46 results about "Gallstones" patented technology

The invention relates to a poria cocos extract and a preparation process thereof. According to the invention, ethanol and N-methyl pyrrolidone are used as extraction solvents to prepare the poria cocos extract, and the extract is rich in poria cocos triterpenes and polysaccharides. Experimental results show that the obtained extract has a remarkable treatment effect on gall-stone model mice, the number of cholesterol crystals in gallbladders of the mice can be remarkably reduced, the content of cholesterol in the gallbladders can be reduced, and the content of phospholipid and bile acid in the gallbladders can be effectively increased.

The invention provides a gall-stone removing and crushing device under a laparoscope, and belongs to the technical field of gall-stone treatment. Comprising a catheter, the top of the catheter is fixedly connected with a first camera, the catheter is internally provided with a bag sealing assembly which is used for forming a controllable closed cavity in a gall bladder and wrapping a target calculus, and the bag sealing assembly comprises a first guide tube slidably connected to the interior of the catheter. The bag sealing assembly, the calculus removing assembly and the calculus crushing assembly are arranged and are matched with one another for use, and the integrated process of wrapping, grabbing, crushing and collecting is formed through the integrated design of a nested guide pipe, the bag sealing assembly constructs a closed cavity to isolate an operation area, and the calculus removing assembly accurately grabs calculus and fixes the calculus in a bag; the stone crushing assembly efficiently crushes target stones in a closed environment, internal and external double-view-angle monitoring is achieved through double cameras in the whole process, and the risk of gallbladder injury caused by the fact that an incision is exposed to the outside in a traditional operation is avoided through cooperation of the three assemblies.

The present invention belongs to the technical field of medical devices, and specifically relates to a bile duct stone removal instrument in ERCP surgery, which is mainly used for removing gallstones in ERCP surgery; it mainly comprises: a main branch, having a first proximal end and a first distal end opposite to each other; a push tube, having a second proximal end and a second distal end opposite to each other, wherein the push tube is sleeved on the outer side of the main branch; a stone removal part, which is arranged around the first proximal end of the main branch and connected to the second proximal end, wherein the stone removal part is configured such that when the second proximal end moves toward the first proximal end, the stone removal part is partially away from the outer wall of the main branch to present an expanded state, and when the second proximal end moves toward the direction away from the first proximal end, the stone removal part is partially close to the outer wall of the main branch to present a contracted state; it mainly solves the problem that the existing stone removal basket or stone removal balloon cannot grasp the stones well, resulting in the need for repeated operations, thereby prolonging the operation time and increasing the pain of the patient.

The Integrated Laser Basket (ILB)—a medical device used for treating various types of stone deposits, including, but not limited to, kidney stones, gallstones, bladder stones, prostate stones, pancreatic stones, or any combination thereof, in human or animal patients. The ILB merges the benefits of laser lithotripsy and stone retrieval in a single device, offering a more comprehensive and minimally invasive approach to stone management. Example methods of using the ILB to treat various types of stone deposits in human and non-human patients are also described.

The utility model discloses a kind of visual microinvasive injectors for living body cultivation gall, belong to the technical field of pharmaceutical manufacturing.A kind of visual microinvasive injector for living body cultivation gall, including upper shell, lower shell, limit ring, sealing plate, bottom plate, sealing ring, buckles and support block, the upper shell is sleeved in the surface of lower shell and limit ring, the limit ring is sleeved in the surface of injector barrel, limit ring one end extends to the outside of upper shell, and the other end is penetrated to the inside of lower shell.The utility model is designed as integrally-formed injector, minimally invasive surgery and visualization technology are integrated, simplify surgical procedure, even non-professional technical personnel can quickly master operation method.Integrally-formed design reduces different tools needed to switch or use in cooperation in surgery, reduces surgery time, reduces operation complexity, improves surgery efficiency and safety.

The utility model relates to the field of calculus bovis selecting devices, in particular to a calculus bovis selecting device capable of reducing loss. Comprising a box body, two rubber gloves are installed in the box body, a connecting pipe is installed at one end of the box body, an air extracting pump is installed at the end, away from the box body, of the connecting pipe, a supporting frame is installed at the end, close to the air extracting pump, of the box body, the air extracting pump is installed on the supporting frame, and a collecting structure is arranged at the end, close to the supporting frame, of the box body. The collecting structure comprises two connecting rods, the two connecting rods are fixedly connected with the box body, and the ends, away from the box body, of the connecting rods are fixedly connected with a shell. The calculus bovis picking device capable of reducing the loss has the advantages that manual picking operation or manual picking operation is carried out in the negative pressure device through the negative pressure device, calculus bovis powder in the picking process can be collected through the air outlet which exhausts air outwards, and the calculus bovis loss is reduced.

