100 results about "Diabetic macular edema" patented technology

The present invention discloses a method for comparing the detection of clinically significant diabetic macular edema by an optical coherence tomography (OCT) grid scanning protocol and biomicroscopic examination. Also provided are computer implemented, automated systems for performing the method thereof and computer readable media encoding the method thereof.

The invention provides methods and compositions for the delivery of lipophilic drugs that are useful for the treatment of various ophthalmological diseases, disorders, and pathologies, including the treatment of age-related macular degeneration, diabetic retinopathy, diabetic macular edema, cancer, and glaucoma.

Disclosed herein are compositions and methods for treating ocular diseases, inter alia, diabetic macular edema, age-related macular degeneration (wet form), choroidal neovascularization, diabetic retinopathy, retinal vein occlusion (central or branch), ocular trauma, surgery induced edema, surgery induced neovascularization, cystoid macular edema, ocular ischemia, uveitis, and the like. These diseases or conditions are characterized by changes in the ocular vasculature whether progressive or non-progressive, whether a result of an acute disease or condition, or a chronic disease or condition.

The present invention relates to the field of ischemic retinopathies. More specifically, the present invention provides methods and compositions useful for treating ischemic retinopathies including diabetic macular edema (DME). The present invention also provides methods for treating ischemic retinopathy comprising the step of administering to a subject diagnosed with ischemic retinopathy an effective amount of an ANGPTL4 antagonist.

Disclosed herein are compositions comprising one or more antibodies that specifically bind active plasma kallikrein (e.g., human plasma kallikrein) and methods of using such compositions for the treatment of retinal diseases, such as diabetic macular edema.

A stable liquid formulation includes a fusion protein having an Fc domain of a human immunoglobulin G (IgG), in particular, a protein in which an Fc domain of a human immunoglobulin G (IgG) and a soluble extracellular domain of a vascular endothelial growth factor (VEGF) receptor are fused (e.g., aflibercept)). A composition for stabilizing a protein and a method for stabilizing a protein in which an Fc domain of an IgG and a soluble extracellular domain of a VEGF receptor are fused are disclosed. The present invention improves therapeutic effects on various ophthalmic diseases (e.g., retinal vein occlusion, diabetic macular edema, choroidal neovascularization and wet age-related macular degeneration, etc.) caused by abnormal angiogenesis, while pursuing stabilization of bioactivity through a stable liquid formulation suitable for intravitreal injection of an anti-VEGF-Fc fusion protein including aflibercept.

The disclosure provides methods and ophthalmic NSAIDs as adjuvants to VEGF inhibitors useful for treating retinal disorders, including but not limited to wet AMD, diabetic retinopathy, diabetic macular edema, central retinal vein occlusion, and branch retinal vein occlusion.

The present invention relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing the fluorinated compounds of the invention, and methods of treating macular degeneration, diabetic retinopathy (DR), macular edema, diabetic macular edema (DME), and macular edema following retinal vein occlusion (RVO), by administering these compounds and pharmaceutical compositions to subjects in need thereof.

The present invention is directed to multi-tyrosine kinase inhibitor compounds. The present invention is further directed to compositions comprising those compounds. Finally, the present invention is directed to methods of treating eye conditions including, but not limited to, diabetic background retinopathy, diabetic macular edema, diabetic proliferative retinopathy, diabetic macular edema with proliferative retinopathy, proliferative fibrovascular disease, diabetic macular edema with proliferative fibrovascular disease, retinopathy of prematurity, dry macular degeneration, dry macular degeneration with drusen and wet macular degeneration, using compounds and compositions of the invention.

The invention provides a cloud retina OCT recognition intelligent diagnosis system based on a software and hardware platform and a use method thereof. The cloud retina OCT recognition intelligent diagnosis system comprises an optical coherence tomography scanner, a doctor client computer, a cloud retina OCT recognition server and a switch. Wherein the optical coherence tomography scanner is connected with the doctor client computer, and the doctor client computer is connected with the cloud retina OCT recognition server through the switch. The choroid neovascularization identification method can rapidly and correctly identify choroid neovascularization, Diabetic macular edema, an OCT image of verruca vitricola and normal retina. The ophthalmic retina OCT cloud server intelligent diagnosissystem based on the embedded software and hardware platform provided by the invention can screen and prevent diseases before diagnosis, assist diagnosis of medical images during diagnosis, analyze examination results, assist operation, and perform medical follow-up visit, chronic disease monitoring, rehabilitation assistance, health management and the like after diagnosis.

Methods of stabilizing and organizing collagen fibrils in extracellular matrix of retinal tissues, particularly Bruch's membranes, and stabilizing retinal pigment epithelial layers lining Bruch's membrane are disclosed. The stabilization and organization may be effected by treating retinal tissues with a protein that crosslinks and organizes collagen fibrils, such as decorin. The stabilization and organization methods include treatment of retinal tissues before, during, or after diagnosis of dry macular degeneration, diagnosis of early stages of diabetic retinopathy and diabetic macular edema to prevent, retard, or limit progression of disorganization of Bruch's membrane and disorganization of retinal pigment epithelial cells lining Bruch's membrane.

The invention discloses a traditional Chinese medicine composition for treating diabetic macular edema. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 20-40 parts of Indian buead peel, 10-30 parts of agaric, 10-20 parts of oriental waterplantain rhizome, 9-15 parts of largehead atractylodes rhizome, 5-15 parts of cassia twig, 5-15 parts of herb of common knotgrass, 5-15 parts of herb of lilac pink, 20-40 parts of lalang grass rhizome, 10-30 parts of motherwort herb, 10-20 parts of plantain seed, 10-30 parts of root of lobed kudzuvine, 10-20 parts of hirsute shiny bugleweed herb, 10-30 parts of Japanese thistle herbor root, 10-30 parts of common cephalanoplos herb, 10-30 parts of Chinese waxgourd peel, 10-20 parts of raw milkvetch root, 3-9 parts of safflower, 9-15 parts of medicinal cyathula root and 10-30 parts of rice beans. The traditional Chinese medicine composition disclosed by the invention has the effects of soothing the liver, strengthening the spleen, activating blood, dissolving stasis, expelling phlegm, promoting diuresis, and clearing heat and removing toxicity, has significant curative effects and reliable functions on diabetic macular edema, is prepared from easily available medicinal raw materials, is simple and convenient to prepare, and cannot cause toxic or side effect.

The present invention provides biomarkers of oxidative stress in subjects with retinitis pigmentosa, age-related macular degeneration, diabetic retinopathy, Fuchs' dystrophy, diabetic macular edema (DME), geographic atrophy, Stargardt's disease, or retinal vein occlusion (RVO), and their use in identifying subjects in need of treatment and methods for staging the severity of the disease.

The present invention relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing the fluorinated compounds of the invention, and methods of treating fibrosis, macular degeneration, diabetic retinopathy (DR), macular edema, diabetic macular edema (DME), and macular edema following retinal vein occlusion (RVO), by administering these compounds and pharmaceutical compositions to subjects in need thereof.