96 results about "Synephrine" patented technology

Chewing gum compositions comprising synephrine, ephedrine and caffeine are provided. The compositions are useful for supporting thermogenesis and anorectic effects, while generating enhanced mental alertness and improved energy levels.

Materials derived from Citrus plants can be administered orally to humans for the purpose of producing or maintaining weight loss as well as improving the person's physical performance and increasing the person's lean muscle mass. The Citrus materials include those portions of the plant that are normally considered waster or inedible, such as the leaves, peel and immature, unripe fruit. The materials contain as least one of the alkaloids from the group consisting of synephrine, hordenine, octopamine, tyramine and N-methylamine. Two species, Citrus aurantium and Citrus reticulata, are particularly useful. The materials can be administered in their natural form or as extracts, and can be administered in various ways including capsules and tablets. The Citrus materials may also be used as a tea. For weight loss and weight control, the materials can be administered concurrently with caloric restriction or in the absence of caloric restriction. The materials may also be administered for the purpose of increasing muscle mass concurrently with a high protein diet as well as with an exercise program.

The invention discloses a method for separating high-purity hesperidin, neohesperidin, naringin and synephrine from fructus aurantii Immaturus, and relates to a method for extraction of effective components of traditional Chinese medicines. The method includes the following steps: (1) enzymolysis, (2) extraction, (3) membrane separation, (4) synephrine separation, (5) naringin separation, (6) neohesperidin separation, and (7) hesperidin separation. The method has the advantages that the method overcomes the shortcomings in prior art, provides a new effective method which is easy to industrially produce, and is capable of combined extraction and separation various effective components in the fructus aurantii Immaturus, the method has the advantages of simple operation, high extraction rate, and high purity of the effective components, and the effective components all are separated, and easy to use.

The invention relates to a cigarette substitute and a preparation method thereof. The method mainly comprises the steps of: performing dehydration treatment on petals of one or more natural flowers and grasses (such as lavender, orange blossom, rose, jasmine, Osmanthus fragrans and the like), leaves of tea (such as green tea, jasmine tea, tea served without refreshments, oolong, iron Goddess, puertea, black tea and the like) or peels of fruits (such as apples, Chinese dates, oranges, tangerines, sunkists, lemons and the like) or a mixture of peels and fruit flesh thereof, and then performingprocessing molding according to the general cigarette manufacturing process, wherein the prior tobacco raw material containing nicotine is substituted. A cigarette prepared by the method has the efficacies that the cigarette cannot cause the hazard to human health, can also emit flowery odor, tea aroma or fruity flavor, and helps to improve the smell of the environment during the combustion; and in addition, the natural ingredients contained in natural fruit peels such as citric acid, vitamin P, vitamin C, synephrine, citrus acid and flavonoids are beneficial to human bodies, thereby further achieving the efficacies of losing weight and decreasing fat, caring skin and whitening, resisting oxidation, anti-aging and the like.

The invention relates to a method for extracting pectin and synephrine by utilizing peels and marc. The pectin comprises three types of protopectin, water soluble pectin and pectic acid, wherein the former is not soluble in water, and the two latter are both soluble in the water. A great number of pectin components and synephrine components exist in the peels and the marc. In the invention, a pectin product is prepared by utilizing a biocatalyst without high temperature and high pressure reaction in the production process, extracting the pectin through effective bonding of acidolysis and enzyme, eliminating the destructive action of pectinase to the pectin through high temperature enzyme killing, releasing the pectin and the synephrine under an acid condition, and extracting and purifying the pectin through a subsequent extraction technology; and a synephrine product is also prepared through resin adsorption, falling film evaporation in waste liquid after the pectin product is prepared. The invention does not relate to toxic chemicals and operation under the room temperature and the normal pressure, is suitable for large scale industrialization, and can dramatically lower the production cost.

The present invention provides compositions and methods that assist in providing weight control. Compositions comprise Caffeine, an adrenergic amine (e.g. synephrine, hordenine, octopamine, tyramine and N-methyltyramine,) forskolin, Guggulsterones, an alpha-2 receptor antagonist (e.g. Yohimbine) and a vinca alkaloid (e.g. vinpocetine.) Black pepper extract may be added as well in various alternative embodiments. Methods utilizing administration of nutrient compositions are disclosed as well.

