101 results about "Drug Dissolution" patented technology

The application belongs to the technical field of drug dissolution and dispersion, and particularly relates to a bunazosin water-based solution preparation and a preparation method. The bunazosin water-based solution preparation provided by the application comprises the following components: bunazosin, gamma-cyclodextrin, lecithin, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, aspartame and water. The above components are mixed to be homogeneous to prepare an oral solution which is uniform, clear and can be stored for a long time. The scheme of the application further enriches the dosage form of bunazosin, improves the convenience of taking bunazosin, and is expected to help improve the oral bioavailability and absorption efficiency of bunazosin. The scheme of the application also provides a reference direction for the mechanism research on the dissolution and dispersion behavior of the insoluble bunazosin macromolecule in a water medium.

A method for improving drug solubility and a drug composite material having improved solubility. The method comprises preparing a silica colloidal suspension from silica nanoparticles having a diameter between 2 nm and 100 nm; rapidly evaporating a solvent by means of controlling the temperature and pressure, so as to obtain a porous surface material with ultra-high density silanol groups retained on the surface; and loading drug molecules. By controlling the size of nanoparticles and the density of silanol groups, drug molecules can be effectively adsorbed under anhydrous conditions, and rapidly desorbed and released in an aqueous environment.

A pyridine amide compound-containing composition and a pharmaceutical composition, a preparation method therefor and a use thereof. The composition comprises an active ingredient and at least one matrix material, wherein the active ingredient is a compound represented by formula I or a pharmaceutically acceptable salt, a stereoisomer, a solvate, an isotopically labeled compound, a polymorph, a metabolite or a prodrug thereof. The composition has a high drug loading capacity, improves drug solubility, and has good stability. The in vivo bioavailability of the composition can reach the same level of bioavailability as that of a clear drug solution.

The present application belongs to the technical field of pharmaceutical preparations, and specifically provides a compound SYN045 soft capsule and a preparation method thereof. The present application adopts a fixed proportion of plant oil and polyoxyethylene glyceryl oleate combination to prepare the content, which helps to reduce the degradation of SYN045 in the content drug solution, ensures the stability of the active ingredient, and obtains a compound SYN045 soft capsule with good drug dissolution, high drug content, low impurity generation, and high bioavailability. Further, through prescription optimization of the soft capsule shell, a fixed proportion of plasticizer is selected, the mass ratio of glycerol and sorbitol is 1:2-3, the transfer of the compound SYN045 to the soft capsule shell is reduced, and thus the quality stability problem of the soft capsule preparation product during drug storage is solved.

The invention provides a drug dissolution degree detection method, system and equipment, a medium and a product. The detection method comprises the following steps: emitting target light into a container from the outside of the container and at a preset position; wherein a solution obtained after medicine is dissolved is stored in the container; acquiring target light intensity information of the solution in the container at each moment within a preset time; and obtaining medicine dissolution information in the container based on the target light intensity information corresponding to different moments. According to the method for detecting the dissolution degree of the medicine, the dissolution degree of the medicine in the container can be detected in time, automatically and accurately, human participation in judgment is not needed, and the use experience of a user is improved.

The application discloses a tripterine self-assembled nanoparticle microsphere, a preparation method and application thereof, and belongs to the technical field of biological medicines. The tripterine self-assembled nanoparticle microsphere takes tripterine self-assembled nanoparticles as a drug core, is formed by cross-linking of a sodium alginate-pectin composite carrier through calcium ions, can significantly improve drug solubility, realizes stable protection and intestinal targeting rapid release in the gastrointestinal tract, and effectively reduces drug systemic exposure and side effect risks. The preparation process is mild and simple, the obtained preparation has high targeting and safety. Pharmacodynamic results show that the microsphere can obviously improve liver steatosis, inflammation and fibrosis related to metabolic-related fatty liver hepatitis, and has better curative effect than conventional preparations. The application provides a novel oral delivery system for preventing and treating metabolic-related fatty liver hepatitis, and has good industrial and clinical transformation prospects.