The invention provides a gallstone removing device for a gallstone operation, and belongs to the technical field of medical instruments. Comprising a minimally invasive channel, a puncture needle tube is inserted in the minimally invasive channel, a supporting tube is inserted in the puncture needle tube, one end of the supporting tube is fixedly connected with a grab handle, the other end of the supporting tube is fixedly connected with an expansion opening, a fixing plate is fixedly connected to the outer wall of the supporting tube, and three sliding blocks are fixedly connected to the inner wall of the expansion opening; two supporting frames are fixedly connected to the outer wall of the top of the grab handle, and a through hole is formed in the grab handle; the clamping assembly is used for clamping gall-stone in the gall bladder of a patient, and the cutting assembly is used for chopping large gall-stone in the gall bladder of the patient. By arranging the cutting assembly, a doctor can cut up the large stone in the gall bladder, if the large stone is not cut, the operation time can be prolonged or the incision on the outer wall of the gall bladder is torn, and the postoperative recovery is influenced. By means of the cutting assembly, a doctor can directly cut the stone during clamping, tools do not need to be replaced, and the operation time is shortened.

The invention discloses a method for culturing calculus bovis by utilizing flora, which is characterized in that cattle gall bladders obtained by slaughtering are used as reaction containers, so that the animal welfare problem caused by living body surgery is completely avoided. A plurality of key steps of bilirubin generation, cholesterol conversion, matrix formation and the like are synergistically completed by adopting functional complementary synthetic flora, and the components of the generated product are closer to a complex system of natural calculus bovis. The breeding is carried out in a closed bioreactor with controllable parameters, uncontrollable factors such as individual cattle difference and feeding environment are eliminated, and the product quality is highly stable and uniform. Automatic monitoring and feedback control are achieved in the whole cultivation process, and technological parameters are accurate and adjustable. The used strains are all non-pathogenic or food-grade safe strains, and the whole process is sterile, free of exogenous pathogen pollution and antibiotic residue risks, and high in biological safety.

The present application relates to the medical field, and is used for treating gallstones, and is a gallstone dissolving agent and a double-needle tube circulating agent gallstone dissolving device. The gallstone dissolving agent is prepared by mixing a weak organic acid and an organic solvent according to a certain concentration ratio. The double-needle tube circulating agent gallstone dissolving device is connected by a medicine bottle, a dropping funnel, a medicine delivery tube, an inner needle tube, a rubber cap, a reversing tee, an outer needle tube, and a drainage tube according to a specified position and sequence. The device has the beneficial effects that after the gallstone dissolving agent is safely dropped into the gallbladder, the gallstone is dissolved by a chemical method and is circulated and removed from the body, the gallstone is completely removed without any residual fragments, the surgical wound is not greater than 1.8 mm, the gallbladder is slightly damaged, and the body recovers quickly. The device is a new breakthrough in gallbladder-preserving and stone-removing surgery.

This invention discloses a method for fabricating a memristor based on a bile functional layer, belonging to the field of bioelectronic device fabrication and in vitro diagnostics of biliary tract diseases. The method sequentially completes FTO substrate pretreatment, bile functional layer preparation, Ag-on-electrode deposition, and memristor detection array fabrication. First, the FTO substrate is physically cleaned and plasma-activated. Then, a 240-260 nm bile functional layer is prepared. Subsequently, an Ag-on-electrode is deposited, and a 5-15 nm Ag atom embedding transition region is constructed. Finally, a 2×2 array is arranged and passivated for isolation. The process parameters of each step are synergistically matched to optimize the interface between the substrate, functional layer, and electrode, fully preserving bile pathological information. The resulting Ag / Bile / FTO structure memristor exhibits high electrical stability and shows significant differences in electrical response to bile samples from normal, gallstone, and gallbladder cancer patients. It enables accurate and rapid in vitro identification of biliary tract diseases, and the process is simple, low-cost, and suitable for clinical application and large-scale production.

