130 results about "Human stomach" patented technology

The invention belongs to the field of drugs, and relates to an antineoplastic drug, particularly an indazole / azaindazole-based diarylcarbamide / thiocarbamide-structure antineoplastic drug. The structural general formulae of the indazole / azaindazole-based diarylcarbamide / thiocarbamide-structure antineoplastic drug are disclosed as Formula (Ia) and (Ib), wherein Z is an N or C atom; W is an atom or group, such as O, S, NH, NOH, NCH or the like; M is O, S, N, CH or the like; n is 1 or 2; and Y and R are respectively halogen atom, H, R1, CF3, OCF3, OH, OR2, OCOR3, NH2, NHR4, NR52, NHCOR6, carboxy group, ester group, cyano-group, sulfhydryl group, alkylthio group, sulfuryl group, sulfoxide group, sulfo-group, sulfonate group, sulfamide group, ketone group, aldehyde group, nitro-group or nitroso-group. The pharmacological experiment proves that the drug has favorable antineoplastic effect on human lung cancer, human kidney cancer, human colon cancer, human liver cancer, human stomach cancer and human breast cancer.

A gastric restrictive device positionable around a human stomach to limit the flow of food therethrough is provided with structure for facilitating suturing of the gastric restrictive device to the stomach and thereby preventing movement of the gastric restrictive device relative to the stomach.

The invention discloses shell-broken ganoderma spore powder and particle combination and a preparation method thereof. Shell-broken ganoderma spore powder is extracted, centrifuged, concentrated, dried and crushed to obtain the shell-broken ganoderma spore powder and particle combination, the content of crude polysaccharide in the shell-broken ganoderma spore powder and particle combination is 10-20g / 100g, and the content of total triterpene in the shell-broken ganoderma spore powder and particle combination is 4-10g / 100g. The shell-broken ganoderma spore powder and particle combination has the advantages that immunities are enhanced, radiation hazards are reduced in an auxiliary manner, the shell-broken ganoderma spore powder is treated by the aid of a special process, the content of effective components are increased, nutrient components in the effective components can be effectively absorbed by human bodies, functions of the shell-broken ganoderma spore powder are effectively played, the shell-broken ganoderma spore powder is conveniently carried and taken, the shell-broken ganoderma spore powder and particle combination has an inhibiting effect on zebra fish human stomach cancer transplantation tumors, human lung cancer transplantation tumors and human lymphocyte cancer transplantation tumors, and the shell-broken ganoderma spore powder and particle combination has a strong inhibiting effect on the zebra fish human stomach cancer transplantation tumors and the human lymphocyte cancer transplantation tumors.

The invention belongs to the technical field of nutrition and health care foods and in particular relates to a method for preparing lactic acid bacteria powder containing collagen peptides and multilayer microcapsule lactic acid bacteria. The method is characterized by comprising the following steps: mixing and stirring 20-30 parts of marine fish skin collagen oligopeptide powder, 5-20 parts of citric acid and 40-50 parts of multilayer microcapsule lactic acid bacteria powder. The method has the beneficial effects that colonization growth and reproduction of probiotics in the human stomach and intestine can be realized, the gastrointestinal environment can be improved, multiple harmful pathogenic bacteria and microorganisms can be killed, various digestive enzymes can be produced in the human body to assist in digestive absorption, and the body is strengthened.

The present invention relates to an indirubin-3′-oxime derivative as potent cyclin dependent kinase inhibitor with anti-cancer activity. More particularly, this invention relates to an indirubin-3′-oxime derivative as potent cyclin dependent kinase inhibitor having excellent anti-cancer activity against human lung cancer cell, human fibro sarcoma cell, human colon cancer cell, human leukemia cell, human stomach cancer cell, human nasopharyngeal cancer cell and / or human breast cancer cell.