This utility model relates to the field of wastewater treatment technology, specifically to a drug dissolving device for wastewater treatment. The device includes a dissolving cylinder, which comprises a cylinder body. A top cover is fixedly connected to the upper end of the cylinder body, and a bottom plate is fixedly connected to the lower end. The top cover is equipped with a stirring mechanism and a feeding mechanism for quantitatively adding drugs. The bottom plate is equipped with an air blowing mechanism for introducing air into the dissolving cylinder, and a sealing mechanism for sealing the dissolving cylinder is located below the bottom plate. A water pipe for adding water to the dissolving cylinder is installed on the side wall of the cylinder body, and an electrically controlled valve is installed on the water pipe. In this utility model, an air pump is used to pump external air into an annular and radial pipes, and then discharges it into the water through air outlets on the annular and radial pipes, creating surging bubbles in the water. Compared to simply having a stirring mechanism, this device further enhances water flow, thereby significantly increasing the drug dissolving speed.

The present application provides a drug-loaded microsphere for loading polypeptide drugs, the polypeptide drug delivery drug-loaded microsphere is W1 / O / W2 structure, which is composed of polypeptide drug active substance and hydrophilic gel as the inner water phase (W1), organic solvent of water-insoluble polymer as the oil phase (O), and solution containing emulsifier as the outer water phase (W2). The sustained-release microsphere of the present application introduces hydrophilic temperature-sensitive gel and water-insoluble polymer to co-load drugs, increases the hydrophilicity of the carrier, and reduces the solubility of polypeptide drugs by preparing metal ion-polypeptide drug active substance insoluble complex, thereby controlling the drug release behavior. Compared with the conventional microsphere, the sustained-release microsphere of the present application has the advantages of reducing drug burst release, shortening the drug release platform period, making the overall drug release behavior of the drug tend to zero-order release, releasing more stably, and improving the compliance of the microsphere preparation.

The present application relates to a low hepatotoxicity actinomycin D solid dispersion and a preparation method thereof. The low hepatotoxicity actinomycin D solid dispersion product is obtained by co-grinding reaction of actinomycin D, plant source functional natural excipient, flow aid and ball milling beads in a ball milling tank. The solid dispersion is prepared by mechanical chemical grinding, without using organic solvent, avoiding drug degradation in high temperature melting process, easily making the drug and excipient amorphous, improving the drug solubility and bioavailability, having the advantages of high preparation efficiency, low production cost, simple operation, green environmental protection and the like; and the plant source polymer is used as a carrier, the solubilization and synergistic effect are enhanced, the hepatotoxicity of actinomycin D is reduced, which is crucial for safe use of antibiotic drugs, and has positive significance for exploring natural, non-toxic, efficient and multifunctional drug loading system excipient.

The utility model discloses a pharmaceutical experiment dissolver which comprises a bottle body, the top end of the bottle body is fixedly connected with a bottle neck, the top end of the bottle neck is fixedly connected with a feeding port, the top end of the feeding port is provided with a cover box, the top face of the cover box is in a net shape, and the bottom face of the cover box is fixedly connected with a sealing plug. When the medicine dissolving device is used for dissolving medicine, the connecting shaft is inserted into the bottle body, then the motor is driven, in the process, fan blades at the output end of the motor can enable the bottle body to have the upward air draft effect through the vent hole, and therefore the medicine dissolving device can be used for dissolving medicine. The motor drives the connecting shaft to rotate in the cavity of the bottle body, the hinged stirring blades are swung in the cavity of the bottle body, and due to the fact that the shrinking openings are arranged to be an upper group and a lower group, when the stirring blades are swung, stirring and dissolving comprehensiveness can be improved, and stirring and dissolving effects are improved. The dissolving efficiency is further improved.

This utility model discloses a drinking water device for pig farming, relating to the field of pig farming technology. Specifically, it is a drinking water device for pig farming, including a drinker with a water storage device installed on the outside. The drinker has a first slot inside, and a drinker frame is installed in the first slot. A second slot is opened through the outer frame of the drinker, and a displacement device that can move up and down according to the water volume is installed at the bottom of the second slot. A spring plate assembly can drive a switch trigger assembly to move up and down according to the water volume. When moving, it can trigger a motor switch to start or stop the motor from injecting water. This allows water to be automatically injected when the pigs' drinking water is insufficient and automatically shut off when the water volume is sufficient, eliminating the need for manual water injection. The medication is placed in the storage tank of the injection device. While water is being injected, the injection device rotates, allowing for intermittent injection of medication without accumulation, which helps the medication dissolve.