To provide a basket-type grasping forceps and a basket-type grasping forceps system that can smoothly release foreign objects such as gallstones from a basket wire into a body cavity without damaging the body cavity. [Solution] The basket-type grasping forceps system 2 comprises a grasping forceps 1, an endoscope M, a monitor M1, and a grasping forceps device 50. The grasping forceps 1 comprises a first grasping forceps 5 and a second grasping forceps 6. The first grasping forceps 5 has a first basket wire 11a, a first operating wire 20a, and a first knob 31. The second grasping forceps 6 has a second basket wire 11b, a second operating wire 20b, and a second knob 32. By moving the first knob 31 toward the rear end along the axial direction of the tube 52, the tip portion 12 rotates laterally, allowing foreign matter inside the basket wire 11 to be discharged outside the basket wire 11.

This invention provides an in vitro cultured bezoar, its preparation method, and its application, belonging to the field of traditional Chinese medicine preparation technology. The preparation method of this invention involves obtaining a bile-resistant, high-β-glucuronidase-active *Escherichia coli* strain through bile gradient acclimation, which is then combined with *Enterococcus faecalis* to form a functional bacterial community. This community is then cultured in vitro through a three-stage process of proliferation, transformation, and crystallization, followed by gradient calcium ion-induced crystallization and vacuum freeze-drying to obtain in vitro cultured bezoar. This invention aims to solve the problems of low conversion efficiency, uneven crystallization, insufficient content of effective components, and unstable product quality in existing technologies. The obtained in vitro cultured bezoar product has significantly higher bilirubin and conjugated bile acid contents than the standards of the *Chinese Pharmacopoeia*, and the process is stable, controllable, and suitable for industrialization.

This invention relates to a choleretic traditional Chinese medicine composition, its preparation method, and its application, belonging to the field of traditional Chinese medicine preparation technology. The microcapsules prepared from this choleretic traditional Chinese medicine composition consist of a core and a coating. The core contains a traditional Chinese medicine extract, pregelatinized starch, sodium alginate, and croscarmellose sodium. The coating contains hydroxypropyl cellulose and hydroxypropyl methylcellulose E5, PEG4000, and talc. The traditional Chinese medicine extract is made from Artemisia capillaris, Lysimachia christinae, Rheum palmatum, Scutellaria baicalensis, Taraxacum mongolicum, Forsythia suspensa, Curcuma longa, Curcuma longa, Bupleurum chinense, Citrus aurantium, and Aucklandia lappa. This choleretic traditional Chinese medicine composition has the effects of promoting bile flow and expelling gallstones, detoxifying and reducing swelling, with a stable drug release rate, definite efficacy, and few toxic side effects. It can be used for the prevention and / or treatment of acute and chronic gallstones and / or cholecystitis.

The present invention provides a device for gallstone surgical removal, which belongs to the field of medical device technology. It includes a minimally invasive channel, a puncture needle tube is inserted into the minimally invasive channel, a support tube is inserted into the puncture needle tube, one end of the support tube is fixedly connected to a handle, the other end of the support tube is fixedly connected to an expansion port, a fixing plate is fixedly connected to the outer wall of the support tube, three sliding blocks are fixedly connected to the inner wall of the expansion port, two support frames are fixedly connected to the top outer wall of the handle, and a through hole is opened on the handle; the clamping component is used to clamp the gallstones in the patient's gallbladder, and the cutting component is used to cut up larger gallstones in the patient's gallbladder. By setting up the cutting component, the present invention allows doctors to cut up large gallstones in the gallbladder. If large stones are not cut, the operation time may be prolonged or the incision on the outer wall of the gallbladder may be torn, affecting postoperative recovery. Using the cutting component, doctors can directly cut stones when clamping, without changing tools, thereby reducing operation time.

The invention provides a traditional Chinese medicine composition for treating gall-stone and a preparation method, a preparation and application of the traditional Chinese medicine composition, and the composition is prepared from the following raw material medicines in parts by weight: 9-12 parts of radix bupleuri, 6-12 parts of radix paeoniae alba, 6-12 parts of fructus aurantii immaturus, 6-12 parts of radix curcumae, 9-15 parts of herba lysimachiae, 5-9 parts of endothelium corneum gigeriae galli, 6-12 parts of rhizoma polygoni cuspidati, 4-6 parts of fructus toosendan and 0.2-0.3 part of bear gall. According to the composition disclosed by the invention, the radix bupleuri and the fructus aurantii immaturus are selected as monarch drugs to synergistically exert the effects of soothing liver and regulating qi, benefiting gallbladder and relaxing bowels, and ascending lucidity and descending turbid; radix paeoniae alba, radix curcumae, lysimachia christinae hance and endothelium corneum gigeriae galli are used as ministerial drugs to further enhance the effects of nourishing blood and liver, promoting qi to activate blood, clearing liver and gallbladder damp-heat, resolving hard mass and Polygonum cuspidatum and szechwan chinaberry fruit are used as adjuvant drugs to assist in clearing heat, promoting diuresis, promoting qi circulation The bear gall is used as a conductant drug to guide all the drugs to directly reach the gallbladder meridian, and the overall effects of clearing heat, benefiting gallbladder, detoxifying and removing urinary calculus are achieved; the composition can inhibit gall-stone formation, promote calculus removal and relieve symptoms, and is high in safety, suitable for being taken for a long time, good in curative effect and high in compliance.

