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57 results about "Laser lithotripsy" patented technology

Laser lithotripsy is a surgical procedure to remove stones from urinary tract, i.e., kidney, ureter, bladder, or urethra.

Anti-clogging adsorption laser surgical endoscope and method

According to the anti-blocking adsorption laser operation endoscope and the method, the anti-blocking adsorption laser operation endoscope is installed at the position far away from an endoscope body and an adsorption opening through an adsorption switch, or the adsorption opening is a plane or a curved surface and comprises a structure of at least two open holes and matched size design. Or an ultrasonic device and an installation mode of the ultrasonic device are adopted, so that the probability that the broken stones block the suction channel is greatly reduced, and blockage is prevented, and meanwhile, the stones are continuously reset at the position of the suction port through a method that the suction switch repeatedly and continuously connects and disconnects the suction port and the suction source; therefore, the continuous laser lithotripsy performance during the operation is kept; through the program control of the suction switch of the anti-blocking adsorption laser operation endoscope, the working intensity of an operation doctor during the operation for controlling an instrument is reduced, so that the operation is more convenient and simpler; through the design of the quick-connection type connector of the anti-blocking broken stone adsorption laser operation endoscope component, instrument sterilization is more convenient, function expansion is more flexible, or independent production is arranged; the invention relates to a method for treating human and animal focuses, especially calculi, by using an anti-clogging laser surgery endoscope catheter.
Owner:BEIJING SHUO YUANZE TECHNOLOGY CO LTD

Multi-mode feedback control method and system for femtosecond laser stone crusher

The invention discloses a multi-mode feedback control method and system for a femtosecond laser stone crusher, and relates to the technical field of medical instruments. The method comprises the following steps: constructing spectral component analysis, collecting spectral signals, and executing target chemical component identification; ultrasonic position detection: acquiring an ultrasonic echo signal through a transducer, and calculating a spatial distance; performing vision-assisted positioning, acquiring image data through an endoscope, and generating space image information; according to the spectrum identification result, the distance parameter and the space image information, multi-source data synchronization processing is completed; generating a laser parameter control instruction according to the fusion result; and executing a real-time feedback regulation and control process, obtaining feedback information, and completing control parameter updating and closed-loop response. Through fusion of multi-modal information such as spectrum identification, ultrasonic distance measurement and visual navigation, real-time identification of stone types, intelligent matching of laser parameters and accurate control of spatial positioning are realized, and the accuracy, safety and intuition of lithotripsy operation are remarkably improved.
Owner:SHUNWEI (JIAXING) OPTICAL TECHNOLOGY CO LTD

Apparatus for laser lithotripsy

The present invention provides a laser system for treating calculi in a human or animal body, comprising: a diode-pumped laser configured to emit radiation in a wavelength range between 1.81 and 2.2 microns; and a driver configured to provide modulated current to the diode-pumped laser and coupled to a controller configured to output a control signal such that the diode-pumped laser emits a sequence of laser pulses, a shape of each laser pulse is formed with: a first sub-pulse and a second sub-pulse spaced temporarily from one another; an energy of the first sub-pulse varying in a range of 0.02 to 0.15 J; a peak power of the first sub-pulse varying in a range of 50 to 500 W; an interval between the first sub-pulse and the second sub-pulse varying in a range of 50 to 900 µs; an energy of the second sub-pulse exceeding the energy of the first sub-pulse and varying in a range of 0.1 to 10 J; a peak power of the second sub-pulse exceeding the peak power of the first sub-pulse and varying in a range of 300 to 20000 W.
Owner:IPG PHOTONICS CORP

Small optical core hybrid fiber for surgical laser procedures such as laser lithotripsy that utilize holmium YAG lasers and / or thulium fiber lasers

PendingUS20260053564A1Surgical instruments for irrigation of substancesHolmium laserHolmium yag laser
A surgical laser fiber for use in surgical laser procedures such as laser lithotripsy includes a relatively small diameter silica core surrounded by a thin intermediate doped silica cladding and a relatively thick outer glass cladding or ferrule surrounding the thin intermediate doped silica cladding, with the result that erosion of the fiber is primarily confined to the silica core, causing the relatively thick outer glass cladding or ferrule to form a standoff that extends beyond the eroded end of the silica core as lasing proceeds. The diameter of the silica core may be approximately 80 μm and a thickness of the outer glass cladding may be approximately 200 μm. The surgical laser fiber may be used with Thulium Fiber Lasers, or may be adapted for use with both Thulium Fiber Lasers and Holmium YAG lasers.
Owner:OPTICAL INTEGRITY INC

