46 results about "Cholestatic liver disease" patented technology

Provided herein are methods of treating or ameliorating a pediatric cholestatic liver disease by non-systemically administering to an individual in need thereof a therapeutically effective amount of a pediatric formulation comprising an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating a pediatric liver disease, decreasing the levels of serum bile acids or hepatic bile acids, treating or ameliorating pruritis, reducing liver enzymes, or reducing bilirubin comprising non-systemically administering to an individual in need thereof a therapeutically effective amount of a pediatric formulation comprising an ASBTI or a pharmaceutically acceptable salt thereof.

The invention provides various novel compositions of berberine in combination with pharmacologically active organic acids, and related methods of their use in treating various diseases or disorders. The invention further provides various novel compounds prepared from berberine and pharmacologically active organic acids and prepared from ursodeoxycholic acid and pharmacologically active organic bases, and pharmaceutical compositions thereof, and methods of their preparation and therapeutic use in treating and / or preventing various diseases or disorders. The compounds and pharmaceutical compositions of the invention can be utilized to treat various diseases or disorders, such as diabetes, diabetic complications, dyslipidemia, hyperlipidemia, obesity, metabolic syndromes, pre-diabetes, atherosclerosis, heart diseases, neurodegenerative diseases, sarcopenia, muscle atrophy, inflammation, cancer and liver diseases and conditions such as fatty liver, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, cholestatic liver diseases or graft-versus-host disease of the liver. The compounds of this invention are also useful in improving liver functions in chronic viral associated liver diseases and alcohol-related liver diseases.

The present invention relates to a novel acid-base addition salt composed of a class of berberine and a pharmacologically active organic acid, its preparation method and as a preparation method for preventing or / and treating various diseases or dysfunctions, such as diabetes, diabetic complications, Dyslipidemia, dyslipidemia in statin non-tolerant patients, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, diabetes combined with dyslipidemia, obesity, metabolic syndrome, prediabetes, inflammation, cancer, and various liver diseases Or dysfunction, such as fatty liver, non-alcoholic fatty liver, non-alcoholic steatohepatitis, cholestatic liver disease, liver transplantation versus host disease, chronic liver disease caused by viruses, and alcoholic liver disease, etc., have broad application prospects.