143results about How to "Change in permeability" patented technology

A method for reversibly, or irreveribly, altering the permeability of cells, tissues or other biological barriers, to molecules to be transported into or through these materials, through the application of acoustic energy, is enhanced by applying the ultrasound in combination with means for monitoring and/or implementing feedback controls. The acoustic energy is applied directly or indirectly to the cells or tissue whose permeability is to be altered, at a frequency and intensity appropriate to alter the permeability to achieve the desired effect, such as the transport of endogenous or exogenous molecules and/or fluid, for drug delivery, measurement of analyte, removal of fluid, alteration of cell or tissue viability or alteration of structure of materials such as kidney or gall bladder stones. In the preferred embodiment, the method includes measuring the strength of the acoustic field applied to the cell or tissue at the applied frequency or other frequencies, and using the acoustic measurement to modify continued or subsequent application of acoustic energy to the cell or tissue. In another preferred embodiment, the method further includes simultaneously, previously, or subsequently exposing the cell or tissue to the chemical or biological agent to be transported into or across the cell or tissue. In another preferred application, the method includes removing biological fluid or molecules from the cell or tissue simultaneously, previously or subsequently to the application of acoustic energy and, optionally, assaying the biological fluid or molecules.

An electrolytic apparatus for using catalyst-coated hollow microspheres to produce gases, store them, and to make them available for later use. The apparatus uses catalyst-coated hollow microspheres in reversible electrochemical processes and reactions, such as those used in conjunction with water dissociation, fuel cells, and rechargeable batteries. The apparatus can be used to manufacture and store hydrogen and or oxygen and to make them available for subsequent use as raw materials for use in electrochemical and chemical reactions or as a fuel and or oxidizer for a combustion engine. The apparatus can be used as a hydrogen-oxygen hermetically seal secondary battery. The apparatus can be used as a hydrogen storage portion of certain types of secondary batteries. Hydrogen and oxygen can be stored within hollow microspheres at moderate temperature and pressure, eliminating the need for expensive storage and handling equipment, and increasing the mobility of hydrogen-powered vehicles. Storage of hydrogen and or oxygen within the microspheres significantly reduces flammability and explosion concerns and resolves many fuel cell scalability issues.

The present invention relates to sustained release compositions of prostacyclin, as well as uses thereof, in particular for the prevention and/or treatment of pulmonary arterial hypertension.

Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir and transport the biological samples to a sensing chamber. The sensing chamber may contain at least two sensing electrodes coated with a biologically reactive element which reacts with the transported biological sample. The sensing chamber may be configured to mitigate the formation of air bubbles which may impede the transport and distribution of the biological sample across the entirety of the sensing chamber.

The invention discloses an intelligent preparation system and preparation method for synthesizing a quick-acting and slow-release integrated efficient ecological compound fertilizer through straw microbial fermentation. The system comprises a cutting unit, a fermentation unit, an intelligent control unit, a waste heat recovery unit, a press filtration unit, a grinding and crushing unit, a blending unit, a granulation and drying unit and a finished product sub-packaging unit, wherein the fermentation unit comprises a fermentation tank, a biogas recovery mechanism, a heating mechanism, a heat exchange mechanism, a sprinkling mechanism, an automatic feeding mechanism and a stirring mechanism. The method comprises the following steps: performing sealed fermentation on straws and animal feces; and performing water press filtration on a fermentation product, then performing high-temperature inactivation, adding an appropriate amount of inorganic quick-acting fertilizer and trace element fertilizer, rooting powder, a drought-resistant water retention agent and clay, mixing, and performing granulation and drying to obtain the compound fertilizer. By adopting the system and the method disclosed by the invention, fresh animal feces are used as a leaven which contains a lot of microorganism bacteria and digestive enzymes and can promote biological degradation and decomposition of the straws; and moreover, the animal feces are further fermented to be beneficial for opening unstable ester bonds in straw cellulose, accelerating the degradation of the straws and shortening the fermentation period.

The invention discloses a method for manufacturing dried coprinus comatus. The method comprises the following steps of material preparing, blanching, salting, brittleness keeping and hardening, color processing, precooking, sugar making, drying, sugar coating, reshaping, packaging and the like. According to the method for manufacturing the dried coprinus comatus, the coprinus comatus is salted, part of water of the coprinus comatus is removed so that the tissue of the coprinus comatus can be compact, the permeability of cells is also changed so that the sugar can permeate into the dried coprinus comatus, and therefore a finished product has a pure flavor and tastes good; the dried coprinus comatus is stable in color and luster due to the brittleness keeping and hardening and the color processing; since high fructose corn syrup is used in the sugar making process, the dried coprinus comatus has a lingering aftertaste, the nutritional ingredients in the coprinus comatus can be maintained sufficiently, and the dried coprinus comatus has the functions of whetting appetite, promoting digestion, and enhancing human body immunity.