An ingestible capsule arranged, in use, to cross a human stomach for carrying out a phototherapic treatment arranged to combat an infection due to the presence of the bacterium Helicobacter pylori, said ingestible capsule comprising at least one primary light source arranged to emit an electromagnetic phototherapic wave having a wavelength λ1, at least one auxiliary light source arranged to emit an electromagnetic phototherapic wave having a wavelength λ2, a wrapper arranged to contain said or each primary light source and said or each auxiliary light source, said wrapper being at least partially transparent to said wavelengths λ1 and λ2, a control unit arranged to selectively activate said or each primary light source and / or said or each auxiliary light source, and at least one energy source arranged to provide energy for feeding said control unit and / or said light sources. In particular, 400 nm<λ1<525 nm and 525 nm<λ2<650 nm. Furthermore, said control unit is configured to receive an information of position reporting in real time an area of said stomach crossed by said ingestible capsule; to determine, known said information of position, a wavelength, a dosage and a duration of administration of said electromagnetic phototherapic waves for an optimal phototherapic treatment of said area of said stomach; to selectively activate said or each primary light source and / or said or each auxiliary light source to provide said optimal phototherapic treatment of said area of said stomach.

The invention discloses an extract of Ginkgo Biloba leaves-cyclodextrin derivative inclusion compound and a preparation method thereof, which is prepared from 10 to 24 percent of total flavonol glycoside, 2 to 6 percent of terpene lactone and 70 to 88 percent of cyclodextrin derivative and auxiliary materials, according to the weight percentage; the preparing method comprises the following steps: dissolving cyclodextrin derivative in water, adding extract of Ginkgo Biloba leaves; stirring for 6 to 8 hours; reducing the pressure and vacuum drying at the temperature of 55 to 65 DEG C; and obtaining the extract of Ginkgo Biloba leaves-cyclodextrin derivative inclusion compound in a solid grinding way. The invention adopts an inclusion technology to greatly enhance the dissolubility and the dissolution of the ginkgo leaves in the water, to enhance the absorption in human stomach and intestine, and to simultaneously greatly increase the stability of the principal components in the extract of Ginkgo Biloba leaves, the extract of Ginkgo Biloba leaves and terpene lactones after being processed by adopting the inclusion technology. The extract of Ginkgo Biloba leaves, after being processed by adopting the inclusion technology, is 1 to 2 times higher than the ordinary preparation in bioavailability, and can be used for preparing the drugs for improving the disease of cardio-cerebrovascular systems, and preventing and remedying coronary heart diseases.

The invention discloses application of a cyclocarya paliurus extract in preparation of a medicine for treating stomach cancer. The cyclocarya paliurus extract with high content is obtained by carrying out water leaching on cyclocarya paliurus leaves, extracting, carrying out membrane dialysis and purification. The cyclocarya paliurus leaves are used as a raw material, the active ingredient of the cyclocarya paliurus is extracted, and the active ingredient is applied to preparation of the medicine for treating stomach cancer, so that the utilization rate of the cyclocarya paliurus leaves is improved; and the anticancer experiment research on in-vitro multiple human stomach tumor cells and in-vivo tumor cancer model finds that the cyclocarya paliurus extract has good inhibition effect on the in-vivo and in-vitro tumor cells and has very significant effect on preventing and controlling stomach cancer.

The application discloses a capsule endoscopy motion control method. The method comprises the steps that the actual motion state of the capsule endoscopy detected by a sensor arranged in the capsule endoscopy is received; the capsule endoscopy is located in a magnetic field produced by a solenoid; based on the actual motion state and an input expected motion state, the control voltage of the solenoid is calculated by means of a control model; the power supply voltage of the solenoid is adjusted based on the control voltage, so that the forced condition of the capsule endoscopy is changed until the capsule endoscopy reaches the expected motion state. According to the method, the magnetic field is produced by the solenoid, and the magnetic field can be effectively adjusted through adjustment of the power supply voltage of the solenoid, so that active control of the capsule endoscopy is achieved in combination with closed-loop feedback control, and the capsule endoscopy is applicable to detection of the highly dynamic environment of a human stomach. The application further discloses a capsule endoscopy motion control system, and the system also has the above advantages.

