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46 results about "Bitter orange extract" patented technology

Bitter orange extract is taken from the peel of bitter oranges, which originated in Asia, and can now be found mostly in Europe, South America, and the United States.

Method for extracting high-purity neohesperidin from immature bitter orange

The invention discloses a method for extracting high-purity neohesperidin from an immature bitter orange. The method comprises the following steps: (1) crushing and impregnating an immature bitter orange raw material in water, adding a compound plant-hydrolase preparation, and performing enzymatic decomposition to obtain an enzymatically decomposed immature bitter orange; (2) performing heating extraction, cooling, centrifugation and filtration on the enzymatically decomposed immature bitter orange to obtain enzymatic immature bitter orange extract; (3) performing water bath heat preservation on the enzymatic immature bitter orange extract, adding a flocculating agent for flocculation treatment, and performing centrifugation and filtration to obtain immature bitter orange flocculation liquid; (4) performing nanofiltration, concentration and vacuum drying on the immature bitter orange flocculation liquid to obtain a neohesperidin crude product; (5) completely dissolving the neohesperidin crude product in an ethanol solution, performing strict filtration, and repeatedly performing cooling crystallization, washing and vacuum drying to obtain a high-purity neohesperidin product. The purity of the product obtained by the method can reach 98.6 percent, and the final yield is more than 90 percent; the method is simple in process, high in operability, low in energy consumption and cost, suitable for industrial production, small in ethanol residue amount, environment-friendly and safe.
Owner:HUNAN HUACHENG BIOTECH

General flavone extractive of immature bitter orange or bitter orange extracted through water decoction and use of general flavone extractive

ActiveCN102048874ASignificantly promote gastric motilitySignificant gastric motilityDigestive systemPlant ingredientsEructationImpurity
The invention relates to a general flavone extractive of an immature bitter orange or a bitter orange. The general flavone extractive is extracted through the following steps: cutting the immature bitter orange or the bitter orange into decoction pieces or smashing the immature bitter orange or the bitter orange, adding 4 to 15 times of water, decocting 1 to 3 times (1 to 3 hours each time), merging the decoction liquids, filtering through processed non-polar big hole resin, eluting by water and alcohol of which the concentration is lower than 20 percent sequentially to remove impurities, eluting by alcohol of which the concentration ranges from 25 to 90 percent and sodium hydrate of which the concentration ranges from 0.5 to 2 percent, collecting alcohol eluant, depressuring and concentrating to obtain a liquid extract of which the relative density is 1.20 to 1.40 (under the temperature ranging from 50 DEG C to 70 DEG C), depressuring and drying under the temperature ranging from 60 DEG C to 80 DEG C, and smashing to obtain the general flavone extractive of the immature bitter orange or the bitter orange. The extractive can be used for preparing medicines used for curing gastrointestinal dyskinesia-type functional indigestion, epigastralgia, abdominal distention, asitia, eructation, nausea, and vomit caused by chemotherapeutics and other reasons, and is prepared into dosage forms acceptable for pharmacology.
Owner:JIANGZI QINGFENG PHARMACEUTICALS INC

Preparation method of water-soluble immature bitter orange extract with bitterness removed

The invention discloses a preparation method of a water-soluble immature bitter orange extract with bitterness removed. The method comprises steps as follows: step one, selecting an immature bitter orange extract containing 10% of synephrine, dissolving the immature bitter orange extract with 10 times of water, heating the solution to the temperature of 70 DEG C to prepare an immature bitter orange extract aqueous solution; step two, adding 1% of an aqueous solution of 5% of a clarifying agent ZTC-B of dry powder to the immature bitter orange extract aqueous solution in step one, performing stirring and heating for 10 min, and adding 1% of an aqueous solution of 5% of a clarifying agent ZTC-A of dry powder, and performing stirring and heating for 10 min; step three, subjecting a filtered filtrate to macroporous adsorption resin HPD-600 to adsorb flavonoid bitterness ingredients of the immature bitter orange extract until the effluent is free of bitterness to obtain the immature bitter orange extract with bitterness removed; step four, performing water elution on the resin column to obtain a water solution; step five, merging, concentrating and drying the water solution and the effluent to obtain the water-soluble immature bitter orange extract with bitterness removed finally. The method has very good technical effects.
Owner:SHAANXI TEEGOO BIOTECH CO LTD

General flavone extractive of immature bitter orange or bitter orange extracted through water decoction and use of general flavone extractive

ActiveCN102048874BSignificantly promote gastric motilitySignificant gastric motilityDigestive systemPlant ingredientsEructationImpurity
The invention relates to a general flavone extractive of an immature bitter orange or a bitter orange. The general flavone extractive is extracted through the following steps: cutting the immature bitter orange or the bitter orange into decoction pieces or smashing the immature bitter orange or the bitter orange, adding 4 to 15 times of water, decocting 1 to 3 times (1 to 3 hours each time), merging the decoction liquids, filtering through processed non-polar big hole resin, eluting by water and alcohol of which the concentration is lower than 20 percent sequentially to remove impurities, eluting by alcohol of which the concentration ranges from 25 to 90 percent and sodium hydrate of which the concentration ranges from 0.5 to 2 percent, collecting alcohol eluant, depressuring and concentrating to obtain a liquid extract of which the relative density is 1.20 to 1.40 (under the temperature ranging from 50 DEG C to 70 DEG C), depressuring and drying under the temperature ranging from 60 DEG C to 80 DEG C, and smashing to obtain the general flavone extractive of the immature bitter orange or the bitter orange. The extractive can be used for preparing medicines used for curing gastrointestinal dyskinesia-type functional indigestion, epigastralgia, abdominal distention, asitia, eructation, nausea, and vomit caused by chemotherapeutics and other reasons, and is prepared into dosage forms acceptable for pharmacology.
Owner:JIANGZI QINGFENG PHARMACEUTICALS INC

Pharmaceutical composition for treating cardiovascular diseases and preparation method thereof

The invention discloses a pharmaceutical composition for treating cardiovascular diseases and a preparation method thereof. The pharmaceutical composition comprises the following raw materials in parts by weight: 50-200 parts of a danshen root extract, 30-120 parts of panax notoginseng total saponins, 30-120 parts of a bitter orange extract, 30-200 parts of a Chinese angelica extract, 30-200 parts of a ginger extract, 5-40 parts of a Chinese angelica volatile oil inclusion compound and 5-40 parts of a ginger volatile oil inclusion compound. The preparation method comprises the following steps: preparing the danshen root extract, preparing the panax notoginseng total saponins, preparing the bitter orange extract, preparing the Chinese angelica and ginger extracts, preparing the Chinese angelica and ginger volatile oil inclusion compounds, and mixing the raw materials. The pharmaceutical composition disclosed by the invention has the positive effects that the active ingredients of each medicinal material are fully extracted and purified, the usage amount of a solvent is relatively small, the time is saved, and the production cost is reduced. The pharmaceutical composition can be used for effectively treating ischemic heart diseases of coronary heart disease, angina pectoris, miocardial infarction and the like, and also has the effect of reducing the blood pressure and blood fat.
Owner:吉林修正药业新药开发有限公司 +1
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