Disclosed are methods and systems and methods employing non-invasive ultrasound-neuromodulation techniques to control the permeability of the blood-brain barrier. For example, such an alteration can permit increased penetration of a medication to increase its therapeutic effect. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Depression (LTD) and Long-Term Potentiation (LTP) via training. Included is control of direction of the energy emission, intensity, frequency (carrier and/or neuromodulation frequency), pulse duration, firing pattern, and phase/intensity relationships for beam steering and focusing on targets and accomplishing up-regulation and/or down-regulation.

The invention discloses a preserved roselle manufacturing method which comprises the following steps of preparing materials, salting the materials, protecting crispness of the materials, hardening the materials, sulphuring the materials, precooking the materials, sugaring the materials, drying the materials, reshaping the materials, packing the materials and the like. Roselle is salted to remove part of water, so that tissues of the roselle are compact, the permeability of cells is changed, and sugar can permeate into preserved roselle conveniently. Thus, the preserved roselle is pure in flavor, delicious in taste and convenient to eat. Furthermore, nutrients of the roselle are fully kept. The preserved roselle has the effects of relieving summer heat, reducing blood pressure, intensifying blood vessel elasticity, curing hypertension, clearing heat, detoxifying, helping digestion, helping produce saliva and slaking thirst.

Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.

The invention discloses a manufacturing method for preserved zizania latifolia and relates to the field of deep processing of foods. Zizania latifolia is gramineous zizania latifolia which belongs to a perennial biennial root herbaceous plant wide in planting area. The manufacturing method comprises the following steps: preparing materials; carrying out blanching; carrying out color protection treatment; carrying out brittleness-keeping and hardening treatment; carrying out salting; carrying out pre-cooking; carrying out sugar preserving; carrying out drying; carrying out sugar-coating; carrying out shaping; and carrying out packaging and the like. According to the method disclosed by the invention, by using a saline solution to blanch, not only can the zizania latifolia turcz be sterilized and de-enzymed, but also the permeability of inner cells of the zizania latifolia turcz can be changed, so that penetration of sugar into the preserved zizania latifolia turcz is facilitated. Through the brittleness-keeping and hardening treatment and the color protection treatment, the preserved zizania latifolia turcz is pure in flavor, tasty in flavor and stable in color and luster, and the nutrients of the zizania latifolia turcz can be fully retained. The preserved zizania latifolia turcz has the functions of inducing diuresis and dispelling water, reducing the blood pressure and clearing away heat and loosing the bowels.

The invention discloses a microorganism oil displacement numerical simulation method. According to the method, the complicated microbial enhanced oil recovery mechanism is summed up as follows: reducing viscosity of crude oil, changing rock permeability and surface wettability, and changing oil-water relative flow ability and residual oil saturation; adopting experimental and mathematical methods to establish quantitative relation between oil displacement parameters and microorganism parameters; achieving microorganism oil displacement numerical simulated calculation through data real-time exchange between a biofield parameter calculation module and an oil pool numerical simulation device, designing a microorganism oil displacement scheme and predicting a microorganism oil displacement effect quickly and efficiently, and meeting the requirement for engineering design of oilfield development. The simulation method fully reflects the microbial enhanced oil recovery mechanism, ensures the truth of a microorganism oil displacement process, reduces complexity of the microorganism oil displacement process and significantly improves efficiency of microorganism oil displacement numerical simulation.

The invention provides organic compost, which comprises 10-50 parts by weight of organic matter, 5-20 parts by weight of humic acid, 0.5-2.0 parts by weight of full nitrogen, 1.0-2.0 parts by weight of full potassium and 0.1-0.5 parts by weight of full phosphorus. The organic compost is prepared by mixing and fermenting heavily-polluted condensate water, crop straws, various plants or byproducts generated by preparing materials during making papers with ammonium sulfite method. The whole preparation technology is simple, wherein the heavily-polluted condensate water generated during making the papers and the crop straws are used for preparing organic fertilizer, the organic fertilizer is reused for the growth of crops, and the straws can be used for the paper-making industry, therefore, the technology is a positive cycle for the sustainable development of the industrial production. The organic compost can reduce the phenomenon of the hardening of soil, improves the structure of soil grains, effectively promote the roots to grow, obviously increase the amount and the thickness of the roots, stimulate the growing development of the crops, enhance the stress resistance performance of the corps, and improve the quality of farm produces, etc.

