101 results about "Bile flow" patented technology

Systems and methods are disclosed for microscale pharmacokinetics. Various organs and their interactions with drug compounds can be simulated in vitro by use of microscale compartments that can be interconnected by microscale channels. Cells or cellular materials associated with the organs can be cultured in such compartments to allow interactions with drug compounds in one or more fluidic flows. Such fluidic systems can include, by way of examples, gastrointestinal flow, blood flow, bile flow, urinary flow, and brain fluid flow. Interactions between fluidic systems can be simulated by a microscale permeable member. In one example, blood-biliary interaction can be simulated by a microscale permeable material having hepatocytes bound to a permeable substrate via a binder.

The invention relates to a bile duct support and a preparation method thereof. The bile duct support is characterized in that non-woven films are electrostatically spinned on the inner wall and the outer wall of a meshy bile duct support knitted by using the present medical alloy silk to form a cladding structure for an alloy silk meshy bile duct support. Because the film adopts medical polyurethane with favorable biocompatibility and high elasticity, the biocompatibility of the bile duct support in the body is improved, and the high elasticity of the support is maintained. A function of hindering the bile flowing through the bile duct by the support alloy silk and stimulation to bile duct endothelial cells and bile duct smooth muscle cells in the bile duct caused by radially expanding the bile duct by the alloy silk are effectively eliminated, and the bile duct is avoided to become narrow again. The bile duct support has simple preparation method, convenient operation, low cost and favorable controllability on preparation of the inner film and the outer film of the bile duct, and the method is suitable for preparing bile ducts with various diameters and lengths.

The invention discloses a traditional Chinese medicine for treating gallstone and belongs to the technical field of traditional Chinese medicines. The Chinese medicine is prepared from the following raw materials: radix bupleuri, pericarpium citri reticulatae viride, pericarpium citri reticulatae, radix curcumae, rhizoma corydalis, endothelium corneum gigeriae galli, rheum officinale, immature bitter orange, corydalis tuber, scutellaria baicalensis, semen plantaginis, fructus aurantii, radix aucklandiae, mangnolia officinalis, toosendan fruit, polygonum cuspidatum, dandelion, oriental wormwood, poria cocos, radix pseudostellariae, radix paeoniae alba, honeysuckle, longhairy antenoron herb, trogopterus dung and liquorice. After the raw materials are combined, the traditional Chinese medicine has the effects of regulating qi-flowing for dehumidifying, dispersing stagnated liver qi for promoting bile flow, clearing away heat, dissipating blood stasis and invigorating spleen for promoting digestion, and has the advantages of simple treatment method, low cost and no side effects to the body on the aspect of treating gallstone. The traditional Chinese medicine has an inhibiting effect for gallstone formation, can reduce excessive aggregation of gallstone compositions in bile, and therefore reduces the risk of gallstone formation.

The invention provides, in part, polyhydroxylated bile acids for treating biliary disorders, for example, biliary disorders arising out of cholestasis or portal hypertesion. The invention also provides, in part, polyhydroxylated bile acids for stimulating bile flow. New compounds 2[alpha],3[alpha],7[alpha],12[alpha]-tetrahydroxy-5[beta]-cholanoic acid and 3[alpha],4[alpha],7[alpha],12[alpha]-tetrahydroxy-5[beta]-cholanoic acid are disclosed, uses thereof and synthesis thereof.

The invention discloses a traditional Chinese medicine soft capsule for soothing the liver, regulating qi and promoting bile flow, a preparation method of the soft capsule, and a GC (gas chromatography) method for detecting the soft capsule. The pharmaceutical composition disclosed by the invention is prepared from peppermint oil and refined corn oil according to the ratio of 1:(1-3), and a capsule shell is prepared from gelatin, glycerol, water and polyethylene glycol according to the ratio of (0.8-1.2):(0.2-0.6):(0.8-1.2):(0.02-1). The invention also provides a preparation method of the soft capsule and a GC method for measuring the content of menthol in the soft capsule. The clinical test of the traditional Chinese medicine soft capsule disclosed by the invention shows that the total efficiency reaches 98.7%, the capsule shell is nearly not hardened in the storage period, the disintegration time does not exceed 16 minutes, the pill pressing process is reasonable, the production controllability is high, the production cycle is short, and the quality of the used peppermint oil is controllable.

