The present invention relates to a calculi treatment mixture and a preparation method thereof. The preparation method comprises: (1) carrying out deep frying on English walnut seed by using edible oil to a crisp state, pounding, and mixing the pounded English walnut seed and white granulated sugar to obtain calculi treatment English walnut seed medicinal instant granules; (2) cleaning lysimachia and herba pyrrosiae; (3) weighing 50-60% by weight of English walnut seed, 15-25% by weight of white granulated sugar, 30-60% by weight of lysimachia, 10-20% by weight of herba pyrrosiae, 10-20% by weight of talc, 10-15% by weight of akabia stem, 10-15% by weight of oriental waterplantain tuber, 5-10% by weight of wenchow turmeric root tuber, 10-20% by weight of japanese climbing fern spore, 5-15% by weight of chicken's gizzard-membrane, 3-7% by weight of licorice root, and 5-15% by weight of asiatic plantain seed; (4) respectively adding water to various components (except English walnut seed and white granulated sugar), boiling two times at a temperature of 100 DEG C, mixing the two obtained solutions, and carrying out cooling and then packaging to obtain a calculi treatment liquid agent; and (5) mixing the calculi treatment English walnut seed medicinal instant granules and the calculi treatment liquid agent to obtain the calculi treatment mixture. The calculi treatment mixture has the following advantages that: a treatment effect is rapid, wherein an effect is provided in the next day after taking the calculi treatment mixture; a use range is wide, wherein the calculi treatment mixture has functions of diuresis promoting, stranguria dredging, heat clearing, calculi removing and the like, and is suitable for treatment of kidney stones, ureteral stones, bladder stones and other urinary system stones; and drug sources are wide, and price is low.