In-vitro laser lithotripsy efficiency detection device

The utility model belongs to the technical field of laser lithotripsy, and discloses an in-vitro laser lithotripsy efficiency detection device. The device comprises a container, a liquid injection mechanism and a collector, the container is provided with a first opening and a second opening, the first opening is used for inserting a laser fiber, the second opening is located at the bottom of the container, the liquid injection mechanism is communicated with the container and can inject liquid into the container, and the collector is provided with a third opening and at least one fourth opening. The third opening is formed in the top of the collector, the fourth opening is formed in the bottom of the collector, the third opening is communicated with the fourth opening, the second opening is communicated with the third opening, and the size of the fourth opening is not larger than that of the second opening. By means of the device, in-vivo lithotripsy conditions can be simulated, so that detection is closer to clinical practical operation, particles obtained after lithotripsy can be distinguished according to the size, the lithotripsy effect of laser lithotripsy is evaluated, and parameter setting of clinical practical operation can be guided easily.
Owner:SHANGHAI RAYKEEN LASER TECH CO LTD

Hollow-core anti-resonance optical fiber design method and system for femtosecond laser stone crusher

The invention discloses a hollow-core anti-resonance optical fiber design method and system for a femtosecond laser stone crusher, and relates to the technical field of medical laser instruments. The method comprises the steps that an anti-resonance transmission unit is constructed, the anti-resonance transmission unit is composed of an air core and anti-resonance quartz cladding tubes periodically arranged on the periphery, the cladding tubes form an anti-resonance transmission band gap with a specific wavelength through precisely designed wall thickness and spacing, and the air core serves as a main transmission channel; a water-cooling temperature control unit is integrated, the water-cooling temperature control unit comprises a spiral or snakelike micro-channel structure integrated in an outer cladding of the anti-resonance transmission unit, the outer cladding is made of a biocompatible high polymer material, a micro-channel and an optical fiber are axially arranged at a preset angle, and a forced convection heat dissipation path is formed by injecting a cooling medium. By optimizing the anti-resonance transmission unit and the water-cooling temperature control unit, stable laser transmission, efficient thermal management and reliability under long-time high-power laser operation are realized.
Owner:SHUNWEI (JIAXING) OPTICAL TECHNOLOGY CO LTD

Evanescent optical fibers for laser lithotripsy

A laser lithotripsy system may include a light energy source and a catheter. The catheter may comprise an optical fiber comprising a core and a cladding that encases the core. The optical fiber may be configured to be optically coupled to receive laser light from the light energy source. The optical fiber may include at least one evanescent portion and at least one non-evanescent portion. When light propagates through the core, an evanescent field may be transmitted out of the optical fiber in the evanescent portion and may not transmitted out of the optical fiber in the non-evanescent portion.
Owner:SHOCKWAVE MEDICAL INC

Anti-clogging lithotripsy laser catheter and method

According to the anti-blocking lithotripsy laser catheter and the method, the anti-blocking lithotripsy laser catheter is installed at the position away from the lithotripsy catheter and an adsorption opening through an attraction switch, or the adsorption opening comprises at least two open holes, and the structural design and the size of the adsorption opening face are matched, or an ultrasonic device and an installation mode thereof are adopted. The probability that the broken stones block the suction channel is greatly reduced, meanwhile, the positions of the stones at the adsorption opening are continuously reset through the method that the adsorption opening and the suction source are repeatedly and continuously connected and disconnected through the suction switch, and therefore the continuous laser lithotripsy performance in the operation is kept. By means of program control of the anti-blocking lithotripsy laser catheter suction switch and the design of the endoscope fixator, the working intensity of an operation doctor during an operation when the operation doctor manipulates an instrument is reduced, and operation is more convenient and simpler; through the design of the quick-connection type connector of the anti-blocking lithotripsy laser guide pipe component, instrument sterilization is more convenient, and independent production is convenient to arrange; the invention relates to a method for treating human and animal calculi by using an anti-blocking lithotripsy laser catheter.
Owner:BEIJING SHUO YUANZE TECHNOLOGY CO LTD