The invention discloses a dynamic human stomach-duodenum in-vitro bionic digestive system comprising a heating incubator and an esophagus model, a stomach model, a duodenum model, peristaltic extrusion devices and a digestion emptying unit which are located in the heating incubator, and the esophagus model, the stomach model and the duodenum model are connected with one another; the peristaltic extrusion devices are arranged on the two sides of the esophagus model, the stomach model and the duodenum model respectively and used for achieving bionic movement of the esophagus model, the stomach model and the duodenum model; and the digestion emptying unit comprises a feeding device connected with an inlet of the esophagus model, a digestive juice adding device connected with the stomach modeland the duodenum model, and an emptying device connected with an outlet end of the duodenum model. According to the dynamic human stomach-duodenum in-vitro bionic digestive system in the invention, the digestive process of the stomach and the duodenum of a human body can be truly simulated, accurate test data is provided for researching the digestive system of the human body, and meanwhile animalexperiments and human body experiments can be properly reduced to a certain extent.

The invention provides metformin hydrochloride enteric-coated sustained-release pellets and a preparation method thereof. The sustained-release pellets are successively composed of a sustained-releasepellet core, a quick release layer, an isolating layer and an enteric-coated layer from inside to outside. The pellets are characterized in that by organically combining double mechanisms of frame sustained release and enteric-coated controlled release and an extrusion roller process, laminated delivery and a fluidized bed coating process, the key process parameters are controlled strictly. The metformin hydrochloride enteric-coated sustained-release pellets are prepared by adopting the process, so that irritation of metformin hydrochloride to human stomach is avoided, a sustained-release long-acting characteristic is achieved too, so that the drug is effective within 24 hours, the compliance of a patient is improved, and the side effect is reduced.

The invention relates to a preparation process of a prebiotic black tea. The process includes the following steps: 1) picking; 2) withering; 3) rolling; 4) fermentation; and 5) drying. The inlet temperature in the step 2) is controlled at 35 DEG C and no more than 38 DEG C, and temperature difference of the front and back of the groove is not greater than 1 DEG C. fructo-oligose is added in the step 4) to make the fructo-oligose penetrate into the tea, so that the tea can protect the human stomach for drinking. The invention has the advantages of reasonable arrangement of process steps, low cost and good preparation effect; reasonable process steps and parameters ensure the manufacture quality of the tea, and the liquid fructo-oligose added in the fermentation process well penetrate into the tea, and can significantly improve the proportion of probiotics intestinal of people by drinking, so as to play the role of protecting human stomach.

The invention relates to a preparation method of hydronopyl triethyl ammonium iodide, and an application of the prepared hydronopyl triethyl ammonium iodide in preparation of an inhibitor for treating tumor. The compound has obvious inhibition effect for tumor cells, and the preparation method of hydronopyl triethyl ammonium iodide is characterized in that hydronopyl chlorine is reacted to sodium iodide to prepare hydronopyl iodine, and the hydronopyl iodine is reacted to triethylamine to obtain hydronopyl triethyl ammonium iodide. The prepared hydronopyl triethyl ammonium iodide has median inhibitory concentration 50 (IC50 ) value of human lung cancer H460 cells, human breast cancer MCF7 cells, human liver cancer SMMC7721 cells, human stomach cancer MK-45 cells as 8.3mum g / ml, 13.25mum g / ml, 2.28mum g / ml and 1.27mum g / ml, which are most basically less than 10 mum g / ml, and partially achieves the requirements of SFDA antitumor drug pharmacodynamics guidance principle, and expresses good antineoplastic activity.

The invention provides a visualized bionic digestion reactor for a stomach body and belongs to the field of bionic reactors. The visualized bionic digestion reactor comprises a first adaptor, a secondadaptor, reaction bottles, a latex bionic stomach, a sampling bottle and a constant-temperature circulating water groove, wherein the reaction bottles comprise a vertical straight-type reaction bottle, a spherical reaction bottle and a horizontal straight-type reaction bottle; the latex bionic stomach comprises a latex bionic stomach body, a latex bionic stomach antrum and a latex bionic pylorus,which are placed in the vertical straight-type reaction bottle, the spherical reaction bottle and the horizontal straight-type reaction bottle respectively; the constant-temperature circulating watergroove is connected with input pipes and output pipes on the reaction bottles through silica gel pipes; valves are connected with the middles of the silica gel pipes and are used for controlling thecirculating water flow. The visualized bionic digestion reactor for the stomach body, provided by the invention, is simple in structure, convenient to detach, good in sealing performance and strong invisibility, can be used for vividly simulating peristalsis of a human stomach and has good digestion simulation repeatability.

