32 results about "Gastric antrum" patented technology

A semi-stationary balloon in the gastric antrum provided with an anchoring rod for inducing weight reduction in human beings is disclosed, a device for inducing a lesser appetite and early prandial satiety, said balloon being made of inflatable per-os medical grade silicone having a volume of up to 240 ml, with an average space of 120 ml to be filled with non-elastic fluid provided with radio-opaque contrast and dye, preferably methylene blue, so that the maximum diameter of 8 cm is reached after it is filled up with a volume of up to 240 ml and the average diameter of 6 cm with a volume of 120 ml, to be endoscopically placed inside the stomach (E); said intra-gastric balloon (1) being positioned in a semi-stationary way in the gastric antrum (GAC) and provided with an anchoring or duodenal rod (2) having a distal counter-weight (5) installed in the duodenum (D); particularly, the inner face of the pear-shaped medium portion of lesser diameter is coated with a malleable ribbon (f) that provides said balloon (1) with resistance and flexibility.

The invention relates to devices that are stabilized at an intraluminal residence site in the gastrointestinal tract by their conformation, including dimensions of length and curvature. The device as a whole corresponds to the conformation of the residence site; more particularly, the curved or angled portions correspond to the curved or angled portions of the residence site and do not conform to an immediately proximal or distal site. In some embodiments, the conformationally stabilized device may effect a change in the residence site shape that contributes to stability of the device. Some embodiments are directed toward curbing appetite and/or reducing food intake, other embodiments may be directed toward other therapeutic ends. Some embodiments of the device are designed to reside wholly in the duodenum; others reside principally within the duodenum but extend proximally into the gastric antrum, while other embodiments are designed to reside elsewhere within the gastrointestinal tract.

The invention relates to a multifunctional balloon catheter integrated with a puncture needle and a system. The balloon catheter adopting unique design and the system can be used for different types of tumor such as benign and malignant bile duct stenosis, esophagus cancer, colorectal cancer, bronchogenic carcinoma, gastric antrum cancer, portal vein and vena cava tumor thrombus of primary hepatic carcinoma and the like, a far-end part where an eccentric balloon and the puncture needle are located is precisely put in the part where tumor of a lumen is located, a swelling balloon pushes the far end of the puncture needle to attach to the tumor, a near end of a rotating system operates a nut of the system and pushes the puncture needle to extend out of the catheter, the far end of the puncture needle with shape memory is bent and punctures the tumor, the puncture needle can be used for injecting a tumor treatment drug into the tumor to treat tumor or sucking tissue for biopsy or is used as a radiofrequency ablation electrode to perform radiofrequency ablation/heating to treat the tumor; on the basis of the system, with the adoption of different designs, the multifunctional balloon catheter can be used for injection of the treatment drug into atherosclerosis plaques and treatment of aortic dissecting aneurysm.

The invention discloses an external drainage tube for nasal-gallbladder bile. An elastic loop tube I, an elastic loop tube II, a drainage tube segmentI, a drainage tube segment II, a drainage tube segment III, a drainage tube segment IV are arranged from the top to the bottom successively and communicated with each other. The drainage tube segment I is similarlyin an arc shape, and the arc shape opens towards the elastic loop tube I. The drainage tube segment II is curved, and forms a sigma shape with an end of an arc tube segmentII. The drainage tube segment III is in an arc shape, and the arc shape opens towards an arc tube segment I. The drainage tube segment IV is in a straight line shape. The end part of the elastic loop tube I, elastic loop tube II and arc tube segment II are all provided with bile drainage orifices. The external drainage tube for the nasal-gallbladder bile has five bends, which is conformed to the five physiological bends of a gallbladder cavity (the elastic loop tube I, the elastic loop tube II), a gallbladder tube-a common bile duct (the drainage tube segmentI), the common bile duct-a duodenum (the front part of the drainage tube segment II), the duodenum-a gastric antrum (end part of the drainage tube segment II), a greater curvature of stomach (the drainage tube segment III). The external drainage tube for the nasal-gallbladder bile is good in comfort.

