63 results about "Gastric emptying" patented technology

The invention discloses a composition for regulating body weight through satiety-sugar control double channels. The composition is prepared from the following components in parts by weight: 5-25 parts of cinnamon extract, 1-20 parts of ganoderma lucidum EGCG composite powder, 10-40 parts of L-arabinose, 5-40 parts of composite fruit and vegetable fiber powder, 5-25 parts of fructus cannabis protein peptide, 1-20 parts of apple polyphenol, 1-20 parts of white kidney bean dietary fiber powder and 1-20 parts of agaricus bisporus powder. The composition is characterized in that digestion and absorption of carbohydrate are inhibited, the swelling ratio larger than or equal to 35 times is achieved through a composite fiber system, gastric emptying is remarkably prolonged, satiety hormones such as GLP-1 are adjusted, and the composition can be used as a non-alternative weight management product and is good in safety.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for strengthening spleen, harmonizing stomach, regulating qi and eliminating mass, a preparation method, a pharmaceutical preparation and application. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 300 to 400 parts of radix bupleuri, 300 to 400 parts of fructus aurantii immaturus, 350 to 450 parts of rhizoma atractylodis macrocephalae, 350 to 450 parts of radix codonopsis, 350 to 450 parts of fructus crataegi, 150 to 250 parts of flos inulae and 350 to 450 parts of pericarpium citri reticulatae. The radix bupleuri mainly enters the liver and gallbladder and has the effects of rising yang qi and soothing liver-qi stagnation, and the fructus aurantii immaturus has the effects of regulating qi and relieving qi stagnation, discharging heat and breaking stagnation and is used as a monarch drug together with the radix bupleuri for ascending and descending, ascending lucidity and descending turbid, regulating qi and eliminating mass. The codonopsis pilosula is used for tonifying the spleen, benefiting the lung, nourishing the blood, promoting the secretion of saliva or body fluid and supporting the healthy energy as a ministerial drug; the hawthorn, the inula flower and the pericarpium citri reticulatae are used for regulating qi-flowing for strengthening spleen, and the hawthorn, the inula flower and the pericarpium citri reticulatae are used as assistants. All the medicines are combined to achieve the effects of tonifying spleen, harmonizing stomach, regulating qi and eliminating mass. The traditional Chinese medicine composition can effectively promote gastric emptying and small intestine propulsion and regulate digestive hormone secretion.

The invention relates to the technical field of medical monitoring, and discloses an intestinal nutrition monitoring system and method based on a critically ill patient, and the method comprises the steps: collecting a dynamic image of a gastric antrum region of the critically ill patient, and recognizing the contraction frequency and amplitude of the gastric antrum of the critically ill patient to calculate a gastric emptying index; calculating the intestinal transport efficacy of the critically ill patient by using the intestinal peristalsis data and the gastric emptying index; constructing an intestinal nutrition transmission scheme of the critically ill patient, and collecting transmission conversion data about the critically ill patient under the nutrition transmission scheme; the intestinal nutrition tolerance of the critically ill patient is analyzed, the metabolic data and the immune state of the critically ill patient after the nutrition transmission scheme are collected, and a target nutrition transmission scheme is constructed; and monitoring the intestinal nutrition status of the critically ill patient under the target nutrition transmission scheme in real time to obtain an intestinal nutrition monitoring report. According to the invention, the comprehensiveness of intestinal nutrition monitoring of critically ill patients can be improved, so that an optimal nutrition collocation scheme is constructed.

The present invention relates to an active oligopeptide RYIVPL, its preparation method and application. The active oligopeptide is RYIVPL, and its amino acid sequence is: Arg-Tyr-Ile-Val-Pro-Leu, which has the remarkable function of stimulating intestinal endocrine cells to secrete cholecystokinin (CCK). Compared with the prior art, the oligopeptide of the present invention can be artificially synthesized by a chemical solid-phase synthesis method, or can be obtained by enzymatic hydrolysis of wheat protein followed by separation and purification. The oligopeptide of the present invention has the characteristics of being safe, non-toxic and having no side effects, not being easily enzymolyzed by gastrointestinal digestive enzymes, and being easily absorbed, and is suitable as a functional component for developing drugs with the functions of delaying gastric emptying, promoting satiety and weight loss, and has great application value and broad prospects in the fields of medicine and the like.

