45 results about "Cholestatic liver disease" patented technology

The present invention relates to formulations and methods for preventing and treating liver injury and fibrosis in cholestasis. This is accomplished by the administration of a composition which includes selected antioxidants.

Provided herein are methods of treating or ameliorating hypercholemia or a cholestatic liver disease by administering to an individual in need thereof a therapeutically effective amount of an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating a liver disease, decreasing the levels of serum bile acids or hepatic bile acids, treating or ameliorating pruritis, reducing liver enzymes, or reducing bilirubin comprising administering to an individual in need thereof a therapeutically effective amount of ASBTI or a pharmaceutically acceptable salt thereof.

Provided herein are methods of treating or ameliorating a pediatric cholestatic liver disease by non-systemically administering to an individual in need thereof a therapeutically effective amount of a pediatric formulation comprising an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating a pediatric liver disease, decreasing the levels of serum bile acids or hepatic bile acids, treating or ameliorating pruritis, reducing liver enzymes, or reducing bilirubin comprising non-systemically administering to an individual in need thereof a therapeutically effective amount of a pediatric formulation comprising an ASBTI or a pharmaceutically acceptable salt thereof.

The invention relates to obeticholic acid crystal form I, which is represented in the description, and a preparation method. The preparation method comprises the following steps: dissolving obeticholic acid in an organic solvent to form a solution, wherein the organic solvent is halogenated alkane or ester, and volatilizing the solution until all solvent is completely volatilized so as to obtain the obeticholic acid crystal form I. Compared with the known solid forms of obeticholic acid, the novel crystal form is more stable and is more suitable for being applied to industrial production. The invention also relates to a pharmaceutical composition of the novel crystal form and an application thereof in the preparation of drugs for treating and/or preventing FXR mediated impaired adjustment, cardiovascular disease, cholestatic liver disease, high HDL cholesterol, high triglyceride, and fibrosis diseases.

The invention provides various novel compositions of berberine in combination with pharmacologically active organic acids, and related methods of their use in treating various diseases or disorders. The invention further provides various novel compounds prepared from berberine and pharmacologically active organic acids and prepared from ursodeoxycholic acid and pharmacologically active organic bases, and pharmaceutical compositions thereof, and methods of their preparation and therapeutic use in treating and/or preventing various diseases or disorders. The compounds and pharmaceutical compositions of the invention can be utilized to treat various diseases or disorders, such as diabetes, diabetic complications, dyslipidemia, hyperlipidemia, obesity, metabolic syndromes, pre-diabetes, atherosclerosis, heart diseases, neurodegenerative diseases, sarcopenia, muscle atrophy, inflammation, cancer and liver diseases and conditions such as fatty liver, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, cholestatic liver diseases or graft-versus-host disease of the liver. The compounds of this invention are also useful in improving liver functions in chronic viral associated liver diseases and alcohol-related liver diseases.

The present invention relates to famesoid X receptors (FXR, NR1 H4) FXR is a member of the nuclear receptor class of ligand-activated transcription factors. More particularly, the present invention relates to compounds useful as agonists for FXR, pharmaceutical formulations comprising such compounds, and therapeutic use of the same Novel isoxazole compounds are disclosed as part of pharmaceutical compositions for the treatment of a condition mediated by decreased FXR activity, such as obesity, diabetes, cholestatic liver disease and metabolic syndrome.

The invention relates to application of colchicin in preparing drugs, in particular to application of colchicin in pharmacotherapy of cholestatic liver disease, the application of colchicin in preparing a cholestatic liver disease drug, and the application of colchicin in preparing the drug for treating gestation intrahepatic cholestasis syndrome, inner primary cirrhose biliaire, primary sclerosing cholangitis severe jaundice or immunity jaundice cholestatic liver disease. The colchicin can effectively lower liver injury and cholestasis caused by cholestatic liver disease, i.e. the colchicin can effectively treat cholestatic liver disease. The colchicin can effectively lighten hepatic cell necrosis, inflammatory cell infiltration and bile capillary hyperplasia caused by cholestasis. The colchicin can effectively increase bile acid, bilirubin and expression of phospholipid transporters BSEP, MRP2 and MDR3 in a bile duct, accelerates excretion of bile acid, bilirubin and phospholipid deposited in the body and reduces liver damage.

The invention provides various novel compositions of berberine in combination with pharmacologically active EPA and DHA, and related methods of their use in treating various diseases or disorders. The pharmaceutical compositions of the invention are useful in treating and/or preventing various diseases or disorders, including metabolic diseases or disorders such as dyslipidemia, hyperglycemia, hypertriglyceridemia, hyperlipidemia, diabetic dyslipidemia, diabetic hyperlipidemia, dyslipidemia in statin-intolerance patients, diabetes, diabetic complications, hypercholesterolemia, or obesity. Additionally, the pharmaceutical compositions of the invention are useful in treating and/or preventing atherosclerosis, heart diseases, neurodegenerative diseases, inflammation, cancers, as well as various liver diseases or disorders, such as fatty liver, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, cholestatic liver diseases or graft-versus-host disease of the liver. Furthermore, the pharmaceutical compositions of the invention are useful in improving liver functions in chronic viral associated liver diseases and alcohol-related liver diseases.

The invention discloses an application of peppermint oil dementholized in preparing a medicament for treating cholestatic liver disease.