The present invention relates to liquid sustained release suspension dosage forms comprising ionized forms of water-soluble drugs. In particular, the invention encompasses a liquid form controlled release drug composition comprising a dispersed phase comprising an ion-exchange matrix drug complex comprising a pharmaceutically acceptable ion-exchange matrix and a water-soluble electrolytic drug associated with the ion-exchange matrix, wherein the surface charge of the ion-exchange matrix is opposite that of the electrolytic drug wherein the dispersed phase further comprises a non-electrolytic, soluble component having low molecular weight and a diffusion controlling membrane and a dispersion medium substantially free of diffusible counterions, further comprising an excipient capable of associating with water and impeding water activity such that drug dissolution is inhibited prior to administration. The invention also provides methods for preparing such compositions and methods of treatment.

The invention discloses a manufacturing method for gold berry preserved fruits, and belongs to the food processing field. The manufacturing method is characterized in that the gold berry preserved fruits take the gold berry as a raw material; and the manufacturing method comprises the steps of preparing materials; hardening to maintain crispiness; vulcanizing; pre-cooking and candying; drying; packaging and detecting. The gold berry is pre-cooked by using a salt solution; internal tissue structure of the raw material can be improved; and permeability of cells is changed, thereby facilitating sugar penetrating through the gold berry preserved fruits. By adopting the crispiness-maintaining hardening and color protection, the preserved fruits have pure flavor, delicious taste and stable color, and have the functions of diminishing inflammation and suppressing pains, and eliminating stasis to subdue swelling.

The invention discloses a multifunctional wet tissue containing orange essence. The wet tissue is characterized by being prepared by pouring the orange essence and auxiliary materials into reverse osmosis (RO) purified water, mixing, uniformly stirring, standing, uniformly spraying the obtained mixed liquid to a spunlaced non-woven fabric, and hermetically packaging. According to a formula, the wet tissue comprises the following components in percentage by weight: 0.05 to 5 percent of orange essence, 0 to 10 percent of auxiliary materials and 85 to 99.95 percent of RO purified water. The wet tissue is safe and non-toxic, has a strong sterilization function and multiple functions, and is widely applied, and wet tissues suitable for various consumer groups can be prepared by adjusting the formula.

The invention discloses a rapid drainage and consolidation treatment method for soft soil foundations, which comprises the following steps: (1) digging the silt to 2-3m below the delivery elevation, and backfilling the first layer of sand to 0.8-3m below the delivery elevation while digging 1.2m, insert the plastic drainage board to a depth of 8m below the handover elevation, cover the second sand cushion to 0.5-1.5m above the handover elevation, set up a drainage system to pump water continuously; (2) start the first dynamic load after 12-18 days after the backfill is in place , the energy is 500-650 kJ, and the depth of the ramming pit does not exceed 1.5m; (3) The second dynamic load after 5-8 days, the energy is 700-900 kJ, and the depth of the ramming pit does not exceed 1.5m, (4) 5-8 Start the third dynamic load after 5-8 days, the energy is 1100-1500 kJ, and the depth of the ramming pit does not exceed 1.5m; m; (6) After 5-8 days, excavate excess filler, perform 600 kilojoule full-field dynamic load once, and level and hand over the work twice. The invention can reduce the cost by 75%, and shorten the construction period from more than 360 days to about 90 days.

The invention relates to a processing method of rose and phyllanthus emblica preserved fruits. The processing method is characterized in that the rose and phyllanthus emblica preserved fruits are processed by taking roses and phyllanthus emblica as raw materials through the processes of material preparation, brittleness-keeping hardening, rose pretreatment, grinding, precooking, candying, drying, coating, packaging and the like. According to the method, rose juice is separated from rose residues, the rose juice is adopted for precooking the phyllanthus emblica raw material, and table salt is added during precooking, so that the internal organizational structure of the raw materials can be improved, the penetrability of cells can be changed, and sugar can permeate into phyllanthus emblica preserved fruits; and the phyllanthus emblica preserved fruits are coated with the rose residues, so that the utilization ratio of the raw materials is effectively improved, and nutrients of finished products of the preserved fruits are increased. Furthermore, the rose and phyllanthus emblica preserved fruits have the effects of promoting qi circulation and removing obstruction in the collateral, harmonizing the blood and the like.

