18 results about "Bile flow" patented technology

The invention relates to the technical field of medical instruments, in particular to an intelligent bile flow monitoring T tube which comprises a microprocessor and a T tube body, a pressure sensor is arranged in the T tube body, the T tube body is formed by communicating a transverse tube and a longitudinal tube, the two ends of the transverse tube are close to the bile duct and the intestinal tract of the liver respectively, and drainage is conducted to the outside from the end of the longitudinal tube. A first flow sensor is arranged on the transverse tube close to the liver bile duct to measure the total flow of bile, a second flow sensor is arranged close to the intestinal tract to measure the amount of bile flowing into the intestinal tract, and a third flow sensor is arranged in the longitudinal tube to measure the flow of bile discharged out of the body. The microprocessor collects and analyzes sensor data through the information collecting and processing module so as to calculate bile flow and pressure, and judges the bile flow direction condition when the third flow sensor data is abnormal. The bile monitoring precision can be improved, in-vitro drainage amount abnormity can be quickly diagnosed, the postoperative management efficiency is enhanced, the complication risk is reduced, the postoperative safety of a patient is improved, and the function and reliability of a bile drainage system are improved by means of an innovative technology.

The invention provides a novel anti-reflux integrated biliary tract stent for bile flow monitoring, which comprises a biliary tract stent in the shape of a woven mesh cylinder, and a flexible covering film is arranged in the biliary tract stent. A flow sensor unit for monitoring the flow and the flow velocity of bile in the biliary tract of a patient in real time and an anti-reflux assembly are mounted in the flexible covering film; wherein the anti-reflux assembly comprises an anti-reflux membrane flap, a plurality of through holes are formed in the anti-reflux membrane flap, and a plurality of anti-reflux flexible parts are arranged in the through holes; the biliary tract bile flow monitoring system has the advantages that a flow sensor in the flow sensor unit can monitor the flow and the flow speed of bile in the biliary tract of a patient in real time, the flow sensor can transmit collected information to an in-vitro terminal device through a Bluetooth module, and therefore the bile flow related characteristics can be monitored in real time; and bile in the biliary tract is prevented from entering the biliary tract stent and flowing back into the biliary tract through the anti-reflux flap and the anti-reflux flexible piece.

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating gallbladder and bile duct disease, which at least comprises the following components in parts by weight: 8-10g of radix curcumae, 14-16g of pericarpium trichosanthis, 5-7g of pericarpium citri reticulatae viride, 8-10g of fructus aurantii, 14-16g of raw endothelium corneum gigeriae galli, 27-33g of lysimachia christinae hance or 8-10g of fried radix bupleuri, 22-26g of fried white paeony root and 5-7g of liquorice. The preparation method of the traditional Chinese medicine composition for treating the gallbladder and bile duct disease comprises the following steps: mixing the raw materials, adding 400ml of clear water, boiling with strong fire, continuously decocting for 30 minutes, filtering and extracting liquid medicine; adding 400ml of clear water into medicine residues, boiling with strong fire, continuing to decoct for 30 minutes, filtering and extracting medicine liquid; and combining the medicine liquid extracted twice. The traditional Chinese medicine composition for treating the gallbladder and bile duct disease has the effects of soothing liver and regulating qi, benefiting gallbladder and removing stagnation, and relieving spasm and pain, and can effectively treat liver and gallbladder qi stagnation, stagnation and turbid stagnation type chronic cholecystitis and gallbladder polyp.

This invention relates to a choleretic traditional Chinese medicine composition, its preparation method, and its application, belonging to the field of traditional Chinese medicine preparation technology. The microcapsules prepared from this choleretic traditional Chinese medicine composition consist of a core and a coating. The core contains a traditional Chinese medicine extract, pregelatinized starch, sodium alginate, and croscarmellose sodium. The coating contains hydroxypropyl cellulose and hydroxypropyl methylcellulose E5, PEG4000, and talc. The traditional Chinese medicine extract is made from Artemisia capillaris, Lysimachia christinae, Rheum palmatum, Scutellaria baicalensis, Taraxacum mongolicum, Forsythia suspensa, Curcuma longa, Curcuma longa, Bupleurum chinense, Citrus aurantium, and Aucklandia lappa. This choleretic traditional Chinese medicine composition has the effects of promoting bile flow and expelling gallstones, detoxifying and reducing swelling, with a stable drug release rate, definite efficacy, and few toxic side effects. It can be used for the prevention and / or treatment of acute and chronic gallstones and / or cholecystitis.

