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8 results about "Synephrine" patented technology
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Synephrine, or, more specifically, p-synephrine, is an alkaloid, occurring naturally in some plants and animals, and also in approved drugs products as its m-substituted analog known as neo-synephrine. p-Synephrine (or formerly Sympatol and oxedrine [BAN]) and m-synephrine are known for their longer acting adrenergic effects compared to norepinephrine. This substance is present at very low concentrations in common foodstuffs such as orange juice and other orange (Citrus species) products, both of the "sweet" and "bitter" variety. The preparations used in traditional Chinese medicine (TCM), also known as Zhi Shi, are the immature and dried whole oranges from Citrus aurantium (Fructus Aurantii Immaturus). Extracts of the same material or purified synephrine are also marketed in the US, sometimes in combination with caffeine, as a weight-loss-promoting dietary supplement for oral consumption. While the traditional preparations have been in use for millennia as a component of TCM-formulas, synephrine itself is not an approved OTC drug. As a pharmaceutical, m-synephrine (phenylephrine) is still used as a sympathomimetic (i.e. for its hypertensive and vasoconstrictor properties), mostly by injection for the treatment of emergencies such as shock, and rarely orally for the treatment of bronchial problems associated with asthma and hay-fever.
InDel molecular marker closely linked with high-accumulation synephrine and application of InDel molecular marker
The invention discloses an InDel molecular marker closely linked with high-accumulation synephrine and application of the InDel molecular marker. The nucleotide sequence of the InDel molecular marker is shown as SEQ ID No. 1. The kit for identifying the content of synephrine in the citrus germplasm is obtained, the kit is used for identifying high-accumulation and low-accumulation synephrine in the citrus germplasm, and the defects that time and labor are wasted, cost is high and the like when high-accumulation synephrine in the citrus germplasm is judged by means of secondary metabolite content determination in the prior art can be overcome. By utilizing a seedling stage molecular marker diagnosis technology, the dependence of medicinal grapefruit identification on a key period of accumulation of medicinal components can be broken through. The kit can be used for screening a single medicinal grapefruit plant with high synephrine accumulation in pericarp, has the advantages of early screening and low cost, and greatly accelerates the screening efficiency of medicinal grapefruit varieties.
Owner:HUAZHONG AGRI UNIV +2
Extraction process of synephrine and application of synephrine in Xiangsha stomach-nourishing emulsion
The invention discloses an extraction process of synephrine and application of the synephrine in a Xiangsha stomach-nourishing emulsion, and relates to the technical field of pharmaceutical production. According to the method disclosed by the invention, by optimizing the extraction conditions of the synephrine, the alcohol precipitation temperature is 50-60 DEG C and the water precipitation temperature is 40-60 DEG C in the extraction process of the synephrine, so that the problem of loss caused by low-temperature precipitation of the synephrine in the traditional process is solved, and the content of the synephrine in the Xiangsha stomach-nourishing emulsion and the product quality are remarkably improved; meanwhile, the cationic flocculant and the diatomite adsorbent are synergistically added into the concentrated liquid medicine, so that the removal rate of impurities is remarkably increased, and the loss rate of synephrine is reduced. According to the technical scheme, efficient extraction of synephrine and stability improvement of the emulsion are both considered, and the method has remarkable industrial application value.
Owner:JIANGXI GUANGENHE PHARM CO LTD
Determination method and application of a reference sample of daotan decoction and fingerprint spectrum of multiple components
The application belongs to the technical field of traditional Chinese medicine preparation, quality control and detection of components, and discloses a determination method and application of a fingerprint spectrum and multi-component content of a Dautan decoction reference sample. The determination method has good precision, repeatability and stability by optimizing the extraction solvent, extraction mode and chromatography mobile phase of the Dautan decoction reference sample. The obtained fingerprint spectrum has a clean background, good separation effect of common peaks, and the percentage of the area of common characteristic peaks in the total chromatographic peak area is greater than or equal to 85%. Moreover, the content of synephrine, hesperidin, neohesperidin and naringin can be determined. The determination method can effectively evaluate the quality of the Dautan decoction and make up for the blank of the prior art.