The invention discloses a heavy metal bioavailability testing device and method for simulating human gastric digestion characteristics. The testing device comprises a container for simulating gastricdigestion reaction; a gastric digestion reaction feed module connected with the container for simulating the gastric digestion reaction and used for supplementing liquid and gas required for simulating the human gastric digestion in the container, thereby simulating the human gastric juice secretion and anaerobic digestion environment; a stirring module located at the bottom of the container for simulating the gastric digestion reaction and used for stirring the liquid in the container, thereby simulating the peristole of the human stomach; a temperature control module connected with the container for simulating the gastric digestion reaction and used for controlling the temperature of the liquid in the container, thereby simulating the temperature environment of the human stomach; a monitoring module located in the container for simulating the gastric digestion reaction and used for monitoring the temperature and pH value of the liquid in the container; and a digestion reaction collection module communicating with the container for simulating the gastric digestion reaction, and used for simulating the gastric emptying and collecting the digested liquid in the container.

The invention discloses a human stomach cancer multidrug-resistant cell strain which is established by employing human stomach cancer cell strain SGC-7091 as an induction object, employing a large-dose impact method and then employing an in-vitro induction method with gradually increased VP concentration and intermittent action. The cell strain is preserved China General Microbiology Center of Committee for Culture Collection of Microorganisms at 14th November, 2013, and the preservation number is CGMCC NO. 8455. The cell strain provided by the invention has typical multidrug-resistant characteristic, and provides an experiment base for further researching drug-resistant reversion approach.

The invention provides a traditional Chinese medicine extract method featuring combined utilization of the all biomimetic digestion technology and the cell membrane biomimetic solid phase extraction technology. The traditional Chinese medicine extract method mainly comprises the following steps: adding corresponding biomimetic digestive juice (simulated saliva, simulated gastric fluid, simulated duodenal juice and simulated bile) according to components and quantities of the digestive juice secreted by different digestive organs in a certain period of time in different digestive phases; then reasonably arranging digestion time of different digestive phases according to evacuation time of different dosage forms of the traditional Chinese medicine in human digestive organs to obtain all biomimetic digestive juice; and then obtaining a monolayer liposome loaded with a traditional Chinese medicine active constituent bundle according to distribution and absorption states of monolayer liposome-water distribution system simulated all biomimetic digestive juice in human stomach and intestines. In the invention, the all biomimetic digestion technology and the cell membrane biomimetic solid phase extraction technology are jointly adopted, the reaction conditions are mild and the method has the beneficial effects of maintaining conformation of the natural products and previous potency of the active constituents.

The invention provides a dendrobium officinale polysaccharide buccal tablet and a preparation method thereof. The dendrobium officinale polysaccharide buccal tablet comprises the following components: 30-100 parts of dendrobium officinale polysaccharide, as well as 380-420 parts of xylitol, 10-30 parts of milk powder, 0.5-1.5 parts of menthol, 0.5-1.5 parts of modified starch and 4-6 parts of magnesium stearate which are used as carriers. The preparation method comprises the following steps: using dendrobium officinale polysaccharide as the main raw material, adding auxiliary materials, uniformly mixing according to a certain proportion, and performing tabletting formation so as to obtain the product. The dendrobium officinale polysaccharide buccal tablet is easy to take and refreshing in taste, and can be directly absorbed through oral mucosa, so that loss generated when nutrition ingredients are absorbed through organs of human stomach and intestine, liver and the like can be avoided, the absorption and utilization rate of the nutrition ingredients in dendrobium officinale polysaccharide is increased, and the important significance is provided for clinic treatment and prevention and development of health products.

The present invention relates to an indirubin-3′-oxime derivative as potent cyclin dependent kinase inhibitor with anti-cancer activity. More particularly, this invention relates to an indirubin-3′-oxime derivative as potent cyclin dependent kinase inhibitor having excellent anti-cancer activity against human lung cancer cell, human fibro sarcoma cell, human colon cancer cell, human leukemia cell, human stomach cancer cell, human nasopharyngeal cancer cell and / or human breast cancer cell.

