544 results about "Gallstones" patented technology

Disclosed is an expandable transluminal sheath, for introduction into the body while in a first, low cross-sectional area configuration, and subsequent expansion of at least a part of the distal end of the sheath to a second, enlarged cross-sectional configuration. The sheath is configured for use in the gastrointestinal system and has utility in the performance of endoscopic retrograde cholangiopancreatography (ERCP). The distal end of the sheath is maintained in the first, low cross-sectional configuration and expanded using a radial dilatation device. In an exemplary application, the sheath is utilized to provide access for a diagnostic or therapeutic procedure such as gallstone or pancreatic stone removal.

This invention also provides a method to prevent, control, and treata lipid metabolism disorder, a billary disorder, cardiovascular disease, obesity or an endocrine disorder by administering at least one agonist of guanalyte cyclase receptor either alone or in combination with a compound typically used to treat the disorder and or with an inhibitor of cGMP-dependent phosphodieasterases.

There is provided a method for controlling the movement of bile and / or gall stones in the biliary duct. The method comprises gently constricting (i.e., without substantially hampering the blood circulation in the tissue wall) at least one portion of the tissue wall to influence the movement of bile and / or gallstones in the biliary duct, and stimulating the constricted wall portion to cause contraction of the wall portion to further influence the movement of bile and / or gallstones in the biliary duct. The method can be used for restricting or stopping the movement of bile and / or gallstones in the biliary duct, or for actively moving the fluid in the biliary duct, with a low risk of injuring the biliary duct.

The invention discloses a new Chinese medicinal composition for treating the symptom of gallstones and a preparation method thereof. The Chinese medicinal composition mainly comprises the following raw material medicaments: pangolin scales, immature bitter orange, curcuma aromatica, green tangerine peel, chicken's gizzard-membrane, peach seed, safflower, common burreed rhizome, zedoary, rhizoma corydalis, frankincense, myrrh, dragon's blood, Chinese honeylocust spine, root of red-rooted salvia, sappan wood, dried lacquer, turtle shell, rhubarb, Chinese dwarf cherry seed, golden thread, honeysuckle, artemisia capillaries, longhairy antenoron herb, pantain seed, talc and Japanese climbing fern spore. The Chinese medicinal composition of the invention can be prepared into any common oral administration preparation according to the conventional method of Chinese medicinal preparations. The Chinese medicinal composition can improve symptoms such as pain, paroxysmal aggravation, abdominal distension, bitter taste, constipation, yellow urine, ictericsclera, yellow body and the like which are caused by gallstones obviously, call away the gallstones, bile duct stones and stones in intrahepatic bile ducts, and has the definite clinical curative effect and obvious curative effect on the treatment of cholecystitis. The Chinese medicinal composition has the advantages of low cost, no toxic or side effect basically and the like.

The invention provides a Chinese sausage containing dietary fibers and fish meat and a production method thereof, which can make up for the shortage of the current sausage market. The technical scheme is as follows: the weight percentage of the dietary fibers is 2 percent to 20 percent, the weight percentage of the fish meat is 10 percent to 40 percent, the weight percentage of livestock meat is 30 percent to 70 percent, the weight percentage of seasoning is 5 percent to 15 percent, and the rest is water. The Chinese sausage has functions, such as preventing constipation and intestinal diseases, eliminating heavy metals and radicals in the body, preventing cardiovascular diseases, diabetes and breast cancer, preventing and treating gallstone, reducing blood pressure and enhancing the immunocompetence of the human body.

The invention discloses an FXR receptor modulator, and a preparation method and an application thereof, belonging to the field of medicinal chemistry. The FXR receptor modulator with a structure characteristic as shown in a formula I in the specification or pharmaceutically-acceptable salts or stereoisomers or solvates or prodrugs thereof can bind with an FXR (i.e., NR1H4) receptor and is used as an agonist or a partial agonist of the FXR receptor, thereby being able to be applied to prevention and treatment of FXR mediated diseases, such as chronic intrahepatic or extrahepatic cholestasis, hepatic fibrosis caused by chronic cholestasis or acute intrahepatic cholestasis, or chronic hepatitis B, or gallstone, or liver cancer, or colon cancer, or inflammatory bowel diseases, etc., wherein a part of compounds specifically can reach an FXR-excited EC<50> of 100 nM or below, show good FXR agonist activity, have excellent application prospects, and provide a new medicine choice for clinical treatment of the FXR mediated diseases.

