78 results about "Pyloric orifice" patented technology

Various obesity treatment tools and methods are described herein, as well as treatments for other gastric-related diseases, e.g., GERD. Treatment includes reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach directly from the interior of the stomach itself. The smaller pouches may be made through the use of individual anchoring devices, rotating probes, or volume reduction devices. A pyloroplasty procedure may also be performed to render the pyloric sphincter incompetent. A gastric bypass procedure may additionally be performed using atraumatic magnetic anastomoses devices so that sugars and fats are passed directly to the bowel while bypassing the stomach. Many of these procedures may be done in a variety of combinations. Treatment may create enforced behavioral modifications by discouraging the ingestion of high-caloric foods.

The invention relates to an orogastric catheter for a longitudinal gastrectomy. The object of the invention is to make available an orogastric catheter that represents an advantageous alternative to the poorly suited catheters used today and that facilitates the work of the surgeon. This novel orogastric catheter is characterized in that this distal part carries a balloon (25) which, in the inflated state, has a shape substantially matching that of the pyloric antrum (4), in such a way as to be able to be lodged in this pyloric antrum (4), the end of the inflated balloon (25) then being in abutment against the pylorus (5), and the distal end of the body of the catheter (20) for its part being in abutment against the pyloric antrum (4), while the part of the body (21) of the catheter (20) arranged above the inflated balloon (25) is wedged against the wall of the lesser curvature (6) of the stomach (1), thus making it possible to determine the position of the start of the closure resection line in the area of the pyloric antrum (4), to define the closure resection line, and to calibrate the pyloric antrum (4) and the gastric sleeve to be preserved.

A method of, and device for, slowing the passage of food through a digestive tract of a patient and thereby treating obesity. The device is an obesity tube comprising (A) an upper ring of a size corresponding to a point under a patient's esophagus and above the patient's diaphragm muscle, and (B) a lower tube having a length and a distal opening. The method comprises stapling the upper ring under the patient's esophagus, above the patient's diaphragm muscle, and placing the lower tube distal to the upper ring. The length of the lower tube depends on whether the tube is to terminate distally in the stomach or terminate past the pylorus, in which case a section can be provided which is thick enough to resist collapsing under pylorus pressure. The lower tube can be entirely or partially non-permeable or semi-permeable. Semi-permeable tubes or sections thereof have walls which permit the passage of gastric hydrochloric acid but not food.

Provided are ingestible polymeric formulations and oral dosage forms for the reduction of gastric volume in the treatment of overweight and obese patients. The formulation includes an acid-sensitive, gelatin coating over a dehydrated hydrophilic polymer. When ingested, the acid-sensitive coating is quickly dissolved by gastric secretions and the hydrophilic polymer is exposed to the aqueous environment of the gastric milieu. The polymer absorbs water and expands to the point that will not allow the polymer to pass beyond the pyloric valve, and the expanded polymer is therefore trapped in the stomach.

The invention provides a duodenal sleeve which is composed of a metal framework and an outer sleeve coated outside the metal framework. The metal framework is of a spiral ring structure and divided into a duodenal spherical cavity section for the metal framework and a duodenal spherical rear section for the metal framework; the spiral ring of the duodenal spherical cavity section for the metal framework is bigger and denser than that of the duodenal spherical rear section for the metal framework; the spiral ring structure of the duodenal spherical cavity section for the metal framework is in a bowl or funnel shape; the top and the bottom of the metal framework are equipped with circular or oval annular closed opening; and the outer sleeve is coated outside the metal framework and the lower end thereof is longer than the bottom end of the metal framework. The invention further provides a conveyor for the duodenal sleeve, comprising a plastic hose, wherein, longitudinal cracks are arranged on the wall of the plastic hose from the head end to the tail end thereof. The duodenal sleeve is used for transporting stomach effluents from a stomach pylorus, replaces gastric bypass operation, avoids that the stomach effluents are directly digested, absorbed and metabolized in duodenum, and treats adiposis and diabetes.