The invention discloses a tumor clinical interventional therapy percutaneous liver puncture biliary drainage auxiliary device, comprising: a clamping protection mechanism comprising a clamping frame assembly and a gooseneck assembly which is arranged on the clamping frame assembly and can be adjusted in position along the vertical direction; the complication monitoring assembly comprises a monitoring host installed on the clamping frame assembly, and a temperature sensor and an ultrasonic flow sensor which are electrically connected with the monitoring host; the temperature sensor is used for monitoring the body temperature of a patient in real time, and the ultrasonic flow sensor is connected with the drainage tube and used for achieving non-invasive monitoring of the bile flow velocity; the binding belt assembly is used for being fixed to the waist and abdomen of a patient in a surrounding mode, and the binding belt assembly is provided with a first through hole used for a drainage tube to pass through and a second through hole used for a temperature probe of a temperature sensor to pass through; the problems that an existing percutaneous liver puncture biliary tract drainage auxiliary device is poor in drainage tube protection effect and insufficient in complication risk monitoring capacity are solved.

The invention relates to the technical field of experimental animal model construction in biomedical research, and discloses a common bile duct flow limiting tube for constructing a chronic cholestasis rat model and a construction method, the flow limiting tube comprises a hard tubular body and a soft protective fixing wing wrapping the tubular body, the inner diameter of the tubular body is 0.12-0.15 mm, and the outer diameter of the tubular body is 0.12-0.15 mm. The length of the tubular body is 0.5 to 0.8 cm; protruding fixing rings are arranged at the two ends of the protection fixing wing, and the total outer diameter of the flow limiting pipe is smaller than or equal to 0.7 mm. The common bile duct flow limiting tube is implanted into the specified position of the common bile duct of an experimental animal through a precise operation, precise control over bile flow is achieved, and therefore a standardized animal model capable of highly simulating the human chronic cholestatic liver disease in the aspects of the pathological process, physiological compensation and systematic expression is established. The model and the construction method thereof can be directly applied to multiple directions of liver pathophysiology mechanism research, drug target verification, new drug curative effect and safety evaluation and the like.

The invention discloses a bile duct millstone stent for ERCP. The bile duct millstone stent comprises a stent inner opening, anti-falling fins, a stent cylinder, stent millstone teeth, stent pore channels, stent outer fins and a stent outer opening. According to the bile duct millstone stent for ERCP, stone can be conveniently and automatically ground and discharged, after the stent bile duct is placed, under the combined action of duodenum physiologic peristalsis, bile flow and human body daily activities, the stent can generate micro-amplitude rotation and axial displacement, so that the stent millstone teeth can effectively scrape and grind common bile duct stone in contact with the stent cylinder, and the stent can be used for effectively removing the bile duct stone. The ground calculus can pass through a pore channel of the stent and is smoothly discharged into the duodenum under the flushing of bile which increases the flow rate and is generated due to the fact that the inner opening is large and the outer opening is small, the design is particularly suitable for emergency treatment of patients who suffer from bile duct calculus obstruction or cannot tolerate long-time ERCP operation, and through clinical use, the surgical instrument is convenient, rapid and flexible to use and operate, and has a wide application prospect. The problem of treatment of complex biliary calculi is effectively solved, and surgical operation safety is guaranteed.

The invention discloses a biliary stent and a preparation method thereof, and relates to the technical field of medical instruments. The biliary stent is of a concentric tubular structure and comprises a fastest degradation inner layer, a sub-fast degradation middle layer and a slowest degradation outer layer from inside to outside, and a plurality of supporting pieces are arranged between the layers. The used materials are all degradable materials with high safety and excellent biocompatibility. The provided biliary stent is a novel biliary stent which can be degraded in a gradient mode and is excellent in biocompatibility. The degradation process can be actively managed, the resilience force of the bile duct wall can be effectively resisted in the degradation period, continuous and reliable bile drainage is provided for bile flow, and the blocking risk is effectively avoided; finally, all degradation products are safely absorbed by the body, no foreign matter is left, secondary operation for taking out is not needed, patient pain and medical cost are reduced, and the method is expected to be vigorously popularized.

The invention relates to the field of gall bladder drainage stents, in particular to a gall bladder drainage plastic stent for ERCP surgery, which comprises a near-end pigtail section, a middle drainage section and a far-end drainage section which are integrally formed in sequence, the near-end pigtail section is used for remaining in a gall bladder, and friction elements are integrated on the outer side wall and the inner side wall of the near-end pigtail section; the middle drainage section is used for penetrating through a gall bladder tube and a common bile duct, the far-end drainage section is used for being reserved in the duodenum, an air bag reinforcing mechanism is arranged on the middle drainage section, preliminary anchoring is achieved through a pigtail ring structure of the near-end pigtail section, and meanwhile the air bag reinforcing mechanism of the middle drainage section is matched, so that the drainage effect is improved. The inflated annular air bag is tightly attached to the inner wall of the gall bladder tube, an anchoring and attaching dual-fixing mode is formed, external force caused by gastrointestinal peristalsis and bile flow is effectively resisted, the risks of stent displacement and slippage are remarkably reduced, and it is guaranteed that a drainage channel is continuous and smooth.

