The invention relates to disease-resistant highly-effective expanded compound feed for trachinotus ovatus. The feed is made of raw materials in the following weight ratios: imported steam fish meal 13-40, imported straight fire fish meal 10-30, biological fish meal ABP600 5-8, soybean meal 5-10, fermented soybean meal 5-8, soya meal 2-4, cotton seed meal 3-5, rape seed meal 3-5, meat and bone meal 3-8, cuttlefish meal 2-5, strong flour 25-33, blood meal 1.0-3.0, soybean lecithin 1.0-3.0, harp seal oil 2.0-5.0, choline chloride (5 percent) 0.4-1.0, vitamin C-phosphate ester (35 percent) 0.1-0.3, calcium dihydrogen phosphate 0.5-1.5, compound vitamins 0.2-0.5, compound mineral salt 0.5-1.5, phagostimulant 0.1-0.3, micro-ecological preparation 0.1-0.3, Beta-1,3 glucan 0.1-0.3, A3Alpha peptidoglycan 0.03-0.08, phytase 0.01-0.04, and non-starch polysaccharase 0.04-0.08. Cultivation experiments prove that the compound feed can meet all the requirements on nutrition of trachinotus ovatus cultivation in mesh cages and ponds, the cultivated trachinotus ovatus grow rapidly, the feed conversion rate is high, the color of the feed is vivid, the feed coefficient is between 1.8-2.1, the cultivation benefit is remarkable, the vitality of the cultivated trachinotus ovatus is good, the survival rate thereof is 6.0-10.5 percent higher than the survival rate when feed of other brands is used, and the death rate during long-distance transportation is reduced by over 60 percent.