and catechin are inserted between layers of layered double hydroxides (LDH) to realize the dual functions of flame retardance and antibiosis. And under a high-temperature condition, bound water and carbon dioxide between LDH layers can be released to improve the flame retardant property. Meanwhile, metal hydroxides of the LDH laminates and lignin are subjected to catalytic reaction in the thermal degradation process, a compact carbonization layer is formed, and external heat and oxygen are effectively prevented from penetrating into the material. Phenolic hydroxyl groups in catechin can interfere with normal metabolism and growth of bacteria and show antibacterial characteristics.

The inventors provide strong evidence that FGFR3 gain of function mutation expressed in the brain induces cognitive and behavior deficit. To provide evidence that the constitutive activation of FGFR3 and its downstream signalling pathways are responsible for these behavioral impairments, the inventors treated the Fgfr3A385E / + mice using subcutaneous injection of catechin isomers for at least seven days. In addition the inventors treated the Fgfr3N534K / + mice with bottle treatments. The treatment rescues the anomalies in short-term learning and in coping strategy. The present invention thus relates to a method of treating a FGFR3-related cognitive deficit in a subject in need thereof comprising administering to the subject a therapeutically effective amount of at least one catechin.

The invention discloses a contact lens care solution capable of moisturizing, lubricating and resisting bacteria for a long time and a preparation method thereof, and the care solution comprises the following components in percentage by mass: 1.0-2.5% of polyglycerol ether-26; 2.0%-3.5% of a composite natural bacteriostatic agent; 1.0 to 2.0 percent of a thickening agent; 1.5%-2.5% of a surface active agent; 0.15%-1.8% of a pH regulator; 8.5-9.0% of an osmotic pressure regulator; and the balance of purified water. The composite natural bacteriostatic agent is a mixture of catechin and ginkgetin. The preparation method comprises the following steps: adding part of purified water into a container, then adding polyglycerol polyether-26, the composite natural bacteriostatic agent, the thickening agent and the surfactant, then supplementing part of purified water, and stirring for dissolving; adjusting the pH value of the solution to 6.5-7.8 and the osmotic pressure to 260-340 mOsm / kg.H2O, finally adding the balance of purified water, and uniformly stirring; and filtering and sub-packaging to obtain the product. According to the invention, polyglycerol ether-26 has high moisturizing and lubricating properties, catechin and ginkgetin have a synergistic effect, so that the antibacterial property can be improved, and as a natural plant extraction component, the eye cream is non-irritant when entering eyes, is higher in safety and can play a role in protecting the eyes.

The invention discloses a catechin-beta-cyclodextrin oleate nanoparticle inclusion compound (CAT-CDO) and a preparation method thereof.The preparation method comprises the steps that a 75% ethanol water solution is added into beta-cyclodextrin oleate (CAT), catechin is dissolved in 20 mL of ethanol solution, the catechin solution is dropwise added into a CAT solution at the temperature of 30 DEG C in a dark place, and a reaction is conducted under stirring; centrifuging the mixed solution to remove undissolved solids, so as to obtain a supernatant which is an inclusion compound solution; and freeze-drying the inclusion compound solution to obtain inclusion compound solid powder. The CAT-CDO prepared by the invention has a good solubilizing effect on CAT, and the antioxidant stability, the release performance, the photo-thermal stability and the cytotoxicity of the CAT are effectively improved. Besides, catechin can be replaced by any other phenolic compounds, and the phenolic compounds and CDO are prepared into a nanoparticle inclusion compound, so that the effects of solubility, antioxidant stability and the like of phenolic substances are improved, and the application performance of the phenolic substances in various fields is further improved.

The invention relates to the technical field of hydrogel materials, in particular to conductive hydrogel with high transparency and high mechanical properties and a preparation method of the conductive hydrogel. The preparation method comprises the following steps: adding carboxylated multi-walled carbon nanotubes (MWCNT-COOH) and catechin into deionized water, and uniformly mixing the solution; the obtained solution is subjected to ultrasonic treatment for 30 min, and catechin modified self-assembled MWCNT-COOH is obtained; aM, BACA and KPS are added into the obtained catechin modified self-assembled MWCNT-COOH solution, deionized water is added to dilute the solution, and the dilution multiple is 10 times. And placing the solution in a drying oven, keeping at 60 DEG C for 6 hours, then placing in a refrigerator, refrigerating at 4 DEG C, and standing for 12 hours to obtain the conductive hydrogel with high transparency and high mechanical property. The preparation process is simple and easy to implement, the raw materials are stable in property, and the biocompatibility is high.

