168 results about "Drug Dissolution" patented technology

The doxylamine succinate pyridoxine enteric-coated tablet comprises a tablet core and a coating layer, the coating layer comprises a first isolation layer, an enteric-coated layer and a second isolation layer, the materials of the enteric-coated layer comprise a plasticizer, an anti-sticking agent, a defoaming agent and a flexible coating material, and the flexible coating material accounts for 24-28% of the mass of the tablet core. By adding the flexible coating material, the stability of the pharmaceutical preparation is improved, the difference between batches is reduced, the drug dissolution rate reaches 90% or above, and the pharmaceutical preparation can be quickly released.

The present invention discloses an intelligent preparation device for tumor chemotherapy drugs, which relates to the technical field of chemotherapy drug preparation, including a straight guide rail, an arc guide rail, a vertical slider installed on the straight guide rail, and an arc slider installed on the arc guide rail. A rotating motor is fixedly provided on the upper surface of the arc slider, a preparation table is fixedly provided at the output end of the rotating motor, and a placement rack for placing medicine bottles is provided at equal angles on the edge of the preparation table. A rotating shaft is fixedly provided in the middle of both sides of the multiple placement racks, and one end of the rotating shaft is rotatably connected to the preparation table. The present invention extracts the liquid medicine in the bottle by simulating the manual side hole needle syringe drug extraction method, and injects the extracted liquid medicine into the bottle again, and repeats this process until the liquid medicine is completely dissolved. The extraction and injection are mechanically controlled to reduce bubbles, and the needle is attached to the side wall of the inclined medicine bottle, which reduces the generation of bubbles while allowing the liquid medicine in the medicine bottle to be completely extracted, thereby increasing the stability of drug dissolution, effectively protecting the operator, and improving the efficiency of tumor chemotherapy drug preparation.

The invention discloses a nano-drug delivery method for enhancing LGP kidney targeted release and application of the nano-drug delivery method, and relates to the technical field of nano-drugs. According to the nano-drug delivery method for enhancing LGP kidney targeted release and the application thereof, a hydrophobic modified chitosan polymer is synthesized; preparing HCS nanoparticles; and constructing a drug loaded nanoparticle, namely, HCS-LGP NPs. According to the invention, the solubility of the medicine is increased, the distribution of the medicine in vivo is changed, and the targeting of the medicine is improved, so that the treatment effect is improved, and adverse reactions are reduced. Due to good biocompatibility and modifiability, chitosan is widely used as a nano delivery carrier of anti-tumor and antibacterial drugs.

The present invention belongs to the field of drug testing instruments, and relates to a drug dissolution tester and a calibration method thereof. The drug dissolution tester comprises a frame, a water bath, a dissolution cup, a stirring paddle and a driving mechanism. The dissolution cup is detachably mounted in a cup hole of the water bath. A calibration cover is placed on the cup mouth of the dissolution cup in a coaxial positioning manner. The surface layer of the calibration cover is a pressure-sensitive imaging layer. A calibration hole adapted to the paddle shaft of the stirring paddle is coaxially arranged in the center of the calibration cover. When the inverted paddle shaft is coaxial with the dissolution cup, the paddle shaft passes through the calibration hole and then extends into the dissolution cup. When the inverted paddle shaft is not coaxial with the dissolution cup, the paddle shaft cannot pass through the calibration hole, and the pressure-sensitive imaging layer of the calibration cover senses the paddle shaft and develops on the calibration cover to indicate the eccentric position of the paddle shaft. A fine-tuning mechanism is installed on the top plate of the water bath, which is used to fine-tune the position of the dissolution cup in the cup hole according to the development. The present invention can quickly calibrate the coaxiality of the paddle shaft and the dissolution cup.

