25 results about "Gallstones" patented technology

The utility model discloses a kind of visual microinvasive injectors for living body cultivation gall, belong to the technical field of pharmaceutical manufacturing.A kind of visual microinvasive injector for living body cultivation gall, including upper shell, lower shell, limit ring, sealing plate, bottom plate, sealing ring, buckles and support block, the upper shell is sleeved in the surface of lower shell and limit ring, the limit ring is sleeved in the surface of injector barrel, limit ring one end extends to the outside of upper shell, and the other end is penetrated to the inside of lower shell.The utility model is designed as integrally-formed injector, minimally invasive surgery and visualization technology are integrated, simplify surgical procedure, even non-professional technical personnel can quickly master operation method.Integrally-formed design reduces different tools needed to switch or use in cooperation in surgery, reduces surgery time, reduces operation complexity, improves surgery efficiency and safety.

The utility model relates to the field of calculus bovis selecting devices, in particular to a calculus bovis selecting device capable of reducing loss. Comprising a box body, two rubber gloves are installed in the box body, a connecting pipe is installed at one end of the box body, an air extracting pump is installed at the end, away from the box body, of the connecting pipe, a supporting frame is installed at the end, close to the air extracting pump, of the box body, the air extracting pump is installed on the supporting frame, and a collecting structure is arranged at the end, close to the supporting frame, of the box body. The collecting structure comprises two connecting rods, the two connecting rods are fixedly connected with the box body, and the ends, away from the box body, of the connecting rods are fixedly connected with a shell. The calculus bovis picking device capable of reducing the loss has the advantages that manual picking operation or manual picking operation is carried out in the negative pressure device through the negative pressure device, calculus bovis powder in the picking process can be collected through the air outlet which exhausts air outwards, and the calculus bovis loss is reduced.

The invention discloses a method for culturing calculus bovis by utilizing flora, which is characterized in that cattle gall bladders obtained by slaughtering are used as reaction containers, so that the animal welfare problem caused by living body surgery is completely avoided. A plurality of key steps of bilirubin generation, cholesterol conversion, matrix formation and the like are synergistically completed by adopting functional complementary synthetic flora, and the components of the generated product are closer to a complex system of natural calculus bovis. The breeding is carried out in a closed bioreactor with controllable parameters, uncontrollable factors such as individual cattle difference and feeding environment are eliminated, and the product quality is highly stable and uniform. Automatic monitoring and feedback control are achieved in the whole cultivation process, and technological parameters are accurate and adjustable. The used strains are all non-pathogenic or food-grade safe strains, and the whole process is sterile, free of exogenous pathogen pollution and antibiotic residue risks, and high in biological safety.

The present application relates to the medical field, and is used for treating gallstones, and is a gallstone dissolving agent and a double-needle tube circulating agent gallstone dissolving device. The gallstone dissolving agent is prepared by mixing a weak organic acid and an organic solvent according to a certain concentration ratio. The double-needle tube circulating agent gallstone dissolving device is connected by a medicine bottle, a dropping funnel, a medicine delivery tube, an inner needle tube, a rubber cap, a reversing tee, an outer needle tube, and a drainage tube according to a specified position and sequence. The device has the beneficial effects that after the gallstone dissolving agent is safely dropped into the gallbladder, the gallstone is dissolved by a chemical method and is circulated and removed from the body, the gallstone is completely removed without any residual fragments, the surgical wound is not greater than 1.8 mm, the gallbladder is slightly damaged, and the body recovers quickly. The device is a new breakthrough in gallbladder-preserving and stone-removing surgery.

This invention discloses a method for fabricating a memristor based on a bile functional layer, belonging to the field of bioelectronic device fabrication and in vitro diagnostics of biliary tract diseases. The method sequentially completes FTO substrate pretreatment, bile functional layer preparation, Ag-on-electrode deposition, and memristor detection array fabrication. First, the FTO substrate is physically cleaned and plasma-activated. Then, a 240-260 nm bile functional layer is prepared. Subsequently, an Ag-on-electrode is deposited, and a 5-15 nm Ag atom embedding transition region is constructed. Finally, a 2×2 array is arranged and passivated for isolation. The process parameters of each step are synergistically matched to optimize the interface between the substrate, functional layer, and electrode, fully preserving bile pathological information. The resulting Ag / Bile / FTO structure memristor exhibits high electrical stability and shows significant differences in electrical response to bile samples from normal, gallstone, and gallbladder cancer patients. It enables accurate and rapid in vitro identification of biliary tract diseases, and the process is simple, low-cost, and suitable for clinical application and large-scale production.

