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2 results about "Oxyntomodulin" patented technology
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Oxyntomodulin (often abbreviated OXM) is a naturally occurring 37-amino acid peptide hormone found in the colon, produced by the oxyntic (fundic) cells of the oxyntic (fundic) mucosa. It has been found to suppress appetite.
Oxyntomodulin binding molecules, and uses thereof
Provided herein are novel N- and C-terminal oxyntomodulin polypeptide binding molecules, and uses thereof, including a method for quantitating oxyntomodulin.
Owner:ELI LILLY & CO
Modulators for GIPR, GLP1r and / or GCGR and uses thereof
PCT designated stageWO2025252023A8Peptide/protein ingredientsAntibody mimetics/scaffoldsAntiendomysial antibodiesPharmaceutical drug
Disclosed herein are novel modulators for GIPR, GLP-1R and / or GCGR. Specifically, provided herein are antibodies that specifically bind GIPR, oxyntomodulin analog peptides, and antibody- peptide conjugates (APCs) comprising an anti-GIPR antibody and an agonist for GLP-1R and / or GCGR (e.g., oxyntomodulin analog). Pharmaceutical compositions comprising these modulators disclosed herein, as well as uses thereof in treating metabolic conditions and disorders, such as diabetes (e.g., type 2 diabetes), NASH, overweight, and obesity are also provided.
Owner:FORTVITA BIOLOGICS INC