Real-time monitoring of liquid media conditions adjacent to the laser lithotripsy treatment area

To monitor conditions of media proximate to an endoscopic treatment or diagnostic site in real time.SOLUTION: Disclosed herein are systems and methods for monitoring a condition associated with a medium proximate to a target region. The system comprises a surgical laser, and a surgical fiber coupled to the surgical laser for delivering laser light to a target region and receiving at least a portion of the laser light reflected from the target region. The system further comprises a processor configured to analyze the collected reflected laser light and determine, based at least in part on the analysis of the reflected laser light, a value of a parameter associated with the medium proximate to the target region.SELECTED DRAWING: Figure 5
Owner:GYRUS ACMI INC

Urinary calculus breaking and removing device based on intelligent positioning and operation method

The invention belongs to the technical field of urinary devices, and particularly relates to a urinary calculus breaking and removing device based on intelligent positioning and an operation method.The urinary calculus breaking and removing device comprises a thick tube part, a thin tube part arranged at the front end of the thick tube part and a probe part arranged at the front end of the thin tube part; the lithotripsy mechanism is composed of a laser lithotripsy probe and an electric control module, and the operation end of the electric control module penetrates through the thin pipe part and extends into the thick pipe part; by arranging the intelligent positioning and tracking unit, the endoscope camera shooting recognition module, the miniature ultrasonic probe and the posture sensing module, the problems that a traditional operation is large in positioning error and has a view blind area are solved, the calculus positioning accuracy is greatly improved, the ureter mucosa injury risk caused by positioning deviation is reduced, and the operation safety is improved. A double-calculus-removing structure composed of the clamping jaw mechanism and the negative-pressure adsorption assembly is arranged, calculus removing, namely calculus removing, is achieved through cooperation of the clamping jaw mechanism and the negative-pressure adsorption assembly, the pain point that fragments are prone to remaining in a traditional operation is solved, and secondary operation is not needed.
Owner:AFFILIATED HOSPITAL OF JIANGSU UNIV

Multi-modal pathological feature fusion uro-lithotripsy parameter optimization method and system

The application discloses a urinary calculus crushing parameter optimization method and system based on multi-modal pathological feature fusion, relates to the technical field of health information science, and extracts a preoperative feature vector F of a patient before operation, and calculates a theoretical fragmentation energy efficiency I according to the preoperative feature vector F, so as to generate an initial laser lithotripsy parameter P, thereby improving the initial accuracy and scientificity of treatment. In the operation, the original signal data set DSA is generated by collecting acoustic signals through a miniature hydrophone, and the pulse fragmentation efficiency η at the time t is calculated t , and the pulse fragmentation efficiency sequence SSEQ is constructed, the objective and real-time quantification of the lithotripsy effect is realized, and the limitation of visual observation is overcome. Finally, the state evaluation result is generated by comparison, and the laser lithotripsy parameter optimization strategy is executed, adaptive regulation is constituted, and the efficiency and safety of the whole operation are ensured.
Owner:DUHUI HEALTH (CHENGDU) MEDICAL TECH CO LTD

Steering handle with multi-channel manifold

Steering handles with manifolds that enable an operator to configure an endoscopic system in situ for a variety of tasks, including irrigation, aspiration, or both. In addition, the disclosed endoscopic systems facilitate rapid reconfiguration of the location of a laser fiber optic within a catheter assembly. The laser fiber optic, for example, can be removed from an irrigation channel of the endoscopic system and reinserted in the aspiration channel during a laser lithotripsy procedure. In some embodiments, the removal and reinsertion can be performed in situ, without removing the catheter from the patient or the treated organ. These aspects of the disclosed system reduce the time required to perform laser lithotripsy procedures, with less trauma to the patient.
Owner:IPG PHOTONICS CORP

Device for autonomous lithotripsy and methods for displaying corrective actions therefor

Disclosed are a device and a method of autonomous stone ablation during laser lithotripsy, the method including inserting a catheter into a lumen; navigating the catheter through the lumen along an insertion trajectory; obtaining at least one image of an object within the lumen; segmenting the at least one image; determining a size of the object; and in response to the size exceeding or being equal to a predetermined size: defining a region of lasing of the object, aligning a tip of the catheter with the region of lasing, and performing lithotripsy.
Owner:CANON USA INC +1