The invention provides a traditional Chinese medicine composition for improving spleen and stomach health and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 to 30 parts of rhizoma dioscoreae, 15 to 20 parts of rhizoma atractylodis macrocephalae, 8 to 15 parts of fructus aurantii, 10 to 15 parts of red dates, 8 to 12 parts of liquorice root, 10 to 15 parts of inulin, 6 to 10 parts of fructus amomi and 5 to 8 parts of cassia twig. The lauric acid modified fenugreek gum (LA-FG) is used as an emulsifier and an immobilized enzyme carrier to construct a water-oil two-phase enzymolysis system, so that the content of effective active ingredients in the traditional Chinese medicine composition, the product stability and the bioavailability are remarkably improved. In addition, the traditional Chinese medicine composition can effectively improve the gastric emptying rate and the small intestine propulsion rate, the level of motilin and anti-inflammatory factors IL-10 is improved, and the effect of improving spleen and stomach health is achieved through multi-target-point synergism. The method successfully breaks through double limitations of a traditional process and an existing scheme, effectively considers volatile oil protection, efficient enzymatic conversion and system stability, and provides a new path for promoting technical upgrading of the traditional Chinese medicine industry.

The invention provides a whole-grain food for assisting in improving constipation and a preparation method thereof, and relates to the technical field of food processing. The whole-grain food comprises a whole-grain base material, beans, potatoes, honey, a functional additive and a microbial agent, the whole grain base material comprises oat flour, germinated brown rice flour, quinoa flour and rye flour; the functional additives comprise inulin, fructo-oligosaccharide, bunge cherry seed powder and sesame powder. The whole grain base material, the beans, the potatoes and the functional additive can promote intestinal tract movement and increase the volume of excrement; the functional additive and the microbial agent enhance flora colonization and optimize intestinal microecology; the resistant starch and the whole grain base material in the potatoes delay gastric emptying, increase satiety and improve defecation at the same time; the honey and the functional additive can relax bowel and reduce dry and hard stool. The health of intestinal tracts and balanced nutrition are both considered, and constipation is safely and effectively improved through multi-way synergism of'dietary fibers, prebiotics, probiotics and intestine moistening components'.

The utility model relates to an automatic gastric emptying monitoring device of a bionic digestive system, which comprises a rotating disc, the rotating disc is rotationally arranged, the included angle between the center line of the rotating disc and the vertical direction is not zero, and a bionic stomach component is arranged on the rotating disc; the weighing assembly comprises a first container, a measuring instrument and a second container, the measuring instrument and the second container are contained in the first container, the measuring instrument is used for weighing the second container, the second container is communicated with the pylorus of the bionic stomach assembly, the first container comprises a container body and a rotating shaft, the container body is provided with a round hole, and the rotating shaft penetrates through the round hole and is rotationally connected with the container body; the rotating shaft is connected with the rotating disc and extends in the horizontal direction. According to the utility model, the weighing assembly is rotatably arranged on the turntable through the rotating shaft and the round hole, and the weighing assembly is adaptively adjusted to be in a horizontal state by utilizing the gravity of the weighing assembly, so that real-time online monitoring of gastric emptying data is realized, automatic sampling of the bionic gastric assembly is also realized, and the difficulty of sampling work is greatly reduced.

The invention relates to the technical field of traditional Chinese medicine compositions and preparations, in particular to a traditional Chinese medicine composition for treating liver depression and spleen deficiency type chronic gastritis and a preparation method thereof. The traditional Chinese medicine composition is prepared from codonopsis pilosula, rhizoma atractylodis macrocephalae stir-fried with bran, radix bupleuri, stir-fried radix paeoniae alba, pericarpium citri reticulatae, fructus aurantii stir-fried with bran, ginger processed pinellia, radix salviae miltiorrhizae, medicated leaven, stir-fried endothelium corneum gigeriae galli and fingered citron according to The traditional Chinese medicine composition is based on the theory of inhibiting wood and supporting soil in traditional Chinese medicine, and all the components have a synergistic effect and have the effects of soothing the liver, relieving depression, strengthening the spleen and harmonizing the stomach. Animal experiments prove that the traditional Chinese medicine composition provided by the invention can significantly improve the gastric emptying rate and the small intestine propulsion rate of a chronic gastritis model, and can down-regulate the gene expression of gastric mucosa intestinal metaplasia related markers CDX2 and MUC2.