The invention relates to the technical field of preparation of biological materials and pharmaceutical preparations, in particular to organic composite hydrogel as well as a preparation method and application thereof. The specific preparation method comprises the following steps: dissolving a targeted drug in orthoester to obtain a targeted drug-orthoester solution; the preparation method comprises the following steps: mixing an oxidized dextran solution, a targeted drug-orthoester solution and a carboxymethyl chitosan solution, carrying out vortex treatment, and standing to prepare the organic composite hydrogel. The solubility of the targeted drug in the hydrogel is improved by utilizing orthoester, the orthoester can carry the targeted drug to efficiently escape from the hydrogel, and the targeted drug can be self-assembled to form nanoparticles along with degradation of the orthoester in the escape process, so that the retention capacity of the targeted drug at a tumor site is enhanced, and the targeting drug can be used for treating tumor tumors. The drug enrichment capacity is improved, meanwhile, the toxic and side effects of the whole body are reduced, and the problems that nano-drugs are poor in solubility, still prone to being removed after intravenous administration and poor in enrichment effect at tumor sites are solved.

A closed-loop sampling system for drug dissolution by flow-through cell method and its use method, comprising a constant-temperature water bath system, a flow-through cell system, a lifting mechanism, a circulating heating system, a solvent monitoring system, a solvent circulation system and a sampling system; the constant-temperature water bath system includes a constant-temperature water bath frame, a constant-temperature water bath, a solvent cup holder, a solvent cup and a solvent cup cover; the flow-through cell system is arranged at the top of the constant-temperature water bath system; the lifting mechanism is arranged on one side of the constant-temperature water bath frame; the circulating heating system includes a heating device and a water circulation pump; the circulating inlet end of the solvent monitoring system is communicated with the heating device, and the circulating outlet end of the solvent monitoring system is respectively communicated with the solvent cup and the flow-through cell; the solvent circulation system includes a solvent circulation pump and a pulse valve; the sampling system includes a sampling mechanism, a sampling pipeline, a sampling valve and a sampling pump. The device of the present invention has a compact structure, high heating efficiency of the heating device, uniform water temperature distribution in the water bath, accurate water temperature control, and temperature and pressure monitoring of the solvent.

The invention belongs to the technical field of anhydrous emulsions, and discloses an anhydrous self-emulsifying drug-loaded emulsion based on a deep eutectic solvent and a preparation method thereof.The preparation method comprises the following steps that 1, betaine and a hydrogen bond donor are mixed, the deep eutectic solvent is prepared through a mixed heating method, a drug is dissolved in the deep eutectic solvent, and a drug solution is prepared; the hydrogen bond donor is levulinic acid or lactic acid; (2) mixing Tween 80 and Span 80 according to a mass ratio of (1-2): 1 to obtain a surfactant, adding absolute ethyl alcohol as a co-emulsifier, adding isopropyl myristate, and uniformly stirring and mixing to obtain a dispersion liquid; and (3) dropwise adding the drug solution in the step (1) into the dispersion liquid in the step (2), and stirring at the same time to finally form the anhydrous self-emulsifying drug-loaded emulsion. According to the invention, the loading capacity, the stability and the bioavailability of the medicine can be obviously improved; in addition, the efficiency of transdermal drug delivery of the emulsion is high, and the emulsion can be applied to skin external preparations.

The invention discloses a pH response hydrogel microneedle, which comprises a microneedle substrate, microneedle tips are arranged on the microneedle substrate, the height of the microneedle tips is 100-1600 microns, the diameter of the tip ends of the microneedle tips is 5-15 microns, and the density of the microneedle tips is 200-1000 pieces per square centimeter. The preparation method comprises the following steps: preparing a hyaluronic acid solution for the microneedle substrate, preparing a methacrylated chondroitin sulfate solution for the microneedle tip, preparing methacrylated orthoester, preparing orthoester, preparing a non-steroidal anti-inflammatory drug solution, preparing a microneedle tip solution, preparing the microneedle and demolding the microneedle to prepare the complete soluble microneedle patch. The invention has the advantages of high drug efficiency, high efficiency in dissolving fat / water drugs, and long-acting slow release.

The circulating stirring and dispensing device for mineral separation comprises a support and further comprises a body internally provided with a stirring assembly, a stirring barrel and a stirring motor. The stirring assembly comprises a first stirring rod, a second stirring rod and a stirring motor; the first stirring rod and the second stirring rod sleeve the rotating shaft from top to bottom; a rotating shaft at the bottom of the stirring barrel penetrates through the filter screen; the bottom of the body is provided with a pair of lead-out pipes with electromagnetic valves, the body is arranged on the support, mineral separation and medicine preparation can be circularly stirred, and the device has the advantages that different solid agents and liquid agents can be evenly mixed and stirred, the agents are rapidly dissolved, and a conveying pipeline cannot be blocked.

