The invention discloses a synephrine loaded multiple emulsion and a preparation method thereof and belongs to the technical field of efficacy cosmetics. The multiple emulsion is composed of synephrine, ethanol, lipid material, lipophilic emulsifier, Vitamin E, hydrophilic emulsifier , sodium alginate, humectant, citric acid, preservative agent, water-soluble essence and deionized water. The method comprises the following steps: taking the components of the multiple emulsion as raw materials; and preparing internal water phase of the synephrine, the liquid oil phase of the synephrine and external water phase of the synephrine respectively. The method has the advantages of simple process, low energy consumption, good safety and the like. The multiple emulsion has the efficacy of oxidation resistance, moisture holding and partial weight losing, has nonirritant and no side effects, and also has characteristics of favorable high-temperature resistance and low temperature resistance, high stability and the like. The method can be widely applied to prepare active ingredient loaded multiple emulsions, and is particularly suitable for preparing the synephrine loaded multiple emulsion. The synephrine loaded multiple emulsion can be widely applied to cosmetics and pharmaceuticals.