The present invention relates to a method and apparatus for laser-based surgery and treatment, in particular of the human body. Inter alia, the present disclosure teaches an apparatus having a femtosecond laser that emits at least one pulse of laser energy having a pulse duration of less than 100 femtoseconds and a fiber optical channel for conducting said emitted pulse of laser energy to a vicinity of a human body to irradiate a localized area of said human body to effect at least one of microsurgery, neurosurgery, treatment of cardiovascular disease, treatment of the skin, tissue removal for biopsy, cutting of a mucous membrane, disintegration or vaporization of a gallstone or a kidney stone, and orthopedic surgery.

Methods and compositions are provided which contains preparations of calcium chelators, bisphosphonates, antibiotics, antimicrobial agents, cytostatic agents, calcium ATPase and pyrophosphatase pump inhibitors, calcium phosphate-crystal dissolving agents, agents effective against calcium phosphate-crystal nucleation and crystal growth, and / or a combination of supportive agents and which may be used for treating and or reducing pathological calcifications, the growth of Nanobacterium and calcification-induced diseases including, but not limited to, Arteriosclerosis, Atherosclerosis, Coronary Heart Disease, Chronic Heart Failure, Valve Calcifications, Arterial Aneurysms, Calcific Aortic Stenosis, Transient Cerebral Ischemia, Stroke, Peripheral Vascular Disease, Vascular Thrombosis, Dental Plaque, Gum Disease (dental pulp stones), Salivary Gland Stones, Chronic Infection Syndromes such as Chronic Fatigue Syndrome, Kidney and Bladder Stones, Gall Stones, Pancreas and Bowel Diseases (such as Pancreatic Duct Stones, Crohn's Disease, Colitis Ulcerosa), Liver Diseases (such as Liver Cirrhosis, Liver Cysts), Testicular Microliths, Chronic Calculous Prostatitis, Prostate Calcification, Calcification in Hemodialysis Patients, Malacoplakia, Autoimmune Diseases. Erythematosus, Scleroderma, Dermatomyositis, Antiphospholipid Syndrome, Arteritis Nodosa, Thrombocytopenia, Hemolytic Anemia, Myelitis, Livedo Reticularis, Chorea, Migraine, Juvenile Dermatomyositis, Grave's Disease, Hypothyreoidism, Type 1 Diabetes Mellitus, Addison's Disease, Hypopituitarism, Placental and Fetal Disorders, Polycystic Kidney Disease, Glomerulopathies, Eye Diseases (such as Corneal Calcifications, Cataracts, Macular Degeneration and Retinal Vasculature-derived Processes and other Retinal Degenerations, Retinal Nerve Degeneration, Retinitis, and Iritis), Ear Diseases (such as Otosclerosis, Degeneration of Otoliths and Symptoms from the Vestibular Organ and Inner Ear (Vertigo and Tinnitus)), Thyroglossal Cysts, Thyroid Cysts, Ovarian Cysts, Cancer (such as Meningiomas, Breast Cancer, Prostate Cancer, Thyroid Cancer, Serous Ovarian Adenocarcinoma), Skin Diseases (such as Calcinosis Cutis, Calciphylaxis, Psoriasis, Eczema, Lichen Ruber Planus), Rheumatoid Arthritis, Calcific Tenditis, Osteoarthritis, Fibromyalgia, Bone Spurs, Diffuse Interstitial Skeletal Hyperostosis, Intracranial Calcifications (such as Degenerative Disease Processes and Dementia), Erythrocyte-Related Diseases involving Anemia, Intraerythrocytic Nanobacterial Infection and Splenic Calcifications, Chronic Obstructive Pulmonary Disease, Broncholiths, Bronchial Stones, Neuropathy, Calcification and Encrustations of Implants, Mixed Calcified Biofilms, and Myelodegenerative Disorders (such as Multiple Sclerosis, Lou Gehrig's and Alzheimer's Disease) in humans and animals. The method comprises administering the various classes of compositions of the present invention, which together effectively inhibit or treat the development of calcifications in vivo.