The invention relates to the technical field of biodegradable materials, in particular to a polylactic acid microsphere with controllable degradation performance and a preparation method and application thereof. Comprising the following steps: S1, dissolving polylactic acid with the molecular weight of 50-200kDa in an organic solvent to obtain an oil phase, and dissolving a medicine in the solvent to obtain a water phase; s2, adding the water phase into the oil phase to form a W / O primary emulsion; s3, adding the W / O primary emulsion into a solution containing a surfactant with the mass volume concentration of 0.5%-2%, and stirring to form a W / O / W system; s4, performing solvent volatilization on the W / O / W system; and S5, collecting the microspheres, and drying. The particle size of the polylactic acid microspheres can be controlled, the high-quality polylactic acid microspheres with controllable degradation performance and drug release performance are prepared, and different biomedical application requirements are met.

The invention provides a drug dissolution prediction method and device and electronic equipment, and the method comprises the steps: carrying out the feature extraction of near infrared spectrum data of a to-be-processed drug, and obtaining a spectrum feature; a machine learning model is utilized to predict the dissolution rate of the effective components in the medicine to be treated according to the spectral characteristics, and the machine learning model is constructed by extracting the spectral characteristics of the effective components according to the near infrared spectrum data of the sample medicine and the dissolution rates of the effective components in the sample medicine at different moments. In the implementation process of the scheme, the dissolution rate of the effective components in the to-be-treated medicine is predicted through the constructed machine learning model, the dissolution rate of the medicine can be obtained, the damage rate of a medicine sample is reduced, the method is suitable for detection of precious or special medicines, and through feature extraction and the machine learning model, the detection accuracy is improved. The requirements on complex equipment and medicine treatment are reduced, so that the dissolution rate of the medicine can be quickly predicted, and the detection efficiency is improved.

The application belongs to the technical field of drug dissolution and dispersion, and particularly relates to a bunazosin water-based solution preparation and a preparation method. The bunazosin water-based solution preparation provided by the application comprises the following components: bunazosin, gamma-cyclodextrin, lecithin, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, aspartame and water. The above components are mixed to be homogeneous to prepare an oral solution which is uniform, clear and can be stored for a long time. The scheme of the application further enriches the dosage form of bunazosin, improves the convenience of taking bunazosin, and is expected to help improve the oral bioavailability and absorption efficiency of bunazosin. The scheme of the application also provides a reference direction for the mechanism research on the dissolution and dispersion behavior of the insoluble bunazosin macromolecule in a water medium.

A method for improving drug solubility and a drug composite material having improved solubility. The method comprises preparing a silica colloidal suspension from silica nanoparticles having a diameter between 2 nm and 100 nm; rapidly evaporating a solvent by means of controlling the temperature and pressure, so as to obtain a porous surface material with ultra-high density silanol groups retained on the surface; and loading drug molecules. By controlling the size of nanoparticles and the density of silanol groups, drug molecules can be effectively adsorbed under anhydrous conditions, and rapidly desorbed and released in an aqueous environment.

The invention relates to the field of pharmaceutical preparations, and discloses a clopidogrel hydrogen sulfate tablet and a preparation method thereof, and the clopidogrel hydrogen sulfate tablet comprises the following components: 30-50 parts of clopidogrel hydrogen sulfate; 5-15 parts of a double-layer nano permeable membrane material; 3 to 12 parts of a pH sensitive release material; 5 to 12 parts of a supramolecular self-assembled nanoparticle material; 5 to 15 parts of a solubility regulator; 2-5 parts of an ionic crosslinking regulatory factor; 10 to 25 parts of an excipient; 0.5 to 2 parts of a lubricant; 0.5 to 2 parts of a stabilizer; the double-layer nano permeable membrane material comprises the following components in parts by weight: an inner layer material: 5-15 parts of hydroxypropyl # imgabs0 #-cyclodextrin; 3 to 10 parts of polyvinylpyrrolidone; an outer layer material: 2-8 parts of ethyl cellulose; and 2 to 10 parts of hydroxypropyl methylcellulose. The double-layer nano permeable membrane is combined with the pH-sensitive controlled release system, so that the dissolution rate of the medicine is adjustable, and accurate release in different pH environments is realized. The technical effects of improving the dissolution efficiency, optimizing medicine absorption and reducing individual differences are achieved.