The invention discloses an extracorporeal circulation type bovine gall-stone preparation device and method, and relates to the field of artificial calculus bovis preparation. The device comprises a bile storage tank, double peristaltic pumps, a three-way valve, a tubular reaction unit, a constant-temperature heating jacket, a pH adjusting unit, a controller, an optional concentration unit and the like. The method comprises the following steps: preparing bile reaction liquid containing a lithogenic precursor, initializing parameters, starting a device, and circulating the reaction liquid; adjusting the pH value, concentrating to form a supersaturated environment for nucleation, simulating pulse flow at a periodic variable flow rate to promote dynamic growth, and finally harvesting, cleaning and drying. The gallbladder environment is simulated, living body dependence is avoided, the stone forming period is short, the similarity of the product and natural calculus bovis is high, and automatic large-scale production can be achieved.

The application provides a medicine composition for treating hepatobiliary diseases and a preparation method thereof, and the active ingredients are composed of a compound shown in formula (I) and Astragalus membranaceus and Saussurea involucrata extract, the weight ratio of the compound shown in formula (I) to the Astragalus membranaceus and Saussurea involucrata extract is 1: (1.5-2.0) by weight; compared with the prior art, the medicine composition of the application has a synergistic effect on hepatobiliary diseases, especially gallstones, and the effect is remarkable.

Systems, devices, and methods for percutaneous removal of gallstones and gallstone fragments to treat cholelithiasis are disclosed. A representative system includes: an access sheath; a suction device, which can be removably coupled to the access sheath; and a catheter that can be removably inserted into the access sheath. Representative systems may also include a comminuting or fracturing control device and / or a comminuting or fracturing instrument. A representative access sheath includes a tubular shaft and a proximal hub having one or more valves. A representative suction device includes: a syringe body; an extended distal tip, which may also have a valve; and a plunger movable within the interior lumen of the syringe body. Representative conduits include; an outer conduit tube; an inner catheter manipulation shaft movable within the lumen of the outer catheter tube; and a basket or cage having a plurality of longitudinal struts.

The present invention provides an endoscope capable of preventing lodging defects caused by foreign objects such as gallstones. The endoscope includes: an operation unit provided with operation members; an insertion unit provided on the front end side of the operation unit and inserted into a subject's body; a front end portion main body located at the front end of the insertion unit and formed with a riser accommodation space; a riser disposed in the riser accommodation space and rotatable between a lodging position and an upright position about a rotation axis, and having a treatment instrument guiding surface; and a top cover mounted on the front end portion main body, covering the riser accommodation space, and having a wall portion defining an opening window that is open on the side facing the treatment instrument guiding surface. The internal space formed by the opposite surface of the treatment instrument guiding surface of the riser and the wall portion of the top cover with the riser in the lodging position is sized to accommodate a virtual sphere with respect to the virtual sphere that can pass through the window gap formed by the riser and the wall portion of the top cover with the riser in the upright position.

This invention provides an extract of *Cimicifuga foetida*, made from *Cimicifuga foetida* produced in Guizhou Province, using an intermittent warm percolation method for water extraction. The extract contains 10%-25% cimicifugoside, 3%-15% iso-cimicifugoside, and 20%-50% plantago asiatica glycoside. The preparation method and applications are also disclosed. The *Cimicifuga foetida* extract provided by this invention has a high content of active ingredients and significant anti-inflammatory and litholytic pharmacological activities. It can be used as a raw material for the treatment and adjuvant treatment of cholecystitis, gallstones, hydronephrosis, kidney stones, nephritis, bladder stones, and uric acid stones. It can also be used as an intermediate raw material for the separation and purification of plantago asiatica glycoside, cimicifugoside, and iso-cimicifugoside chemical standards or reference standards. The preparation method provided by this invention effectively solves the problem of extraction and enrichment of active ingredients in *Cimicifuga foetida*, and has advantages such as low production cost, ease of large-scale production, and stable and controllable quality.