To provide a basket-type grasping forceps and a basket-type grasping forceps system that can smoothly release foreign objects such as gallstones from a basket wire into a body cavity without damaging the body cavity. [Solution] The basket-type grasping forceps system 2 comprises a grasping forceps 1, an endoscope M, a monitor M1, and a grasping forceps device 50. The grasping forceps 1 comprises a first grasping forceps 5 and a second grasping forceps 6. The first grasping forceps 5 has a first basket wire 11a, a first operating wire 20a, and a first knob 31. The second grasping forceps 6 has a second basket wire 11b, a second operating wire 20b, and a second knob 32. By moving the first knob 31 toward the rear end along the axial direction of the tube 52, the tip portion 12 rotates laterally, allowing foreign matter inside the basket wire 11 to be discharged outside the basket wire 11.

This invention provides an in vitro cultured bezoar, its preparation method, and its application, belonging to the field of traditional Chinese medicine preparation technology. The preparation method of this invention involves obtaining a bile-resistant, high-β-glucuronidase-active *Escherichia coli* strain through bile gradient acclimation, which is then combined with *Enterococcus faecalis* to form a functional bacterial community. This community is then cultured in vitro through a three-stage process of proliferation, transformation, and crystallization, followed by gradient calcium ion-induced crystallization and vacuum freeze-drying to obtain in vitro cultured bezoar. This invention aims to solve the problems of low conversion efficiency, uneven crystallization, insufficient content of effective components, and unstable product quality in existing technologies. The obtained in vitro cultured bezoar product has significantly higher bilirubin and conjugated bile acid contents than the standards of the *Chinese Pharmacopoeia*, and the process is stable, controllable, and suitable for industrialization.

This invention relates to a choleretic traditional Chinese medicine composition, its preparation method, and its application, belonging to the field of traditional Chinese medicine preparation technology. The microcapsules prepared from this choleretic traditional Chinese medicine composition consist of a core and a coating. The core contains a traditional Chinese medicine extract, pregelatinized starch, sodium alginate, and croscarmellose sodium. The coating contains hydroxypropyl cellulose and hydroxypropyl methylcellulose E5, PEG4000, and talc. The traditional Chinese medicine extract is made from Artemisia capillaris, Lysimachia christinae, Rheum palmatum, Scutellaria baicalensis, Taraxacum mongolicum, Forsythia suspensa, Curcuma longa, Curcuma longa, Bupleurum chinense, Citrus aurantium, and Aucklandia lappa. This choleretic traditional Chinese medicine composition has the effects of promoting bile flow and expelling gallstones, detoxifying and reducing swelling, with a stable drug release rate, definite efficacy, and few toxic side effects. It can be used for the prevention and / or treatment of acute and chronic gallstones and / or cholecystitis.

The invention discloses an extracorporeal circulation type bovine gall-stone preparation device and method, and relates to the field of artificial calculus bovis preparation. The device comprises a bile storage tank, double peristaltic pumps, a three-way valve, a tubular reaction unit, a constant-temperature heating jacket, a pH adjusting unit, a controller, an optional concentration unit and the like. The method comprises the following steps: preparing bile reaction liquid containing a lithogenic precursor, initializing parameters, starting a device, and circulating the reaction liquid; adjusting the pH value, concentrating to form a supersaturated environment for nucleation, simulating pulse flow at a periodic variable flow rate to promote dynamic growth, and finally harvesting, cleaning and drying. The gallbladder environment is simulated, living body dependence is avoided, the stone forming period is short, the similarity of the product and natural calculus bovis is high, and automatic large-scale production can be achieved.

The application provides a medicine composition for treating hepatobiliary diseases and a preparation method thereof, and the active ingredients are composed of a compound shown in formula (I) and Astragalus membranaceus and Saussurea involucrata extract, the weight ratio of the compound shown in formula (I) to the Astragalus membranaceus and Saussurea involucrata extract is 1: (1.5-2.0) by weight; compared with the prior art, the medicine composition of the application has a synergistic effect on hepatobiliary diseases, especially gallstones, and the effect is remarkable.