This invention also provides a method to prevent, control, and treata lipid metabolism disorder, a biliary disorder, cardiovascular disease, obesity or an endocrine disorder by administering at least one agonist of guanalyte cyclase receptor either alone or in combination with a compound typically used to treat the disorder and or with an inhibitor of cGMP-dependent phosphodieasterases.

The present invention relates to the preparation of biodegradable, X-ray visible, anti-infectious, antitumor, anti-fibrosis and anti-calculus multi-layer composite medicine composite polymer biliary rack. Several kinds of degradable polymer material are used in preparing the multi-layer rack, and the degradation speed gets faster from inside to outside of the rack cavity. During the degradation, the rack falls down from inside to outside, and the induced gall silt and gallstone fall from the rack to drain into intestinal tract without forming large gallstone to prevent re-stenosis and infection.

This invention also provides a method to prevent, control, and treat a lipid metabolism disorder, a billary disorder, cardiovascular disease, obesity or an endocrine disorder by administering at least one agonist of guanalyte cyclase receptor either alone or in combination with a compound typically used to treat the disorder and or with an inhibitor of cGMP-dependent phosphodieasterases.

The invention relates to a health-care konjak rice glue ball and a preparation method thereof. The preparation method comprises the following steps: preparing rice glue ball powder; preparing stuffing; molding the stuffing; quick-freezing; rolling circles of the molded stuffing; packaging; and refrigerating. In the health-care konjak rice glue ball, the konjaku flour is utilized as a main raw material, the konjac glucomannan in the konjaku flour not only is an excellent water-soluble dietary fiber with low calorie, low fat and high cellulose, but also has an important regulating effect in nutritive equilibrium, functions of losing weight, relaxing bowel and regulating cholesterol metabolism, and obvious curative effects on diseases such as arteriosclerosis, gallstone, constipation, diabetes, obesity and the like, thus being a health-care food; lotus rhizome contains various nutritions, is rich in calcium, phosphonium, ferrum and multivitamins and has various functions of reducing fever and moistening the lung, strengthening the spleen and stimulating the appetite, reducing the blood pressure, arresting hemorrhage and the like, thus being a favorable tonic for the old, the young, women, children and weak patients; and sweet potatoes are rich in multivitamins, amino acid and dietary fiber which are essencial to a human body as well as various mineral substances such as calcium, ferrum and the like, are high in amylopectin content and can be easily digested and absorbed by the human body, thus being a health-care food.

The invention relates to a beverage containing water-soluble dietary alga fiber carrageenan. The invention has the following characteristics that: the beverage comprises the water-soluble dietary alga fiber carrageenan, sugar, fruit juice or food flavor, citric acid and water, the weight percentage of the water-soluble dietary alga fiber carrageenan ranges from 0.01 percent to 20 percent, the weight percentage of the sugar ranges from 0.0001 percent to 20 percent, the weight percentage of the fruit juice or food flavor ranges from 0.0001 percent to 40 percent, the weight percentage of the citric acid ranges from 0.0001 percent to 2 percent, and the rest is water. The beverage can prevent constipation and intestinal diseases, eliminate heavy metals and radicals in the body, prevent cardiovascular diseases, diabetes and breast cancer and gallstone, reduce blood pressure and enhance the immunocompetence of the human body. The beverage does not contain high-calorific-value ingredients such as protein and fat, belonging to a low-calorific-value functional beverage, and the beverage not only enriches Chinese food culture, but also greatly improves the physical health of people.

The invention relates to a dietary fiber and fish sausage and a production method thereof, which can fill the disadvantages of the conventional fish sausages in the current market. The invention adopts the technical scheme that the sausage comprises dietary fiber, fish and seasonings. The weight percentages of the dietary fiber, the fish and the seasonings are respectively 2-30%, 50-90% and 2-20%, and the rest is water. The sausage has the advantages of preventing constipation and bowel disease, removing heavy metals inside the body, removing free radicals, preventing cardiovascular disease, diabetes,and breast cancer, preventing and curing gallstones, lowering blood pressure and strengthening the human immune functions.