The utility model discloses a pretreatment device for medicine inspection. The pretreatment device comprises a medicine dissolving tank, a filtering tank and a medicine dissolving solution collecting tank which are communicated with one another, the medicine dissolving tank is also communicated with a solvent storage tank; a stirring device is arranged in the medicine dissolving tank, the stirring device comprises a stirring shaft rotationally arranged in the medicine dissolving tank and a stirring motor connected with the stirring shaft, a plurality of crushing teeth are arranged on the stirring shaft, and the medicine dissolving tank is sleeved with a grinding cylinder on the outer side of the stirring device; a plurality of filtering holes are formed in the side wall of the grinding cylinder, a plurality of first grinding teeth are further arranged on the side wall of the grinding cylinder, and the first grinding teeth and the smashing teeth are arranged in a staggered mode; and an electric heating sheet is arranged in the solvent storage tank. The device can effectively grind and crush medicines, can also control the dissolving temperature, and greatly improves the crushing and grinding effect and dissolving efficiency of the medicines.

A pyridine amide compound-containing composition and a pharmaceutical composition, a preparation method therefor and a use thereof. The composition comprises an active ingredient and at least one matrix material, wherein the active ingredient is a compound represented by formula I or a pharmaceutically acceptable salt, a stereoisomer, a solvate, an isotopically labeled compound, a polymorph, a metabolite or a prodrug thereof. The composition has a high drug loading capacity, improves drug solubility, and has good stability. The in vivo bioavailability of the composition can reach the same level of bioavailability as that of a clear drug solution.

A glycoside drug oral preparation for treating cerebral ischemic stroke during the recovery period and a preparation method therefor. The glycoside drug is (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-(4-methoxyphenyl)butoxy)tetrahydro-2H-pyran-3,4,5-triol. The oral preparation can provide a high drug loading capacity, release the drug within a short time period, and ensure rapid drug dissolution, and the prepared tablet has high stability, involves a simple preparation process and is suitable for large-scale industrial production.

The present application belongs to the technical field of pharmaceutical preparations, and specifically provides a compound SYN045 soft capsule and a preparation method thereof. The present application adopts a fixed proportion of plant oil and polyoxyethylene glyceryl oleate combination to prepare the content, which helps to reduce the degradation of SYN045 in the content drug solution, ensures the stability of the active ingredient, and obtains a compound SYN045 soft capsule with good drug dissolution, high drug content, low impurity generation, and high bioavailability. Further, through prescription optimization of the soft capsule shell, a fixed proportion of plasticizer is selected, the mass ratio of glycerol and sorbitol is 1:2-3, the transfer of the compound SYN045 to the soft capsule shell is reduced, and thus the quality stability problem of the soft capsule preparation product during drug storage is solved.

The invention provides a drug dissolution degree detection method, system and equipment, a medium and a product. The detection method comprises the following steps: emitting target light into a container from the outside of the container and at a preset position; wherein a solution obtained after medicine is dissolved is stored in the container; acquiring target light intensity information of the solution in the container at each moment within a preset time; and obtaining medicine dissolution information in the container based on the target light intensity information corresponding to different moments. According to the method for detecting the dissolution degree of the medicine, the dissolution degree of the medicine in the container can be detected in time, automatically and accurately, human participation in judgment is not needed, and the use experience of a user is improved.

The application discloses a tripterine self-assembled nanoparticle microsphere, a preparation method and application thereof, and belongs to the technical field of biological medicines. The tripterine self-assembled nanoparticle microsphere takes tripterine self-assembled nanoparticles as a drug core, is formed by cross-linking of a sodium alginate-pectin composite carrier through calcium ions, can significantly improve drug solubility, realizes stable protection and intestinal targeting rapid release in the gastrointestinal tract, and effectively reduces drug systemic exposure and side effect risks. The preparation process is mild and simple, the obtained preparation has high targeting and safety. Pharmacodynamic results show that the microsphere can obviously improve liver steatosis, inflammation and fibrosis related to metabolic-related fatty liver hepatitis, and has better curative effect than conventional preparations. The application provides a novel oral delivery system for preventing and treating metabolic-related fatty liver hepatitis, and has good industrial and clinical transformation prospects.