Described herein are methods of treating a disease by treatment with oral sustained release methotrexate alone or in combination with folates. In some embodiments, these approaches improve the pharmacotherapeutic performance of methotrexate therapy.Described herein are novel pharmaceutical compositions for oral administration. Also described herein are novel pharmaceutical compositions for the controlled, sustained delivery of one or more drugs to the stomach or upper gastrointestinal tract. Further described are novel pharmaceutical compositions with increased gastrointestinal residence time. More particularly, novel pharmaceutical compositions which can simultaneously, float in gastric fluid, adhere to the mucosal surfaces of the gastrointestinal tract, swell to a size which delays passage through the pylorus, are described herein. In some embodiments, the pharmaceutical compositions comprise methotrexate. In some embodiments, the pharmaceutical compositions comprise methotrexate and a folate compound. Also described herein are methods for treating or preventing diseases, by administration of the pharmaceutical compositions described herein.

A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a plurality of disc-shaped flanges connected in series. The blocking portion may be disposed in a contracted position wherein the plurality of disc-shaped flanges is disposed in a stacked configuration and a resting position wherein the plurality of disc-shaped flanges is disposed in a linear configuration. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its resting and contracted positions. Insertion and removal systems are also provided for use with the pyloric valve.

The invention belongs to the technical field of medicine-food homologous formula food and particularly relates to special diet for gastric ulcer patients. Shown by researches of recent years on reasons inducing gastric ulcer, the most common reason inducing the ulcer is that the stomach and intestine protection mechanisms are damaged by helicobacter pylori and non-steroidal anti-inflammatory drugs. The traditional Chinese medical science always stresses that dietotherapy is better than medication, so as to avoid injection and medication and even pain of surgery. According to the special diet, whole grains are perfectly combined with medicine-food homologous and new-resource-food traditional Chinese medicines, and diet and health preserving are organically combined so as to regulate, prevent and resist gastric ulcer; probiotics are creatively utilized as a pioneer based on the inheritance of Chinese traditional Chinese medicine treasure treatment methods, and the proliferation of the probiotics is promoted, so that the movement functions of the spleen and stomach are enhanced; and meanwhile, various natural and original ecological medicine-food homologous edible materials are added according to the physical characteristics of gastric ulcer patients, so that the special diet has the unique advantage of integrated dietotherapy, prevention and regulation effects.

The invention relates to a traditional Chinese medicine combination for curing gastric diseases and a preparation method thereof, which solve the problem that the original traditional Chinese combinations for curing gastric diseases do not have prominent effects and have high recurrence rate. The medicine combination is prepared by corydalis tuber, Chinaberry fruit, turmeric root tuber, evodia rutaecarpa, coptis chinensis, villous amomum fruit, costus root, radix linderae, rhizoma cyperi, frankincense, myrrh and cuttlebone. The traditional Chinese medicine combination has the functions of soothing the liver and regulating vital energy, removing heat from the liver, promoting blood circulation to arrest pain, promoting wound healing and granulation, and can be used for curing gastric and duodenal ulcer, gastritis, stomachache, salivation and sour regurgitation, nausea, retching, epigastric distension and depression; besides, the traditional Chinese combination has special curative effects on gastric ulcer and duodenal ulcer and has inhibiting effect on helicobacter pylori.

The present invention relates to methods for treating pathological conditions associated with Helicobacter sp infections, specifically H. pylori infection. The present invention further relates to methods for treating pathologies characterized by excess gastric acid secretion. The methods of the present invention comprise oral administration of pentagastrin effective locally in the stomach in conjunction with a gastric proton pump inhibitor. It is disclosed herein for the first time that PG administered orally exerts a local effect in the stomach and may be used in combination with a PPI for treating pathological conditions characterized by excess gastric acid secretion and in pathological conditions associated with Helicobacter sp infections.