Evanescent optical fibers for laser lithotripsy

A laser lithotripsy system may include a light energy source and a catheter. The catheter may comprise an optical fiber comprising a core and a cladding that encases the core. The optical fiber may be configured to be optically coupled to receive laser light from the light energy source. The optical fiber may include at least one evanescent portion and at least one non-evanescent portion. When light propagates through the core, an evanescent field may be transmitted out of the optical fiber in the evanescent portion and may not transmitted out of the optical fiber in the non-evanescent portion.
Owner:SHOCKWAVE MEDICAL INC

Steering handle with multi-channel manifold

Steering handles with manifolds that enable an operator to configure an endoscopic system in situ for a variety of tasks, including irrigation, aspiration, or both. In addition, the disclosed endoscopic systems facilitate rapid reconfiguration of the location of a laser fiber optic within a catheter assembly. The laser fiber optic, for example, can be removed from an irrigation channel of the endoscopic system and reinserted in the aspiration channel during a laser lithotripsy procedure. In some embodiments, the removal and reinsertion can be performed in situ, without removing the catheter from the patient or the treated organ. These aspects of the disclosed system reduce the time required to perform laser lithotripsy procedures, with less trauma to the patient.
Owner:IPG PHOTONICS CORP

Endoscope camera interference mitigation

The present disclosure provides an endoscopic laser lithotripsy device and a method for such a device, wherein image acquisition, laser emission, illumination and / or image processing are configured to mitigate distortion in captured images caused by the laser.
Owner:LUMENIS LTD

Air-cooled laser

1. The name of the design product: air-cooled laser. 2. The use of the design product: for output laser light source, can carry out laser welding, laser cutting and laser lithotripsy, etc. 3. The design points of the design product: in shape. 4. The picture or photo that can best show the design points: perspective view.
Owner:WUXI ZHONGLEI OPTOELECTRONIC TECH CO LTD

Ureteroscope irrigation catheter

This invention provides a ureteroscopic irrigation catheter, belonging to the field of medical device technology. The ureteroscope includes a scope body and a tubing. An imaging probe is installed at the end of the tubing. An infusion catheter is inserted through the tubing, and the gap between the catheter and the inner wall of the tubing forms a return channel. The inner wall of the catheter is equipped with a spiral flow-guiding structure to generate centrifugal force to evenly disperse the water flow. This invention systematically solves the problems of thermal damage and visual interference in ureteroscopic holmium laser lithotripsy through fluid dynamics optimization and a dual-channel drainage structure, combining clinical safety and ease of operation.
Owner:TAIZHOU ENZE MEDICAL CENT GROUP

Negative pressure stone basket and integrated endoscope catheter

An outer opening of the negative-pressure stone basket and a connecting part of the negative-pressure stone basket are arranged in the area, close to the top end, of the head of the endoscope catheter in a sleeving mode, a plurality of water inlet channels are formed in the position close to an inner opening of the negative-pressure stone basket, and the water inlet channels are distributed in the circumferential direction of the inner opening of the negative-pressure stone basket. Water flow can enter the water inlet channel through the outer opening of the water inlet channel due to negative pressure suction of the inner cavity of the negative-pressure stone basket containing part and then enters the inner cavity of the negative-pressure stone basket containing part through the inner opening of the water inlet channel, during laser lithotripsy operation, water enters an endoscope sheath gap between the sheath tube and the endoscope catheter, the working channel of the endoscope catheter is connected with negative pressure, and the working channel of the endoscope catheter is connected with negative pressure. The inner opening of the negative pressure stone basket is close to or tightly attached to a target stone, the optical fiber extends out of the inner opening of the working channel of the endoscope catheter to touch or be adjacent to the target stone to release energy to damage the stone, and water flow continuously enters the inner cavity of the containing part of the negative pressure stone basket through the water inlet channel due to negative pressure suction. And the heat energy generated by the stone powder and the laser is discharged out of the body along with the water flow through an endoscope catheter working channel.
Owner:ANHUI HAPPINESS WORKSHOP MEDICAL INSTRUMENTS CO LTD