The present application relates to a kind of traditional Chinese medicine composition for treating calculus, raw material is: walnut kernel 25-35 parts, black fungus 10-20 parts, giant knotweed 15-25 parts, powder 25-35 parts of yam, sea gold sand 25-35 parts, 10-20 parts of yujin, 25-35 parts of huashi grass, 25-35 parts of shaddock, 10-20 parts of goose tube stone, 25-35 parts of yiwren, 10-20 parts of magnolia officinalis, 25-35 parts of xuanming powder, 10-20 parts of rhubarb, 10-20 parts of plantago, 10-20 parts of bupleurum, 10-20 parts of small chrysanthemum, 5-10 parts of cumin, 10-20 parts of Sichuan donkey's hide, 5-10 parts of raw licorice.The present application has the effect of clearing heat and promoting bile secretion, dissolving stone and stopping bleeding cooling blood, through the concept of dissolving stone and expelling stone, large stone is small, small stone is small, gallstones are discharged with bile into intestine, kidney stones, ureter and bladder stones are discharged with urine, adjust liver, gallbladder, kidney and other qi stagnation, and be supplemented with constitution conditioning syndrome differentiation treatment, it has good curative effect on various stones of liver, gallbladder, kidney and urinary tract, and it is both the treatment of principle and secondary, relieve the suffering of the majority of patients.

The invention relates to the technical field of biomedicine, and particularly discloses an in-vitro diagnosis marker for gall-stone and application thereof.The in-vitro diagnosis marker is jointly composed of a metabolism marker and an inflammation marker, the metabolism marker is the concentration ratio of lithocholic acid to ursodesoxycholic acid (LCA / UDCA), and the inflammation marker is the concentration ratio of CD133 to lipopolysaccharide (CD133 / LPS); the invention further provides a kit containing the marker and a detection method of the kit. The kit integrates specific detection reagents for LCA, UDCA, CD133 and LPS, two specific value markers can be rapidly, sensitively and simultaneously detected through an optimized sample treatment and detection process, and result judgment is carried out based on a preset reference interval upper limit and a composite judgment rule.

The medical system includes a basket treatment tool a processor. The processor determines, one or more of: a first determination, based on a transmissive image including the biliary duct, of whether a size of a gallstone allows the basket treatment tool to remove the gallstone from the papillary orifice, or a second determination, based on a resistance when the basket treatment tool is pulled, of whether the resistance allows the basket treatment tool to remove the gallstone from the papillary orifice; and controls the basket treatment tool to remove the gallstone from the papillary orifice when one or more of the first determination or the second determination determines that the gallstone is removable from the papillary orifice.

The invention provides a liver targeted presentation inhibition sequence combination for improving gall-stone disease. The liver targeted presentation inhibition sequence combination comprises small interfering RNA and a short hairpin RNA sequence as shown in SEQ ID NO.4, and the small interfering RNA comprises a small interfering RNA basic sequence as shown in SEQ ID NO.3. The invention also provides a preparation method of the liver targeted presentation inhibition sequence combination for improving gall-stone disease. The invention also provides an application. The inhibition sequence combination is used for preparing a medicine for inhibiting FMO3 level and inhibiting TMA-FMO3-TMAO axis mediated bile acid metabolism and cholesterol transporter. The liver targeted presentation inhibition sequence combination has good specificity and high transfection efficiency, inhibits TMA-FMO3-TMAO axis mediated bile acid metabolism and cholesterol transporter by inhibiting the FMO3 level, has good potential for improving cholelithiasis and other related diseases, and is used for preparing cholelithiasis related drugs.

The invention belongs to the technical field of biological medicines, and particularly relates to application of resveratrol in preparation of a medicine for preventing or treating gallstone. The resveratrol can regulate liver cholesterol metabolism, reduce bile cholesterol saturation and relieve liver inflammation by up-regulating expression and functions of PPAR gamma in the liver, so that gall-stone formation is remarkably reduced, and related symptoms such as gallbladder dilatation and cholestasis are relieved. Therefore, the invention provides a new medicine for effectively preventing and treating the cholesterol gallstone, and the resveratrol provided by the invention has good clinical application value and application prospect as the medicine for preventing and treating the cholesterol gallstone. The medicine has the advantages of novel action target, reliable curative effect, no toxic or side effect, abundant resources and low price.