Owner:GUANGDONG JINGJING MINGFANG TECH CO LTD
Method and device for separating synephrine and naringin in extract of fructus aurantii
This invention discloses a method and apparatus for separating synephrine and naringin from Citrus aurantium extract, belonging to the field of traditional Chinese medicine separation technology. Based on ion-exchange membrane electrodialysis, this invention utilizes the special properties of ion-exchange membranes to achieve efficient separation of naringin and synephrine from Citrus aurantium extract. By adding acidic solutions such as hydrochloric acid, the alkaloids such as synephrine in the Citrus aurantium extract exist in ionic form, thereby directly separating synephrine and naringin through ion-exchange membrane electrodialysis. This invention can efficiently separate synephrine and naringin from Citrus aurantium extract, recovering over 90% of synephrine, greatly improving the efficiency and safety of synephrine recovery. Simultaneously, sodium chloride and hydrochloric acid can also be recovered, enhancing the economic efficiency of the process. Furthermore, this process consumes no chemical reagents and has low energy consumption, making it an economical, green, environmentally friendly, and highly efficient production method with significant industrial application value.
Owner:ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Use of synephrine in the preparation of medicaments for the treatment of cholestatic liver disease
This invention relates to a novel use of synephrine in the preparation of drugs for treating cholestatic liver disease, belonging to the field of pharmaceutical technology. Cholestatic liver disease is characterized by jaundice and conjugated bilirubin and / or total bilirubin hyperconjugation caused by impaired bilirubin excretion due to various reasons. Its causes include common bile duct stones, pancreatic duct cancer, common bile duct malignant tumors, pancreatic cancer, biliary parasitic diseases, viral hepatitis cirrhosis, alcoholic liver disease, fatty liver disease, drug-induced liver injury, primary biliary cirrhosis, intrahepatic sclerosing cholangitis, and certain congenital diseases such as Dubin-Johnson syndrome and Rotor syndrome. This invention establishes a mouse cholestasis model using bile duct ligation and administers synephrine by gavage to evaluate its protective effect against liver injury. The results showed that synephrine significantly improved jaundice caused by cholestasis, reduced hepatocellular necrosis and inflammatory infiltration caused by cholestasis, alleviated bile duct dilation, decreased serum total bilirubin (TBIL) and direct bilirubin (DBIL), and reduced the levels of total bile acids (BA) in liver tissue and plasma. Furthermore, the above-mentioned effects of synephrine in improving cholestasis showed a clear dose-dependent effect. This invention reveals for the first time the application of synephrine in cholestatic liver disease, demonstrating good safety and promising clinical development prospects.
Owner:NANJING UNIV
Method for synthesizing synephrine through multi-enzyme cascade catalysis
The invention provides a method for synthesizing synephrine through multi-enzyme cascade catalysis, and belongs to the technical field of biology. According to the invention, a multi-enzyme cascade production process from p-hydroxybenzaldehyde to synephrine is systematically carried out for the first time. According to the method provided by the invention, cheap raw materials p-hydroxybenzaldehyde and glycine are taken as substrates, and under the action of L-threonine aldolase, tyrosine decarboxylase and methyltransferase, synephrine is generated through condensation reaction, decarboxylation reaction and methylation reaction. The method provided by the invention has the advantages of easily available raw materials, mild reaction conditions, simple and controllable process and excellent industrial production prospect.
Owner:BEIJING UNIV OF CHEM TECH
System and method for preventing alopecia
PendingUS20260041652A1Salicyclic acid active ingredientsPharmaceutical delivery mechanismSalicylic acidHair follicle
A method for treatment or of traction alopecia comprising applying a composition comprising a pilomotor effective amount of a combination of salicylic acid, synephrine and tyramine, or a pharmaceutically acceptable salt or hydrate thereof, topically to a portion of skin on the head that includes at least one hair follicle to increase the epilatory force threshold of the at least one hair follicle.
Owner:FOLLEA INTERNATIONAL LTD
Ratio electrochemical sensor based on Hem / CNT / Ti3C2Tx ternary composite material and preparation and application thereof
The invention discloses a ratio electrochemical sensor based on a Hemin / CNT / Ti3C2Tx ternary composite material as well as preparation and application of the ratio electrochemical sensor. The method comprises the following steps: dissolving Ti3C2Tx and Hemin / CNT in a polar aprotic organic solvent, carrying out ultrasonic treatment and centrifugation, suspending the obtained Hemin / CNT / Ti3C2Tx in water, dispensing on the surface of a glassy carbon electrode, and drying. The method solves the problems that an existing method is low in sensitivity and poor in interference resistance, and the trace synephrine in the honey cannot be rapidly and accurately detected. Compared with the existing method for electrochemically detecting the synephrine, the ratio electrochemical sensor disclosed by the invention has ultralow detection limit and wider linear range, and is suitable for directly detecting the high-concentration synephrine in complicated samples such as honey and the like.
Owner:XIHUA UNIV