The invention relates to the technical field of blueberry puree preparation, and relates to a blueberry puree prepared based on cryogenic grinding, oxidation and isolation. The blueberry puree comprises the following components in parts by weight: 90-100 parts by weight of blueberries, 0.1-0.5 parts by weight of a composite stabilizer, 1-5 parts by weight of a honey protective agent, 0.03-0.05 parts by weight of an L-cysteinease inhibitor, and 0.3-0.7 parts by weight of a citric acid buffer. The composite stabilizer is obtained by mixing phytic acid, sodium pyrophosphate, and modified catechin in a ratio of 1:0.2-0.6:1-3, and the modified catechin is prepared by a glycosylation reaction of catechin and rhamnose in the presence of a rhamnosyltransferase catalyst. The composite stabilizer is used to improve the antioxidant capacity and the ability to stabilize active components in the blueberry puree preparation process, thereby extending the shelf life. At the same time, the cryogenic grinding, oxidation and isolation preparation technology is used to retain the nutrients and active substances in the blueberries to the greatest extent, thereby ensuring the high quality of the product.

The invention discloses oral multi-effect analgesic and anti-inflammatory gel and a preparation method thereof, and belongs to the technical field of medical gel. The gel is prepared from mussel mucin grafted hydroxypropyl chitosan, a poly (N-isopropylacrylamide)-co-acrylic acid copolymer, quercetin-zinc coordination nanoparticles, a local anesthetic compound wrapped by temperature-sensitive lipidosome, a gamma-polyglutamic acid-catechin gel matrix, aloe polysaccharide, dipotassium glycyrrhizinate, and sodium hyaluronate and potassium sorbate which can be selectively added, wherein the local anesthetic compound is prepared from the mussel mucin grafted hydroxypropyl chitosan, the poly (N-isopropylacrylamide)-co-acrylic acid copolymer, the quercetin-zinc coordination nanoparticles, the temperature-sensitive lipidosome, the gamma-polyglutamic acid-catechin gel matrix, the aloe polysaccharide and the dipotassium glycyrrhizinate. During preparation, part of the components and water are stirred to obtain a mixed solution, and then the other components are added and stirred into gel. According to the gel, the leakage rate of local anesthetics is reduced by stabilizing the liposome through the zinc ions, the quercetin adjusts the phase transition temperature of the liposome to realize preferential drug release at the pain part, the mussel mucin and the copolymer form a reversible hydrogen bond network to enhance the mucous membrane adhesive force, and the inflammatory environment triggers the gel permeation drug release, so that the gel has the advantages of multiple-effect synergy, strong adhesion and the like; the problems that existing oral gel is short in analgesia time and insufficient in anti-inflammation can be effectively solved.

The present invention provides a method for identifying HPLC characteristic spectra of bergenia medicinal materials, decoction pieces, extracts and their formula particles, comprising the following steps: A) dissolving a test sample with a solvent, extracting, and obtaining a test solution; B) determining the test solution with high performance liquid chromatography to obtain HPLC characteristic spectra of bergenia medicinal materials, decoction pieces, extracts and their formula particles; the chromatographic conditions of the high performance liquid chromatography are: the chromatographic column is a C18 column; the mobile phase A is methanol, and the mobile phase B is a 0.1% phosphoric acid solution, and the gradient elution. The present invention adopts high performance liquid chromatography, selects methanol-0.1% phosphoric acid solution as the mobile phase for gradient elution, and uses arbutin, gallic acid, catechin, bergenin, and ellagic acid as reference substances to establish HPLC characteristic spectra of bergenia medicinal materials, decoction pieces, extracts and their formula particles, with good repeatability and precision, stable and reliable methods, and can control the quality of bergenia medicinal materials, decoction pieces, extracts and their formula particles.

This invention relates to a method for manufacturing a catechol-containing co-polymer through a suspension polymerization or a solution polymerization process. In some illustrative embodiments, this disclosure relates to a process of a free radical suspension polymerization for large-scale manufacturing catechol-containing copolymers. In some other illustrative embodiments, this disclosure relates to a solution polymerization of free radical, cationic, or anionic process for large-scale manufacturing catechol-containing copolymers. The process and the product thereof are within the scope of this disclosure.

The present invention provides an oral composition that can be used for anti-obesity, suppressing fat absorption, suppressing an increase in neutral fat, suppressing sugar absorption, suppressing an increase in blood sugar level, reducing body fat, or reducing BMI. An oral composition containing gallic acid and catechins, The oral composition has a mass ratio of gallic acid:catechins=1:0.1 to 5. The oral composition preferably further contains ellagic acid. It is also preferably used for anti-obesity, suppression of fat absorption, suppression of increase in neutral fat, suppression of sugar absorption, suppression of increase in blood glucose level, reduction of body fat, or reduction of BMI.

To provide fish and shellfish feed, fish and shellfish feed additives, a method for producing fish and shellfish feed, and a method for raising fish and shellfish that can produce fish and shellfish in good health. [Solution] The following components (A) and (B): (A) Non-polymerized catechins 0.001-1.5% by mass (B) Oligosaccharides A fish and shellfish feed containing [this ingredient].