The invention relates to the field of plant extracts, in particular to application of a hawthorn extract in preparation of a medicine for treating gall-stone. Dry hawthorn pulp is smashed, heated and extracted with an ethanol solution, filtered, concentrated and dried to obtain the hawthorn extract, the hawthorn extract can inhibit and treat gall-stone, the content of total bile acid (TBA) in a guinea pig gall-stone model is increased, the content of Ca < 2 + > and TBIL (total bilirubin) is reduced, and all indexes return to the normal level. In addition, the composite extract prepared by the invention and the combination of the composite extract and the hawthorn extract can effectively inhibit and treat gall-stone.

The invention discloses a traditional Chinese medicine prescription for treating lithiasis and a treatment method thereof. The invention discloses a traditional Chinese medicine prescription for treating lithiasis and a treatment method thereof, and belongs to the technical field of traditional Chinese medicines. Aiming at different pathogenesis characteristics of gall-stone and kidney stone, the prescription adopts a traditional Chinese medicine formula with dialectical compatibility to realize the treatment effect of treating both symptoms and root causes; the gallstone prescription comprises traditional Chinese medicines such as fructus gardeniae, herba lysimachiae and radix paeoniae alba, and the kidney stone prescription comprises traditional Chinese medicines such as herba pyrrosiae, fructus ligustri lucidi and lygodium japonicum; according to the treatment method, treatment based on syndrome differentiation is taken as the core, an individualized treatment scheme is formulated by determining the type, size and position of calculus and the physique of a patient, and the treatment course is adjusted by combining regular curative effect evaluation; the traditional Chinese medicine composition is scientific in prescription compatibility, exact in curative effect, simple and non-invasive in treatment method, low in cost, capable of effectively ablating calculi, promoting excretion, conditioning viscera functions and reducing the recurrence rate, solves the problems of residual tiny calculi, large trauma and the like in western medicine treatment, and is suitable for clinical treatment and popularization of lithiasis.

The application provides a kind of Xiaoshi Lidan traditional Chinese medicine composition UPLC fingerprint detection method, and combines chemical pattern recognition method, 12 common peaks are calibrated, 8 common peaks are identified among them by chemical reference substance, the similarity of 15 batches of Xiaoshi Lidan traditional Chinese medicine composition fingerprint is above 0.932, through HCA, PCA and OPLS-DA etc. Analysis and verification of neural network model, 15 batches of Xiaoshi Lidan traditional Chinese medicine composition samples are divided into 3 categories, and 7 main chemical markers that may cause quality difference are screened out, which are 2, 6 (baicalin), 4, 8, 7, 9 (rhein) and 5 (hesperidin) chromatographic peaks. The fingerprint detection method has the advantages of simplicity, feasibility, short detection time (about 25 minutes), stability and good repeatability, can evaluate the internal quality of Xiaoshi Lidan traditional Chinese medicine composition, further guarantee the internal quality stability of product, and provide reference.

The present invention relates to the treatment of secretory disorders, and provides novel methods of treatment of these disorders comprising the administration of fibroblast growth factor 21 (FGF21) or derivatives thereof. The methods of the invention are useful in conditions including exocrine pancreatic insufficiency (EPI), for example EPI resulting from cystic fibrosis, alcoholism, pancreatitis, pancreatic cancer, gallstones, celiac disease, high triglycerides, or lupus. The methods of the present invention find further utility in the treatment of salivary flow disorders, for example Sjorgen's syndrome, and the treatment of EPI or pancreatitis resulting from surgical procedures.

This invention discloses a gallbladder stone removal device, comprising a mesh-like stent made of one or more interwoven braided filaments and a stent delivery system. The mesh-like stent includes a stent body and distal and proximal stent ends located at its two ends. When the mesh-like stent is in the released state, the diameter of the distal stent end is greater than or equal to the diameter of the stent body, and the diameter of the proximal stent end is greater than or equal to the diameter of the stent body. After the distal stent end of this invention is released, the stent diameter is greater than the inner diameter of the cystic duct and the common bile duct, forming a funnel-shaped structure that completely conforms to the bile duct wall. Combined with an external negative pressure suction device, gallstones in the gallbladder can be drawn into this funnel-shaped structure in one go and finally removed from the biliary system, eliminating the need for multiple insertions and removals of the gallbladder using a stone retrieval basket, thus avoiding damage to the gallbladder and bile ducts. The stent made of biodegradable filaments completely degrades within three months in the biliary system, eliminating the need for secondary surgery and avoiding complications.