The invention discloses a closed bile reinfusion device and belongs to the technical field of medical apparatus and instruments. The closed bile reinfusion device comprises a bile collection bag and a bile reinfusion device, wherein an input tube and an output tube are arranged on the bile collection bag; and the bile reinfusion device comprises a box body, a first storage slot, a conveying channel, a filter, an electronic scale, a sterilizer, a heater, a cooler, a peristaltic pump, a motor and a controller. The filter can be utilized for filtering crystals, bile sands, fiber secretions and the like existing in drained bile, the electronic scale can be utilized for detecting stock in the bile collection bag; the sterilizer, the heater and the cooler can be utilized for respectively sterilizing bile flowing through the output tube in a bile reinfusion process; and the peristaltic pump and the controller can be utilized for automatically completing control on stock quantity of the bile and automatic reinfusion, so that in vitro bile reinfusion can be timely and effectively realized. Compared with the prior art, the closed bile reinfusion device has the advantages of high refluxing efficiency, high accuracy and strong practicability.

The invention discloses a traditional Chinese medicine composition for dispersing stagnated liver qi for promoting bile flow and applications thereof. The composition is prepared from the following Chinese herbal medicine raw materials in parts by weight by decocting with water and extracting: 10-15 parts of radix bupleuri, 25-36 parts of polygonum cuspidatum, 12-18 parts of curcuma aromatica, 10-15 parts of radix aucklandiae, 10-15 parts of melia toosendan, 7-11 parts of radix scutellariae, 25-36 parts of flos lonicerae, 10-15 parts of rhizoma cyperi, 10-15 parts of semen raphani, 10-15 parts of corydalis yanhusuo, 10-15 parts of rhubarb, 25-36 parts of dandelion, 25-36 parts of christina loosestrife herb, 7-11 parts of salvia miltiorrhiza, 5-8 parts of mirabilite, 10-15 parts of fructus aurantii immaturus, 25-36 parts of folium isatidis, 25-36 parts of herba artemisiae, and 10-15 parts of magnolia officinalis. The composition disperses stagnated liver qi for promoting bile flow, regulates qi to alleviate pain, diminishes inflammation and removes urinary calculus, and can be applied to the treatment of acute cholecystitis, infection of biliary tract, common bile duct and gallstone.

The invention discloses a medicine for treating cystitis and a preparation method thereof, and belongs to the field of a traditional Chinese medicine. The effective components of the medicine comprise dayflower, grifola, juncus effuses, cortex phellodendri, immature bitter orange, rhizoma anemarrhenae, cordate houttuynia, dianthus superbus, achyranthes aspera, caulis bambusae in taeniam, caulis lonicerae, herba pyrrosiae, tetrapanax papyriferus, plantain, frogs and notopterygium root. The medicine disclosed by the invention has the effects of dispersing stagnated liver qi for promoting bile flow, eliminating vexation, descending qi, clearing heat, removing toxicity, eliminating dampness and treating stranguria, is used for treating cystitis, high in curative ratio, obvious in treatment effect, short in treatment course and low in cost and worthy of wide popularization and application in clinical practice and quickly takes effects without toxic or side effect; and after the cystitis is healed by using the medicine, the cystitis does not relapse.

