35 results about "Human Immunoglobulin G" patented technology

The present invention provides, among other aspects, methods for the treatment of Alzheimer's disease in a subject in need thereof, the method including administration of a therapeutically effective amount of a pooled human immunoglobulin G (IgG) composition to a subject with moderately severe Alzheimer's disease, a subject carrying an ApoE4 allele, or both, where the amount of pooled human IgG is from 300 mg / kg to 800 mg / kg body weight of the subject per two week period, and where the amount is administered in one or more doses during the two week period after initiation of a therapeutic regimen. Also provided, are methods for selecting a treatment regimen for a subject with Alzheimer's disease, including diagnosing the severity of the Alzheimer's disease, determining if the subject carries an APOE4 allele, or both, and assigning a treatment regimen including administration of pooled human immunoglobulin G and / or an anti-beta amyloid monoclonal antibody.

A method for increasing the therapeutic efficacy of a human immunoglobulin G class 1 (IgG1) antibody, includes: mutating the human CH1γ1 domain from the antibody, to restore the pairing between CH1 and CL domains that is typical of the other IgG subclasses, or by substituting the human CH1γ1 domain by the CH1 domain from a human IgG2 (CH1γ2), IgG3 (CH1γ3) or IgG4 (CH1γ4); the antibody obtained by such method, includes a) a light chain including the following amino acid sequences: i) the Light Chain Variable Region (LCVR) specific from an antigen; and ii) a human kappa (κ)Constant (CL) domain; and b) a heavy chain including the following amino acid sequences: i) the Heavy Chain Variable Region (HCVR) specific from the antigen; ii) the CH2 and CH3 domains from a human IgG1; and iii) the CH1 domain from a human IgG1, mutated to restore pairing between CHI and CL domains.

The invention studies a molecularly imprinted electrochemical sensor based on an electrode modified by an electro-copper-based MOFs sensitive film, and a preparation method and detection method thereof, belonging to the field of electrochemical sensing. The present invention selects the specific protein human immunoglobulin G (IgG) in serum as the research object, and successfully constructs a new type of high-sensitivity molecular imprinting electrode by combining nanocomposite materials, a new imprinting method, a new template processing idea and a new detection method. chemical sensor. First, copper-based MOFs were synthesized on the surface of glassy carbon electrode by electrodeposition to modify the electrode to improve conductivity and increase specific surface area, then chitosan and glutaraldehyde were sequentially modified to provide attachment sites for IgG, and then directly on the surface of the modified electrode A polymer film is formed by electropolymerization of pyrrole, and the template is finally eluted to obtain a molecularly imprinted polymer-modified electrode. The molecularly imprinted electrochemical sensor has high sensitivity and good selectivity, and has been successfully applied to the detection of target proteins in actual samples.

The present invention provides, among other aspects, methods for the treatment of Alzheimer's disease in a subject in need thereof, the method including administration of a therapeutically effective amount of a pooled human immunoglobulin G (IgG) composition to a subject with moderately severe Alzheimer's disease, a subject carrying an ApoE4 allele, or both, where the amount of pooled human IgG is from 300 mg / kg to 800 mg / kg body weight of the subject per two week period, and where the amount is administered in one or more doses during the two week period after initiation of a therapeutic regimen. Also provided, are methods for selecting a treatment regimen for a subject with Alzheimer's disease, including diagnosing the severity of the Alzheimer's disease, determining if the subject carries an APOE4 allele, or both, and assigning a treatment regimen including administration of pooled human immunoglobulin G and / or an anti-beta amyloid monoclonal antibody.