The invention discloses a method for extracting synephrine and hesperidin from citrus aurantium, and relates to a method for producing and processing traditional Chinese medicine. The method comprises the following steps of: step 1, washing and crushing a citrus aurantium raw material into citrus aurantium granules; adding an acid solution for soaking the citrus aurantium granules, then carrying out percolation and extracting extract, concentrating the extract under the reduced pressure to obtain extractum, and drying the extractum under the reduced pressure to obtain synephrine; step 2, adding a weak base solution into the leached citrus aurantium granules which are extracted after being soaked by the acid solution, carrying out decoction and removing impurities, then adding a mixed solvent of sodium hydroxide and calcium chloride into the citrus aurantium granules, and extracting to obtain extract; step 3, adding hydrochloric acid into the extract for neutralization until the pH value is 3-7, standing still and crystallizating; and step 4, collecting crystalline, and drying to obtain the hesperidin. Compared with the prior art, the method can be used for extracting two components without using an organic solvent, so that the production cost is reduced, the production technology is simplified, the synephrine yield is more than 15%, the content of the synephrine is more than 10%, the hesperidin yield reaches more than 27%, and the content of the hesperidin is more than 96%; and therefore, the method is suitable for industrialized mass production.

A stimulant-containing nutrition bar where the stimulant added to the bar exhibits a physical structure which is compatible with the manufacturing process used to prepare a nutrition bar. Simultaneously, the physical structure and the chemical composition of the stimulant reduces the amount of bitter taste which is experienced by a person eating the nutrition bar. Stimulants of the kind which are useful in the nutrition bar must be approved as food grade materials and are typically selected from the group consisting of caffeine, theobromine, green tea with high EGCG, taurine, ginseng, synephrine, and combinations thereof. The amount of stimulant present in the nutrition bar ranges from about 0.08% by weight to about 0.16% by weight of the nutrition bar.

The invention discloses a method for extracting levo-synephrine from green tangerine orange peel. The method comprises the following steps: refluxing and extracting the levo-synephrine in green tangerine orange peel powder twice by 15 to 45 percent alcohol at a temperature of 80 DEG C, decompressing and concentrating the extract to 80 to 85 percent of solid which is placed on a D101 macroporous absorption resin column, and eluting the solid by 15 percent alcohol; decompressing and concentrating the eluant to obtain a crude product of the levo-synephrine after spraying and drying; dissolving the crude product of the levo-synephrine by pure alcohol, adding silica gel with the same mass as the crude product, stirring the mixture evenly, removing the alcohol, preparing a silica-gel adsorption sample, sampling by a dry method, using the eluant prepared by methylene chloride and methanol as well as ammonia water the volume ratio of which are 6-9:2:0.1 to elute and collect the levo-synephrine component; and decompressing and concentrating the levo-synephrine component separated and eluted by the silica gel column, and obtaining the levo-synephrine product after spraying and drying. The content of the synephrine in the product prepared by the method is higher than 90 percent.

The invention discloses a method for simultaneously determining twenty-two flavones and phenolic acids in citrus fruits by adopting high performance liquid chromatography-diode array detector-fluorescence detector (HPLC-DAD-FLD). The method is capable of simultaneously determining twenty-two phenolic compounds in citrus fruits such as gallic acid, synephrine, chlorogenic acid, protocatechuic acid,caffeic acid, p-coumaric acid, rhamnosylvitexin, eriocitrin, ferulic acid, rutin, benzoic acid, narirutin, naringin, hesperidin, diosmin, neohesperidin, quercetin, naringenin, kaempferol, nobiletin,hesperetin, acacetin and the like, derivatization is not needed, and the method is high in accuracy, high in sensitivity and excellent in repeatability.

The invention discloses a method for detecting a Simotang preparation. The method is characterized in that: high performance liquid chromatography detection is carried out on a test sample of the Simotang preparation, and a chromatographic condition is selected from one of the following two modes: a mode 1 is characterized in that: the chromatographic column is a strongly cationic exchange chromatographic column, the mobile phase comprises methanol and an aqueous solution with a volume percentage of 0.2% and a pH value of 3.8 according to a volume ratio of 40-80:60-20, and the detection wavelength is 215nm; and a mode 2 is characterized in that: the chromatographic column is an octadecylsilane bonded silica gel column, the mobile phase comprises methanol and an aqueous solution of SDS and with a mass percentage of 0.1% according to a volume ratio of 50:50, the flow velocity is in a gradient mode, and the detection wavelength is 230nm. The method of the invention, which allows three alkaloid components of arecolidine, synephrine and norisobolidine in the Simotang preparation to be simultaneously determined, the resolution of chromatographic peaks, a theoretic stage number, a symmetry factor, and the peak purity obtained through the method to be good, and a linear relation between the concentration and the peak area to be good in a large concentration range, has the advantages of excellent precision, repeatability and accuracy.