The invention discloses a medicine for treating gastritis. The medicine is a green pure Chinese herbal medicine compound preparation which is prepared from the following components: angelica, radix paeoniae alba, agilawood, radix bupleuri, dried immature fruit of citron orange, magnolia officinalis, cassia twig, dried orange peel, betelnut, myristica fragrans, fructus amomi, fried endothelium corneum gigeriae galli, radix curcumae, cedar seed, trogopterus dung, rhizoma atractylodis, jujube kernel, pomegranate seed, polygala tenuifolia, cinnabar and the like. The medicine has the effects of dispersing stagnated liver qi for promoting bile flow, regulating qi and strengthening spleen, and tonifying qi and harmonizing stomach, is quick in taking effect, small in side effect, high in cure rate and economical, and can be used for treating liver depression and dyspeptic retention, expansion of both sides of the chest, gastric cavity sharp pain, eructation and acid regurgitation, nausea and vomiting, distaste for food and body fatigue.

The invention relates to a traditional Chinese medicine composition enema for treating senile constipation. The traditional Chinese medicine composition enema is prepared from the following raw materials in percentage by weight: 24.3%-30% of fructus cannabis, 12.5%-16% of cistanche, 5%-6.4% of radix ophiopogonis, 6.9%-8% of root of rehmannia, 4.1%-5% of radix scrophulariae, 11.1%-12% of pseudo-ginseng, 5%-6.4% of mangnolia officinalis, 5%-6.4% of selfheal, 3.2%-4.1% of porcine bile, 5.2%-6.3% of semen plantaginis and 6.94%-7.73% of rhodiola rosea. The traditional Chinese medicine composition enema comprises multiple herbal essences, is capable of promoting bowel movement and lubricating the intestines, has the effects of removing hepatotoxin, dispersing stagnated liver qi for promoting bile flow, removing heat to cool blood, invigorating the circulation of blood, promoting the circulation of qi, accelerating metabolism and reducing accumulation of overnight excrement and achieves the purpose of natural defecation, so that the senile constipation is healed in the end.

The invention discloses traditional Chinese medicine particles for treating icteric hepatitis and a preparation method thereof. The traditional Chinese medicine particles are prepared from the following raw materials in parts by weight: 10-15 parts of herba artemisiae scopariae, 14-18 parts of fructus gardeniae, 5-10 parts of cortex phellodendri, 15-20 parts of lysimachia christinae hance, 10-15 parts of solanum lyratum thunb, 8-16 parts of radix bupleuri, 5-10 parts of polygonum cuspidatum, 13-17 parts of poria cocos, 15-20 parts of white atractylodes rhizome, 19-26 parts of radix curcumae longae, 10-15 parts of radix paeoniae rubra, 7-13 parts of rhizoma alismatis, 5-10 parts of herba scutellariae barbatae, 12-16 parts of hypericum japonicum thunb, 10-15 parts of dianthus superbus, 10-15 parts of creeping woodsorrel herb, 5-10 parts of vitis bryoniifolia root, 10-15 parts of leaf of Chinese aralia, 8-16 parts of triqretrous tadehagi herb, 14-18 parts of herba centellae, 10-15 parts of corn stigma, and 15-20 parts of cortex moutan. The drugs are in compatibility and bring out the best in each other, so that the traditional Chinese medicine particles have the efficacies of clearing heat and detoxifying, soothing liver and promoting bile flow, removing jaundice and eliminating dampness, promoting blood circulation and removing blood stasis and the like, has the advantages of good absorption effect, remarkable curative effect, high cure rate, no relapse after healing, low treatment cost, treatment of both symptoms and root causes, no side effects, safety and economy.

The invention relates to oyster porridge and a preparation method of the oyster porridge, and belongs to the technical field of health care porridge. The oyster porridge is composed of the following raw materials in parts by weight: 150-200 parts of rice, 80-100 parts of millet, 40-50 parts of oyster, 15-20 parts of pork lean, 10-20 parts of celery, 6-9 parts of dried beancurd stick, 5-10 parts of white radish, 3-8 parts of mushroom, 10-12 parts of rose flower, 2-4 parts of caraway, 3-5 parts of sesame oil, 3-10 parts of starch, 1-3 parts of pepper powder, 1-3 parts of salt and 3-8 parts of cooking wine. The oyster porridge provided by the invention is characterized in that oyster and porridge are combined so that the porridge has the effects of tranquilizing mind, suppressing hyperactive yang and nourishing yin, astringing and securing, and dispersing stagnated liver qi to promote bile flow, and thereby being health care porridge with obvious functions, and the porridge is simple and convenient to make and also convenient for people to eat.