This invention provides an extract of *Cimicifuga foetida*, made from *Cimicifuga foetida* produced in Guizhou Province, using an intermittent warm percolation method for water extraction. The extract contains 10%-25% cimicifugoside, 3%-15% iso-cimicifugoside, and 20%-50% plantago asiatica glycoside. The preparation method and applications are also disclosed. The *Cimicifuga foetida* extract provided by this invention has a high content of active ingredients and significant anti-inflammatory and litholytic pharmacological activities. It can be used as a raw material for the treatment and adjuvant treatment of cholecystitis, gallstones, hydronephrosis, kidney stones, nephritis, bladder stones, and uric acid stones. It can also be used as an intermediate raw material for the separation and purification of plantago asiatica glycoside, cimicifugoside, and iso-cimicifugoside chemical standards or reference standards. The preparation method provided by this invention effectively solves the problem of extraction and enrichment of active ingredients in *Cimicifuga foetida*, and has advantages such as low production cost, ease of large-scale production, and stable and controllable quality.

The present application relates to a kind of traditional Chinese medicine composition for treating calculus, raw material is: walnut kernel 25-35 parts, black fungus 10-20 parts, giant knotweed 15-25 parts, powder 25-35 parts of yam, sea gold sand 25-35 parts, 10-20 parts of yujin, 25-35 parts of huashi grass, 25-35 parts of shaddock, 10-20 parts of goose tube stone, 25-35 parts of yiwren, 10-20 parts of magnolia officinalis, 25-35 parts of xuanming powder, 10-20 parts of rhubarb, 10-20 parts of plantago, 10-20 parts of bupleurum, 10-20 parts of small chrysanthemum, 5-10 parts of cumin, 10-20 parts of Sichuan donkey's hide, 5-10 parts of raw licorice.The present application has the effect of clearing heat and promoting bile secretion, dissolving stone and stopping bleeding cooling blood, through the concept of dissolving stone and expelling stone, large stone is small, small stone is small, gallstones are discharged with bile into intestine, kidney stones, ureter and bladder stones are discharged with urine, adjust liver, gallbladder, kidney and other qi stagnation, and be supplemented with constitution conditioning syndrome differentiation treatment, it has good curative effect on various stones of liver, gallbladder, kidney and urinary tract, and it is both the treatment of principle and secondary, relieve the suffering of the majority of patients.

The invention relates to the technical field of biomedicine, and particularly discloses an in-vitro diagnosis marker for gall-stone and application thereof.The in-vitro diagnosis marker is jointly composed of a metabolism marker and an inflammation marker, the metabolism marker is the concentration ratio of lithocholic acid to ursodesoxycholic acid (LCA / UDCA), and the inflammation marker is the concentration ratio of CD133 to lipopolysaccharide (CD133 / LPS); the invention further provides a kit containing the marker and a detection method of the kit. The kit integrates specific detection reagents for LCA, UDCA, CD133 and LPS, two specific value markers can be rapidly, sensitively and simultaneously detected through an optimized sample treatment and detection process, and result judgment is carried out based on a preset reference interval upper limit and a composite judgment rule.

The medical system includes a basket treatment tool a processor. The processor determines, one or more of: a first determination, based on a transmissive image including the biliary duct, of whether a size of a gallstone allows the basket treatment tool to remove the gallstone from the papillary orifice, or a second determination, based on a resistance when the basket treatment tool is pulled, of whether the resistance allows the basket treatment tool to remove the gallstone from the papillary orifice; and controls the basket treatment tool to remove the gallstone from the papillary orifice when one or more of the first determination or the second determination determines that the gallstone is removable from the papillary orifice.

The invention provides a liver targeted presentation inhibition sequence combination for improving gall-stone disease. The liver targeted presentation inhibition sequence combination comprises small interfering RNA and a short hairpin RNA sequence as shown in SEQ ID NO.4, and the small interfering RNA comprises a small interfering RNA basic sequence as shown in SEQ ID NO.3. The invention also provides a preparation method of the liver targeted presentation inhibition sequence combination for improving gall-stone disease. The invention also provides an application. The inhibition sequence combination is used for preparing a medicine for inhibiting FMO3 level and inhibiting TMA-FMO3-TMAO axis mediated bile acid metabolism and cholesterol transporter. The liver targeted presentation inhibition sequence combination has good specificity and high transfection efficiency, inhibits TMA-FMO3-TMAO axis mediated bile acid metabolism and cholesterol transporter by inhibiting the FMO3 level, has good potential for improving cholelithiasis and other related diseases, and is used for preparing cholelithiasis related drugs.

The invention relates to the field of plant extracts, in particular to application of a hawthorn extract in preparation of a medicine for treating gall-stone. Dry hawthorn pulp is smashed, heated and extracted with an ethanol solution, filtered, concentrated and dried to obtain the hawthorn extract, the hawthorn extract can inhibit and treat gall-stone, the content of total bile acid (TBA) in a guinea pig gall-stone model is increased, the content of Ca < 2 + > and TBIL (total bilirubin) is reduced, and all indexes return to the normal level. In addition, the composite extract prepared by the invention and the combination of the composite extract and the hawthorn extract can effectively inhibit and treat gall-stone.