The present application belongs to the technical field of oral solid preparation, and particularly relates to a mosapride citrate orally disintegrating tablet and a preparation method thereof. Raw and auxiliary materials comprise mosapride citrate, a filling agent, a disintegrating agent, a glidant, a lubricant and a flavoring agent. The present application screens and optimizes the auxiliary material formula, adopts dry granulation, optimizes the preparation process, improves the compressibility and fluidity of the material, saves energy, improves the production quality and stability, makes the prepared orally disintegrating tablet disintegrate rapidly, has excellent taste, greatly improves the medication compliance of patients, simultaneously improves the drug dissolution and improves the bioavailability. In addition, compared with other types of solid oral preparations of the product, the mosapride citrate orally disintegrating tablet is particularly suitable for the elderly and patients with difficulty in swallowing, and provides convenience in special and urgent situations such as lack of drinking water for taking medicine.

There is provided a composite having a higher dissolution of a drug, the composite including at least a solid dispersion containing the drug and a carrier other than polyvinylpyrrolidone as well as HPMCAS outside the solid dispersion. More specifically, there is provided a composite including at least a solid dispersion containing at least a drug and a carrier selected from the group consisting of a vinylpyrrolidone-vinyl acetate copolymer, methyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl methyl cellulose phthalate and first hydroxypropyl methyl cellulose acetate succinate; and second hydroxypropyl methyl cellulose acetate succinate outside the solid dispersion.

The utility model provides a coating production wastewater treatment and recycling device, and relates to the field of wastewater treatment. The ejection piece structure is installed at the top end of the device body and provided with a storage structure through a supporting rod, a medicine outlet piece is arranged at the bottom of the storage structure, an opening is formed in the side edge of the bottom of the medicine outlet piece, and the opening of the medicine outlet piece is located in the side edge of the stirring paddle. The control storage structure is installed and used, due to the fact that the medicine outlet piece is of a semi-opening structure, air can be stored in the medicine outlet piece, after the sealing plate ascends, the through hole can be opened, medicine is continuously discharged through the through hole, the stirring paddle pushes liquid to impact the medicine outlet piece, the medicine is impacted and dispersed after being discharged, and the medicine is rapidly dissolved and mixed while being dispersed; the mixing efficiency and the treatment efficiency are improved, and the problems that in the using process of a common coating production wastewater treatment and recycling device, medicine dissolving is strenuous after medicine adding, and the dispersion effect is limited are solved.

The invention discloses a preparation method of inositol nicotinate tablets, and belongs to the technical field of pharmaceutical preparations. By optimizing the existing process and coating components, stable dissolution of drugs is realized, and the method comprises the following steps: dispersing inositol nicotinate in mixed oil to prepare an oil phase, mixing and emulsifying the oil phase and a water phase, performing spray drying to obtain drug milk powder, coating the drug milk powder with modified chitosan, and directly tabletting the coated drug milk powder and auxiliary materials. The preparation method comprises the following steps: uniformly dispersing inositol nicotinate in mixed oil to promote the inositol nicotinate to maintain the uniformity of the drug content in the subsequent process, and adsorbing solid particles on the surfaces of drug-containing oil drops through an emulsification technology to protect the drug components; coating components are reasonably designed, so that fixed-point release of the medicine is realized, the medicine is endowed with anti-pressure ability, and the medicine can be directly tableted; and the coated medicine particles are mixed with auxiliary materials and then are directly tableted, so that the process is simplified, and the coating structure of the medicine particles is protected at the same time. The preparation method can prepare the inositol nicotinate tablet with stable drug dissolution, and the inositol nicotinate tablet is good in taste and small in stimulation to gastric mucosa.