The present invention relates to the fields of biomedical engineering and microfluidics, and in particular to a liver organ chip model and its use, wherein the liver organ chip model comprises a top chip, an intermediate chip and a bottom chip, wherein the intermediate chip is arranged between the top chip and the bottom chip, and the liver organ chip model is provided with a sample addition hole, a collection hole and a cell culture chamber, wherein the cell culture chamber is arranged on the intermediate chip, and the sample addition hole and the collection hole are both connected to the cell culture chamber. The liver organ chip model can be used for drug development, toxicology, nutrition and other research. The liver organ chip model adds a bile flow function, realistically reproduces the physiological structure of the liver lobule, and then reproduces the systemic function of the liver organ, more realistically simulates the interaction between drugs or other substances and the liver; and can realize the co-culture of liver non-parenchymal cells such as sinusoidal endothelial cells, bile duct endothelial cells, fibroblasts and other immune cells.

The invention relates to a structural tube called 'H drainage tube for biliary tract drainage', and aims to establish natural drainage of bile from the bile duct to the small intestine. An H drainage tube is an internal biliary drainage tube and plays a crucial role in biliary drainage under the condition of malignant biliary obstruction such as pancreatic head cancer, spent testis papilla, duodenum, bile duct cancer and hepatocellular carcinoma, and due to local advanced diseases and metastasis, the Hdrainage tube and the H drainage tube are not suitable for curing surgery. The H drainage tube plays an important role in the case of anatomical structure changes, gastric outlet obstruction and previous gastric bypass surgery. Unlike existing palliative methods for malignant biliary obstruction, H drainage tubes provide liver function recovery and nutritional condition improvement, reduce systemic endotoxemia and enhance the likelihood of immune response by internal drainage and recovery of bile flow into the enteric cavity. The H drainage tube has the capabilities of flushing, dredging under the condition of obstruction, collecting bile samples and performing contrast imaging on bile ducts. Thus, it can also be used in temporary methods intended to improve the overall condition of a patient and to prepare for surgical resection or performing palliative radiotherapy or chemotherapy. The H drainage tube can also be applied to patients with highly non-resectable lesions of the common hepatic duct and is intended for biliary tract drainage and guiding bile into the small intestine. Postoperative complications are minimized due to the design and method of placement of the H drainage tube. It significantly improves the quality of life of a patient, which is the main objective of palliative treatment. It is important to the patient that it has a positive psychological impact, without external drainage and without the need to use bags for biliary tract contents, thereby achieving better quality of life.

The invention provides a biliary tract fluid multi-modal research platform and method based on a PIV experiment and CFD simulation, the biliary tract fluid multi-modal research platform comprises a high-performance calculation unit, a PIV measurement unit and a bionic experiment unit, and the high-performance calculation unit is connected with the PIV measurement unit and the bionic experiment unit through wires; wherein the bionic experiment unit comprises a supporting box, an experiment box used for containing a biliary tract system geometric model is arranged in the supporting box, and a first micro injection pump and a second micro injection pump which are located on the left side and the right side of the experiment box and connected with the high-performance calculation unit through wires are further arranged in the supporting box; compared with the prior art, the method has the following beneficial effects that by integrating a particle image velocimetry (PIV) experiment and a computational fluid dynamics (CFD) simulation technology, multi-dimensional quantitative analysis of the bile flow state is realized, so that fluid behaviors in the biliary tract can be accurately simulated and analyzed, and a fluid dynamic mechanism of biliary tract related diseases can be deeply known.

The invention relates to a method for precisely customizing a simulated organ for clinical and teaching. The method comprises the following steps: S1, establishing a deep learning model of the simulated organ; s2, acquiring three-dimensional data of the simulation organ model; s3, 3D printing data processing of the simulated organ model is carried out, a part A printing model and a part B printing model are established, the part A printing model corresponds to the blood vessel, bile duct or focus structure of the simulated organ and can be externally connected with a circulating pump, and the part B printing model corresponds to the outline of the simulated organ; and S4, assembling the simulated organ model. Compared with the prior art, the manufacturing method has the advantages of being short in manufacturing period and low in cost, the blood vessel, bile duct or focus structure of the manufactured simulated organ is accurately positioned, blood circulation and bile flow of the organ are simulated through a real blood vessel and biliary tract system, and a real operation state can be provided in teaching and operation training.