The invention relates to a traditional Chinese veterinary medicine preparation for treating piglet diarrhea as well as a preparation method and application of the traditional Chinese veterinary medicine preparation. The traditional Chinese medicine composition is prepared from the following raw materials and auxiliary materials, wherein the raw materials comprise poria cocos, humifuse euphorbia herb, catechu, smoked plum, scorched hawthorn fruit, radix paeoniae alba, liquorice, fructus evodiae, radix aucklandiae, rhizoma atractylodis macrocephalae and hawthorn fruit; the auxiliary materials comprise a disintegrating agent modified starch, a filling agent dextrin, a flavoring agent sucrose and steviosin; the mass ratio of the raw materials to the auxiliary materials is 1: (1-3), starch, mannitol, dilauroyl peroxide and a solvent DMSO react to obtain cross-linked starch, and then the cross-linked starch, water, anhydrous sodium sulfate, sodium chloride, acetic anhydride and a sodium hydroxide solution react to obtain the modified starch. According to the present invention, the piglet diarrhea can be effectively treated, the drinking water administration mode is adopted, the advantages of accurate metering, rapid effect, convenient administration and the like are provided, the clinical medication safety on piglets is high, the growth performance of piglets is not affected, and the method is suitable for mass production and large-scale use.

The present application belongs to the field of metal wire cleaning, and provides a cleaning and passivation method for special-shaped copper wire with grooves and small wire diameter; first, the copper wire is pre-blowed by an annular air knife to remove surface attachments, and is introduced into a groove guide water pipe; then, directional hot water consistent with the groove direction of the copper wire is used for strong flushing, and catechin gel mother liquor is added in the cleaning liquid and a brush is arranged for cooperative brushing; the copper wire is introduced into an ultrasonic cleaning tank for reciprocating deep purification, and the purified copper wire is introduced into a hot air duct arranged in the groove for deep dehydration and guide flow drying; the copper wire is introduced into a passivation chamber provided with an ultrasonic atomizer, and a passivation liquid containing a succinimidazole agent is atomized into uniform fine mist droplets to cover the copper wire; after the copper wire is finally dried by hot air, film formation and solidification are completed, and then the copper wire is wound, effectively solving the problems of difficult cleaning of special-shaped copper wire grooves and uneven passivation film, and improving the surface quality and oxidation resistance of the product.

The present inventors provide strong evidence that FGFR3 gain-of-function mutations expressed in the brain induce cognitive and behavioral disorders. To provide evidence that the constitutive activation of FGFR3 and its downstream signaling pathways are responsible for these behavioral disorders, the present inventors used subcutaneous injections of catechin isomers for at least 7 days to investigate the effects of FGFR3 on cognitive and behavioral disorders. A385E / + Furthermore, the present inventors treated mice with Fgfr3 N534K / + Mice are treated with bottle treatment. Treatment restores abnormalities in short-term learning and coping strategies.Therefore, the present invention relates to a method for treating FGFR3-related cognitive impairment in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one catechin.

The invention discloses a platelet increasing capsule characteristic chromatogram and a construction method and application thereof, and belongs to the technical field of quality control of traditional Chinese medicine compound preparations. According to the method, 13 control components including gallic acid, catechin, paeoniflorin, forsythiaside B, benzoic acid, astragalus smicus glycoside, forsythin, arctiin, liquiritigenin, benzoyl paeoniflorin, paeonol, arctigenin and indirubin are selected, a high performance liquid chromatography-mass spectrometry technology is applied, multiple batches of preparation samples are analyzed, and the content of the components in the preparation samples is determined. And establishing a characteristic spectrum of the chemical components. Compared with a traditional method, the technology has good precision and reproducibility, the data result is accurate and reliable, meanwhile, the technology can identify the 13 components at the same time under the same chromatographic condition, the analysis efficiency is remarkably improved, synchronous monitoring of multiple effective components is achieved, and the consistency and stability of the preparation quality can be guaranteed.

The invention discloses an MBBR (Moving Bed Biofilm Reactor) composite modified filler as well as a preparation method and application thereof, the MBBR composite modified filler comprises the following raw material components in parts by mass: 5-15 parts of elemental iron-carbon powder, 80-95 parts of a framework material, 5-10 parts of a corrosion inhibition carbon source and 3-5 parts of paraffin oil, wherein the corrosion inhibition carbon source comprises modified chitosan and starch, and the mass ratio of the modified chitosan to the starch is (1.5-4): 1; the modified chitosan comprises chitosan, 2-hydroxy-1, 4-naphthoquinone which is grafted on the chitosan through a-C = N-bond, and catechin which is grafted on the 2-hydroxy-1, 4-naphthoquinone. The iron-carbon micro-electrolysis technology is combined with the MBBR process, so that the biodegradability of the refractory wastewater is improved, and the wastewater treatment effect of the MBBR process is improved.

The invention discloses an application of a catechin derivative WM-21 in preparation of neuroprotection and anti-neuroinflammation drugs, and belongs to the technical field of biomedicines.The catechin derivative WM-21 is (2R, 3S)-2-(3, 4-dihydroxyphenyl)-6-((E)-styrene) chroane-3, 5, 7-triol (C22H19O6), and the chemical structural formula of the catechin derivative WM-21 is shown in the formula (I); the catechin derivative WM-21 provided by the invention has a neuroprotective effect on a plurality of nerve cells, has certain application potential in preparation of neuroprotective drugs, and is beneficial to prevention or alleviation of nervous system diseases. # imgabs0 #