Control handle with multi-channel manifold

A steering handle with a manifold enables an operator to configure the endoscopic system in situ for a variety of different tasks, including irrigation, aspiration, or both. In addition, the disclosed endoscope system facilitates rapid reconfiguration of the position of the laser fiber within the catheter assembly. For example, a laser fiber may be removed from a lavage channel of an endoscopic system and reinserted into a suction channel during a laser lithotripsy procedure. In some embodiments, removal and reinsertion may be performed in situ without removing the catheter from the patient or the organ being treated. These aspects of the disclosed system reduce the time required to perform a laser lithotripsy procedure, with less trauma to the patient.
Owner:IPG PHOTONICS CORP

Lithotripsy system with dispersed laser nodes

A lithotripsy system to deliver laser energy from one or more laser sources to a stone (e.g., to move the stone) includes a capture portion, a first laser node, and a second laser node. The capture portion is configured to move from a storage state to a deployed state. In the deployed state, the capture portion is configured to at least partially enclose the stone. The first laser node and the second laser node are coupled to the capture portion and are configured to deliver laser energy to the stone, and the first laser node is spaced apart from the second laser node.
Owner:GYRUS ACMI INC

Attracting laser surgical device systems and methods

The suction laser operation equipment system provides laser and suction output of a laser operation, the suction output takes suction pulses with specific duration and pulse gaps with specific duration as cycles and is repeatedly output, and the system synchronizes the suction output and the laser output. An adsorption opening of a stone crushing instrument used in cooperation adsorbs stones, the continuous laser stone crushing efficiency is kept, and the crushed stones are synchronously attracted and cleaned; suction force output in the suction laser surgical equipment system replaces a suction switch of a lithotripsy instrument to implement the function of periodically connecting and disconnecting an adsorption opening with a system suction source in an operation, so that the situation that a suction channel is blocked by broken stones due to the fact that the lithotripsy suction device is provided with the switch is avoided, and the automation level of operating the lithotripsy instrument is improved; the operation of the lithotripsy instrument is simplified; the invention discloses suction output and a control method for synchronous output of suction and laser.
Owner:BEIJING SHUO YUANZE TECHNOLOGY CO LTD

Endoscope tip integrated with hyperelastic memory metal wire mesh basket and medical endoscope

The invention provides an integrated hyperelastic memory wire mesh basket endoscope tip and a medical endoscope. The integrated hyperelastic memory wire mesh basket endoscope tip is characterized by comprising a wire mesh basket assembly and a tip assembly, the metal wire mesh basket assembly comprises a plurality of hyperelastic memory metal wires and a mesh basket sleeve; the tip assembly comprises a tip body and a tip sleeve. When urinary system calculus laser lithotripsy is carried out, calculus can be grabbed and fixed, and innovative medical technical guarantee is provided for doctors to quickly and effectively complete the operation. The endoscope tip integrated with the hyperelastic memory metal wire mesh basket and the medical endoscope have efficient and convenient surgical treatment effects.
Owner:ZHUHAI BIOLENI HEALTH TECH CO LTD

Adjustable aperture kidney stone lithotripsy and removal integrated instrument

This invention relates to the field of medical device technology, and in particular to an integrated device for lithotripsy and stone removal of kidney stones with adjustable aperture, comprising an integrated tube; the integrated tube further comprises a lithotripsy module and a lithotripsy extraction module, and the other end of the lithotripsy module and the lithotripsy extraction module are connected to a pressure regulating module, which is used to adjust the air pressure in the internal pipes of the lithotripsy module and the lithotripsy extraction module respectively; during the lithotripsy and stone removal process, there is no need to repeatedly change the device, which can reduce damage to the patient and improve the efficiency of lithotripsy and stone removal. A flexible connector is provided between the laser lithotripsy probe and the connecting tube, and a first flexible air tube is arranged on its outer side; by injecting air into the first flexible air tube at different positions through the external pressure regulating module, air pressure difference is formed in each air tube, driving the controllable cover to bend, thereby driving the laser lithotripsy probe to deflect, realizing the adjustable probe angle, which facilitates precise fragmentation of stones at different positions and ensures the quality of lithotripsy.
Owner:JIANGSU UNIV

Waveform control device for laser lithotripsy apparatus, laser lithotripsy method, and crushing method