This utility model relates to the field of wastewater treatment technology, specifically to a drug dissolving device for wastewater treatment. The device includes a dissolving cylinder, which comprises a cylinder body. A top cover is fixedly connected to the upper end of the cylinder body, and a bottom plate is fixedly connected to the lower end. The top cover is equipped with a stirring mechanism and a feeding mechanism for quantitatively adding drugs. The bottom plate is equipped with an air blowing mechanism for introducing air into the dissolving cylinder, and a sealing mechanism for sealing the dissolving cylinder is located below the bottom plate. A water pipe for adding water to the dissolving cylinder is installed on the side wall of the cylinder body, and an electrically controlled valve is installed on the water pipe. In this utility model, an air pump is used to pump external air into an annular and radial pipes, and then discharges it into the water through air outlets on the annular and radial pipes, creating surging bubbles in the water. Compared to simply having a stirring mechanism, this device further enhances water flow, thereby significantly increasing the drug dissolving speed.

The present application provides a drug-loaded microsphere for loading polypeptide drugs, the polypeptide drug delivery drug-loaded microsphere is W1 / O / W2 structure, which is composed of polypeptide drug active substance and hydrophilic gel as the inner water phase (W1), organic solvent of water-insoluble polymer as the oil phase (O), and solution containing emulsifier as the outer water phase (W2). The sustained-release microsphere of the present application introduces hydrophilic temperature-sensitive gel and water-insoluble polymer to co-load drugs, increases the hydrophilicity of the carrier, and reduces the solubility of polypeptide drugs by preparing metal ion-polypeptide drug active substance insoluble complex, thereby controlling the drug release behavior. Compared with the conventional microsphere, the sustained-release microsphere of the present application has the advantages of reducing drug burst release, shortening the drug release platform period, making the overall drug release behavior of the drug tend to zero-order release, releasing more stably, and improving the compliance of the microsphere preparation.

The present invention provides a furosemide solid preparation and a preparation method thereof, relating to the technical field of medicine. The solid preparation described in the present invention comprises the following components: furosemide, microenvironment pH regulator, preparation porosity regulator, diluent, disintegrant, lubricant. The microenvironment pH regulator is sodium bicarbonate, and the preparation porosity regulator is hydrophilic AEROSIL 200Pharma. In the present invention, porous AEROSIL 200Pharma is used to adsorb furosemide, and then sodium bicarbonate, the microenvironment pH regulator, is used to adjust the pH value of the saturated solution around the drug particles, which can improve the solubility of the drug and increase the drug dissolution.

The present application relates to a low hepatotoxicity actinomycin D solid dispersion and a preparation method thereof. The low hepatotoxicity actinomycin D solid dispersion product is obtained by co-grinding reaction of actinomycin D, plant source functional natural excipient, flow aid and ball milling beads in a ball milling tank. The solid dispersion is prepared by mechanical chemical grinding, without using organic solvent, avoiding drug degradation in high temperature melting process, easily making the drug and excipient amorphous, improving the drug solubility and bioavailability, having the advantages of high preparation efficiency, low production cost, simple operation, green environmental protection and the like; and the plant source polymer is used as a carrier, the solubilization and synergistic effect are enhanced, the hepatotoxicity of actinomycin D is reduced, which is crucial for safe use of antibiotic drugs, and has positive significance for exploring natural, non-toxic, efficient and multifunctional drug loading system excipient.

The utility model discloses a pharmaceutical experiment dissolver which comprises a bottle body, the top end of the bottle body is fixedly connected with a bottle neck, the top end of the bottle neck is fixedly connected with a feeding port, the top end of the feeding port is provided with a cover box, the top face of the cover box is in a net shape, and the bottom face of the cover box is fixedly connected with a sealing plug. When the medicine dissolving device is used for dissolving medicine, the connecting shaft is inserted into the bottle body, then the motor is driven, in the process, fan blades at the output end of the motor can enable the bottle body to have the upward air draft effect through the vent hole, and therefore the medicine dissolving device can be used for dissolving medicine. The motor drives the connecting shaft to rotate in the cavity of the bottle body, the hinged stirring blades are swung in the cavity of the bottle body, and due to the fact that the shrinking openings are arranged to be an upper group and a lower group, when the stirring blades are swung, stirring and dissolving comprehensiveness can be improved, and stirring and dissolving effects are improved. The dissolving efficiency is further improved.