The invention discloses an application of hydroxyacetophenone and its derivatives in preparing drugs for curing cholelithiasis, which can enhance the excretion of bile and lower down the content of cholesterin and bilirubin in the bile, thus realizing the dual effects of bile expelling and lithiasis resolving. Therefore, the invention can be applied to treat lithiasis.

The present invention relates to compounds of formula I wherein R1, R2, R3, R4, R5, U, V, W, k and m are as defined in the description and claims, and pharmaceutically acceptable salts and / or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and / or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasit infections, gallstones, tumors and / or hyperproliferative disorders, and treatment and / or prophylaxis of impaired glucose tolerance and diabetes.

A nutraceutical formula and food-based medicinal composition is provided comprising homeopathic ingredients in combination with traditional herbal and nutraceutical ingredients for relieving the symptoms associated with presence or formation of kidney stones and gallstones. The formulation includes ingredients balanced in a synergistic manner to elicit complementary effects which both reduce the symptoms of kidney stones and gallstones and provide the potential to eliminate their occurrence in the body and prevent future recurrence. Methods of making and using core medicinal formulations and food-based compositions are also described.

The invention discloses a stone removal device for hepatological surgery department. The stone removal device comprises a moving box body, a drainage tank and a physiological saline tank are installedinside the moving box body, the drainage tank is connected to a negative pressure gas pump, the drainage tank is also connected to a drainage electric control valve, the physiological saline tank isconnected to a pressurized gas pump, the physiological saline tank is also connected to a cleaning electric control valve, a carbon dioxide gas treatment box is also installed inside the moving box body, the upper end of the carbon dioxide gas treatment box is connected to a gas intake pump through a second electronic control valve, the gas intake pump is connected to a gas outlet control valve, acontrol box is installed at the upper end of the moving box body, and a display screen and a control keyboard are installed at the upper end of the control box. The stone removal device is used for removing all gallstones in a gallbladder under the direct vision of a fiber choledochoscope, can achieve the functions of negative pressure drainage, physiological saline cleaning and tissue bulging bycarbon dioxide, greatly facilitates the stone removal work, improves the surgical efficiency of medical staff, facilitates the surgery, greatly reduces the preparation time and workload of the medical staff, provides a patient with good medical experience and is conducive to disease rehabilitation.

The present invention relates to novel dihydroindole and tetrahydroquinoline derivatives and pharmaceutically acceptable salts and / or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and / or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and / or hyperproliferative disorders, and treatment and / or prophylaxis of impaired glucose tolerance and diabetes.

Catheter apparatus for performing diagnostic and therapeutic modalities in the biliary tree includes a catheter with multiple lumens. A first lumen is adapted to receive a guidewire and can serve as a transport lumen for contrast agent. A second lumen carries a cutting wire for performing a sphincterotomy. A third lumen can be used as an inflation lumen for a distally located balloon. Expansion of the balloon occludes a portion of the biliary tree and allows the catheter to sweep any gallstones through the sphincter of Oddi into the duodenum.

The invention relates to Chinese medicinal herb pills for treating cholecystitis and gallstone. The Chinese medicinal herb pills are prepared from 22 gouts of Chinese medicinal herbs, namely coptis root, baikal skullcap root, phellodendron, corydalis tuber, curcuma, costus root, loosestrife herb, Japanese climbing fern spore, dark plum, white peony root, fine-leaf schizonepeta herb, green tangerine peel, immature bitter orange, turmeric, polygonum cuspidatum, Szechwan chinaberry fruit, gentian, bupleurum, oriental wormwood, chicken's gizzard-membrane, compound of glauber-salt and liquorice and slaked lime. The pills can lighten the pathological change of cholecystitis, promote gallbladder contraction and promote gallstone excretion and biliary excretion; by the pills, biliary excretion components are radically changed, the metabolism requirement of the human body is met, calculi are gradually disintegrated and deposited, the micro environment in the gall bladder is recovered when the calculi are discharged, and the aim of thoroughly discharging the calculi is fulfilled. The Chinese medicinal herb pills have the advantages of quick response, short treatment course, high healing rate, low recurrence rate, treatment for both symptoms and root causes, no toxic or side effects and the like.