The invention discloses a traditional Chinese medicine prescription for treating lithiasis and a treatment method thereof. The invention discloses a traditional Chinese medicine prescription for treating lithiasis and a treatment method thereof, and belongs to the technical field of traditional Chinese medicines. Aiming at different pathogenesis characteristics of gall-stone and kidney stone, the prescription adopts a traditional Chinese medicine formula with dialectical compatibility to realize the treatment effect of treating both symptoms and root causes; the gallstone prescription comprises traditional Chinese medicines such as fructus gardeniae, herba lysimachiae and radix paeoniae alba, and the kidney stone prescription comprises traditional Chinese medicines such as herba pyrrosiae, fructus ligustri lucidi and lygodium japonicum; according to the treatment method, treatment based on syndrome differentiation is taken as the core, an individualized treatment scheme is formulated by determining the type, size and position of calculus and the physique of a patient, and the treatment course is adjusted by combining regular curative effect evaluation; the traditional Chinese medicine composition is scientific in prescription compatibility, exact in curative effect, simple and non-invasive in treatment method, low in cost, capable of effectively ablating calculi, promoting excretion, conditioning viscera functions and reducing the recurrence rate, solves the problems of residual tiny calculi, large trauma and the like in western medicine treatment, and is suitable for clinical treatment and popularization of lithiasis.

The application provides a kind of Xiaoshi Lidan traditional Chinese medicine composition UPLC fingerprint detection method, and combines chemical pattern recognition method, 12 common peaks are calibrated, 8 common peaks are identified among them by chemical reference substance, the similarity of 15 batches of Xiaoshi Lidan traditional Chinese medicine composition fingerprint is above 0.932, through HCA, PCA and OPLS-DA etc. Analysis and verification of neural network model, 15 batches of Xiaoshi Lidan traditional Chinese medicine composition samples are divided into 3 categories, and 7 main chemical markers that may cause quality difference are screened out, which are 2, 6 (baicalin), 4, 8, 7, 9 (rhein) and 5 (hesperidin) chromatographic peaks. The fingerprint detection method has the advantages of simplicity, feasibility, short detection time (about 25 minutes), stability and good repeatability, can evaluate the internal quality of Xiaoshi Lidan traditional Chinese medicine composition, further guarantee the internal quality stability of product, and provide reference.

This invention discloses a gallbladder stone removal device, comprising a mesh-like stent made of one or more interwoven braided filaments and a stent delivery system. The mesh-like stent includes a stent body and distal and proximal stent ends located at its two ends. When the mesh-like stent is in the released state, the diameter of the distal stent end is greater than or equal to the diameter of the stent body, and the diameter of the proximal stent end is greater than or equal to the diameter of the stent body. After the distal stent end of this invention is released, the stent diameter is greater than the inner diameter of the cystic duct and the common bile duct, forming a funnel-shaped structure that completely conforms to the bile duct wall. Combined with an external negative pressure suction device, gallstones in the gallbladder can be drawn into this funnel-shaped structure in one go and finally removed from the biliary system, eliminating the need for multiple insertions and removals of the gallbladder using a stone retrieval basket, thus avoiding damage to the gallbladder and bile ducts. The stent made of biodegradable filaments completely degrades within three months in the biliary system, eliminating the need for secondary surgery and avoiding complications.

The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition containing ox gall, a pharmaceutical preparation and application, the present application provides a traditional Chinese medicine composition containing ox gall, which has the effects of clearing heat and resolving toxins, cooling liver and resolving lung, dispersing wind and relieving pain, and the preparation has a wide range of uses, the preparation method of the composition provided by the present application is easy to operate, and through years of production practice accumulation, the quality of the obtained product is stable and controllable, and the product is used for preparing drugs for treating liver and lung heat accumulation, wind and fire disturbance, dizziness, oral and nasal sores, wind and fire toothache, sudden eye inflammation, skin itching and other diseases in clinic, and has a wide application value.

The present application relates to a kind of traditional Chinese medicine composition for treating gallstone, traditional Chinese medicine agent and preparation method thereof.The traditional Chinese medicine composition is composed of the following weight parts of raw materials: 30-60 parts of giant knotweed, 10-35 parts of soapberry thorn, 20-40 parts of saussurea, 20-40 parts of vinegar fumitory, 20-40 parts of bran-fried bitter orange fruit, 25-60 parts of fried chicken gizzard, 20-40 parts of vinegar galangal, 20-40 parts of stone see through.The traditional Chinese medicine composition for treating gallstone and traditional Chinese medicine agent in the present application have the advantages of convenient use, good treatment effect, significant curative effect, no toxic side effects, not easy to relapse, etc.

