100 results about "Lipophilic drug" patented technology

Stable solutions of lipophilic drugs, such as cyclosporin, forming a polar lipid self-emulsifying drug delivery system. The solutions can include lipophilic drugs, such as cyclosporin, dissolved in a polar lipid, such as having a C₆-C₁₂ fatty acid monoglyceride content of at least about 50%, surfactants and triglycerides. The composition forms a fine emulsion on exposure to water. The encapsulated dosage form of this composition needs neither a hydrophilic component nor air-tight blister packaging, and is particularly suitable for oral administration.

Methods for improving solubility and bioavailability of lipophilic compounds are described. Particularly, described are stabilized superstaturated solid solutions, particularly in power form, of lipophilic drugs, such as steroidal molecules.

A formulation for drug delivery, providing enhanced modulation of solubility, stability, absorption, metabolism, and/or pharmacokinetic profile of a lipophilic therapeutic agent by formulation with sterols and/or sterol esters, resulting in higher bioavailability of a therapeutic agent administered to a subject in need of such therapeutic agent. The formulation contains a therapeutic agent and a sterol or sterol ester, and can, optionally, further contain a solubilizer and/or an enhancing agent. Also described are pharmaceutical compositions containing the formulations and methods of making and methods of using the formulations and pharmaceutical compositions. Formulations of the disclosure can be constituted to minimize the synthesis of dihydrotestosterone when the therapeutic agent includes testosterone or testosterone esters.

The invention provides methods and compositions for the delivery of lipophilic drugs that are useful for the treatment of various ophthalmological diseases, disorders, and pathologies, including the treatment of age-related macular degeneration, diabetic retinopathy, diabetic macular edema, cancer, and glaucoma.

The present invention provides microspheres comprising a plurality of nanocapsules accommodated in a gel forming polymer, the plurality of nanocapsules comprising an oil core carrying a non hydrophilic active agent and a shell of polymeric coating. The invention also provides a method for preparing the microspheres of the invention, pharmaceutical compositions comprising the same as well as methods of use of the microspheres, specifically, in therapeutic, cosmetic and diagnostic applications.

The present invention relates to pharmaceutical compositions and methods for the mucosal and oral administration of monoterpenes and derivatives thereof. The compositions of this invention further comprise one or more surfactants and cosolvents and are in the form of self-emulsifying compositions. The compositions of the invention may further comprise water-insoluble therapeutic agents, vaccines and diagnostics. Such agents include but are not limited to taxanes, steroids, topoisomerase inhibitors such as etoposide and other water-insoluble or lipophilic drugs.

The present invention is the preparation process of new cyclodextrin inclusion of lipophilic medicine, and solves the problem in preparing inclusion of lipophilic medicine with poor water solubility and lower stability. The preparation process completed inside co-solvent system of tert-butyl alcohol and water includes the following steps: dissolving the lipophilic medicine and cyclodextrin as including material separately in tert-butyl alcohol and water, mixing the obtained two kinds of solution to obtain single phase solution, and drying the mixed solution to obtain powder of cyclodextrin inclusion of lipophilic medicine. The present invention may prepare powder for injection, injection, tablet, capsule or other form. The present invention has simple preparation process, easy operation, short preparation period, low power consumption and no organic solvent residue, and is suitable for industrial production.

The invention provides compositions and methods for delivery of a bioactive agent to an individual. Delivery vehicles are provided that include a bioactive agent in disc shaped particles that include one or more lipid binding polypeptides circumscribing the perimeter of a lipid bilayer in which the bioactive agent is localized. Chimeric lipid binding polypeptides are also provided and may be used to add additional functional properties to the delivery particles.

The invention discloses a double-layer sustained and controlled release nanoparticle and a preparation method thereof and application in preparation of antitumor medicines. The double-layer sustained and controlled release nanoparticle is formed by a lactic acid-glycolic acid copolymer nanoparticle inner core and a polyethylene glycol questin grafting chitosan casing covering an outer layer of the lactic acid-glycolic acid copolymer nanoparticle inner core and can simultaneously load hydrophilic and lipophilic medicines. The drug entrapment rate is high, time-ordered release of inner layer medicines and outer layer medicines can be achieved, the double-layer sustained and controlled release nanoparticle has the effects of sustained release and controlled release, and in addition, the double-layer sustained and controlled release nanoparticle further has the advantages of being controllable in grain size, uniform in particle size distribution, smooth and round in forma and good in stability and dispersibility and the like.