The invention provides a novel metformin hydrochloride enteric-coated preparation, which is an oral dosage form prepared from a therapeutically effective amount of biguanide compound and pharmaceutically acceptable auxiliary materials, and is characterized in that the dissolution rate of metformin hydrochloride in a medium with the pH value of 4.5 within 120 minutes is not higher than 15%; and the dissolution rate of metformin hydrochloride in a medium with the pH value of 6.8 within 20 minutes is not lower than 85%, preferably, the dissolution rate in a medium with the pH value of 4.5 within 120 minutes is not higher than 7.5%, and the dissolution rate in a medium with the pH value of 6.8 within 15 minutes is not lower than 85%. The metformin hydrochloride enteric-coated preparation meeting the technical requirements of medicine dissolution improves the gastrointestinal tract tolerance of metformin hydrochloride and reduces adverse reactions caused by medicines under the condition that the hypoglycemic curative effect is not reduced or even improved, can be taken before meals, and can also be taken after meals or during meals, so that the metformin hydrochloride enteric-coated preparation is suitable for clinical application. The medicine taking compliance of a patient is improved.

This application discloses a method to solubilize poorly soluble drugs in a liquid crystal vehicle for long-acting injectables. Poorly soluble acidic drugs-hydrophobic basic compounds ion pairs are incorporated into liquid crystal vehicles to solubilize and slowly release the drug after parenteral administration. Ion pairs such as Meloxicam-Dodecylamine, Sulfadiazine-Dodecylamine, Methotrexate-Dodecylamine, Levothyroxine-Dodecylamine, Meloxicam-Tridodecylamine, and Meloxicam-Bupivacaine are incorporated into liquid crystal vehicles to solubilize and control release the drugs.

The invention discloses a preparation method and application of a fat-soluble drug solid dispersion based on a zwitterionic hyperbranched polymer. According to the solid dispersion, a zwitterionic hyperbranched polymer HP-CB is used as a carrier, and a fat-soluble drug is loaded in an internal hydrophobic cavity; the preparation method of the solid dispersion comprises the following steps: loading a fat-soluble drug in a polymer by using a solvent evaporation method, freeze-drying to form the solid dispersion, and further compounding the solid dispersion with a cream matrix to prepare the nanoparticle composite cream. The solid dispersion has excellent hydrophilicity, low protein adsorptivity and good biocompatibility, the drug solubility and the transdermal permeability are remarkably improved, drug crystallization is effectively inhibited, the stability of a preparation is improved, and further prepared cream has the advantages of softening cuticles, promoting hydration and enhancing the sealing performance and has good application prospects. The traditional Chinese medicine composition can effectively improve chronic inflammatory skin diseases such as psoriasis, and has good clinical application prospect and industrialization value.

This application relates to the field of pharmaceutical technology and specifically discloses an upadacitinib sustained-release tablet and a method for preparing the same. Based on the solubility characteristics of upadacitinib, the present invention develops an upadacitinib sustained-release tablet with a gastric retention effect. This sustained-release tablet overcomes the drawback that drug dissolution is affected by differences in gastrointestinal pH, achieving sustained release in a low pH environment. Furthermore, the production process is simple, making it suitable for industrial production and clinical use.

A pharmaceutical composition, and a preparation method therefor and the use thereof. The pharmaceutical composition contains: (4aR,8R)-3-acryloyl-11-chloro-10-(2-fluoro-6-hydroxyphenyl)-8-(2-isopropyl-4-methylpyridin-3-yl)-6-methyl-2,3,4,4a,6,8-hexahydro-1H-pyrazino[1′,2′:4,5]pyrazino[2,3-c][1,8]naphthyridin-5,7-dione or a pharmaceutically acceptable salt thereof as an active ingredient; and one or more selected from a filler, a disintegrant, a lubricant, a glidant and a binder. The pharmaceutical composition has good stability and drug dissolution, and the preparation process is simple and is suitable for industrial production.

The present application belongs to the field of natural medicine, and provides a valerian self-microemulsion drop pill and a preparation method thereof, which is prepared from the following components by weight: valerian volatile oil 20-40 parts, valerian extract powder 8-10 parts, oil phase 10-30 parts, emulsifier 40-80 parts, co-emulsifier 10-50 parts, and base 200-650 parts. The volatile oil and alcohol-soluble components of valerian are extracted, and are prepared into self-microemulsion together with oil ester, emulsifier and co-emulsifier, so as to increase the drug solubility, promote the absorption of the drug, and improve the bioavailability. Then, the self-microemulsion is solidified in the form of drop pill, so as to obtain the valerian self-microemulsion drop pill with high drug solubility, high bioavailability and good stability. By controlling the mass ratio of the base and the valerian self-microemulsion, the heating temperature of the drug-containing base, and the drop distance, the forming rate of the drop pill can reach more than 90%.