The present invention relates to a method for preparing an itraconazole-containing solid dispersion. The itraconazole-containing solid dispersion according to the preparing method of the present invention has both improved solubility and rapid dissolution rate so that it has an excellent bioavailability. The itraconazole-containing solid dispersion of the present invention is also independent of pH variation of human stomach so that it can minimize the absorption variation of intra- and inter-individuals. In addition, the itraconazole-containing solid dispersion according to the preparing method of the present invention is stable for a long time. The present invention also provides an economical and environment-friendly method for manufacturing an itraconazole-containing composition because the method adds a lactic acid in a solution comprising itraconazole to decrease the amount of an organic solvent needed to dissolve itraconazole.

The invention relates to an external drug for slimming and a preparation method thereof. The external drug is prepared from, by weight, 30-70 parts of rheum officinale, 20-30 parts of purple perilla, 15-35 parts of safflowers, 20-40 parts of hawthorn fruits, 10-20 parts of semen cassia, 30-50 parts of apocynum venetum, 20-35 parts of rhizoma anemarrhenae, 10-30 parts of mint leaves, 15-35 parts of coix seeds, 15-25 parts of honeysuckle, 5-10 parts of pericarpium citri reticulatae and 25-40 parts of lemon grass. The preparation method comprises the steps that the pericarpium citri reticulatae, the safflowers, the apocynum venetum and the mint leaves are extracted through supercritical fluid for use; the raw materials except the pericarpium citri reticulatae, the safflowers, the apocynum venetum and the mint leaves are chopped, vacuum drying is performed, and then a product and extraction essential oil are mixed on the basis of the weight ratio being 8:2. According to the external drug for slimming, the efficacy of the drug enters the human body from the Shenque point through hot compress and acts on the waist and abdomen where damp toxin and fat are accumulated, and the external drug can achieve detoxification, remove stasis and achieve natural weight loss, and is convenient to use and rapid in action, the weight will not bounce back, no toxic or side effect is generated, and meanwhile harm caused by oral drugs to human stomach functions is avoided.

A provided catsup formula comprises the following ingredients by weight: 2000 g of tomato, 400 g of white sugar, 150 mL of white vinegar, 50 g of salt, 15 g of five-spice powder, 40 g of minced onion, 30 g of minced garlic, and 25 g of powdered pepper. The catsup formula is added with minced onion and minced garlic, and can relatively well promote digestion function of human stomach compared with common western catsups, and also is capable of satisfying the diversification pursuit on seasoning flavor of people. The catsup prepared according to the catsup formula is sour and sweet and tasty, possesses the sweet taste in the sour taste, and possesses the sour taste in the sweet taste, is capable of promoting appetite, and does not enable an eater to feel greasy after being eaten for a long time.

The invention discloses an application of wogonin to prepare stomach cancer medicine in pharmacy domain, which is characterized by the following: possessing distinctive growth inhibitory action of the wogonin for human stomach cancer MGC803 bare mouse transplanting tumor. This invention provides better choice for stomach cancer patient.

The invention relates to a new strain of Lactobacillus reuteri isolated from the human stomach, exhibiting antioxidant and antimicrobial activity, in particular an anti-Helicobacter effect, considerable resistance to the conditions of the gastric ecosystem, and the capacity to adhere to the epithelium. The invention also relates to a probiotic or biotherapeutic product which contains the strain of L. reuteri and is suitable for use in the treatment or prophylaxis of gastric diseases caused by the Helicobacter pylori bacteria, in order to prevent the secondary effects associated with conventional antibiotic treatments.