The invention pertains to a self-emulsifying pharmaceutical composition containing a lipophilic drug, a surfactant, and a hydrophilic carrier. The invention also provides a method for making the pharmaceutical composition for increasing the bioavailability of a drug by self-emulsification.

The invention discloses an iontophoretic transdermal drug delivery system which comprises a low and middle frequency pulse electronic generator, a conductor wire and a hydrosol pulse electrode; the low and middle frequency pulse electronic generator is connected with the hydrosol pulse electrode through the conductor wire; a drug carrier of the hydrosol pulse electrode of the system is prepared from a medical hydrosol and has the characteristics of good compatibility and permeability promoting property to drugs and good compatibility with human bodies; and the drug carrier can be used as a transdermal drug delivery carrier for macromolecular drugs, micromolecular drugs, hydrophilic drugs, lipophilic drugs and the like and can also be used as a transdermal drug delivery carrier of some biological drugs of polypeptide, protein and the like. Low and middle frequency pulse electrons generated by the system have a good permeability promoting action and a directional introduction function to the drugs.

The present invention relates to the paclitaxel mixed composition and water-in-oil type emulsion formulation for chemoembolization and preparation method thereof. The combinatory formulation of anticancer drugs can be easily prepared since the emulsion formulation of the present invention can include other hydrophilic or lipophilic drugs.

An adhesive which comprises aqueous and nonaqueous polymers suitable for holding an lipophilic drug, etc., and has tackiness and cohesiveness which are sufficient for the plaster of a patch; and a patch employing the adhesive. The adhesive contains a polymer which comprises one or more kinds of acrylic or methacrylic monomer units, at least one kind of the monomer units having a hydroxy group, and which has been crosslinked with a boron compound.

The invention discloses a nanometer lipid cubic crystal preparation, which comprises fat-soluble medicine, amphiphilic lipid, stabilizer and water. The invention also discloses a preparation method of the nanometer lipid cubic crystal preparation and an application of the nanometer lipid cubic crystal in preparation of an ophthalmic drug preparation for treating ophthalmic diseases. The nano lipid cubic crystal preparation of the present invention can significantly improve the corneal penetration ability of drugs, has better stability than liposomes and nanoparticles, can realize high-pressure high-temperature sterilization, has good drug release characteristics, and has broad clinical applications and market prospects.

Diacyl lipid-polymer conjugates are used to enhance the solubility of lipophilic drugs in aqueous solution. The conjugates comprise a backbone, two lipophilic acyl groups and a hydrophilic polymer.

Methods of treatment of conditions which require phytosterol therapy without adversely affecting the bioavailability of lipophilic vitamins or lipophilic drugs, consisting of administering a mixture of phytosterol ester(s) (PS-E) and 1,3-diglyceride(s) (DAG) dissolved in an edible oil or fat are described herein, together with a method of improving weight management and a method of treating metabolic conditions that result in overweight. Dietary nutrients, food supplements and food articles containing said mixture are also described herein.

The invention discloses a preparation method and application of cyclodextrin-drug host-guest supramolecular modified hydrogel, which comprises the following steps: firstly, adopting cyclodextrin derivatives grafted with double bonds to include lipophilic drugs under the action of host-guest to form nano drug boxes which are uniformly dispersed under the condition of water phase; then introducing the nano drug boxes into a photocrosslinkable hydrogel solution to crosslink under ultraviolet light to form a corresponding liquid drug-carrying gel matrix. According to the invention, the crosslinking density, mechanical strength and drug-carrying density of the hydrogel can be adjusted by changing the grafting rate and mass fraction of the ingredients. The hydrogel has good biocompatibility andcan be used for three-dimensional culture of cells, can encapsulate stem cells with rapid proliferation and multiple differentiation potentials and achieves directional differentiation of the stem cells under the induction of drugs. The material is combined with stem cell therapy to achieve rapid tissue repair, which has obvious advantages.