Application of peppermint oil dementholized in preparing medicament for treating cholestatic liver disease

A kind of technology of cholestasis, peppermint oil, applied in the application field in medicine

Active Publication Date: 2011-10-12
SICHUAN JISHENGTANG PHARMLS
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mentha oil (Oleum Menthae Dementholatum) is the main chemical component in Peppermint. It is a traditional Chinese medicine, which has the effects of cooling and relieving itching, anti-inflammatory and analgesic, expectorant, choleretic, and stone-dissolving [Liu Hongjie et al., Peppermint Oil research progress, Shandong University of Traditional Chinese Medicine Journal 2006, 30 (6): 502-505], mainly used clinically to treat chronic cholecystitis [Han Jie et al., clinical observation of 25 cases of chronic cholecystitis treated with Danshu Capsules, Chinese patent medicine, 2007, 29(1): Attachment 8-9], gallstones [Huang Xin et al., Observation on the Curative Effect of Danshu Capsules in the Treatment of Cholelithiasis, Chinese General Medicine, 2005, 8(1): 55-56], Chronic Calculus Cholecystitis, irritable bowel syndrome [Yan Jun et al., Pharmacological and clinical research of peppermint oil in the treatment of irritable bowel syndrome, foreign medicine and plant medicine volume, 2006, 21(2): 50-62], postpartum abdominal distention [Zhang Wen, hot compress with peppermint oil in the treatment of postpartum abdominal distension, J.huaihua Med., 2001, 19(3): 264-265], recovery of intestinal function in the elderly after operation [Jiang Guilin, The effect of hot compress with peppermint oil in the recovery of intestinal function in the elderly Clinical observation, Journal of Practical Clinical Medicine (Nursing Edition), 2006, 2(4): 42-43], biliary dyspepsia [Huang Ningxin, Discussion on the clinical significance of Danshu in the treatment of biliary dyspepsia, Chinese primary medicine, 2005 , 12 (8): 1099] and other diseases, but the use of peppermint oil in the preparation of medicines for the treatment of cholestatic liver disease has not been reported so far

Method used

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  • Application of peppermint oil dementholized in preparing medicament for treating cholestatic liver disease
  • Application of peppermint oil dementholized in preparing medicament for treating cholestatic liver disease
  • Application of peppermint oil dementholized in preparing medicament for treating cholestatic liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1 Therapeutic effect of peppermint oil on rat cholestatic liver disease induced by ANIT

[0013] animal

[0014] SD rats, SPF grade, 6-8 weeks old, weighing 180-250g, male; the certificate number is SCXK (Sichuan) 2008-24, provided by the Institute of Experimental Animals, Sichuan Academy of Medical Sciences.

[0015] Medicines and reagents

[0016] Peppermint oil, light yellow oily liquid, Nantong Peppermint Factory Co., Ltd., batch number 20090414, menthone content is 19.4%, menthol content is 37.2%, adult clinical daily dosage is 2.7g / 60kg based on 60kg, which is 0.045g / kg.

[0017] In the experiment, the peppermint oil was set into three dose groups: high, medium, and low dose groups: the doses of the high, medium, and low dose groups of rats were 14, 7, and 3.5 times the human dose, and the actual dose was 630 mg / kg, 315mg / kg, 157.5mg / kg, administration volume is 10ml / kg·d.

[0018] Ursodeoxycholic acid capsules, Dr. Falk Pharma GmbH, batch number 09012683L, specific...

Embodiment 2

[0041] Example The therapeutic effect of dimenthol oil on ethinyl estradiol-induced cholestatic liver disease in rats

[0042] Animal Wister rat, SPF grade, 6-8 weeks old, weight 180-220g, male; certificate number is: SCXK (Sichuan) 2008-24; provided by Institute of Experimental Animals, Sichuan Academy of Medical Sciences.

[0043] Medicines and reagents

[0044] Peppermint oil, light yellow oily liquid, provided by Nantong Peppermint Factory Co., Ltd., batch number 20090414, menthone content 19.4%, menthol content 37.2%, the daily clinical dosage of 60kg for adults is 2.7g / 60kg, which is 0.045g / kg, during the experiment Set peppermint oil into three dose groups of high, medium and low. The doses of the high, medium and low dose groups of rats are 14, 7, and 3.5 times the human dose respectively. The actual doses are 630mg / kg and 315mg / kg, 157.5mg / kg, the administration volume is 10ml / kg; Ursodeoxycholic acid capsules, Dr.falkPharma GmbH, batch number: 09012683L, specifications: 2...

Embodiment 3

[0069] Example 3 Effect of CCL4-induced liver injury in mice

[0070] animal

[0071] Kunming mouse, ordinary grade, 6-8 weeks old, 18-22g, half male and half male; the certificate number of the mouse is: SCXK (Sichuan) 2008-24, provided by the Institute of Experimental Animals, Sichuan Academy of Medical Sciences.

[0072] Medicines and reagents

[0073] Peppermint oil, light yellow oily liquid, Nantong Peppermint Factory Co., Ltd., batch number 20090414, menthone content is 19.4%, menthol content is 37.2%, adult clinical daily dosage is 2.7g / 60kg based on 60kg, which is 0.045g / kg.

[0074] In the experiment, the menthin oil was set into three dose groups: high, medium and low dose groups: the doses of mice in the high, medium and low dose groups were 20, 10, and 5 times the human dose, and the actual dose was 0.90g / kg , 0.45g / kg, 0.225g / kg, the administration volume is 20ml / kg·d.

[0075] Bifendate dropping pills, specification: 1.5mg / 250 pills, Zhejiang Pharmaceutical Co., Ltd. Xinch...

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Abstract

The invention discloses an application of peppermint oil dementholized in preparing a medicament for treating cholestatic liver disease.

Description

Technical field [0001] The invention relates to the use of peppermint oil, in particular to the application of peppermint oil in the preparation of medicines for treating cholestatic liver disease. Background technique [0002] Cholestatic liver disease is mainly caused by bile secretion or excretion disorders, which can be caused by bile secretion disorders of liver cells or bile duct epithelium or blockage of bile flow. However, cholestasis caused by any cause can lead to the retention of toxic substances such as bile acids, causing liver cell damage and cholestatic liver disease. Cholestatic liver diseases include primary biliary cirrhosis, primary sclerosing cholangitis, drug-induced cholestasis, intrahepatic cholestasis of pregnancy, chronic intrahepatic cholestasis of infants, fibrous cholestatic hepatitis, etc. Disease [Edited by Lu Lungen, Zeng Minde, Cholestatic Liver Disease, People's Medical Publishing House, 2007: 162-163], clinically often manifested as jaundice, it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/534A61P1/16
Inventor 孟保华罗弟祥高小平
Owner SICHUAN JISHENGTANG PHARMLS
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