The invention provides a biliary tract stent capable of monitoring biliary tract wall pressure and bile flow, which comprises a biliary tract stent, the first pressure sensor unit and the second pressure sensor unit are used for monitoring the pressure change of the inner wall of the biliary tract of a patient in real time, and the flow sensor unit is used for monitoring the flow and the flow speed of bile in the biliary tract of the patient in real time. Each of the first pressure sensor unit and the second pressure sensor unit comprises a pressure sensor; the system has the following beneficial effects that the pressure change of the inner wall of the biliary tract of a patient can be monitored in real time through the pressure sensor, and the flow and flow velocity of bile in the biliary tract of the patient can be monitored in real time through the flow sensor in the flow sensor unit; in addition, the pressure sensor and the flow sensor can transmit collected information to the microprocessor unit or terminal equipment through the Bluetooth module, so that a doctor can know complicated pathological changes in the biliary tract of a patient and relevant characteristics of bile flow in time.

A process for preparing a natural aromatic cooking condiment, which process comprises: S1, raw material pretreatment; S2, primary centrifugation; S3, secondary centrifugation; S4, extract mixing; S5, mixed solution concentration; and S6, sterilization and packaging. In the process, an Osmanthi fragrantis flos powder, a Chrysanthemi flos powder, and a loquat powder are added, wherein the Osmanthi fragrantis flos powder has the effects of maintaining beauty and youth and invigorating the spleen and stomach, the Chrysanthemi flos powder is rich in nutrients such as saccharides, amino acids and vitamins, and is capable of regulating intestinal microbial flora and promoting gastric peristalsis to prevent constipation, and the loquat powder has the effects of clearing heat and moistening the lungs, dissipating phlegm and relieving a cough, lubricating the intestines and relieving constipation, clearing liver-fire and promoting bile flow, and clearing heat and removing toxicity, which increase the nutritional value of the natural aromatic cooking condiment while improving the taste. By means of adding a process of bioenzymatic degradation to the centrifugation process, so as to subject chicken to enzymolysis, the original aroma of the chicken is reserved, and also, the prepared natural aromatic cooking condiment is easy to digest and absorb due to the bioenzyme-aided decomposition of the proteins in the chicken.

The invention relates to the technical field of medical drainage, and discloses a hepatobiliary and pancreatic surgery bile reinfusion device which comprises a main body, the main body comprises a pipe sleeve, the upper end and the lower end of the pipe sleeve are connected with an upper pipe and a lower sleeve respectively, the bottom of the lower sleeve is connected with a lower pipe, and a conveying assembly is arranged in the pipe sleeve; the conveying assembly is used for conducting drainage and reinfusion on bile. According to the bile reinfusion device for the hepatobiliary and pancreatic surgery department, bile of a patient can be drained and collected through the arranged drainage device, the drainage device is connected to the bile outflow position through a hose, the drained bile can be filtered through the gravity drooping sense of gauze, and meanwhile when the whole main body slightly moves through the centered drooping sense of a ball body, the drainage effect is good. When bile is drained, the gauze element is stretched by the ball body to automatically shake, impurities on the surface are shaken off, or adhesion and blocking of the impurities on the gauze element are reduced, the filtering effect of the gauze element is always kept, and therefore the drainage and collection quality of the bile is improved.

This invention discloses a deep learning-based method for predicting the disease evolution of hepatobiliary patients, belonging to the fields of medical imaging and deep learning technology. The invention first acquires multi-temporal abdominal CT images, time-series clinical laboratory indicators, and medical history follow-up data of hepatobiliary patients; it then uses a variant U-Net network with Lagrange pseudo-ordering structure constraints to accurately segment the CT images and extract radiomics features; based on the segmentation results, a three-dimensional model is constructed, and numerical simulations of hepatobiliary blood perfusion and bile fluid dynamics are performed using local entropy production theory to obtain dynamic biomechanical features; cross-dimensional feature alignment and fusion are achieved by fusing attention mechanisms and a multimodal network for complex community discovery, and then chaotic theory is introduced for phase space reconstruction to enhance dynamic features; this invention achieves an upgrade from statistical correlation to physiological causality in prediction, improving model generalization and clinical interpretability, and is suitable for prognostic assessment and intelligent early warning of disease progression in hepatobiliary diseases.

The utility model discloses a nasobiliary drainage device and a fixing waistband. The nasobiliary drainage device comprises a sample bottle, an adjusting part arranged at the top of the sample bottle, a drainage tube connected with the adjusting part, and a water outlet tube arranged at the bottom of the sample bottle, wherein the adjusting part is provided with an inflow port, two outflow ports and a filter screen arranged at one of the outflow ports; the bile flows out from different outflow ports, so that the filter screen located at one outflow port can filter impurities in the bile when the bile is returned; according to the device, bile can be filtered in the conveying process, so that bile in a sample bottle does not need to be poured out again, secondary pollution of the bile can be avoided, and meanwhile, the accuracy of bile capacity reading is guaranteed by replacing a bag with a bottle.