The invention discloses a rat stomach antrum pressure sensor probe which comprises an elastic saccule, an upper catheter, a lower catheter, a tee joint, an injector and a pressure transducer. The two ends of the upper catheter are connected with the elastic saccule and the upper end of the tee joint respectively. The two ends of the lower catheter are connected the lower end of the tee joint and the pressure transducer. A horizontal through opening of the tee joint is connected with the injector. The elastic saccule is a condom front section air bag. A probe structure is greatly simplified, and the back end platform requirement is lowered. The structure is simplified, storing is easy, manufacturing can be carried out through a condom and the injector by a user, and related experiment cost is saved.

The invention discloses a rotatable scraper spoon used under an endoscope. The rotatable scraper spoon comprises a first handle and a sliding handle slidably arranged on the first handle, wherein a sheath tube is arranged at the front end of the first handle; a mandrel penetrates through the sheath tube and can move back and forth in the sheath tube; one end of the mandrel is connected with the sliding handle; a scraper spoon is fixed at the other end of the mandrel; and the scraper spoon is driven to extend out and retract from the front end of the sheath tube by moving the sliding handle back and forth. The sliding handle is pushed and pulled to drive the mandrel to move back and forth, then the mandrel drives the scraper spoon to move back and forth to get gastric juice by scraping, andafter the gastric juice is scraped by the scraper spoon, the sliding handle is pulled to move backwards to enable the scraper spoon to extend into the sheath tube. The inner wall of the sheath tube can exert a certain sealing effect on the gastric juice in the scraper spoon, so that the gastric juice in the scraper spoon is prevented from leaking out and flowing into a digestive tract, and then the functions of extracting gastric juice on a gastric antrum and a gastric body and collecting the gastric juice and tissues under an endoscope are further realized.

The invention relates to a traditional Chinese medicine composition for treating child anorexia and a preparation method of the traditional Chinese medicine composition for treating child anorexia. The traditional Chinese medicine composition is prepared from 12 kinds of raw material medicine materials of radix codonopsis, bighead atractylodes rhizomes, radix ophiopogonis, polygonatum odoratum, herba dendrobii, haws, white peony roots, dried orange peel, Chinese yams, endothelium corneum gigeriae galli, striga asiatica and licorice roots through technologies of performing pretreatment, performing decoction, performing ethanol precipitation, performing concentration, performing drying and the like. The traditional Chinese medicine composition has the efficacy of benefitting qi, invigoratingthe spleen, nourishing yin, nourishing the stomach and resolving food stagnation, and is used for diseases of anorexia or apastia caused by infantile deficiency and weakness of spleen qi and defectsof stomach yin, lack of lustre in complexion, loss of spirit, emaciated or puffy bodies, easiness to sweat, loose stool or constipation, or retention of food and drink, abdominal fullness and distention and the like. The animal experiment result indicates that the traditional Chinese medicine composition disclosed by the invention can increase the food intake of an anorexia model bandicoot, can promote secretion of gastrin of the gastric antrum part, can achieve the effect of treating both manifestation and root cause of the child anorexia, and has great broad market development prospects.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents (TA) within the GI tract and in particular to an antrum wall (AW). Particular embodiments provide a swallowable device (SD) such as a capsule for delivering drugs or other TA into the AW. The SD may contain a pressure sensitive component or assembly which triggers release and insertion of a therapeutic agent preparation (TAP) comprising at least one TA into the AW in response to external pressure, such as pressure applied to the swallowable capsule or other SD by antrum contractions. Particular embodiments of the SD may be shaped so that they self-align within an antrum to properly orient before injection of the TAP into the AW. Embodiments of the invention are particularly useful for orally delivering drugs or other TAs which are degraded within the GI tract and require parenteral injection.