The invention relates to the technical field of plant separation and extraction, and in particularly discloses a method of combined extraction of essential oil, pectin, hesperidin, synephrine and limonin from citrus. The method comprises the following steps: inactivating the citrus, buffing and performing enzymolysis to obtain essential oil, a water phase and skin residues; separating the water phase through strong acidic cation-exchange resin to collect effusive liquid, and eluting to obtain synephrine; separating the effusive liquid using ultra-filtration method to obtain pectin and liquid passing through the ultra-filtration film; refluxing and extracting the liquid passing through the ultra-filtration film using ethanol to obtain supernatant and filter residue; crystallizing, and freeze-drying the filter residues to obtain aurantiamarin; separating the supernatant using macroporous resin, and eluting using ethanol to obtain limonin. The method is used for processing fresh citrus to co-produce the citrus pericarp essential oil, pectin, hesperidin, synephrine and limonin; the utilization rate of the resource is improved, the environment pollution is reduced, and the economic and social benefits are notable.

The invention discloses an orange active ingredient extraction method which dries and crushes orange seedcase or green orange fruit, and then takes supercritical fluid as extraction medium for the extraction. Through the extraction method, the extractive orange active ingredient has high purity without pollution during the extraction process, and the technique is simple; the method can also extract the alkaloid such as the active ingredient synephrine with pertinence. The extraction method provides a new method for the orange active ingredient extraction and utilization.

The invention provides a quality control method for a traditional Chinese medicine composition for treating infantile indigestion with food retention, relating to a quality control method for traditional Chinese medicine compositions. The quality control method comprises one or more of the following methods: 1, a test article prepared in the invention and an emodin comparison substance are respectively dripped on one silica gel G thin-layer plate containing sodium cellulose glycolate as an adhesive for performing chromatographic comparison; 2, a test article prepared in the invention and a dehydrocostuslactone comparison substance are respectively dripped on one silica gel G thin-layer plate containing sodium cellulose glycolate as an adhesive for performing chromatographic comparison; and 3, a test article prepared in the invention and a synephrine comparison substance are respectively dripped on one silica gel G thin-layer plate containing sodium cellulose glycolate as an adhesive for performing chromatographic comparison. According to the quality control method provided by the invention, the components for identifying medicinal materials and assaying are selected by screening the medicinal materials, thus effectively controlling the product quality and obtaining higher accuracy, sensitivity and stability of the method.

The invention relates to a technology for jointly extracting synephrine, hesperidin and PMFs (polymethoxy latednavones) from fructus aurantii immaturus. The technology comprises the following steps: a, smashing fructus aurantii immaturus, and subpackaging equal quantity of the smashed fructus aurantii immaturus in a percolation tank I and a percolation tank II respectively; adding a dilute acid solution in the percolation tank I, soaking, stirring and percolating; adding effluent liquid into the percolation tank II, soaking, stirring and percolating; mixing the leachate, performing vacuum concentration, adsorbing synephrine by a resin column, desorbing and collecting a desorption solution by using weak aqua ammonia, and performing vacuum drying to obtain dried synephrine; b, washing fructus aurantii immaturus dregs to be neutral with clear water, soaking with a dilute strong base solution, stirring, percolating, performing vacuum concentration, adding absolute methanol or absolute ethyl alcohol, performing still standing, filtering, performing vacuum concentration on the filtrate, and recycling alcohol to obtain a mother solution; c, adsorbing PMFs from the mother solution through the resin column and a chromatographic column, enabling methyl alcohol or ethyl alcohol to pass through the columns for desorbing under static pressure, collecting the stripping liquid, performing vacuum concentration, and recycling an eluent to obtain PMFs; acidizing the effluent liquid passing through resin, standing, and performing devitrification to obtain dried hesperidin.

Materials derived from Citrus plants can be administered orally to humans for the purpose of producing or maintaining weight loss as well as for improving the person's physical performance and increasing the person's lean muscle mass. The Citrus materials include those portions of the plant that are normally considered waste or inedible, such as the leaves, peel, and immature, unripe fruit. The materials contain at least one of the alkaloids from the group consisting of synephrine, hordenine, octopamine, tyramine and N-methyltyramine (1). Two species, Citrus aurantium and Citrus reticulata, are particularly useful. The materials can be administered in their natural form or as extracts, and can be administered in various ways including capsules and tablets. The Citrus materials may also be used as a tea. For weight loss and weight control, the materials can be administered concurrently with caloric restriction or in the absence of caloric restriction. The materials may also be administered for the purpose of increasing muscle mass concurrently with a high protein diet as well as with an exercise program.