Provided is a waveform control device for a laser lithotripsy apparatus including: a processor including hardware, the processor being configured to: pulse a laser beam; change an output of the pulsed laser beam; continuously emit the laser beam until a bubble generated from a laser emission end by an irradiation of the laser beam reaches a crushing target; and after the bubble generated from the laser emission end reaches the crushing target, reduce the output of the laser beam or turn off the irradiation of the laser beam during a period in which there is the bubble between the laser emission end and the crushing target, and the bubble does not couple the laser emission end and the crushing target.
Owner:OLYMPUS CORPORATION(JP)

Intravascular laser lithotripsy catheter

An intraluminal device for transmitting pressure waves includes a flexible elongate member configured for positioning within a body lumen. The flexible elongate member includes an outer sheath having a sealed distal end, a reaction chamber, and a sealed acoustic window. The flexible elongate member also includes an optical fiber configured to be coupled to a light source and translate longitudinally within the outer sheath. When the reaction chamber is filled with a photoreactive fluid, the light beam emitted by the optical fiber causes the photoreactive fluid to generate a set of pressure waves that are delivered to a location of the body cavity via the sealed acoustic window. The sealed acoustic window and the sealed distal end prevent photoreactive fluid from entering the body cavity.
Owner:KONINKLIJKE PHILIPS NV

Output adjustment device for lithotripsy apparatus, suction force generation method, and attracting method

Provided is an output adjustment device for a laser lithotripsy apparatus including: a processor including hardware, the processor being configured to: pulse a laser beam; adjust an output of the pulsed laser beam; monotonically increase the output of the laser beam as a first period to generate a bubble binding body containing a plurality of bubbles from a laser emission end; monotonically decrease the output of the laser beam with a gradient larger than a predetermined gradient as a second period following the first period to cause the bubble binding body to disappear so that a crushing target is attracted to the laser emission end; and before the bubble binding body is generated, raise a liquid temperature in a region where the bubble binding body is generated by generating the bubbles and causing the bubbles to disappear.
Owner:OLYMPUS CORPORATION(JP)

A laser lithotripsy system

The application provides a laser lithotripsy system, and relates to the technical field of endoscopes. The laser lithotripsy system comprises a catheter assembly, a visual assembly and a laser light guide assembly. The catheter assembly has a distal end, a proximal end and a plurality of channels. The plurality of channels are arranged from the distal end to the proximal end and extend through the catheter assembly. The visual assembly has a probe end. The probe end is arranged in one of the channels. The visual assembly is used for acquiring an image of the distal end of the catheter assembly. The laser light guide assembly has a laser exit end. The laser exit end is arranged in one of the channels. The laser light guide assembly is used for transmitting a lithotripsy laser to the distal end of the catheter assembly. The application can introduce the laser lithotripsy technology into an ERCP operation to replace the use of a lithotripsy basket, and the operation efficiency is high.
Owner:SHENZHEN CONCEMED MEDICAL TECHNOLOGY CO LTD

In-vitro device for evaluating heat effect in laser lithotripsy process and evaluation method

The invention relates to an in-vitro device and an evaluation method for evaluating a heat effect in a laser lithotripsy process, and the in-vitro device comprises a urinary tract simulation assembly which at least comprises a ureter simulation tube and is used for simulating a ureter on which calculi grow; the lithotripsy assembly is used for performing laser lithotripsy on the calculus from one end of the ureter simulation tube and is mounted on the urinary tract simulation assembly; the body temperature simulation assembly is used for simulating the human body temperature environment, and the urinary tract simulation assembly is installed in the body temperature simulation assembly; and the monitoring assembly is used for monitoring the heat effect in the stone crushing process. The device can effectively simulate and reflect the real heat effect of laser treatment in the clinical operation process, and provides more accurate guidance for the treatment process.
Owner:ZHONGNAN HOSPITAL OF WUHAN UNIV

Devices and methods for efficient hard and soft tissue ablation

Systems and methods for use in laser lithotripsy procedures. The system may include a laser source configured to generate pulsed laser energy, an optical fiber configured to direct the pulsed laser energy to a target, and a controller. The controller is configured to receive an input parameter, determine at least one process parameter, and calculate an N factor (Nf) corresponding to a number of laser pulses delivered to a treatment region on the target and having a diameter approximately equal to that of the laser pit produced by the pulsed laser energy. Nf is compared to a maximum N factor value (Nfmax), and in response to the comparison, the laser operating parameters are adjusted or used to control the laser source.
Owner:IPG PHOTONICS CORP