The invention discloses a preparation method of tacrolimus capsules, and relates to the technical field of medicines. The preparation method comprises the following steps: S1, preparing a drug-loaded pellet core; s2, coating and curing a flexible buffer layer, namely curing for 8 hours under the conditions that the temperature is 100 DEG C and the relative humidity is 35%, so that the xanthan gum is in a swelling state; s3, coating with a high-barrier layer; s4, protective controlled release layer coating: preparing a coating solution from the third polymer grafted with the lipophilic bile salt derivative and phospholipid; and S5, capsule filling. Through functional gradient multilayer structure design and fine regulation and control of phospholipid composition and spatial distribution, multiple technical problems of poor chemical stability of tacrolimus, brittle rupture of a coating, burst drug release, dissolution and absorption disorder and release drift caused by individual difference of gastric emptying are synergistically solved; the excellent mechanical strength, stable and controllable release kinetics and obvious solubilization promoting effect of the pellet are realized. The method is clear in technological parameters and suitable for industrial production.

The present invention discloses a long-acting GGG triple-target agonist. The compound of the present invention simultaneously achieves excellent agonist ability at the nM level for the three targets of GLP-1 / GIP / GCGR, and can fully excite the corresponding target organ tissue cells. The compound of the present invention can promote insulin secretion and lower blood sugar; it can also inhibit food intake, delay gastric emptying, increase energy consumption, and ultimately observe a weight loss effect. The compound of the present invention can reduce pancreatic β-cell apoptosis, increase the number of pancreatic β-cells, and improve pancreatic cell function. The compound of the present invention can also improve blood lipids, reduce liver fat accumulation, and inhibit the development of liver inflammation. The compound or composition of the present invention can be used to prevent and / or treat metabolic disorders and related complications. The compound or composition of the present invention can be used to treat bone diseases related to endocrine diseases, metabolic disorders, kidney disease, etc., such as osteoporosis and osteoarthritis.

This invention discloses a method and apparatus for modeling the gastric emptying characteristics of compressed dry food. The method includes: obtaining a set of gastrointestinal digestive enzyme concentration ranges; the set of gastrointestinal digestive enzyme concentration ranges includes salivary amylase concentration range, pepsin concentration range, and pancreatic enzyme concentration range; based on the set of gastrointestinal digestive enzyme concentration ranges, performing measurement processing on the compressed dry food to obtain a set of gastric retention rate values; and performing gastric emptying characteristic modeling on the set of gastric retention rate values ​​to obtain a set of gastric emptying models.

Treatment of hyperinsulinemic hypoglycemia comprises administration of an effective amount of a glucagon-like peptide-1 receptor antagonist (GLPIRA) alone or in combination with an amylinomimetic agent or any anti-gastric emptying agent. Patients suffering from hyperinsulinemic hypoglycemia after bariatric surgery experience particular benefit, as there is no current method effective for their treatment. Prevention or reduction of acute adverse effects of postprandial hypoglycemia, such as palpitations, tremor, weakness, sweating, confusion, fatigue, blurred vision, seizures, or loss of consciousness, and prevention of chronic adverse effects of hyperinsulinemic hypoglycemia, such as cognitive impairment, can be achieved by treatment with GLP1RA.

The application relates to a composition for treating reflux esophagitis and application thereof. The composition comprises the following components in parts by weight: 2-8 parts of scutellaria baicalensis, 3-7 parts of licorice, 5-10 parts of beeswax and 80-120 parts of vegetable oil. The composition for treating reflux esophagitis contains scutellaria baicalensis, licorice, beeswax and vegetable oil, and through mutual cooperation among the components, the drug prepared from the composition can significantly increase the plasma motilin level of a patient, further increase the pressure of the lower esophageal sphincter, promote gastric emptying and prevent acid reflux, promote the recovery of reflux esophagitis, the esophagus of the patient is obviously improved, and no adverse reaction is found; meanwhile, the content of lipid peroxide can be obviously reduced, the activities of superoxide dismutase and glutathione peroxidase are increased, the esophageal mucosa is protected and treated, the pathological changes of the esophagus are obviously improved, and the treatment effect is excellent.