This utility model discloses a drinking water device for pig farming, relating to the field of pig farming technology. Specifically, it is a drinking water device for pig farming, including a drinker with a water storage device installed on the outside. The drinker has a first slot inside, and a drinker frame is installed in the first slot. A second slot is opened through the outer frame of the drinker, and a displacement device that can move up and down according to the water volume is installed at the bottom of the second slot. A spring plate assembly can drive a switch trigger assembly to move up and down according to the water volume. When moving, it can trigger a motor switch to start or stop the motor from injecting water. This allows water to be automatically injected when the pigs' drinking water is insufficient and automatically shut off when the water volume is sufficient, eliminating the need for manual water injection. The medication is placed in the storage tank of the injection device. While water is being injected, the injection device rotates, allowing for intermittent injection of medication without accumulation, which helps the medication dissolve.

The invention relates to the technical field of pharmaceutical preparations, in particular to oral in-situ gel and a preparation method and application thereof.The in-situ gel is prepared from, by weight, 0.09-2.5 parts of American cockroach extract, 0.3-3 parts of gel matrix, 86.7-99.4 parts of water and a pH regulator, the in-situ gel is formed by a periplaneta americana extract, a gel matrix and water according to a specific ratio in the presence of a pH regulator, the gel is a clear pale yellow to yellow solution at room temperature, the gel is formed in gastric juice after oral administration as a solution, the gel can be retained in the stomach, more importantly, the burst release of the medicine can be remarkably reduced, and the curative effect of the medicine is improved. The medicine dissolution is improved, and the medicine is ensured to be continuously and slowly released to play a role in treating the peptic ulcer.

The utility model relates to the technical field of drainage tubes, in particular to an anti-clogging drainage tube, which comprises a drainage section, a drainage section, a drainage section and a drainage section, the flow guide section is connected to the end, away from the patient, of the drainage section, and the outer diameter of the flow guide section is larger than that of the drainage section; the detachable filtering section is detachably connected to the end, away from the drainage section, of the flow guide section, and a filtering net is arranged in the detachable filtering section; the liquid outlet section is connected to one end, far away from the flow guide section, of the detachable filtering section so as to lead out filtered accumulated liquid; due to the fact that the detachable filtering section is additionally arranged, the detachable filtering section can be detached to clean foreign matter after being used for a period of time, compared with medicine cleaning, the detachable filtering section can be cleaned more thoroughly, the using effect is stable, and residues are not caused; the technical problem that in the prior art, due to the fact that a drainage tube dissolves foreign matter through medicine, the foreign matter blocking phenomenon still exists can be effectively solved.

The present application belongs to the technical field of oral solid preparation, and particularly relates to a mosapride citrate orally disintegrating tablet and a preparation method thereof. Raw and auxiliary materials comprise mosapride citrate, a filling agent, a disintegrating agent, a glidant, a lubricant and a flavoring agent. The present application screens and optimizes the auxiliary material formula, adopts dry granulation, optimizes the preparation process, improves the compressibility and fluidity of the material, saves energy, improves the production quality and stability, makes the prepared orally disintegrating tablet disintegrate rapidly, has excellent taste, greatly improves the medication compliance of patients, simultaneously improves the drug dissolution and improves the bioavailability. In addition, compared with other types of solid oral preparations of the product, the mosapride citrate orally disintegrating tablet is particularly suitable for the elderly and patients with difficulty in swallowing, and provides convenience in special and urgent situations such as lack of drinking water for taking medicine.

There is provided a composite having a higher dissolution of a drug, the composite including at least a solid dispersion containing the drug and a carrier other than polyvinylpyrrolidone as well as HPMCAS outside the solid dispersion. More specifically, there is provided a composite including at least a solid dispersion containing at least a drug and a carrier selected from the group consisting of a vinylpyrrolidone-vinyl acetate copolymer, methyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl methyl cellulose phthalate and first hydroxypropyl methyl cellulose acetate succinate; and second hydroxypropyl methyl cellulose acetate succinate outside the solid dispersion.