The present invention relates to a pharmaceutical composition containing a polypeptide inhibitor and a use of the pharmaceutical composition. The composition has good stability and drug dissolution rate; the product has controllable quality; and a preparation method has simple process, strong operability, good reproducibility, and is suitable for large-scale industrial production.

The invention relates to a drug dissolution curve prediction method and device based on multi-agent collaborative optimization and a storage medium. The prediction method comprises the steps that a drug particle microscopic image is segmented, and feature parameters are extracted; a weight self-adaptive retrieval enhancement generation mechanism is utilized to dynamically retrieve physical and chemical parameters related to drugs from the knowledge graph; processing the parameters based on a large language model to generate a candidate drug dissolution curve; iterative optimization is carried out through a multi-agent decision-making platform, and the platform comprises a retrieval agent, a grazing agent, a review agent, an editing agent and a judgment agent which are respectively responsible for evidence retrieval, curve generation, multi-dimensional evaluation, problem correction and comprehensive score output. Compared with the prior art, the method ensures that the curve accords with the physical law through intelligent agent cooperation, automatically corrects abnormal points, remarkably improves the prediction accuracy and efficiency, reduces the consumption of experimental resources, and provides efficient digital support for the quality design of solid preparations.

The invention relates to the technical field of medical gel preparations, and discloses bioactive gel for treating oral ulcer and a preparation method thereof.The preparation method comprises the steps that medicine for treating the oral ulcer is dissolved in a solvent to prepare a solution, then the solution is prepared into nano-emulsion, and the nano-emulsion is prepared into the bioactive gel. The preparation method provided by the invention solves the problem of non-uniform dispersion of fat-soluble drugs in aqueous gel, improves the slow-release effect of drugs in the oral ulcer gel, enhances the treatment effect of the oral ulcer gel, and has the advantages that the oral ulcer gel is prepared by mixing the nano-emulsion and the gel matrix at a low temperature (less than 25 DEG C). The preparation method provided by the invention has the advantages that the problem of non-uniform dispersion of the fat-soluble drugs in the aqueous gel is solved; the bioactive gel for treating oral ulcer, provided by the invention, is high in biocompatibility and strong in adhesive force, not only has a good drug sustained release effect, but also can realize the simultaneous action of multiple functions of resisting inflammation, easing pain, promoting tissue regeneration and the like, promotes healing of the ulcer, shortens the treatment time and remarkably improves the treatment experience of a patient.

The utility model relates to the related technical field of medicine dissolving devices, in particular to a medicine dissolving device for pharmacokinetic detection, which comprises a pharmacokinetic detection frame, a motor, a dissolution cup and a mounting component, the motor is arranged at a driving position on the pharmacokinetic detection frame, the dissolution cup is arranged at a stirring position on the motor, and the mounting component is arranged on the motor. According to the device, when the shaft lever is driven by the motor on the pharmacokinetic detection frame, the shaft lever can be mounted in the dissolution cup, medicine dissolution observation is carried out through the dissolution cup and the transparent glass, and when a solution in the dissolution cup is too much, a user can manually screw the shaft lever to carry out spiral lifting and adjust the length of the shaft lever, so that the shaft lever is convenient to use. Therefore, the distance between the shaft rod and the dissolution cup can be adjusted through the connecting shaft sleeve and the shaft rod. Spiral adjustment is performed, so that the problem that the dissolved medicine overflows along with the rotation of the shaft rod and the dissolution cup when the solution in the dissolution cup is excessive is avoided, and the dissolution cup and the transparent glass medicine are conveniently stirred and dissolved.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a cefpodoxime proxetil and clavulanate potassium compound preparation and a preparation method thereof. In the cefpodoxime proxetil and potassium clavulanate compound preparation provided by the invention, the cefpodoxime proxetil and potassium clavulanate have a synergistic effect, so that the antibacterial effect can be enhanced, the antibacterial spectrum can be expanded, and drug-resistant bacterium infection can be effectively treated; according to the cefpodoxime proxetil premix, auxiliary materials such as lactose, calcium carboxymethyl cellulose and lauryl sodium sulfate are compounded, and a preparation process of firstly mixing cefpodoxime proxetil, lactose, a cosolvent and calcium carboxymethyl cellulose to prepare the premix is adopted, so that all the components are fully mixed and play a synergistic effect, the dissolution speed and bioavailability of the medicine are improved, and the bioavailability of the medicine is improved; the uniformity of preparation components is guaranteed, the stability of the whole process is enhanced, and the method is suitable for large-scale production.