The invention provides a device capable of realizing automatic simulation of gastrointestinal continuous digestion and an application method of the device. The device comprises a stomach reactor, a stirrer, a constant-temperature water circulation system, a gastrointestinal fluid conveying system, a gastric emptying control device, an automatic pH titration device, a small intestine reactor and asample receiving device. According to the application method, to-be-digested food is conveyed into a stomach digester, stomach digestive fluid is input at a constant speed, the stirrer simulates stomach peristalsis, a micropore glass plate at the bottom of the stomach reactor simulates a pylorus to realize stomach "sieving emptying", the to-be-digested food is conveyed into a pH regulation chamberfor automatic pH regulation, small intestine digestion is simulated in the small intestine reactor provided with an internally-arranged latex sleeve, and the pressure-changing water circulation system is adopted to realize regular vibration of the latex sleeve so as to simulate the stomach peristalsis. Through the device and the application method, the whole reaction process can be continuous andautomatic under the situation that parameters are set; and moreover, the device is simple in structure, free of a complicated control system and easy to assemble and can be used to realize a digestion simulation experiment in a scientific research experiment.

The present invention is directed to polypeptides and compositions thereof useful for the prevention or treatment of an inflammatory bowel disease in particular Crohn's disease or ulcerative colitis (UC), and of coeliac disease. More particularly, the invention relates to agents and compositions thereof that useful for the prevention and treatment of hypersensitivity and / or hyperirritability of the colon and / or small intestine.

A compound of the formula (I):wherein R1 represents an amino group which may be substituted; R2 represents a carboxy group which may be esterified or amidated; R3, R4, R5 and R6 each represent a hydroxy group which may be protected; Q represents an aryl group which may be substituted; or a salt thereof is disclosed. The compound (I) possesses ant-Helicobacter pylori activity, and is useful in the prevention or treatment of various diseases associated with Helicobacter bacteria, such as duodenal ulcer, gastric ulcer, chronic gastritis and cancer of the stomach.

The invention relates to a transpyloric device for accepting chyme from the stomach and conducting said chyme on in a bypass-like manner through a patient's duodenum; said device is held in place by balloon segments which sit on a preferably radially collapsible and self-erecting transpyloric conducting element; the filling level of the balloon segments, and thus the axial sealing force acting primarily on the shoulder surfaces of the pylorus or the surrounding area thereof, can be adjusted by the user, and the force applied to the stomach and duodenum structures adjoining the pylorus is reduced to a level that is permanently bearable for the organs even when the filling pressure of the segments rolling against each other is elevated. The invention also relates to an applicator for putting a bypass device of said type in place in the region of the transition from the stomach to the duodenum.

The present invention provides a Chinese medicine compound for curing gastric and duodenal ulcer, made from the raw materials with weight portions such as yanhusuo, dandelion, nutgrass flastedge, mastic gum, alum and liquorice, and a preparation method of capsule, tablet, pill, granule, powder, dropping pill and oral liquid of the compound. The present invention has the functions of obvious sterilization and bacteriostasis on helicobacter pylori, reduction of gastric juice amount, gastric free acid and total acidity, and pepsin output, as well as pain alleviating and inflammation resisting, so the present invention has the functions of inhibiting stress type, ostium pyloricum deligation, acetic acid and ethanol ulcer, as well as pain alleviating and inflammation resisting. In addition, the present invention can reduce the stimulus factors of chronic gastricism, gastric ulcer and gastratrophia lesions, improve the symptoms of patients with gastric ulcer and play a promoting role in repairing and improving gastric mucosal lesion.

The invention relates to a pyloric state detection system applying signal analysis, and the system comprises a content extraction mechanism which is used for calculating the entity area of a pyloric target based on a received photographing focal length, the overall depth of field, and the number of reference pixels; a radius identification equipment which is connected with a content extraction mechanism and is used for calculating the radial radius of the pyloric target based on the shape of the to-be-analyzed region corresponding to the pyloric target and the entity area of the pyloric target; and an anomaly detection mechanism which is connected with the radius identification equipment and is used for sending a pylorus anomaly instruction when the absolute value of the difference value between the maximum radial radius and the standard pylorus radius exceeds a limit. The pyloric state detection system applying signal analysis is simple to operate and wide in application. The targetedrecognition mode can be adopted to perform recognition operation on the pylorus radius of the patient according to the pylorus shape of the current patient and the pylorus entity area of the currentpatient, whether the pylorus of the current patient is in a diseased state or not can be judged.

