The invention discloses a special-disease calculus-removing decoction for treating renal calculus, relates to a traditional Chinese medicine composition, and belongs to the traditional Chinese medicine field. The invention is characterized in that the raw material herbs comprise: grifola, rhizoma alismatis, poria cocos, radix astragali, plantain seeds, dianthus superbus, semen abutili, semen lepidii, combined spicebush roots, radix cyathulae, white peony roots, corydalis tuber, talcum powder, verbena, cornu cervi degelatinatum, desmodium, lygodium japonicum, chicken gizzard membrane (taken after mixing it with water), donkey-hide gelatin (molten by heat), stir-baked squama manitis (taken after mixing it with water), cinnamon, processed monkshood (fried firstly), fructus amomi, rhizoma zingiberis, and licorice. The beneficial effects are that the decoction adopts traditional Chinese medicine theory, and has significant rapid efficacy of dissolving calculus, removing calculus, and expelling calculus; the decoction is economical, cheap, high-efficient, simple, practical, and easy to accept by patients, and is an advanced traditional Chinese medicine therapy for treating urinary system calculus diseases.