The invention discloses application of schisandrol B in preparation of a medicine for preventing and treating cholestatic liver disease. By giving an excess amount of lithocholic acid, a mice intrahepatic cholestasis model is made, or a mice extrahepatic cholestasis model is made by bile duct ligation, then the mice intrahepatic cholestasis model and the mice extrahepatic cholestasis model are respectively collaboratively given the schisandrol, liver injury can be effectively alleviated, the bile acid level is reduced, glutamic-pyruvic transaminase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activity are decreased significantly, liver tissue necrosis degree is significantly alleviated, at the same time, total bile acid and total bilirubin content in serum are significantly reduced, and the total bile acid and total bilirubin content discharged with urine are increased. The results show that the schisandrol B can prevent and treat cholestatic liver injury induced by lithocholic acid and bile duct ligation, and prove that the effect mechanism may be involved in regulation of CYP3A11, UGT1A1 and OATP1A4 mediated bile acid metabolism and excretion.

The invention relates to application of flavonone compounds in the preparation of a farnesol X receptor stimulant. The flavonone compounds including dihydromyricetin, astilbin, isoastilbin, engeletin, isoengeletin, dihydroquercetin and dihydrokaempferol have a relatively strong FXR stimulation effect and can be used as a potential farnesol X receptor stimulant. The flavonone compounds including dihydromyricetin, astilbin, isoastilbin, engeletin, isoengeletin, dihydroquercetin and dihydrokaempferol have a remarkable inhibition effect to the active increase of Tbil, ALT, APL and gamma-GT caused due to ANIT-induced cholestasis, are capable of obviously improving the inhibition to ANIT-induced hepatic cell injury, inflammatory cell infiltration and bile excretion, have a relatively good treatment effect to cholestasis type hepatitis and can be used as potential drugs for treating the cholestasis type hepatitis.

The invention provides applications of a poultry bile conversion product in preparing medicines for resisting cholestatic liver diseases. The research shows that the poultry bile conversion product has the effects of improving cholestasis and alleviating liver injuries for a model mouse with the cholestatic liver diseases, can effectively reduce the levels of serum glutamic pyruvic transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bile acid (TBA), cholesterol and total bilirubin (TBIL) of the model mouse, can alleviate the degree of the liver tissue injuries, and has the effect of resisting cholestatic liver diseases. The invention discloses the applications of the poultry bile conversion product in preparing the medicines for resisting cholestatic liver diseases.

The invention relates to application of engelhardia roxburghiana extract in preparing a medicament for treating cholestatic liver disease. The engelhardia roxburghiana extract ER and ER-A2 have certain FXR activating action, and the engelhardia roxburghiana extract ER-A3 and ER-B2 have relatively strong activating action on FXR and can be directly used as a farnesol X receptor agonist. In addition, the engelhardia roxburghiana extract ER-A3 and ER-B1 prepared by the invention have remarkable inhibiting action on activity rise of Tbil, ALT, APL and gamma-GT caused by cholestasis induced by ANIT, obviously improve the hepatocyte damage, inflammatory cell infiltration and bile excretion caused by ANIT and have relatively good therapeutic action on cholestatic liver disease, and can be used as a potential drug for treating cholestatic liver disease.

The invention relates to a novel acid-alkali addition salt containing berberine and organic acid with pharmacological activity, a preparation method of the novel acid-alkali addition salt and an application of the novel acid-alkali addition salt in preparation of medicines for preventing or/and treating various diseases or dysfunction, such as diabetes, diabetic complications, dyslipidemia, and dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, diabetes mellitus combined dyslipidemia, obesity, metabolic syndrome, prediabetes mellitus, inflammation, cancer and various liver diseases or dysfunctions of statin non-tolerant patients, such as fatty liver, non-alcoholic fatty liver, non-alcoholic steatohepatitis, cholestatic liver diseases, liver transplantation versus host diseases, chronic liver diseases caused by viruses, alcoholic liver diseases and the like; the novel acid-alkali addition salt has a wide application prospect.

The invention provides an application of a composition prepared from the following raw materials in preparing drugs for treating cholestatic hepatitis. The pharmaceutical composition is a preparation prepared from the following raw materials in parts by weight: 350-400 parts of hawthorns, 350-400 parts of salvia miltiorrhiza, 350-400 parts of radix pueraiae, 20-30 parts of panax notoginseng, and 20-30 parts of radix aucklandiae. According to the invention, research findings shows that xinkeshu medicaments have a good treatment effect on cholestatic liver diseases, and provide new choices for clinical medication.

The invention discloses a new application for litazone drugs. The new application is characterized in that the litazone drugs used as the drugs for preventing and/or treating cholestatic liver disease have the effect better than that of the drug UDCA used in clinic at present.

The present invention discloses a new application of 15d-PGJ2 medicine used for preventing and/or treating cholestatic liver disease.

The invention discloses application of an MMI-0100 oligopeptide compound in preparation of a medicine for treating cholestatic liver diseases. The amino acid sequence of the MMI-0100 oligopeptide compound is as follows: YARAAARQARAKALARQLGVAA. After MMI-0100 drug treatment, the fibrosis lesion of the mouse liver is relieved, the infiltration of inflammatory cells is reduced, meanwhile, the hyperplasia degree of the bile duct is relieved, the mRNA expression level of the liver fibrosis gene alpha-SMA is reduced, and the results show that the MMI-0100 has a good treatment effect on the cholestatic liver injury.