This invention relates to the field of gastric residual volume detection technology, specifically a Bluetooth transmission device for ultrasound monitoring of gastric residual volume during enteral nutrition for infants and young children. The device includes a main body structure and a transmission device-mounted control system. The control system includes an ultrasound signal acquisition module, a signal processing module, a Bluetooth transmission module, a residual volume calculation module, and a graded alarm module. This invention achieves this by selecting a target frequency band to match the acoustic impedance characteristics of gastric fluid, dynamically tuning the probe's transmission power based on abdominal wall thickness to reduce gas and tissue interference and improve signal accuracy. It corrects signal mapping deviations based on a three-dimensional gastric cavity model, compensates for postural shifts, generates a gastric fluid distribution model to enhance accuracy, dynamically segments data packets and embeds time-series tags to ensure complete transmission and anti-interference capabilities, combines intake rate and gastric emptying curve correction parameters to quantify volume and compensate for errors, improving calculation reliability, and generating graded alarm commands to link with clinical operations.

The invention discloses a two-way positioning release sustained-release pharmaceutical composition and a preparation method thereof, the pharmaceutical composition is a double-layer tablet, and the double-layer tablet comprises an upper-layer tablet and a lower-layer tablet. The upper-layer tablet is a slow-release intragastric positioning release preparation part and contains 1 / 3 marked amount of active ingredients; the lower-layer tablet is a quick-release gastrointestinal tract release preparation part and contains 2 / 3 labeled amount of active ingredients. A new preparation technology and a new dosage form are adopted, the lower-layer tablet in the double-layer tablet can enable the medicine to be rapidly disintegrated in the stomach, the disintegrated medicine forms a particle dispersion, and the particle dispersion can be rapidly emptied by the stomach to enter the intestinal tract, so that the absorption of the medicine is promoted; the upper-layer tablet floats in the stomach after absorbing water, then the medicine is slowly dissolved out, the medicine dissolved out of the preparation can be metabolized into active metabolite OP-1118 in an acid environment in the stomach, then the active metabolite OP-1118 is absorbed through the gastrointestinal tract, and part of the medicine can be absorbed immediately after uniformly and slowly entering the intestinal tract, so that the bioavailability is improved.

The present invention relates to a pharmaceutical composition comprising a polypeptide, and more particularly, to a pharmaceutical composition for preventing or treating obesity, diabetes, or non-alcoholic fatty liver disease. The pharmaceutical composition is safe without any side effects such as vomiting or nausea and has the effects of reducing food intake, enhancing insulin secretion, inhibiting gastric emptying, promoting lipolysis and reducing triglyceride levels.

To provide polypeptide-containing pharmaceutical compositions.SOLUTION: The invention relates to a pharmaceutical composition comprising a polypeptide, more specifically, a pharmaceutical composition for preventing or treating obesity, diabetes or non-alcoholic fatty liver disease. Th pharmaceutical composition is safe without any side effects such as nausea or vomiting with effects of reducing food intake, enhancing insulin secretion, suppressing gastric emptying, promoting lipolysis, and lowering a level of triglycerides. The invention relates to a polypeptide-containing pharmaceutical composition, medical use of the polypeptide-containing pharmaceutical composition, for example, use in treatment or prevention of obesity, diabetes or non-alcoholic fatty liver disease.SELECTED DRAWING: None

The invention provides a digestion-assisting fermented beverage and a preparation method thereof, and relates to the technical field of functional beverages, and the IPC classification number belongs to A23L2. The digestion-assisting fermented beverage disclosed by the invention is prepared from hawthorn, emblic leafflower fruit, bighead atractylodes rhizome, dried orange peel, poria cocos, malt and liquorice through enzymolysis and fermentation. Wherein the hawthorn is used as a monarch drug for eliminating meat accumulation, promoting the circulation of qi and relieving flatulence; the rhizoma atractylodis macrocephalae has the effects of tonifying spleen, eliminating dampness and enhancing small intestine peristalsis, and is a ministerial drug; the dried orange peel and the poria cocos are used for clearing damp and regulating intestinal flora, and the malt is used for eliminating grain accumulation and activating amylase; and liquorice harmonizes and protects stomach. All the medicines are combined to achieve the effects of promoting digestion, eliminating stagnation, tonifying spleen, eliminating dampness, promoting the circulation of qi and regulating the middle warmer. Test results show that the fermented beverage not only has good antioxidant activity, but also has an excellent effect of promoting gastrointestinal digestion.

