6 results about "Arecoline" patented technology

The present invention discloses a traditional Chinese medicine preparation for preventing and / or treating myocardial infarction, its preparation method and application, belonging to the technical field of pharmaceuticals. The traditional Chinese medicine is obtained by extracting Areca catechu with 20% - 95% ethanol. The present invention first reveals that the Areca catechu extract has an anti-myocardial infarction effect. The experimental results show that the crude extract of Areca catechu can significantly inhibit H2O2-induced cardiomyocyte death, improve the left ventricular ejection fraction of myocardial infarction mice, and reduce the myocardial infarction area, and the effect is equivalent to that of the positive drug Suxiao Jiuxin Pills, while arecoline has no cardiomyocyte protection effect. The present invention is of natural origin, simple to prepare, and low in cost, and can be used as a new supplement or alternative for clinical prevention and treatment of myocardial infarction, and has important clinical value and application prospects.

This application provides a composition and a product thereof. The composition includes arecoline and an acid. The composition is convenient to use and widely used, with a low pH value and weak irritation.

This invention utilizes *Allium macrostemon* to obtain its aqueous extract, petroleum ether extract, dichloromethane extract, ethyl acetate extract, and n-butanol extract. The effects of these aqueous extracts and extracts of different polarities on the learning and memory functions of D-galactose-induced aging model mice were investigated using Y-maze, darkness avoidance, Morris water maze, and laser speckle cerebral blood flow assays. Reactive oxygen species (ROS), SOD, and MDA were also measured. Multiple experiments demonstrated that *Allium macrostemon* can improve memory function in mice. Furthermore, the effects of *Allium macrostemon* extract on arecoline- or oxidative tremor-induced tremor behavior in mice were studied. The results showed that *Allium macrostemon* extract can effectively shorten the duration of tremors, proposing a new application for *Allium macrostemon* extract in the preparation of drugs for the prevention and / or treatment of neurodegenerative diseases, providing broad application prospects for the treatment or adjuvant therapy of neurodegenerative diseases.

The application discloses an arecoline ester derivative, a preparation method and application thereof, relates to the technical field of chemical pesticides, and has a brand-new molecular structure, and the bacteriostatic activity and insecticidal activity of the arecoline ester derivative are significantly enhanced compared with arecoline; the arecoline ester derivative has certain inhibiting effects on Puccinia recondita, Diplodia natalensis, Gibberella saubinetii, Pyricularia grisea, Phomopsis vexans, Physalospora piricola, Pestalotiopsis versiflorea, and Colletotrichum gloeosporioides; and the arecoline ester derivative also has certain insecticidal activity on Aedes aegypti larvae.

This invention discloses an enantioselective imine reductase mutant and its application in the production of S-arecoline, belonging to the field of enzyme engineering technology. The imine reductase mutant is obtained by single- or multi-point mutation of the substrate-binding pocket key amino acid site of wild-type imine reductase derived from *Pseudomonas* sp. RC4D1. This mutant can efficiently catalyze the asymmetric reduction of pseudo-arecoline, maintaining high enzyme activity while increasing the optical purity of the product S-arecoline to 99.9%. Combined with a glucose dehydrogenase coenzyme cycle system, it significantly reduces production costs. The reaction conditions are mild and environmentally friendly, enabling the industrial-scale production of S-arecoline and providing a high-purity raw material for fiber-free areca chewing gum.

The application discloses a multi-layer embedding areca alkaloid sustained-release system and a preparation method and application thereof, relates to the technical field of areca alkaloid, and the sustained-release system comprises an areca alkaloid core layer, an antioxidation layer and a protective layer. The areca alkaloid sustained-release core layer is located in the innermost layer, the antioxidation layer is wrapped outside the sustained-release core layer, and the protective layer is wrapped outside the antioxidation layer. The areca alkaloid is wrapped by the sustained-release core layer, the antioxidation layer and the protective layer in sequence, can effectively resist the damage of gastric acid and other environmental conditions to the structure of the areca alkaloid, prevents the oxidation inactivation of the areca alkaloid, realizes the target of targeting the intestinal tract of the active areca alkaloid, and meanwhile, can avoid the contact of the areca alkaloid with other organ tissues, and reduces the side effects of the areca alkaloid.