The invention relates to the technical field of medical instruments, in particular to a degradable bile duct bracket with stone dissolution function and a preparation method thereof. The degradable bile duct bracket is prepared by the following raw materials in proportion: 60-98% by weight (wt) of degradable polymer, 0.1-2.0 % by weight of nucleating agent, 1-15 % by weight of plasticizer, and the balance of stone dissolution drug, wherein the total weight amounts to 100%. The degradable bile duct bracket is obtained by evenly mixing the degradable polymer, the nucleating agent, the plasticizer and the stone dissolution drug, and then fusing and extruding the mixture through a medical catheter precise extruder; by successfully selecting proper degradable polymer, nucleating agent and plasticizer, the defects of the plastic bracket and metal bracket in the bile duct interventional therapy are overcome; moreover, by adding the stone dissolution drug, the curative effective of gall-stone is improved; therefore, the degradable bile duct bracket has wide application prospect.

The invention discloses a drug for removing the gall stone, aiming at removing the gall stone out of a human body without a surgery, and avoiding the pain to patients caused by the surgery. The drug for removing the gall stone disclosed by the invention consists of a main formula and a subsidiary formula, wherein the main formula consists of the following components: olive oil and lemon juice; and the subsidiary formula consists of the following medicinal materials: radix bupleuri, the root of red-rooted salvia, rhizoma corydalis, rhizoma cyperi, fructus toosendan, Chinese angelica, white paeony root, poncirus trifoliate, curcuma aromatica, fingered citron, radix astragali, chrysanthemum, felwort, serrate rabdosia herb, oriental wormwood, plantain herb, lysimachia christinae hance, cordate houttuynia, rhizoma alismatis, endothelium corneum gigeriae galli, talc and liquorice. Compared with the prior art, the drug adopts the main formula which is prepared by mixing the olive oil and the lemon juice, so that the gall stone can be removed out of the human body through the intestinal tract after the main formula is taken by the patient with an empty belly, and the gall bladder can be recovered, and the gall stone can be removed without the surgery in combination with the subsidiary formula which has the functions of nourishing the liver and benefitting the gall bladder, therefore, the pain to the patients caused by the surgery can be reduced, the time and the money cost by hospitalization can be avoided, and the treatment cost can be reduced.

The long-term usage of AICR (5-aminio, 4-imidazole carboxamide riboside) to produce sustained metabolic and biological changes in mammals that overcome insulin resistance, i.e., increase insulin sensitivity, and result in benefits in diseases and conditions such as diabetes, hypertension, atherosclerosis, polycystic ovary syndrome and gallstones is described long-term usage of AICAR, particularly intermittent administration, e.g., three days per week, appears to have some of the positive effects of exercise, having an impact on the amount Of food consumed by a subject and resulting in reduced fat build-up and increase in muscle mass. Therefore, AICAR administration has a positive impact in reducing obesity. AICAR can also Prove useful in preventing or treating vascular diseases associated with hyperglycemia, high plasma levels of free fatty acids (FFA) and triglyceride, and insulin resistance by virtue of the fact that this agent activates fatty acid oxidation. Animal tests have Shown that chronic intermittent treatment with AICAR has not resulted in any noticeable toxic effects. AICAR and related compounds are activators of AMP-activated protein kinase (AMPK) and, furthermore, are effective at decreasing malonyl CoA levels in the animal.

The invention provides an oral administration traditional Chinese preparation for treating rhinitis, comprising one of the two groups of weight portion, group 1, biond magnolia flower 45-55, dahurian angelica root 45-50, pangolin scales 40-50, Ligusticum wallichii 45-55, cocklebur fruit 45-55, asarum herb 20-30, borneol 20-25, dragon's blood resin 18-25, artificial ox gallstone 20-25, group 2, silver flower 45-50, Chinese honeylocust spine 25-35, wrinkled gianthyssop 25-35, chrysanthemum flower 20-30, aristolochia stem 10-15, dandehon herb 45-55, herba schizonepetae 25-35, bupleurum root 20-30, peppermint 10-20, Chinese ephedra 15-25, calcium sulphate 55-65 and licorice root 25-35.