The present invention discloses a Chinese medicinal composition which is used for treating stomach diseases, and a preparation method thereof. The composition mainly consists of fructus trihosanthis cortex, Chinese goldthread, cuttlebone and pinellia. The medicinal materials are mixed with supplementary materials and taste rectifying agnet to directly or indirectly prepare oral preparaions which are acceptable in pharmacy, such as capsule, oral liquid, syrup, tablets, oral disintegrating tablets, dripping pills, gargarisma, granules, floating tablets in the stomach, and so on. The composition has the effects of eliminating the heat, easing the stomach, inhibiting the acid and removing the pains, and can be used for killing the helicobacter pylori. When in clinical use, the composition can be used for treating acute gastritis, chronic superficial gastritis, bile reflux gastritis and peptic ulcer.

The invention relates to a hericium erinaceus beverage capable of invigorating the stomach and nourishing the stomach, and a preparation method of the hericium erinaceus beverage, wherein the hericium erinaceus beverage is prepared from 0.1%-15% of hericium erinaceus as a raw material component. The hericium erinaceus beverage is good in quality, color and mouth feel, free from color brown stains, clear and transparent in liquid, free from mushroom flesh precipitation, and free from flavor changes; the hericium erinaceus beverage has the efficacies of repairing gastric mucosa damage caused by chronic gastritis, gastric ulcers or duodenal ulcers, alleviating abdomen pains caused by the chronic gastritis, the gastric ulcers or the duodenal ulcers, being capable of performing auxiliary treatment on the chronic gastritis, the gastric ulcers and the duodenal ulcers, and restraining helicobacter pylori, and is suitable for crowds suffering from gastric diseases (the chronic gastritis, the gastric ulcers and the duodenal ulcers) to drink.

The present invention provides systems and methods for treating and controlling obesity and / or type II diabetes. In one aspect of the invention, an internal bypass device includes gastric and duodenal anchors coupled to each other and positioned on either side of the pylorus and a hollow sleeve designed to extend from the pylorus through at least a proximal portion of a patient's small intestine. The gastric and duodenal anchors are movable between collapsed configurations for advancement through the esophagus and an expanded configuration for inhibiting movement of the anchors through the pyloric sphincter. Thus, the bypass device can be placed and removed endoscopically through the patient's esophagus in a minimally invasive outpatient procedure and it is “self-anchoring” and does not require invasive tissue fixation within the patient's GI tract, thereby reducing collateral tissue damage and minimizing its impact on the digestive process.

The invention provides a helicobacter pylori preparation capable of preventing and treating oral cavity and stomach, the helicobacter pylori preparation adopts lactoferrin and polylysine for compatibility, the adopted dosage form is spray, through research on the compatibility, the killing effect on helicobacter pylori people can be greatly improved, and the helicobacter pylori preparation can beused for preventing and treating oral cavity and stomach diseases. Meanwhile, the spray dosage form can kill oral helicobacter pylori, and the preparation can reach the stomach by swallowing drinkingwater and the like, so that the helicobacter pylori in the stomach can be killed in an auxiliary manner.

The invention relates to a Chinese herbal medicine for treating raccoon pyloric duodenal ulcer and gastric perforation. The Chinese herbal medicine is powder prepared from the following raw materials in parts by weight: 4-6 parts of licorice roots, 2-4 parts of forged concha arcae, 2-4 parts of fried cuttlebone, 0.5-1 part of bletilla, 1-2 parts of rhizoma corydalis, 2-3 parts of costus roots, 2-4 parts of baical skullcap roots, 1-2 parts of Chinese rhubarb and 0.5-1 part of henbane. The Chinese herbal medicine is used for treating raccoon pyloric duodenal ulcer and gastric perforation, and has the characteristics of short course of treatment, low cost, high curing rate, security and no toxic and side effect, and is convenient for orally taking.