The invention discloses an artificial bile duct bionic stent with a double-layered compound structure and a preparation method of the artificial bile duct bionic stent. The preparation method includes using biodegradable polyester as raw materials; preparing a compact membrane-shaped inner duct by a coating method; preparing a polyester outer duct with a communicated porous structure by a gelatin porogen method; and compounding the outer duct with the inner duct so as to obtain the artificial bile duct bionic stent with the double-layered compound structure. Repeatability of a preparation process is good. The inner duct of the artificial bile duct bionic stent can support bile circulation and prevent bile leakage, and the outer duct can support cell growth and regeneration to form new bile duct tissues. The artificial bile duct bionic stent is fine in biocompatibility, free of cytotoxicity and capable of realizing regeneration and repair of a bile duct, avoids secondary surgery, can be used for tissue engineering bile duct construction and bile duct coloboma repair, and has a good clinical application prospect.

The invention discloses a traditional Chinese medicine composition for treating simple obesity, and a preparation method and an application thereof. The traditional Chinese medicine composition is prepared by using 5-30 parts by mass of white atractylodes rhizome, 10-30 parts by mass of fried turtle shell, 10-20 parts by mass of inula flowers, 10-20 parts by mass of curcuma zedoary and 10-20 parts by mass of giant knotweed rhizome as raw materials. Specifically, the preparation method comprises the following steps of weighing all medicines according to the above proportions; smashing the fried turtle shell; adding water 10 times by volume that of the fried turtle shell; decocting for 30 minutes; adding traditional Chinese medicinal materials; adding water and decocting for two times, wherein the volume of added water in each time is 8-10 times that of a total mass of the medicines; and the time for each decoction is 0.5-1 hour; merging extract solutions obtained by the two times of decoction; filtering, concentrating, and drying to obtain a dry extract. Animal experiments show that the composition can significantly reduce body weight, liver weight and fat weight of high-fat obese rats, significantly reduce the contents of liver cholesterol and liver triglyceride in the high-fat obese rats, regulate lipid metabolism and improve liver functions. The medicine effects are related to the fact that the composition can increase bile flow, regulate and increase bile acid subfractions that can promote bile secretion and the lipid metabolism.

The present invention discloses a qi supplementing and blood tonifying nutritious noodle and a preparation method thereof. The noodle is made of flour, pork liver, black beans, longan meat, sorghum flour, lonicera fragrantissima, honey dew melons, root-mustard, hylocereus undulatus, tricholoma matsutake, c.pepo l.var. patisson, rosa davurica, arctium lappa L. leaves, red ginseng rootlets, roseapple pericarp and other raw materials. The nutritious noodle has a good taste, green and healthy raw materials and a reasonable and scientific formula, is in line with the tastes and eating habits of most consumers, and is fragrant, delicious, digestible and nutritious. In addition, the nutritious noodle also has health-care efficacies and achieves effects of dispersing stagnated liver qi and promoting bile flow, strengthening stomach and promoting digestion, invigorating and supplementing blood and tonifying qi and promoting salivation in regular consumptions.

The invention discloses a liver-fire-clearing and bile-flow-promoting preparation for treating tinnitus. The liver-fire-clearing and bile-flow-promoting preparation is mainly prepared from the following active pharmaceutical ingredients in parts by weight: 8-14 parts of bamboo shavings, 10-16 parts of corn stigma, 7-13 parts of citronella, 9-14 parts of scutellaria indica, 8-13 parts of franchet peashrub, 7-14 parts of loranthus parasiticus, 9-15 parts of herb of white clover, 8-12 parts of hollyhock flowers, 9-13 parts of root of sandhill tylophora, 10-14 parts of arundina graminifolia, 8-15 parts of radix puerariae, 6-14 parts of fleshfingered citron flowers, 7-11 parts of apocynum venetum, and 6-12 parts of murraya paniculata. The liver-fire-clearing and bile-flow-promoting preparation is prepared through summary on many years of clinical practices, has the efficacies of clearing liver fire and promoting bile flow, and tonifying Qi and kidney, and is significant in curative effect.