The invention provides an esomeprazole sodium composition for injection, relating to the field of drugs and drug production technology. The main drug of the composition includes esomeprazole sodium and melatonin, wherein the melatonin comprises a quick release part and a cyclodextrin-inclusion slow release part. The esomeprazole sodium composition for injection is fast in potency and reliable in effect, and applicable to a patient who is not suitable for orally taking medicine, and a drug which is not suitably taken orally; the drug administration design of combining quick release and slow release meets the physiological secretion characteristic of the melatonin, solves the defect of short half life period of the melatonin, and improves the bioavailability of the product; the synergism of the esomeprazole sodium on treating reflux esophagitis can be achieved, gastric dynamics can be enhanced to promote gastric emptying. The coordinated movement of stomach antrum, pylorus and duodenum can be promoted, and the reflux of gastric content can be completely prevented.

The invention provides a separation and culturing method of gastric antrum interstitial cells of SD (Sprague Dawley) rats. The separation and culturing method comprises the following steps: selecting4-5-week-old SD rats as elementary bodies; stripping gastric antrum tissues, and performing centrifugal operation under the effect of II-type collagenase and separating out ICC cells; performing culturing in an M199 complete culture medium, and then performing digestion operation and centrifugation treatment to obtain the separated ICC cells. According to the method disclosed by the invention, byusing the 4-5-week-old SD rats (110 plus/minus 10g) as an experimental animal, the defect of low cell acquisition ratio caused by highly differentiation of the ICC cells of adult rats is avoided; meanwhile, according to the separation and culturing method disclosed by the invention, the concentration of the II-type collagenase is adjusted, and damage of low-concentration long-time digestion or high-concentration short-time digestion on cells is avoided; purification is carried out by adopting the principles of cell contact inhibition and advantage competition, so that the damage of gradient centrifugation on the fragile cells is avoided.

The present invention discloses a new usage of a preparation of agastachis for restoring health, in particular to the usage of the preparation of agastachis for restoring health in the preparation of the drugs for lowering the vasoactive intestinal peptide. More particularly, the present invention is the application of the preparation of agastachis for restoring health in the preparation of the drugs for lowering the vasoactive intestinal peptide in the plasma; the application in the preparation of the drugs for lowering the vasoactive intestinal peptide in the gastric antrum tissue homogenate; the application in the preparation of the drugs for lowering the vasoactive intestinal peptide in the jejunum tissue homogenate; the application in the preparation of the drugs for lowing the vasoactive intestinal peptide positive products in the gastric antrum, jejunum mucosa and myenteric plexus; and the application in the preparation of the drugs for lowering vasoactive intestinal peptide and promoting gastric motility. The pharmacological studies show that the preparation of agastachis for restoring health can reduce the release of vasoactive intestinal peptide and promote the gastric motility.

The invention discloses a nasal gallbladder bile drainage catheter with an expansile saccule, wherein an elastic loop pipeI, an elastic loop pipe II, a drainage pipe segment I, a drainage pipe segmentII, a drainage pipe segment III, and a drainage pipe segment IV are interconnected and arranged on the nasal gallbladder bile drainage catheter from stem to stern. The drainage pipe segment I is shaped arc-like, and the arc opens towards the elastic loop pipe I. The drainage pipe segment II is shaped curved and forms a 'Sigma' shape with the final segment of an arc pipe segment II. The drainage pipe segment III is arc-shaped, and the arc opens towards an arc pipe segment I. The drainage pipe segment IV is shaped like a straight line. Bile drainage orifices are arranged on the elastic loop pipe I, the elastic loop pipe II, and the final segment of the arc pipe segment II. A saccule is arranged on the exterior wall of the head segment of the arc pipe segment II. The nasal gallbladder bile drainage catheter with the expansile saccule involves five curves, conforms to five physiological curves including gallbladder cavity, gallbladder duct to common bile duct, common bile duct to duodenum, duodenum to gastric antrum, greater gastric curvature, and has a good comfort level.