18 results about "Tissue viability" patented technology

Systems and methods are disclosed for using patient-specific anatomical models and physiological parameters to predict viability of a target tissue or vessel to guide diagnosis or treatment of cardiovascular disease. One method includes: receiving a patient-specific vessel model and a patient-specific tissue model of a patient anatomy; receiving one or more patient-specific physiological parameters (e.g. blood flow, anatomical characteristics, etc.) for one or more physiological states; estimating a viability characteristic of the patient-specific tissue or vessel model (e.g., via a trained machine learning algorithm), using the patient-specific physiological parameters; and outputting the viability characteristic to an electronic storage medium or display.

Several embodiments relate to methods of repairing and / or regenerating damaged or diseased tissue comprising administering to the damaged or diseased tissues compositions comprising exosomes. In several embodiments, the exosomes comprise one or more microRNA that result in alterations in gene or protein expression, which in turn result in improved cell or tissue viability and / or function.

The invention relates to the technical field of seedling raising, and discloses an efficient tissue culture and rapid propagation seedling raising method for xanthoceras sorbifolia bunge, which comprises the following steps: selecting and pretreating explants, selecting current-year robust branches of the xanthoceras sorbifolia bunge, cutting stem segments with axillary buds as the explants, cleaning, trimming and disinfecting the explants, performing surface disinfection on the pretreated explants, and performing tissue culture and rapid propagation seedling raising on the pretreated explants to obtain the xanthoceras sorbifolia bunge. When the Xanthoceras sorbifolia Bunge is subjected to efficient tissue culture and rapid propagation seedling culture, an operation standard considering thorough sterilization and tissue activity protection is established by standardizing an explant selection standard and executing a step-by-step surface disinfection procedure, so that the microbial contamination rate caused by incomplete disinfection of the explant can be reduced, meanwhile, tissue activity damage caused by excessive disinfection is reduced, and the survival rate of the Xanthoceras sorbifolia Bunge is improved. Therefore, sufficient and healthy sterile initial materials are guaranteed to be obtained, the problems of high primary culture pollution rate and induction starting failure are solved, and a reliable foundation is laid for establishment of a whole tissue culture and rapid propagation system.

The present invention provides systems and methods for generally accelerating wound healing, more specifically by supplying oxygen to a wound to accelerate the healing of damaged tissue and / or promote tissue viability. [Solution] The oxygen supply system 200 for the wound 602 includes an outer frame 202 that defines an oxygen outlet. An oxygen generation subsystem is included in the outer frame and coupled to the oxygen outlet. A control subsystem is coupled to the oxygen generation subsystem and is configured to receive humidity information indicating the humidity experienced by the oxygen generation subsystem. The control system then uses the humidity information to control the power supplied to the oxygen generation subsystem in order to control the oxygen flow produced by the oxygen generation subsystem and supplied to a restricted airflow enclosure that passes through the oxygen outlet into contact with the wound.

A surgical stapler system for real-time tissue perfusion assessment during clamping includes a powered surgical stapler with a handle assembly, adapter assembly, and an end effector comprising a reload assembly with staples and an anvil assembly. Integrated into the system is a near-infrared spectroscopy (NIRS) system featuring light sources and photodetectors. The method involves clamping tissue between the reload and anvil assemblies, transmitting near-infrared light through the clamped tissue, and detecting backscattered light to determine tissue perfusion levels. The perfusion data is processed and displayed in real-time, allowing adjustments to the clamping force to ensure adequate perfusion before stapling. The system enhances surgical outcomes by providing real-time feedback on tissue viability during critical phases of the stapling procedure.

Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a silk fibroin component.

The present disclosure relates to skin tissue systems, devices, and methods. The described system includes a system comprising: a tissue sample; an insert; and a porous layer configured to facilitate transport of a substance into the tissue sample; wherein the skin tissue system is capable of supporting tissue viability for at least one week. The described methods include methods for skin tissue analysis comprising: contacting an array of skin tissue with at least one test agent; measuring more than one data set after the contact; mapping more than one data set based on the score group results; and generating at least one threshold criterion for selecting a therapeutic agent from the at least one test agent based on the mapped data set. Such innovations described herein provide ex vivo model tissue systems and the use of model tissue systems for analyzing activities, such as screening for nutrient, pharmaceutical activity, and toxicity in tissue samples.

This disclosure relates to skin tissue systems, devices, and methods. Systems described include ones comprising: a tissue sample; an insert; and a porous layer configured to promote mass transport into the tissue sample; wherein the skin tissue system is capable of supporting tissue viability for at least one week. Methods described include ones for skin tissue analysis comprising: contacting a skin tissue array with at least one test agent; measuring a plurality of datasets following the contacting; mapping the plurality of datasets based on a scoring panel result; and generating at least one threshold criteria for selecting the therapeutic agent from the at least one test agent based on the mapped datasets. Such innovations described herein provide for an ex vivo model tissue system and use of the model tissue system for analytical activities such as screening of nutrients, pharmaceutical activity, and toxicity in tissue samples.

