Anchored non-piercing duodenal sleeve and delivery systems

Abstract

An intragastric implant for obesity treatment is disclosed. The device delays digestion by providing a duodenal sleeve, and may also slows gastric emptying by limiting flow through the pyloric sphincter. The implant includes an elongated axially-compressible duodenal sleeve having a non-tissue-piercing anchor on a proximal end sized to lodge within the duodenal bulb. The anchor may have oppositely-directed anchoring flanges to resists migration in both directions. The sleeve may also have barbed ribs to resist proximal movement back up into the stomach. A method of implant includes collapsing / compressing the device and transorally advancing it through the esophagus to be deployed within the duodenum. A dissolvable jacket may constrain the implant for delivery and naturally dissolve upon implant. Removal of the implant may occur in the reverse.

Description

RELATED APPLICATIONS[0001]The present application claims priority under 35 U.S.C. §119 to U.S. Provisional Application No. 61 / 479,714, filed Apr. 27, 2011, to U.S. Provisional Application No. 61 / 485,009, filed May 11, 2011, and to 61 / 394,592, filed Oct. 19, 2010, the disclosures of which are incorporated by reference herein.FIELD OF THE INVENTION[0002]The present invention is directed to intragastric devices used for the treatment of obesity, and in particular to duodenal sleeves having a non-piercing anchor and delivery systems therefor.BACKGROUND OF THE INVENTION[0003]Over the last 50 years, obesity has been increasing at an alarming rate and is now recognized by leading government health authorities, such as the Centers for Disease Control (CDC) and National Institutes of Health (NIH), as a disease. In the United States alone, obesity affects more than 60 million individuals and is considered the second leading cause of preventable death. Worldwide, approximately 1.6 billion adul...

AI Technical Summary

Benefits of technology

[0016]A further aspect disclosed herein is a transorally inserted, intragastric system for the treatment of obesity. The system has an implant with a sleeve for placement in the duodenum having an axially collapsible tubular body with proximal and distal ends. A radially collapsible anchor surrounding the proximal end of the tubular body has a radially expanded state that prevents passage through the pyloric sphincter. The implant is formed of a material that will resist structural degradation over a period of at least six months within the gastrointestinal tract. Finally, a jacket is sized to surround and retain the implant in its collapsed configuration, the jacket being easily removable from around the implant. Preferably, the sleeve includes exterior ribs to resist movement within the duodenum in one direction.

Problems solved by technology

Millions of obese and overweight individuals first turn to diet, fitness and medication to lose weight; however, these efforts alone are often not enough to keep weight at a level that is optimal for good health.

However, surgery might not be an option for every obese individual; for certain patients, non-surgical therapies or minimal-surgery options are more effective or appropriate.

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