The invention provides, in part, polyhydroxylated bile acids for treating biliary disorders, for example, biliary disorders arising out of cholestasis of portal hypertension. The invention also provides, in part, polyhydroxylated bile acids for stimulating bile flow. New compounds 2α,3α,7α,12α-tetrahydroxy-5β-cholanoic acid and 3α.4α,7α,12α-tetrahydroxy-5β-cholanoic acid are disclosed, uses thereof and synthesis thereof.

The invention mainly relates to a preparation process of granules for protecting liver and promoting bile flow. The preparation process comprises the following steps of: 1, distilling raw sytingamicrophylla through water vapor; drying; circularly performing sealing and soaking and ultrasonic-assisted extraction twice; performing alcohol precipitation to the obtained sytingamicrophylla extracting solution at low temperature; carrying out pressure-reduced concentration to obtain a sytingamicrophylla extractive concrete to stand by service for later use; and 2, adding starch and dextrin to the sytingamicrophylla extractive concrete obtained in step 1 based on the weight ratio of (1-1.2): (1.5-2.0): (0.5-1.0); preparing a soft material; granulating; and straightening to accomplish the preparation of the granules. The preparation process provided by the invention is mild; the bioavailability is high; the granules for protecting liver and promoting bile flow, prepared by the process, are high in content of pharmaceutical ingredients, show have remarkable, stable and long-term effect, and have no toxic and side effects.

The invention provides, in part, polyhydroxylated bile acids for treating biliary disorders, for example, biliary disorders arising out of cholestasis or portal hypertension. The invention also provides, in part, polyhydroxylated bile acids for stimulating bile flow.

The invention relates to a Chinese herbal medicine composition for treating calculus. The composition is prepared through compatibility of the following raw materials according to a weight ratio: 0.5-1.5g of bear gall powder, 5-20g of radix curcumae, 10-50g of virgate wormwood herb, 10-30g of Japanese climbing fern spore, 5-15g of shearer's pyrrosia leaf and 3-10g of rhubarb root and rhizome. All the materials are ground into 100-mesh fine powder by utilizing a grinder, and the fine powder is mixed and then filled into capsules to prepare capsules. The Chinese herbal medicine composition has the functions of clearing heat and resolving depression, inducing diuresis and treating stranguria, dispersing stagnated liver qi to promote bile flow and dissolving and removing urinary calculus, is suitable for treating renal calculus, vesical calculus, biliary calculus, calculus of intrahepatic duct and cholecystitis, especially has better curative effects on patients with renal calculus, is safe and efficient, has short courses of treatment, takes an effect quickly and avoids relapse.

The invention relates to an immunostimulatory injection for livestock. The injection can be used as a diluent to enhance immune effects of vaccine especially serum and strongly enhance the antibacterial efficacy of the antibiotic powder injection; and the injection can be individually used to protect liver, promote bile flow, bring down a fever and improve the growth performance of animal bodies. The invention is characterized in that immunostimulatory injection is prepared by the following steps of: taking 10-20 g of Radix Astragali and 5-10 g of dried orange peel, slicing, decocting, concentrating by the use of ethanol to prepare a liquid A for standby; cutting off 5-10 g of radix bupleuri, adding water and distilling, dissolving by adding PEG 400 so as to prepare a liquid B for standby; adding the liquid B into the liquid A, adding injection water to 85-95 ml, using a pH conditioning agent, adding 0.1-0.2 g of active carbon, slightly boiling for 1 h, standing until it cools, adding 1 ml of benzyl alcohol for a constant volume of 100 ml; filtering, embedding, and sterilizing. The injection is produced at low cost, has good effect when singly used or used as a diluent, and especially has substantial synergism for ceftiofur sodium.