The invention belongs to the field of biology, and discloses a tissue sample preservation solution which comprises a basic culture medium, the basic culture medium contains fetal calf serum and MitoQ, and FBS and MitoQ are added and used on the basis of the basic culture medium, so that the activity of tissue cells can be remarkably improved; in the research process, we have the following specificity that: 1, in the presence of FBS, only MitoQ in the mitochondrial targeting antioxidant can show a relatively strong tissue activity maintaining effect; 2, the effect of MitoQ in a basic culture medium is not fully played, and the MitoQ must be played in the presence of FBS; meanwhile, the invention further provides a tissue preservation method.

The present disclosure provides devices and methods for measuring subepidermal moisture as an indication of tissue viability and providing information about the location of non-viable tissue boundaries.

Systems and methods of the invention generally relate to prolonging viability of bodily tissue, especially an organ such as a lung, by adjusting pressure as needed to maintain a constant pressure within the organ even during external pressure fluctuations due, for example, to transportation of the organ in an airplane. Gas passing into and out of the organ may be conditioned to prolong tissue viability.

A system for monitoring anastomoses is provided. The system includes a probe and a control module in connection with the probe.The probe includes optical sensor assemblies. Each sensor assembly includes an optical emitter and an optical detector The sensor assemblies are spaced from one another so that following insertion of the probe into a lumen of a subject, the sensor assemblies can interrogate limbs of an anastomosis.The control module is configured to operate the optical emitters to illuminate respective limbs of the anastomosis and to receive signals from the optical detectors, the signals being representative of light reflected by tissue of the limbs. The control module is also configured to compare signals from the detectors and derive therefrom an indication of tissue vitality in the lumen of either side of the anastomosis.

The invention provides an integrated system and method for fabricating, regenerating, and maintaining synthetic living wood tissue constructs. The platform utilizes a formulation subsystem that prepares plant-derived precursor cells, lineage-directing Exomix signaling vesicles, and a supportive cellulose-based hydrogel into a printable bio-ink. An additive biofabrication subsystem generates structured constructs containing organized cambial, xylem, and phloem domains, microfluidic vascular channels, and embedded niche reservoirs. A maintenance and repair subsystem preserves tissue viability, delivers targeted regeneration cues, and supports long-term integration with damaged or aging wood substrates. Environmental control modules regulate electrical, mechanical, thermal, and biochemical parameters to guide differentiation and maturation. The invention enables sustainable production of regenerative wood materials with enhanced strength, decay resistance, and customizable properties, addressing limitations of natural wood through controlled biomanufacturing and restoration workflows.

A surgical stapler system for real-time tissue perfusion assessment during clamping includes a powered surgical stapler with a handle assembly, adapter assembly, and an end effector comprising a reload assembly with staples and an anvil assembly. Integrated into the system is a near-infrared spectroscopy (NIRS) system featuring light sources and photodetectors. The method involves clamping tissue between the reload and anvil assemblies, transmitting near-infrared light through the clamped tissue, and detecting backscattered light to determine tissue perfusion levels. The perfusion data is processed and displayed in real-time, allowing adjustments to the clamping force to ensure adequate perfusion before stapling. The system enhances surgical outcomes by providing real-time feedback on tissue viability during critical phases of the stapling procedure.

Several embodiments relate to methods of repairing and / or regenerating damaged or diseased tissue comprising administering to the damaged or diseased tissues compositions comprising exosomes. In several embodiments, the exosomes comprise one or more microRNA that result in alterations in gene or protein expression, which in tum result in improved cell or tissue viability and / or function.

An imaging system for viability assessment of a tissue of a living subject includes a light source for emitting a beam of light; a light delivery member coupled to the light source for delivering the beam of light onto a tissue surface of the living subject to illuminate the tissue surface; a light collection member configured to collect light from the illuminated tissue surface responsive to the illumination; a detector coupled to the collection member for acquiring images of the light from the illuminated tissue surface; and a controller arranged to operate the detector to acquire the images of the light from the illuminated tissue surface, receive the acquired images from the detector, and process the acquired images t for the intraoperative assessment of tissue viability.

Disclosed are miniaturized, wearable microneedle biosensor devices, systems, and methods for measuring intradermal concentrations of various metabolites (including but not limited to lactate, pyruvate, and / or glucose) in order to directly assess the viability of living tissue (e.g., human or other mammalian soft tissue). In a variety of implementations, for example, the disclosed microneedle biosensor devices are self-contained in terms of power source, sample acquisition, measurement, and data transmission capabilities, e.g., allowing it to function autonomously once placed. In some implementations, for example, the disclosed microneedle biosensor devices can assess the viability of soft tissue (e.g., skin with or without fat, fascia, or muscle) during and after reconstructive surgery in which soft tissue is repositioned, rotated, or transferred to another site in the body (including but not limited to both microvascular free tissue transfer and regional pedicled flaps).

Methods and materials for cryopreservation of precision-cut tissue slices, including precision-cut liver slices (PCLS), where the slices are vitrified. A cryoprotective solution comprising high amounts of ethylene glycol in combination with sucrose are used and high cooling rates greater than the critical cooling rate for avoidance of ice formation are used in a method which results in vitrification of the tissue slices without toxicity and with increased viability after rewarming. Methods and materials can be used for production of PCLS which can be stored at cryoprotective temperatures for extended periods of time.