The present invention relates to a pharmaceutical composition including a polypeptide, and more particularly, to a pharmaceutical composition for preventing or treating obesity, diabetes, or non-alcoholic fatty liver disease. The pharmaceutical composition is safe without any side effects such as vomiting or nausea, and has effects of reducing food intake, enhancing insulin secretion, suppressing gastric emptying, promoting lipolysis, and lowering a level of triglycerides.

The invention belongs to the technical field of pharmaceutical preparations, and provides a probucol sustained-release capsule for reducing the blood fat level and a preparation method thereof, and the probucol sustained-release capsule is prepared by filling a capsule shell with sustained-release pellets, the sustained-release pellet comprises a blank pellet core, a medicine carrying layer, an isolating layer and a sustained-release layer from inside to outside, wherein the medicine carrying layer comprises probucol and an adhesive in a mass ratio of (200-250): (8-12); the slow-release layer is prepared from eudragit RL PO, a plasticizer, a pore-foaming agent and an anti-sticking agent according to the mass ratio of (250 to 300) to (20 to 25) to (20 to 22) to (10 to 18); the pore-foaming agent is prepared from polyethylene glycol 400 and PVP K25 in a mass ratio of (8-12): (3-5). The probucol sustained-release capsule provided by the invention not only has an excellent sustained-release effect, but also enables drug absorption to be less affected by gastric emptying, reduces stimulation to gastrointestinal tracts, and can improve patient compliance.

The present invention relates to Lacticaseibacillus paracasei HP7 with preventive or alleviative efficacy for functional dyspepsia and uses thereof. The composition comprising the Lacticaseibacillus paracasei HP7 strain (accession number: KCTC 13143 BP) of the present invention as an active ingredient was confirmed to increase expression of intestinal tight junction genes, improve gastrointestinal peristalsis and gastric emptying effects, enhances gastric weight and gastric emptying levels associated with gastric emptying, and significantly increase blood hormone levels related to digestive activity, thereby improving dyspepsia.

The application discloses a kind of for skin source fermentation food flavour substance dynamic evaluation method and bionic digestion device.The bionic digestion device includes bionic stomach module and flow path system, bionic stomach module is connected with flow path system;Bionic stomach module is connected with gastric emptying regulation module by flow path system;Gastric emptying regulation module is connected with bionic small intestine module, and the digestion product in bionic stomach module is transported to bionic small intestine module to simulate gastric emptying process;Digestion liquid supplement module is connected with bionic stomach module and bionic small intestine module;Detection module is installed in bionic stomach module, gastric emptying regulation module, bionic small intestine module and flow path system;Sampling module is connected with flow path system, and the side deviating from flow path system is connected with flavour response detection unit.By establishing continuous bionic digestion system, the simulation degree of bionic digestion system to human real digestion process is improved, and the continuous evaluation of flavour change of skin source fermentation food in digestion process is realized.

Described herein are methods and compositions for treatment of diabetes and / or obesity. Bitter oligopeptide molecules formulated for enteric delivery modulate signals involving receptors facing the lumen of the gastrointestinal tract, said signaling related hormones such as glucagon-like peptide-1 (GLP-1) and peptide tyrosine-tyrosine (PYY) that involve inhibition of gastric emptying and appetite. As a novel way to treat diabetes with limited adverse effects the described invention uses body's own endocrine system to treat diabetes, which is an advantage over current therapies that may simply provide disease management without cure or require more radical approaches such as surgical intervention.

The invention relates to the technical field of stomach residual volume detection, in particular to ultrasonic stomach residual volume monitoring Bluetooth transmission equipment for infant enteral nutrition. The equipment comprises a body structure and a transmission equipment carrying control system, wherein the transmission equipment carrying control system comprises an ultrasonic signal acquisition module, a signal processing module, a Bluetooth transmission module, a residual volume calculation module and a grading alarm module. According to the method, the target frequency band is screened to be matched with the acoustic impedance characteristics of the liquid in the stomach, the transmitting power of the probe is dynamically tuned in combination with the abdominal wall thickness, gas and tissue interference is reduced, signal precision is improved, signal mapping deviation is corrected based on the gastral cavity three-dimensional model, body position deviation is compensated, the liquid distribution model in the stomach is generated, and accuracy is enhanced; data packets are dynamically segmented, time sequence labels are embedded, transmission completeness and interference resistance are ensured, parameters are corrected by combining the intake rate and a gastric emptying curve, the volume is quantified, errors are compensated, the calculation reliability is improved, and graded alarm instructions are generated to be linked with clinical operation.