This invention discloses an anhydrous swallowable granule and its preparation method. The anhydrous swallowable granule comprises the following components: mesoporous silica-drug, filler, disintegrant, and binder, with the following weight percentages: mesoporous silica-drug 15%–40%, filler 45%–80%, disintegrant 0%–20%, and binder 1%–3%. This invention uses a suitable solvent to dissolve the drug and loads it into the mesoporous silica pores via solvent impregnation, forming a mesoporous silica-drug. This mesoporous silica-drug allows the drug molecules to exist in an amorphous or non-crystalline form and possesses relatively good powder properties. Further addition of filler, disintegrant, binder, and flavoring agent prepares a drug granule suitable for direct swallowing. This formulation has good taste and compliance, achieves complete dissolution within 5 minutes, and shows no detectable drug components in 3 mL of simulated saliva for at least 30 seconds. It can be swallowed directly, increasing medication compliance and safety for elderly and infant patients, and demonstrating good efficacy.

The invention relates to a grinding device for pharmacy. The grinding device comprises a supporting base, a tamping rod frame is connected to the supporting base, a grinding tank is arranged on the lower portion of the tamping rod frame, an electric secondary telescopic rod is connected to the upper portion of the tamping rod frame, a grinding block is connected to the telescopic end of the electric secondary telescopic rod, and a driving piece is connected between the tamping rod frame and the grinding tank. The technical scheme of the invention has the beneficial technical effects that the electric secondary telescopic rod is adopted to drive the grinding block to realize lifting, extruding and grinding, so that each medicine raw material can be in uniform contact with the extruding and grinding surface of the grinding block, the problem of non-uniform grinding caused by local accumulation and corner residues of medicines is effectively avoided, and the granularity consistency of final ground products is ensured. The synergistic grinding mode is especially suitable for scenes with high requirements on the fineness of medicine powder in pharmaceutical research and preparation production, high-quality raw materials can be provided for subsequent medicine dissolution, mixing and preparation forming, and the dissolution rate and the medicine effect stability of the medicine are indirectly guaranteed.

The invention discloses an isosorbide dinitrate sustained-release tablet and a preparation method thereof, sodium alginate is used as a sustained-release skeleton, lactose, calcium hydrophosphate and dextrin are used as filling agents, and the hydrophilicity of lactose is beneficial for water to rapidly permeate into the tablet to start medicine dissolution; the hydrophobic and rigid structure of the calcium hydrophosphate hinders rapid penetration of water and drug diffusion; partial dissolvability of dextrin can form local corrosion or channels; through combination of multiple aspects, the permeation rate and diffusion path of moisture and the corrosion / expansion degree of a tablet matrix can be adjusted, a more controllable and more stable drug release environment is constructed together, and the sustained release requirement is met.

The invention discloses near-infrared luminous drug-loaded nanoparticles as well as a preparation method and application thereof. The preparation method of the drug-loaded nanoparticles comprises the following steps: S1, dissolving aggregation-induced emission molecules NDA-NH2 and a drug in a solvent to obtain a drug-containing NDA-NH2 solution; s2, dissolving oxidized hyaluronic acid in ultrapure water to obtain an oxidized hyaluronic acid aqueous solution; and S3, mixing the drug-containing NDA-NH2 solution with the oxidized hyaluronic acid aqueous solution under stirring, carrying out ultrasonic treatment, and after the reaction is finished, carrying out dialysis and freeze-drying to prepare the near-infrared luminous drug-loaded nanoparticles. Oxidized hyaluronic acid is used as a base material, NDA-NH2 is modified on an oxidized hyaluronic acid chain through a Schiff base reaction, and drug-loaded nanoparticles are formed through self-assembly by providing a hydrophobic core. The drug-loaded nano particle has excellent near-infrared imaging capability and photo-thermal effect, can be used as an imaging unit, a treatment unit and a controlled release unit at the same time, and realizes functional combination of near-infrared two-region imaging, photo-thermal and controllable drug release.