The invention discloses a peganum harmala lipid transfer protein (PHP) and relates to the preparation and use of new protein with antifungal, anticancer and antivirus activities. The method uses seeds of a peganum harmala plant as raw materials and comprises the following steps: preparing a coarse product, performing cationic exchange chromatographic separation and purifying by using a molecular sieve; and gradually separating and collecting a purified component having antibacterial activity, dialyzing, desalting, freeze-drying and thus, obtaining purified PHP. In the invention, a filter paper disc agar diffusion method is adopted, and researches prove the protein has growth inhibiting effect on five plant pathogenic fungi, namely alternaria alternate, penicillium degitatum, rhizopus stuolonifer, magnaporthe grisea and penicillium italicum. An 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method proves that the protein has inhibiting effect on proliferation of human esophageal carcinoma cell Eca109, human cervical cancer cells HeLa, human stomach cancer cells MGC-7, mouse melanoma cells B16 and the like. The protein can inhibit the activity of human immunodeficiency virus 1 (HIV-1) reverse transcriptase. The protein can be used for developing medicines for resisting agricultural pathogenic fungi, tumors and viruses.

The invention relates to compound loquat buccal tablets and a preparation method thereof. Based on loquat, olive, almond, tangerine peel, platycodon grandiflorum, mulberry, chrysanthemum, licorice and the like are added; and the buccal tablets have main effects of clearing heat from throat, drying damp, eliminating phlegm, relieving cough and asthma, dispelling wind and dissipating heat, and relieve the symptoms such as cough with lung heat, mouth parching and tongue scorch, swelling and pain in throat, phlegm obstruction and asthma caused by wind heat. The buccal tablets are prepared from medicinal and edible materials, and are exquisite in formula, safe and effective by extraction and concentration of active ingredients and convenient to carry and use; and because the active medicinal ingredients can be directly absorbed through oral mucosa in the oral taking process, loss of nutrition and medicinal ingredients absorbed by organs such as human stomach, intestines and liver is avoided, and the absorption and utilization rate of the medicinal ingredients is improved. The compound loquat buccal tablets have important value and make great contribution to clinical health care and the like, and have comprehensive effects which are superior to those of similar products in the market; and a new optional formulation is provided for clinical patients.

The invention discloses a method for detecting polymorphism rs9005 of a human stomach cancer susceptibility gene IL-1RN through MspI. A polymerase chain reaction-restrictive fragment length polymorphism method is adopted, target DNA fragments are amplified through a polymerase chain reaction, then digestion is conducted on the DNA fragments to be detected with restriction enzyme, the restriction enzyme identifies and cuts a specific sequence, then a product obtained after digestion is subjected to electrophoresis, then specific cutting loci of the sequence are analyzed through a restriction enzyme map, and difference of gene sequences of different sources is compared through fragment diversity. Briefly speaking, the corresponding target fragments are amplified through the PCR, then a restriction enzyme digestion reaction is conducted, and difference of the sequences is analyzed by observing the restrictive map after electrophoresis is conducted. The method is good in repeatability, easy to operate and low in cost, and the digestion result is easy to identify.

An enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Galβ1-4Glc or Galβ1-4GlcNAc-group via a β-1,3 bond; a nucleic acid encoding the same; and a method of diagnosing cancer and / or tumor, in particular, digestive cancer and / or tumor using the expression dose of a gene of the above enzyme as an indication. A gene of a novel enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal β1-4Glc or Gal β1-4GlcNAc-group via a β-1,3 bond is cloned from human stomach cells and its base sequence is determined. Then this enzyme is expressed. Since this enzyme is scarcely or never produced in cancer and / or tumor, in particular, digestive cancer and / or tumor cells, cancer and / or tumor can be diagnosed with the use of the expression of the enzyme gene as an indication.

The invention discloses lactobacillus salivarius which is separated from human gastric mucosa and can be used for preventing and treating stomach diseases caused by helicobacter pylori. The preservation number of lactobacillus salivarius is CGMCC NO.8379. The invention further provides a product for preventing and / or treating stomach diseases caused by helicobacter pylori. The product comprises active components comprising the lactobacillus salivarius. In addition, the invention further provides a product for inhibiting helicobacter pylori. The product comprises active component comprising the lactobacillus salivarius. The application shows that the selected lactobacillus salivarius can not only be well applicable to the human stomach environment and has very high functions of preventing helicobacter pylori growth, adhesion and planting, but also can remarkably reduce inflammation caused by helicobacter pylori in stomach tissue of mice.