The invention provides a method for extracting naringin, synephrine and pectin from young shaddock fruits. The method comprises the following steps: performing extraction on steamed young shaddock fruits for one time or a plurality of times with water, and combining extracting solution and collecting residues; adding water-soluble halogenated inorganic salt into the extracting solution to separate out naringin crystals; filtering and collecting filtrate and the naringin crystals, wherein the adding amount of the halogenated salt is 10 weight percent to 30 weight percent of the young shaddock fruits; carrying out concentration, drying and halide salt removal on the filtrate obtained by salt separation to obtain a synephrine crude product; dissolving the residues obtained by extracting into water and adjusting the pH (Potential of Hydrogen) to be 1 to 2; heating and carrying out acidolysis; decomposing starch and carrying out enzyme deactivation, de-coloring, pectin gelling, filtering and concentration to obtain the pectin. By adopting the method provided by the invention, the problems of an existing process that the use amount of organic solvents is more, the utilization rate of the raw materials is low and the like are solved.

This invention provides compounds having the structural formula:

wherein:

• • R₁ is an acyl or sulfonyl group,
  • R₂ is an acyl group selected from the group consisting of acyl groups derived from cycloaliphatic, aromatic or heterocyclic monocarboxylic acids, imidazolylcarbonyl and triazolylcarbonyl, and
  • R₃ is hydrogen or an amino-protecting group,

a stereoisomer thereof, a solvate thereof, or a salt thereof, being useful as anti-inflammatory agents and anti-cancer agents.

The invention discloses a tangerine peel brick tea and a preparation method thereof, which are prepared from 100 parts of tea leaves, and 10 to 40 parts of tangerine peel and tangerine peel juice. Thetangerine peel juice is sprayed on the tangerine peel so that the moisture content of the tangerine peel is 40 to 60 percent. Before scenting tangerine peel and tea, the tangerine peel juice is usedto soften the tangerine peel, which is beneficial to scent of the later fragrance, and also helps the tangerine peel on the surface of the tangerine peel adhere to the surface of the tea during the contact with the tea, the dried tangerine peel juice is fixed on the surface of the tea through later drying to increase the taste of tangerine peel in the finished tea. The dried tangerine peel brick tea provided by the invention has the interaction of the tangerine peel fragrance and the tea fragrance, the taste is fresh and sweet after adding water, the tangerine peel fragrance is rich, and the tea fragrance is not lost, and the quality characteristics are distinct. In addition, due to the tangerine peel contains more flavonoids, synephrine, tangerine peel, pectin, orange pigment, vitamin, inositol, synephrine, selenium and copper, the tangerine peel brick tea has both health benefits of tangerine peel and tea, which is a natural and healthy flavored tea.

The invention provides a method for electrochemically detecting synephrine by a polycurcumin-nickel-carbon nanotube paste electrode, and belongs to the technical field of detection of the synephrine. After a carbon rod is prepared into a carbon nanotube paste electrode, cyclic voltammetry scanning is carried out on a three-electrode system composed of the carbon nanotube paste electrode, a platinum-wire electrode and a calomel electrode in a mixed solution of a curcumin solution, a nickel-ammonia compound solution and a sodium hydroxide solution; curcumin is electrically polymerized and nickel (II) is deposited to form the polycurcumin-nickel (II)-carbon nanotube paste electrode; a linear relation between synephrine peak current and synephrine concentration is obtained through the polycurcumin-nickel (II)-carbon nanotube paste electrode by adopting a differential pulse voltammetry, so that the content of the synephrine can be determined. The method provided by the invention is simple to operate, realizes rapid detection and high sensitivity, and can be used for highly sensitively identifying the synephrine in the solution.

The invention relates to a method for extracting effective components in dropped fruit of tangerines and tangerine peels. The method comprises the following steps: degreasing the materials, performing backflow by ethanol with concentration being 75% and performing ultrasonic-assisted extraction to obtain an extract, concentrating the extract and layering the extract by chloroform, and respectively obtaining the high-purity hesperidin finished product, the synephrine finished product and the limonin finished product by using different methods. The method is adapted to industrial production, can increase the comprehensive utilization rate of dropped fruit of tangerines and tangerine peels, increases the economical utilization value, and promotes the further development of a tangerines industry.