The invention provides an application of a traditional Chinese medicine composition in preparing a medicine for preventing gall-stone. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 128 to 137 parts of radix scutellariae, 128 to 137 parts of radix bupleuri, 103 to 120 parts of radix et rhizoma rhei, 128 to 137 parts of fructus aurantii, 128 to 137 parts of herba artemisiae scopariae, 171 to 200 parts of rhizoma polygoni cuspidati, 137 to 150 parts of fructus gardeniae, 250 to 342 parts of herba lysimachiae, 128 to 137 parts of radix paeoniae alba, 128 to 137 parts of radix aucklandiae, 90 to 103 parts of rhizoma pinelliae preparata and 34 to 40 parts of rhizoma zingiberis recens. The traditional Chinese medicine composition disclosed by the invention can be used for remarkably reducing the formation of gall-stone and preventing the occurrence of gall-stone diseases.

This invention provides a traditional Chinese medicine composition for treating gallstones and its application. It comprises the following raw materials in parts by weight: Bupleurum chinense 6-12 parts, Scutellaria baicalensis 6-12 parts, Curcuma longa 2-5 parts, Artemisia capillaris 3-8 parts, Lysimachia christinae 2-6 parts, Coptis chinensis 4-8 parts, Anemarrhena asphodeloides 3-8 parts, Ophiopogon japonicus 3-8 parts, Citrus reticulata peel (processed with vinegar) 1-3 parts, Paeonia lactiflora 1-3 parts, Astragalus membranaceus 1-5 parts, Poria cocos 1-5 parts, Prunus persica kernel (processed with vinegar) 1-5 parts, Trichosanthes kirilowii peel 1-5 parts, Amomum villosum 1-5 parts, Pogostemon cablin 1-5 parts, Liquidambar formosana 1-5 parts, Luffa cylindrica 1-5 parts, Gleditsia sinensis thorns 1-5 parts, Coix lacryma-jobi 1-5 parts, Zea mays silk 1-5 parts, and Taraxacum mongolicum 1-5 parts. The traditional Chinese medicine composition of this invention has high safety, no toxic side effects, and exhibits synergistic effects among its components, resulting in good therapeutic efficacy and reduced adverse reactions.

The application discloses a method for cultivating bovine bezoar in vivo based on temperature-sensitive gel, which comprises the following steps: implanting a bovine bezoar bed into a bovine gallbladder; then, mixing prepared temperature-sensitive polyacrylamide hydrogel with cultured bovine bezoar conversion bacteria, and injecting the mixture into the bovine bezoar bed; or, first, injecting the prepared temperature-sensitive polyacrylamide hydrogel into the bovine bezoar bed, and finally, injecting the cultured bovine bezoar conversion bacteria into the bovine bezoar bed. The gel solution is injected into the bovine bezoar bed in the form of injection, so that the generated wound is small, the health of the bovine is not adversely affected, and the operation is convenient and fast. The gel is injected into the bovine bezoar bed, the bovine bezoar bed protects the gel, so that the gel is not rapidly degraded, the viscosity of the gel is maintained for a long time, the stable and continuous enrichment of bovine bezoar small particles is realized, the initial core of the bovine bezoar is formed, and the efficiency and quality of the in-vivo cultivation of the bovine bezoar are improved, so that the method has good practicability.

The present application discloses a composition for treating gallstones, which is prepared from the following raw materials in the following weight ratio: 30-60 parts of Herba Artemisiae Scopariae, 10-15 parts of Radix Bupleuri, 10-20 parts of Radix Anemarrhenae, 10-15 parts of Radix Gentianae Macrophyllae, 10-20 parts of Radix Clematidis, 10-15 parts of Rhizoma Sparganii, 10-20 parts of Rhizoma Curcumae, 10-20 parts of Semen Persicae, 10-20 parts of Flos Carthami, 10-15 parts of Rhizoma Chuanxiong, 10-30 parts of Semen Ziziphi Spinosae, 10-15 parts of Scorpio, 15-30 parts of Endothelium Corneum Gigeriae Galli and 10-30 parts of Fructus Crataegi. The composition can relieve the clinical symptoms such as upper abdominal pain, hypochondrium pain, shoulder and back pain caused by hepatobiliary duct stones, improve liver metabolic function disorder, repair hepatobiliary duct pathological stenosis gradually, and prevent the regeneration of hepatobiliary duct stones.