The present invention relates to a method for enhancing oil and oil residue recovery from oil-containing rock formations by supplementing a water cycle of a water alternate gas process with nutrients such that the formation resident microorganisms are stimulated as an additional oil release mechanism. The method alters three-phase relative permeability in order to increase displacement efficiency while increasing oil release by microbially assisted water alternate gas processing.

The invention relates to pH-sensitive starch-based micro-capsules embedded with fat-soluble functional factors and a preparation method thereof, and belongs to the field of starch-based hydrogel micro-capsule preparation. The preparation method of the pH-sensitive starch-based micro-capsules embedded with the fat-soluble functional factors comprises the following steps: performing acid hydrolysison starch so as to obtain acid-hydrolyzed carboxymethyl starch; mixing the acid-hydrolyzed carboxymethyl starch with xanthan gum so as to obtain a compound solution of starch and colloid; adding an emulsifier and fat-soluble functional factors, and carrying out emulsification so as to obtain an emulsion; and then, carrying out drying so as to obtain the micro-capsules. The micro-capsules preparedby the preparation method are capable of resisting hydrolysis by gastric acid and enzymes in gastric juice; and thus, bioavailability of core materials, namely the fat-soluble functional factors is improved. The release rate of the fat-soluble functional factors in simulated gastric juice is only 20-40%; and the cumulative release rate of the fat-soluble functional factors in human body digestivetract (simulated gastric juice and simulated intestinal juice) is up to 80-95%. Therefore, the problems of bad water-solubility, liable oxidation, low oral availability and the like of the fat-solublefunctional factors are solved; so that, the micro-capsules can be added into products, such as beverages and the like, as a nutrient fortifier or a food additive. Thus, the micro-capsules have wide application prospects.

The invention discloses a culture medium to detect Bifidobacterium and a quick detection and counting method, and relates to the technical field of Bifidobacterium detection. The culture medium hereincomprises a basic medium, and rendering substrate 5-bromo-4-chloro-3-indol-alpha-D-galactoside and/or 5-bromo-4-chloro-3-indol-beta-D-galactoside; alpha-galactosidase generated by metabolism in the Bifidobacterium culture process reacts with the rendering substrate to release indole, so that a blue Bifidobacterium colony is present on the culture medium, or blue halo is present around the Bifidobacterium colony; interfering bacteria cannot display blue color without alpha-galactosidase; the rendering substrate can inhibit other interfering bacteria; the colony can grow quickly after a surfactant is added; the growth of other interfering bacteria can be inhibited by adding antibiotics to the culture medium herein. The culture medium, when used to detect and count Bifidobacterium, allows the Bifidobacterium colonies to be counted conveniently and quickly; the results are significant, detection cost is low, and accuracy is high.

The invention discloses a method for establishing a joint cartilage two-phase model on the basis of joint hyperelastic solid phase characteristics, and relates to a method for establishing a joint hyperelastic two-phase model. In order to solve the problem that a model which takes a cartilage solid phase as a linear elastic material has a great difference with a practical situation and even fails when the model generates large deformation by aiming at a joint cartilage, the method comprises the following steps of: firstly, obtaining the geometric model of human tissues which need to be researched according to the CT (Computed Tomography) data reconstruction of the joint; then, obtaining the unit number and the node coordinate of the model as the original data input by deformation calculation, and establishing the joint cartilage two-phase model based on a theory of mixtures and a control equation based on v-p variables; and then, establishing a joint cartilage mechanics equilibrium equation, and carrying out finite element calculation. The method is suitable for establishing and simulating the joint cartilage two-phase model.

The present invention relates to a disinfection liquid. The chlorhexidine gluconate bath disinfection liquid comprises, by weight, 1.5-2.5% of CHG, 0.3-1.5% of a compound preservative, 0.5-2.0% of a thickening agent, 2.0-10.0% of a surfactant, 0.5-5.0% of a skin moisturizing agent, 0.5-5.0% of a moisturizing agent, 0.1-2.0% of a penetrant, a proper amount of a pH value regulating agent, and the balance of water. The preparation method comprises: adding a sufficient amount of water to a reaction kettle, heating to a temperature of 50 DEG C, adding the thickening agent under stirring, completely swelling after 30 min, sequentially adding the surfactant, the skin moisturizing agent, the moisturizing agent, the penetrant and the pigment, uniformly mixing, then adding the CHG, stirring for 10 min, cooling to a room temperature, adding the preservative and the essence, stirring for 5 min, adjusting the material liquid to achieve the weak alkaline state, standing, and defoaming. According to the present invention, the CHG can quickly penetrate into the skin stratum corneum and can be adsorbed on the stratum corneum so as to achieve the rapid, complete and durable sterilization purpose.