The present application relates to a pharmaceutical composition comprising a polypeptide, and more particularly, to a pharmaceutical composition for preventing or treating obesity, diabetes, or non-alcoholic fatty liver disease. The pharmaceutical composition is safe without any side effects such as vomiting or nausea and has an effect of reducing food intake, enhancing insulin secretion, inhibiting gastric emptying, promoting lipolysis, and lowering triglyceride levels.

The invention relates to a local anesthesia intervention preoperative diet planning system, and belongs to the technical field of preoperative diet management. The system comprises: a fluorescence measurement unit configured to determine a gastric emptying trend line of a patient using fluorescence indication during a preoperative planning phase; the diet planning unit is configured to generate feeding time and feeding type planning of the patient according to the gastric emptying trend line of the patient and preset operation time; the blood glucose detection unit is configured to monitor the blood glucose of the patient in real time. Preferably, the diet planning unit is further configured to individually correct the gastric emptying rate of the patient according to the real-time monitoring value of the blood glucose of the patient, and adjust the feeding time and feeding type planning of the patient according to the corrected gastric emptying rate.

This invention discloses a linear maltodextrose energy gel and its preparation method, belonging to the field of functional food technology. Using linear maltodextrose with a purity greater than 95% as the basic raw material, the prepared linear maltodextrose energy gel significantly prolongs the exhaustive swimming time of mice by 85.61%, reduces serum lactate by 38.43% and urea nitrogen by 42.67% after exhaustive exercise, and increases liver glycogen by 98.30% and muscle glycogen reserves by 115.63%, effectively alleviating exercise fatigue and reducing bodily damage. The energy gel has a uniform texture, suitable sweetness and viscosity, good palatability when swallowed, and a refreshing aftertaste without any off-flavor. In preparing high-energy-density energy gels, good viscosity and taste can be maintained without adding hydrocolloids. This reduces production costs and simplifies the production process while avoiding the adverse effects of hydrocolloids on gastric emptying speed and sticky texture, resulting in a higher quality energy gel.

The invention discloses a gastric emptying parameter detection system for gastric ultrasonic examination, and belongs to the field of medical images. The gastric emptying parameter detection system for the gastric ultrasonic examination comprises an ultrasonic image acquisition module, an image processing module and a gastric emptying parameter calculation module. The problem that an existing gastric emptying function detection method has limitation is solved, standard section image acquisition can be accurately carried out on the antral sinus part before and after each drinking node through the image acquisition module, and the image processing module extracts and draws gastral cavity boundaries in a time sequence ultrasonic image through an image segmentation algorithm; the gastric emptying parameter calculation module calculates gastric emptying parameters including initial emptying time, emptying curve slope, semi-emptying time, emptying rate at a specific time point and the like based on gastral cavity area data of a time sequence, and the gastric emptying parameter calculation module calculates the gastric emptying parameters including the initial emptying time, the emptying curve slope, the semi-emptying time, the emptying rate at the specific time point and the like based on the gastric cavity area data of the time sequence, so that the accuracy and reliability of gastric emptying area measurement are improved. And objective evaluation of the gastric emptying function can be realized.

Microphysiological platforms are configured for measuring kinetic rates relating to drug absorption. These kinetic rates include GI region-specific kinetic rates of drug absorption. The kinetic rates include bioavailability of the drug over time in various tissues. The kinetic rates include drug permeability in various tissues. The kinetic rates include measurements of microbial transformations that occur. The kinetic rates include measured effects of gastric emptying and transit times. The kinetic rates include measurements of fasting and fed states for various tissues.

The present invention relates to a drug combination for preventing and / or treating obesity. The drug combination is a drug combination of a THR-β agonist and a GLP-1 receptor agonist. The drug combination can achieve a synergistic effect, reduces weight by promoting fat metabolism, reducing fat content, controlling appetite, slowing gastric emptying, increasing satiety, etc., can be used as an effective strategy for solving obesity problems, and has wide prospects for application.