The present invention relates to a cholecystitis and gallstone treatment traditional Chinese medicine, which is characterized in that the cholecystitis and gallstone treatment traditional Chinese medicine is prepared from the following raw materials, by weight, 9 g of Chinese gentian, 30 g of lysimachia, 6 g of baikal skullcap root, 15 g of cape jasmine, 15 g of corydalis tuber, 6 g of oriental waterplantain tuber, 6 g of akabia stem, 15 g of Chinese thorowax root, 6 g of angelica, 12 g of rehmannia dride rhizome, and 3 g of licorice root. According to the present invention, the cholecystitis and gallstone treatment traditional Chinese medicine is prepared from the Chinese herbals, has functions of liver soothing, qi regulating, pain relieving, cholaneresis, organ soothing, heat clearing, dampness eliminating, calculus eliminating, constipation relieving, pathogenic fire reducing and pain reducing, and has characteristics of wide sources of the medicine components, simple preparation, low cost, significant treatment effect, reliable effect, mild medicine property, and no toxic and side-effect, wherein clinical trial results show that a cure rate is 80%, and the total effective rate is 98.3%.

The invention discloses an orally-administered traditional Chinese medicine composition. The composition is prepared from traditional Chinese medicine raw materials such as desmodium, rhubarb, Herba Artemisiae Capillaris, achyranthes, Alisma orientale, tuckahoe, an animal gall product and so on, has functions of clearing heat and promoting diuresis, soothing liver and benefiting gall, regulating qi and dredging stranguria, promoting urination, promoting the secretion of bile, resisting inflammation, killing pain, relieving fever, resisting bacteria and so on, is used for treating diseases such as cholelithiasis and urinary calculus or hepatobiliary lithiasis caused by damp-heat of liver and gallbladder as well as symptoms such as right epigastric pain, upper abdomen fullness and distention, nausea, anorexia to greasiness, jaundice, yellow and greasy fur or osphyalgia, hematuria and so on, and has definite treatment effect and no apparent adverse reaction. The invention also relates to a preparation method, an administration method and a quality checking method for the orally-administered traditional Chinese medicine composition.

The invention provides a Chinese medicine preparation capable of diminishing inflammation, relieving pains, resisting bacteria, expelling stone and benefiting gallbladder, a preparation method thereof and applications of the Chinese medicine preparation in preparing medicines for treating urinary system calculi, urinary tract infection, cholecystitis, gall-stone and prostatitis. According to the theory of Chinese medicines, through the experiment and screening for many years, the invention reselects raw drugs in the prescription, optimizes the preparation technology, greatly enhances the medicinal functions of promoting diuresis for stranguria and removing heat for detumescence, has unexpected obvious curative effect on treating urinary system diseases, and especially produces unexpected effects of resisting bacteria, resisting prostatitis, relieving pains and benefiting gallbladder which are not provided in the prior art. The Chinese medicine preparation of the invention exerts the traditional advantages of Chinese medicines, takes effect quickly, obviously improves the subjective symptom and the physical sign, and does not have obvious side effect.

The invention discloses a traditional Chinese medicine oral liquid, in particular a traditional Chinese medicine oral liquid for treating cholecystitis and gallstones and a preparation method thereof. The traditional Chinese medicine oral liquid for treating cholecystitis and gallstones is characterized by comprising the following components: wine Coptis chinensis, wine Scutellaria baicalensis, wine rheum officinale, honeysuckle, desmodium, vinegar fried turmeric, elecampane, bran fried fructus aurantii, vinegary radix bupleuri, vinegary corydalis tuber, radix clematidis, fructus amomi, vinegar fried endothelium corneum gigeriae galli, burnt hawthorn, smoked plum, Lygodium japonicum, Codonopsis pilosula, bran fried Chinese yam, honey astragalus and pepper. The traditional Chinese medicine oral liquid is specially used for treating cholecystitis and gallstones, and properties of the material medicines are changed or alleviated by means of compatibility so that medicine with strong property are alleviated. The invention has obvious clinical efficacy, treats both principal and secondary aspect of disease and is safe and reliable and better exerts functions of medicines without damaging liver and kidney. The traditional Chinese medicine oral liquid has good taste, is convenient to take, beneficial to storage and can be taken by diabetics and hyperpietics safely. Totally 360 patients are treated and total effective rate reaches 98%.