The invention discloses an inflatable visual stomach tube traction device, and belongs to the field of medical instruments. Generally, for a non-surgical patient, bare-handed application of the gastrointestinal tube can only reach the stomach, the gastrointestinal tube is difficult to enter the small intestine through pylorus, and the gastrointestinal tube easily gets stuck when touching the bottom gastric varus area. The inflatable visual stomach tube traction device is characterized in that an air bag strap (3) is sleeved outside a combined guide air bag (2), the combined guide air bag (2) is fixedly connected with a sealing plug (4), the other end of the sealing plug (4) is sleeved with a sleeve (5), and the outer wall of the sleeve (5) is sleeved with a stomach tube (6); an endoscope (1) sequentially penetrates through the stomach tube (6), the sleeve (5), the sealing plug (4) and the combined guide air bag (2), and a camera is installed at the front end of the endoscope (1); and agroup of inflating pipes (7) are uniformly arranged at the periphery of the endoscope (1). The stomach tube traction device can bend and rotate, the degree of freedom is more flexible, and bending, twisting, rotating and other operations can be achieved through the control quantity of gas in different channels.

The invention provides a composition with an auxiliary protection effect on gastric mucosal injury and application, and relates to the technical field of health care products. The composition comprises the following components in parts by weight of 30-60 parts of a water extract of hericium erinaceus sporocarp, 18-40 parts of a poria cocos water extract, 2-8 parts of a liquorice water extract and 10-25 parts of an astragalus membranaceus water extract. The composition disclosed by the invention can relieve gastric mucosal injury, and the inhibition rate can reach 40-67.5% under medium-concentration and high-concentration doses; the composition has the effects of protecting gastric mucosa epithelium from being damaged by ethanol and preventing ulcer; and the composition has a certain inhibition effect on helicobacter pylori. The composition disclosed by the invention has an obvious protective effect on ethanol-induced gastric mucosal acute injury, also has a good antibacterial effect on helicobacter pylori, is pleasant in taste, does not need to be added with seasoning auxiliary materials, and can be used for improving or protecting gastric mucosal health.

The invention belongs to the field of medical data mining, and particularly relates to a helicobacter pylori stomach video full-automatic intelligent analysis system and a marking method thereof.The helicobacter pylori stomach video full-automatic intelligent analysis system comprises an image acquisition module, an image preprocessing module, an effective frame module, an anatomical position positioning module, a deep learning module and a mark display module; the image preprocessing module is used for preprocessing images of a video stream, the effective frame module is used for classifying and screening the images of the video stream, and the anatomical position positioning module is used for identifying the specific position of an endoscope in the stomach currently. And the deep learning module is used for predicting the helicobacter pylori infection probability for the pictures of different anatomical positions. In the testing process, a doctor does not need to step on a pedal to input a specific picture for helicobacter pylori infection recognition, manual intervention is not needed in the whole process, and full automation and high intelligence can be achieved.

A medicine for preventing the infection of pylorospirobacillus is prepared from 3 kinds of antigen protein and CpG-ODN through dissolving them in aseptic distilled water at 4 deg.C and mixing. It is applied by dropping it in nasal cavity.

A novel intraluminal therapy system for providing a quick and effective way to treat gastrointestinal infections. The invention includes a brand new system of treating Helicobacter pylori infections and an agent dispenser for an endoscope apparatus, comprising a pump, a catheter connected to the pump and a nozzle connected to the catheter. The devices are used along with a complex of antibiotic and / or antimicrobial agents to eradicate Helicobacter pylori while performing an endoscopic procedure.

The invention discloses application of andrographolide, and belongs to the field of medicine application. The medicine is used to protect gastric mucosa, is capable of mitigating gastric mucosal injury caused by drinking, helicobacter pylori and abnormal gastric acid secretion, is suitable for long-term administration, and has no obvious side effect.