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Vildagliptin composition

A composition and composite technology, which can be applied in the direction of drug combination, active ingredients of heterocyclic compounds, metabolic diseases, etc., and can solve problems such as stability reduction

Active Publication Date: 2014-11-26
JIANGSU HANSOH PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the lubricant magnesium stearate used in it often coordinates with the active ingredient to cause degradation reactions of the active ingredient, including ring closure, hydrolysis, etc., resulting in a decrease in its stability during preparation or storage

Method used

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  • Vildagliptin composition
  • Vildagliptin composition
  • Vildagliptin composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025]

[0026] The components except the lubricant were added into the mixer according to the prescription amount for mixing, and then the lubricant of the prescription amount was added, mixed for 15 minutes respectively, and then compressed with a tablet machine.

Embodiment 2

[0028]

[0029] The components except the lubricant were added into the mixer according to the prescription amount for mixing, and then the lubricant of the prescription amount was added, mixed for 15 minutes respectively, and then compressed with a tablet machine.

Embodiment 3

[0031]

[0032] The components except the lubricant were added into the mixer according to the prescription amount for mixing, and then the lubricant of the prescription amount was added, mixed for 15 minutes respectively, and then compressed with a tablet machine.

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PUM

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Abstract

The invention relates to a vildagliptin composition. Specifically the composition comprises vildagliptin, (a) at least one medicinal diluent, (b) at least one disintegrating agent, and (c) lubricant, optionally comprises other pharmaceutical adjuvant, and does not use fatty acid magnesium salts as the lubricant. The composition has a better stability and drug dissolution.

Description

technical field [0001] The invention belongs to the field of chemical pharmacy, and in particular relates to a stable vildagliptin composition. Background technique [0002] Vildagliptin is a selective, competitive and reversible DPP-IV inhibitor. Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like polypeptide-1 (GLP-1) are important hormones for maintaining glucose concentration in the body, and both have incretin-stimulating effects. In patients with type 2 diabetes, the insulin-stimulating effect of GIP is impaired, and only GLP-1 can stimulate the secretion of insulin hormone, which promotes the secretion of insulin by acting on the receptors on the membrane of pancreatic B cells. GLP-1 also inhibits glucagon secretion and gastric emptying to increase satiety (appetite suppression). DPP-IV binds to proteins and exists in many tissues, such as kidney, liver, brush border of small intestinal membrane, pancreatic duct, lymphocytes, endothelial cells, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/40A61K47/38A61K47/12A61P3/10
Inventor 刘晓枫王晨
Owner JIANGSU HANSOH PHARMA CO LTD